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Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Nature Neuroscience - Mon, 02/01/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4228

Authors: Barbara Franke, Jason L Stein, Stephan Ripke, Verneri Anttila, Derrek P Hibar, Kimm J E van Hulzen, Alejandro Arias-Vasquez, Jordan W Smoller, Thomas E Nichols, Michael C Neale, Andrew M McIntosh, Phil Lee, Francis J McMahon, