Nature Neuroscience. doi:10.1038/nn.4136
Authors: Karin Foerde, Joanna E Steinglass, Daphna Shohamy & B Timothy Walsh
People routinely make poor choices, despite knowledge of negative consequences. We found that individuals with anorexia nervosa, who make maladaptive food choices to the point of starvation, engaged the dorsal striatum more than healthy controls when making choices about what to eat, and that activity in fronto-striatal circuits was correlated with their actual food consumption in a meal the next day.
Nature Neuroscience. doi:10.1038/nn.4137
Authors: Marc Aurel Busche, Maja Kekuš, Helmuth Adelsberger, Takahiro Noda, Hans Förstl, Israel Nelken & Arthur Konnerth
Nature Neuroscience. doi:10.1038/nn.4135
Authors: Emily S Finn, Xilin Shen, Dustin Scheinost, Monica D Rosenberg, Jessica Huang, Marvin M Chun, Xenophon Papademetris & R Todd Constable
Nature Neuroscience. doi:10.1038/nn.4143
Authors: Min Xu, Shinjae Chung, Siyu Zhang, Peng Zhong, Chenyan Ma, Wei-Cheng Chang, Brandon Weissbourd, Noriaki Sakai, Liqun Luo, Seiji Nishino & Yang Dan
Nature Neuroscience. doi:10.1038/nn.4131
Authors: Laura A DeNardo, Dominic S Berns, Katherine DeLoach & Liqun Luo
Nature Neuroscience. doi:10.1038/nn.4129
Authors: Hila Harris, David Israeli, Nancy Minshew, Yoram Bonneh, David J Heeger, Marlene Behrmann & Dov Sagi
Inflexible behavior is a core characteristic of autism spectrum disorder (ASD), but its underlying cause is unknown. Using a perceptual learning protocol, we observed initially efficient learning in ASD that was followed by anomalously poor learning when the location of the target was changed (over-specificity). Reducing stimulus repetition eliminated over-specificity. Our results indicate that inflexible behavior may be evident ubiquitously in ASD, even in sensory learning, but can be circumvented by specifically designed stimulation protocols.
Nature Neuroscience. doi:10.1038/nn.4132
Authors: Hirohide Asai, Seiko Ikezu, Satoshi Tsunoda, Maria Medalla, Jennifer Luebke, Tarik Haydar, Benjamin Wolozin, Oleg Butovsky, Sebastian Kügler & Tsuneya Ikezu
Nature Neuroscience. doi:10.1038/nn.4130
Authors: Jan Brascamp, Randolph Blake & Tomas Knapen
Nature Neuroscience. doi:10.1038/nn.4128
Authors: Ruben Coen-Cagli, Adam Kohn & Odelia Schwartz
Nature Neuroscience. doi:10.1038/nn.4133
Authors: Wan-chun Liu, Jessica Kohn, Sarah K Szwed, Eben Pariser, Sharon Sepe, Bhagwattie Haripal, Naoki Oshimori, Martin Marsala, Atsushi Miyanohara & Ramee Lee
Nature Neuroscience. doi:10.1038/nn.4126
Authors: Gail Chan, Charles C White, Phoebe A Winn, Maria Cimpean, Joseph M Replogle, Laura R Glick, Nicole E Cuerdon, Katie J Ryan, Keith A Johnson, Julie A Schneider, David A Bennett, Lori B Chibnik, Reisa A Sperling, Elizabeth M Bradshaw & Philip L De Jager
We used a protein quantitative trait analysis in monocytes from 226 individuals to evaluate cross-talk between Alzheimer loci. The NME8 locus influenced PTK2B and the CD33 risk allele led to greater TREM2 expression. There was also a decreased TREM1/TREM2 ratio with a TREM1 risk allele, decreased TREM2 expression with CD33 suppression and elevated cortical TREM2 mRNA expression with amyloid pathology.
A positive-negative mode of population covariation links brain connectivity, demographics and behavior
Nature Neuroscience. doi:10.1038/nn.4125
Authors: Stephen M Smith, Thomas E Nichols, Diego Vidaurre, Anderson M Winkler, Timothy E J Behrens, Matthew F Glasser, Kamil Ugurbil, Deanna M Barch, David C Van Essen & Karla L Miller
We investigated the relationship between individual subjects' functional connectomes and 280 behavioral and demographic measures in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of population co-variation: subjects were predominantly spread along a single 'positive-negative' axis linking lifestyle, demographic and psychometric measures to each other and to a specific pattern of brain connectivity.
Nature Neuroscience. doi:10.1038/nn.4123
Authors: Scott Pluta, Alexander Naka, Julia Veit, Gregory Telian, Lucille Yao, Richard Hakim, David Taylor & Hillel Adesnik
Nature Neuroscience 18, 1343 (2015). doi:10.1038/nn.4127
We present a special issue focusing on recent advances in the understanding of the effects of stress on the nervous system and behavior, as well as the role of the nervous system in regulating responses to stress.
Nature Neuroscience 18, 1344 (2015). doi:10.1038/nn.4109
Author: Robert M Sapolsky
It is a truism that the brain influences the body and that peripheral physiology influences the brain. Never is this clearer than during stress, where the subtlest emotions or the most abstract thoughts can initiate stress responses, with consequences throughout the body, and the endocrine transducers of stress alter cognition, affect and behavior. For a fervent materialist, few things in life bring more pleasure than contemplating the neurobiology of stress.
Nature Neuroscience 18, 1347 (2015). doi:10.1038/nn.4111
Authors: Ahmad R Hariri & Andrew Holmes
Nature Neuroscience 18, 1353 (2015). doi:10.1038/nn.4086
Authors: Bruce S McEwen, Nicole P Bowles, Jason D Gray, Matthew N Hill, Richard G Hunter, Ilia N Karatsoreos & Carla Nasca
Nature Neuroscience 18, 1364 (2015). doi:10.1038/nn.4115
Authors: Sumantra Chattarji, Anupratap Tomar, Aparna Suvrathan, Supriya Ghosh & Mohammed Mostafizur Rahman
Nature Neuroscience 18, 1376 (2015). doi:10.1038/nn.4087
Author: Amy F T Arnsten
Nature Neuroscience 18, 1386 (2015). doi:10.1038/nn.4113
Authors: Georgia E Hodes, Veronika Kana, Caroline Menard, Miriam Merad & Scott J Russo