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The coding of cutaneous temperature in the spinal cord

Nature Neuroscience - Mon, 07/25/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4350

Authors: Chen Ran, Mark A Hoon & Xiaoke Chen

Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning

Nature Neuroscience - Mon, 07/25/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4351

Authors: Lin Xiao, David Ohayon, Ian A McKenzie, Alexander Sinclair-Wilson, Jordan L Wright, Alexander D Fudge, Ben Emery, Huiliang Li & William D Richardson

Sensory and decision-related activity propagate in a cortical feedback loop during touch perception

Nature Neuroscience - Wed, 07/20/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4356

Authors: Sung Eun Kwon, Hongdian Yang, Genki Minamisawa & Daniel H O'Connor

Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior

Nature Neuroscience - Mon, 07/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4347

Authors: Alexi Nott, Jemmie Cheng, Fan Gao, Yuan-Ta Lin, Elizabeta Gjoneska, Tak Ko, Paras Minhas, Alicia Viridiana Zamudio, Jia Meng, Feiran Zhang, Peng Jin & Li-Huei Tsai

Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics

Nature Neuroscience - Mon, 07/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4346

Authors: Yair Shemesh, Oren Forkosh, Mathias Mahn, Sergey Anpilov, Yehezkel Sztainberg, Sharon Manashirov, Tamar Shlapobersky, Evan Elliott, Laure Tabouy, Gili Ezra, Elaine S Adler, Yair J Ben-Efraim, Shosh Gil, Yael Kuperman, Sharon Haramati, Julien Dine, Matthias Eder, Jan M Deussing, Elad Schneidman, Ofer Yizhar & Alon Chen

Infantile amnesia reflects a developmental critical period for hippocampal learning

Nature Neuroscience - Mon, 07/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4348

Authors: Alessio Travaglia, Reto Bisaz, Eric S Sweet, Robert D Blitzer & Cristina M Alberini

ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks

Nature Neuroscience - Mon, 07/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4345

Authors: Ritchie Ho, Samuel Sances, Genevieve Gowing, Mackenzie Weygandt Amoroso, Jacqueline G O'Rourke, Anais Sahabian, Hynek Wichterle, Robert H Baloh, Dhruv Sareen & Clive N Svendsen

Postsynaptic, not presynaptic NMDA receptors are required for spike-timing-dependent LTD induction

Nature Neuroscience - Mon, 07/11/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4343

Authors: Brett C Carter & Craig E Jahr

Neural activity promotes long-distance, target-specific regeneration of adult retinal axons

Nature Neuroscience - Mon, 07/11/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4340

Authors: Jung-Hwan A Lim, Benjamin K Stafford, Phong L Nguyen, Brian V Lien, Chen Wang, Katherine Zukor, Zhigang He & Andrew D Huberman

Fast and slow transitions in frontal ensemble activity during flexible sensorimotor behavior

Nature Neuroscience - Mon, 07/11/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4342

Authors: Michael J Siniscalchi, Victoria Phoumthipphavong, Farhan Ali, Marc Lozano & Alex C Kwan

Multilaminar networks of cortical neurons integrate common inputs from sensory thalamus

Nature Neuroscience - Mon, 07/04/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4339

Authors: Nicolás A Morgenstern, Jacques Bourg & Leopoldo Petreanu

Epigenetics, behavior and early nicotine

Neuroscience in the News - Tue, 06/28/2016 - 12:00am

Nature Neuroscience 19, 863 (2016). doi:10.1038/nn.4330

Authors: Rafael Maldonado & Miquel Martin

Early nicotine exposure during brain development may cause long-lasting neurobiological and behavioral alterations in adulthood. Jung et al. present insights into the mechanisms mediating these developmental changes.

PAM helps solve VTA's SHANKless problem

Neuroscience in the News - Tue, 06/28/2016 - 12:00am

Nature Neuroscience 19, 864 (2016). doi:10.1038/nn.4336

Authors: Michael F Priest & Yevgenia Kozorovitskiy

Developmental knockdown of Shank3 affects excitatory synaptic transmission, activity of midbrain dopamine neurons, and behavior. Optogenetic dopamine release or enhancing metabotropic glutamate receptor signaling rescues these deficits.

The dynamic nature of value-based decisions

Neuroscience in the News - Tue, 06/28/2016 - 12:00am

Nature Neuroscience 19, 866 (2016). doi:10.1038/nn.4329

Authors: Katherine E Conen & Camillo Padoa-Schioppa

During a binary choice task, neuronal activity in monkey orbitofrontal cortex alternated between two network states. The internal dynamics revealed by a linear decoder correlated with the reaction time and with the eventual choice.

Hyperkinetic disorders and loss of synaptic downscaling

Neuroscience in the News - Tue, 06/28/2016 - 12:00am

Nature Neuroscience 19, 868 (2016). doi:10.1038/nn.4306

Authors: Paolo Calabresi, Antonio Pisani, John Rothwell, Veronica Ghiglieri, Josè A Obeso & Barbara Picconi

Segregated cholinergic transmission modulates dopamine neurons integrated in distinct functional circuits

Nature Neuroscience - Mon, 06/27/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4335

Authors: Daniel Dautan, Albert S Souza, Icnelia Huerta-Ocampo, Miguel Valencia, Maxime Assous, Ilana B Witten, Karl Deisseroth, James M Tepper, J Paul Bolam, Todor V Gerdjikov & Juan Mena-Segovia

Shifted pallidal co-release of GABA and glutamate in habenula drives cocaine withdrawal and relapse

Nature Neuroscience - Mon, 06/27/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4334

Authors: Frank J Meye, Mariano Soiza-Reilly, Tamar Smit, Marco A Diana, Martin K Schwarz & Manuel Mameli

Dynamic regulation of RNA editing in human brain development and disease

Nature Neuroscience - Mon, 06/27/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4337

Authors: Taeyoung Hwang, Chul-Kee Park, Anthony K L Leung, Yuan Gao, Thomas M Hyde, Joel E Kleinman, Anandita Rajpurohit, Ran Tao, Joo Heon Shin & Daniel R Weinberger

Glucose-responsive neurons of the paraventricular thalamus control sucrose-seeking behavior

Nature Neuroscience - Mon, 06/20/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4331

Authors: Gwenaël Labouèbe, Benjamin Boutrel, David Tarussio & Bernard Thorens

Feeding behavior is governed by homeostatic needs and motivational drive to obtain palatable foods. Here, we identify a population of glutamatergic neurons in the paraventricular thalamus of mice that express the glucose transporter Glut2 (encoded by Slc2a2) and project to the nucleus accumbens. These neurons are activated by hypoglycemia and, in freely moving mice, their activation by optogenetics or Slc2a2 inactivation increases motivated sucrose-seeking but not saccharin-seeking behavior. These neurons may control sugar overconsumption in obesity and diabetes.

Bidirectional prefrontal-hippocampal interactions support context-guided memory

Nature Neuroscience - Mon, 06/20/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4327

Authors: Ryan Place, Anja Farovik, Marco Brockmann & Howard Eichenbaum

We compared the dynamics of hippocampal and prefrontal interactions in rats as they used spatial contexts to guide the retrieval of object memories. Functional connectivity analysis indicated a flow of contextual information from the hippocampus to prefrontal cortex upon the rat's entry into the spatial context. Conversely, upon the onset of object sampling, the direction of information flow reversed, consistent with prefrontal control over the retrieval of context-appropriate hippocampal memory representations.

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