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Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control

Nature Neuroscience - Mon, 08/29/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4376

Authors: Alessandro Furlan, Gioele La Manno, Moritz Lübke, Martin Häring, Hind Abdo, Hannah Hochgerner, Jussi Kupari, Dmitry Usoskin, Matti S Airaksinen, Guillermo Oliver, Sten Linnarsson & Patrik Ernfors

Episodic sequence memory is supported by a theta–gamma phase code

Nature Neuroscience - Mon, 08/29/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4374

Authors: Andrew C Heusser, David Poeppel, Youssef Ezzyat & Lila Davachi

Genome-wide, integrative analysis implicates microRNA dysregulation in autism spectrum disorder

Nature Neuroscience - Mon, 08/29/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4373

Authors: Ye E Wu, Neelroop N Parikshak, T Grant Belgard & Daniel H Geschwind

Focus on the neuroscience toolbox

Neuroscience in the News - Fri, 08/26/2016 - 12:00am

Nature Neuroscience 19, 1117 (2016). doi:10.1038/nn.4379

We present a special issue on the neuroscience toolbox, highlighting recent technological advances, approaches and collaborative initiatives that are enabling new avenues of research.

Worldwide initiatives to advance brain research

Neuroscience in the News - Fri, 08/26/2016 - 12:00am

Nature Neuroscience 19, 1118 (2016). doi:10.1038/nn.4371

Authors: Sten Grillner, Nancy Ip, Christof Koch, Walter Koroshetz, Hideyuki Okano, Miri Polachek, Mu-ming Poo & Terrence J Sejnowski

To highlight worldwide efforts to fund neuroscience research and address the growing threat of brain disorders, Nature Neuroscience asked leaders of six global brain initiatives to write about their programs.

Opportunities and challenges in modeling human brain disorders in transgenic primates

Neuroscience in the News - Fri, 08/26/2016 - 12:00am

Nature Neuroscience 19, 1123 (2016). doi:10.1038/nn.4362

Authors: Charles Jennings, Rogier Landman, Yang Zhou, Jitendra Sharma, Julia Hyman, J Anthony Movshon, Zilong Qiu, Angela Roberts, Anna Wang Roe, Xiaoqin Wang, Huihui Zhou, Liping Wang, Feng Zhang, Robert Desimone & Guoping Feng

Disentangling neural cell diversity using single-cell transcriptomics

Neuroscience in the News - Fri, 08/26/2016 - 12:00am

Nature Neuroscience 19, 1131 (2016). doi:10.1038/nn.4366

Authors: Jean-Francois Poulin, Bosiljka Tasic, Jens Hjerling-Leffler, Jeffrey M Trimarchi & Rajeshwar Awatramani

Genetically encoded indicators of neuronal activity

Neuroscience in the News - Fri, 08/26/2016 - 12:00am

Nature Neuroscience 19, 1142 (2016). doi:10.1038/nn.4359

Authors: Michael Z Lin & Mark J Schnitzer

Technologies for imaging neural activity in large volumes

Neuroscience in the News - Fri, 08/26/2016 - 12:00am

Nature Neuroscience 19, 1154 (2016). doi:10.1038/nn.4358

Authors: Na Ji, Jeremy Freeman & Spencer L Smith

Improving data quality in neuronal population recordings

Neuroscience in the News - Fri, 08/26/2016 - 12:00am

Nature Neuroscience 19, 1165 (2016). doi:10.1038/nn.4365

Authors: Kenneth D Harris, Rodrigo Quian Quiroga, Jeremy Freeman & Spencer L Smith

The Human Connectome Project's neuroimaging approach

Neuroscience in the News - Fri, 08/26/2016 - 12:00am

Nature Neuroscience 19, 1175 (2016). doi:10.1038/nn.4361

Authors: Matthew F Glasser, Stephen M Smith, Daniel S Marcus, Jesper L R Andersson, Edward J Auerbach, Timothy E J Behrens, Timothy S Coalson, Michael P Harms, Mark Jenkinson, Steen Moeller, Emma C Robinson, Stamatios N Sotiropoulos, Junqian Xu, Essa Yacoub, Kamil Ugurbil & David C Van Essen

Heat is absolute, cold is relative

Neuroscience in the News - Fri, 08/26/2016 - 12:00am

Nature Neuroscience 19, 1188 (2016). doi:10.1038/nn.4367

Authors: Ine Vandewauw & Thomas Voets

In vivo imaging of the spinal cord provides insights into the coding of skin temperature. Intriguingly, while heat-responsive dorsal horn neurons encode absolute temperatures, cold-responsive neurons report relative drops.

