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A new fate mapping system reveals context-dependent random or clonal expansion of microglia

Nature Neuroscience - Mon, 04/17/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4547

Authors: Tuan Leng Tay, Dominic Mai, Jana Dautzenberg, Francisco Fernández-Klett, Gen Lin, Sagar, Moumita Datta, Anne Drougard, Thomas Stempfl, Alberto Ardura-Fabregat, Ori Staszewski, Anca Margineanu, Anje Sporbert, Lars M Steinmetz, J Andrew Pospisilik, Steffen Jung, Josef Priller, Dominic Grün, Olaf Ronneberger & Marco Prinz

Dynamic hidden states underlying working-memory-guided behavior

Nature Neuroscience - Mon, 04/17/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4546

Authors: Michael J Wolff, Janina Jochim, Elkan G Akyürek & Mark G Stokes

Comprehensive transcriptome analysis of neocortical layers in humans, chimpanzees and macaques

Nature Neuroscience - Mon, 04/17/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4548

Authors: Zhisong He, Dingding Han, Olga Efimova, Patricia Guijarro, Qianhui Yu, Anna Oleksiak, Shasha Jiang, Konstantin Anokhin, Boris Velichkovsky, Stefan Grünewald & Philipp Khaitovich

Sharp wave ripples during learning stabilize the hippocampal spatial map

Nature Neuroscience - Mon, 04/10/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4543

Authors: Lisa Roux, Bo Hu, Ronny Eichler, Eran Stark & György Buzsáki

The neural correlates of dreaming

Nature Neuroscience - Mon, 04/10/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4545

Authors: Francesca Siclari, Benjamin Baird, Lampros Perogamvros, Giulio Bernardi, Joshua J LaRocque, Brady Riedner, Melanie Boly, Bradley R Postle & Giulio Tononi

Abnormal wiring of CCK+ basket cells disrupts spatial information coding

Nature Neuroscience - Mon, 04/10/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4544

Authors: Isabel del Pino, Jorge R Brotons-Mas, André Marques-Smith, Aline Marighetto, Andreas Frick, Oscar Marín & Beatriz Rico

Dopamine transients are sufficient and necessary for acquisition of model-based associations

Nature Neuroscience - Mon, 04/03/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4538

Authors: Melissa J Sharpe, Chun Yun Chang, Melissa A Liu, Hannah M Batchelor, Lauren E Mueller, Joshua L Jones, Yael Niv & Geoffrey Schoenbaum

GLP-1 acts on habenular avoidance circuits to control nicotine intake

Nature Neuroscience - Mon, 04/03/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4540

Authors: Luis M Tuesta, Zuxin Chen, Alexander Duncan, Christie D Fowler, Masago Ishikawa, Brian R Lee, Xin-An Liu, Qun Lu, Michael Cameron, Matthew R Hayes, Theodore M Kamenecka, Matthew Pletcher & Paul J Kenny

Cocaine, cadherins and synaptic plasticity

Neuroscience in the News - Wed, 03/29/2017 - 12:00am

Nature Neuroscience 20, 499 (2017). doi:10.1038/nn.4535

Authors: Kristina Valentinova & Manuel Mameli

Addictive substances hijack the reward system partly via synaptic plasticity onto dopamine neurons. Cadherins may contribute to cocaine-evoked adaptations, supporting the notion that drug addiction is a synaptic disease.

A neuronal mechanism for recall of bad events

Neuroscience in the News - Wed, 03/29/2017 - 12:00am

Nature Neuroscience 20, 501 (2017). doi:10.1038/nn.4525

Authors: Chenguang Zheng & Laura Lee Colgin

Hippocampal place cells are traditionally thought to represent locations where animals currently are or predict where they are headed. However, new results reveal that place cells also represent distant places that are actively avoided.

Adolescence, brain maturation and mental health

Neuroscience in the News - Wed, 03/29/2017 - 12:00am

Nature Neuroscience 20, 503 (2017). doi:10.1038/nn.4530

Author: Adriana Galván

The rate of development of the brain connectome distinguishes adolescents with and without psychiatric symptoms. Those with symptoms exhibit delayed development of connectome distinctiveness as compared to healthy adolescents.

Motivational neural circuits underlying reinforcement learning

Neuroscience in the News - Wed, 03/29/2017 - 12:00am

Nature Neuroscience 20, 505 (2017). doi:10.1038/nn.4506

Authors: Bruno B Averbeck & Vincent D Costa

Activity-induced histone modifications govern Neurexin-1 mRNA splicing and memory preservation

Nature Neuroscience - Mon, 03/27/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4536

Authors: Xinlu Ding, Sanxiong Liu, Miaomiao Tian, Wenhao Zhang, Tao Zhu, Dongdong Li, Jiawei Wu, HaiTeng Deng, Yichang Jia, Wei Xie, Hong Xie & Ji-Song Guan

Purine synthesis promotes maintenance of brain tumor initiating cells in glioma

Nature Neuroscience - Mon, 03/27/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4537

Authors: Xiuxing Wang, Kailin Yang, Qi Xie, Qiulian Wu, Stephen C Mack, Yu Shi, Leo J Y Kim, Briana C Prager, William A Flavahan, Xiaojing Liu, Meromit Singer, Christopher G Hubert, Tyler E Miller, Wenchao Zhou, Zhi Huang, Xiaoguang Fang, Aviv Regev, Mario L Suvà, Tae Hyun Hwang, Jason W Locasale, Shideng Bao & Jeremy N Rich

Cerebellar granule cells acquire a widespread predictive feedback signal during motor learning

Nature Neuroscience - Mon, 03/20/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4531

Authors: Andrea Giovannucci, Aleksandra Badura, Ben Deverett, Farzaneh Najafi, Talmo D Pereira, Zhenyu Gao, Ilker Ozden, Alexander D Kloth, Eftychios Pnevmatikakis, Liam Paninski, Chris I De Zeeuw, Javier F Medina & Samuel S-H Wang

Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow

Nature Neuroscience - Mon, 03/20/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4533

Authors: Thomas A Longden, Fabrice Dabertrand, Masayo Koide, Albert L Gonzales, Nathan R Tykocki, Joseph E Brayden, David Hill-Eubanks & Mark T Nelson

C1 neurons mediate a stress-induced anti-inflammatory reflex in mice

Nature Neuroscience - Mon, 03/13/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4526

Authors: Chikara Abe, Tsuyoshi Inoue, Mabel A Inglis, Kenneth E Viar, Liping Huang, Hong Ye, Diane L Rosin, Ruth L Stornetta, Mark D Okusa & Patrice G Guyenet

Regulatory T cells promote myelin regeneration in the central nervous system

Nature Neuroscience - Mon, 03/13/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4528

Authors: Yvonne Dombrowski, Thomas O'Hagan, Marie Dittmer, Rosana Penalva, Sonia R Mayoral, Peter Bankhead, Samara Fleville, George Eleftheriadis, Chao Zhao, Michelle Naughton, Rachel Hassan, Jill Moffat, John Falconer, Amanda Boyd, Peter Hamilton, Ingrid V Allen, Adrien Kissenpfennig, Paul N Moynagh, Emma Evergren, Bernard Perbal, Anna C Williams, Rebecca J Ingram, Jonah R Chan, Robin J M Franklin & Denise C Fitzgerald

Manipulating fear associations via optogenetic modulation of amygdala inputs to prefrontal cortex

Nature Neuroscience - Mon, 03/13/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4523

Authors: Oded Klavir, Matthias Prigge, Ayelet Sarel, Rony Paz & Ofer Yizhar

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