Nature Neuroscience. doi:10.1038/nn.3843
Authors: Colin G McNamara, Álvaro Tejero-Cantero, Stéphanie Trouche, Natalia Campo-Urriza & David Dupret
We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest. When applied during spatial learning of new goal locations, dopaminergic photostimulation improved the later recall of neural representations of space and stabilized memory performance. These findings reveal that midbrain dopaminergic neurons promote hippocampal network dynamics associated with memory persistence.
Nature Neuroscience. doi:10.1038/nn.3846
Authors: Alexander C W Smith, Yonatan M Kupchik, Michael D Scofield, Cassandra D Gipson, Armina Wiggins, Charles A Thomas & Peter W Kalivas
Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administered cocaine and transient increases in MMP-9 during cue-induced cocaine relapse. Cue-induced heroin and nicotine relapse increased MMP activity, and increased MMP activity was required for both cocaine relapse and relapse-associated synaptic plasticity.
Nature Neuroscience. doi:10.1038/nn.3842
Authors: Liane Schmidt, Erin Kendall Braun, Tor D Wager & Daphna Shohamy
Nature Neuroscience. doi:10.1038/nn.3836
Authors: Laurence T Hunt, Raymond J Dolan & Timothy E J Behrens
Nature Neuroscience. doi:10.1038/nn.3835
Authors: Douglas A Ruff & Marlene R Cohen
Nature Neuroscience. doi:10.1038/nn.3831
Authors: Ryan Insolera, Hisham Bazzi, Wei Shao, Kathryn V Anderson & Song-Hai Shi
Anchoring the neural compass: coding of local spatial reference frames in human medial parietal lobe
Nature Neuroscience. doi:10.1038/nn.3834
Authors: Steven A Marchette, Lindsay K Vass, Jack Ryan & Russell A Epstein
Nature Neuroscience. doi:10.1038/nn.3832
Authors: Mathieu Roy, Daphna Shohamy, Nathaniel Daw, Marieke Jepma, G Elliott Wimmer & Tor D Wager
Nature Neuroscience. doi:10.1038/nn.3815
Authors: Robert A Hill, Kiran D Patel, Christopher M Goncalves, Jaime Grutzendler & Akiko Nishiyama
Nature Neuroscience. doi:10.1038/nn.3827
Authors: Suewei Lin, David Owald, Vikram Chandra, Clifford Talbot, Wolf Huetteroth & Scott Waddell
Nature Neuroscience. doi:10.1038/nn.3828
Authors: Nevena Milenkovic, Wen-Jie Zhao, Jan Walcher, Tobias Albert, Jan Siemens, Gary R Lewin & James F A Poulet
Nature Neuroscience. doi:10.1038/nn.3826
Authors: Masayoshi Murakami, M Inês Vicente, Gil M Costa & Zachary F Mainen
Nature Neuroscience 17, 1289 (2014). doi:10.1038/nn.3830
Large-scale consortia have benefited many fields chasing big data. In the face of new projects, neuroscientists should consider banding together.
Nature Neuroscience 17, 1290 (2014). doi:10.1038/nn.3820
Author: David T Blake
The tactile sensors in our fingers have variable sensitivity across the skin. Does this variability harm or help the CNS in touch perception? Work now shows that this variability may provide the CNS with more information about micropositioning and stimulus orientation.
Nature Neuroscience 17, 1291 (2014). doi:10.1038/nn.3819
Authors: Sietse Jonkman & Paul J Kenny
How do enhancers facilitate transcription of plasticity-related genes in response to synaptic stimulation? A study implicates a specific histone modification and suggests that FOS regulates enhancer function.
Nature Neuroscience 17, 1293 (2014). doi:10.1038/nn.3825
Authors: Iva D Tzvetanova & Klaus-Armin Nave
Long axonal projections seem to be metabolically coupled to ensheathing glial cells. Targeting LKB1, a regulator of energy homeostasis, specifically in Schwann cells causes a loss of predominantly small unmyelinated fibers.
Nature Neuroscience 17, 1295 (2014). doi:10.1038/nn.3817
Author: Aniruddha Das
As we learn through visual experience, where does that memory form? A study now shows that neural responses at even the earliest stage of visual cortex get reshaped in a way that faithfully reflects ongoing learning.
Nature Neuroscience 17, 1297 (2014). doi:10.1038/nn1014-1297
Author: Sébastien Thuault
Nature Neuroscience 17, 1298 (2014). doi:10.1038/nn.3810
Authors: Stephen V Mahler, David E Moorman, Rachel J Smith, Morgan H James & Gary Aston-Jones
Nature Neuroscience 17, 1304 (2014). doi:10.1038/nn.3811
Authors: Edita Navratilova & Frank Porreca