The hippocampus grows up

Neuroscience in the News - Fri, 08/26/2016 - 12:00am

Nature Neuroscience 19, 1190 (2016). doi:10.1038/nn.4368

Authors: Andrii Rudenko & Li-Huei Tsai

The inability of adults to retrieve episodic memories of infancy is referred to as infantile amnesia. A study now provides one of the first explanations of the neurobiological mechanisms underlying this phenomenon.

Is the brain prewired for letters?

Neuroscience in the News - Fri, 08/26/2016 - 12:00am

Nature Neuroscience 19, 1192 (2016). doi:10.1038/nn.4369

Authors: Stanislas Dehaene & Ghislaine Dehaene-Lambertz

Even before a child learns to read, the future location of his or her letter-processing area can be predicted from its connections to the rest of the brain. Reading acquisition thus piggybacks on a pre-existing brain circuit.

Hypothalamic arcuate nucleus tyrosine hydroxylase neurons play orexigenic role in energy homeostasis

Nature Neuroscience - Mon, 08/22/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4372

Authors: Xiaobing Zhang & Anthony N van den Pol

Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca2+ channel–vesicle coupling

Nature Neuroscience - Mon, 08/15/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4364

Authors: Mathias A Böhme, Christina Beis, Suneel Reddy-Alla, Eric Reynolds, Malou M Mampell, Andreas T Grasskamp, Janine Lützkendorf, Dominique Dufour Bergeron, Jan H Driller, Husam Babikir, Fabian Göttfert, Iain M Robinson, Cahir J O'Kane, Stefan W Hell, Markus C Wahl, Ulrich Stelzl, Bernhard Loll, Alexander M Walter & Stephan J Sigrist

Representation of egomotion in rat's trident and E-row whisker cortices

Nature Neuroscience - Mon, 08/15/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4363

Authors: Edith Chorev, Patricia Preston Ferrer & Michael Brecht

Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration

Nature Neuroscience - Mon, 08/15/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4360

Authors: Melanie von Schimmelmann, Philip A Feinberg, Josefa M Sullivan, Stacy M Ku, Ana Badimon, Mary Kaye Duff, Zichen Wang, Alexander Lachmann, Scott Dewell, Avi Ma'ayan, Ming-Hu Han, Alexander Tarakhovsky & Anne Schaefer

Diminished KCC2 confounds synapse specificity of LTP during senescence

Neuroscience in the News - Mon, 08/08/2016 - 12:00am

Nature Neuroscience 19, 1197 (2016). doi:10.1038/nn.4357

Authors: Isabella Ferando, Guido C Faas & Istvan Mody

The synapse specificity of long-term potentiation (LTP) ensures that no interference arises from inputs irrelevant to the memory to be encoded. In hippocampi of aged (21–28 months) mice, LTP was relayed to unstimulated synapses, blemishing its synapse specificity. Diminished levels of the K+/Cl− cotransporter KCC2 and a depolarizing GABAA receptor-mediated synaptic component following LTP were the most likely causes for the spreading of potentiation, unveiling mechanisms hindering information storage in the aged brain and identifying KCC2 as a potential target for intervention.

Connectivity precedes function in the development of the visual word form area

Neuroscience in the News - Mon, 08/08/2016 - 12:00am

Nature Neuroscience 19, 1250 (2016). doi:10.1038/nn.4354

Authors: Zeynep M Saygin, David E Osher, Elizabeth S Norton, Deanna A Youssoufian, Sara D Beach, Jenelle Feather, Nadine Gaab, John D E Gabrieli & Nancy Kanwisher

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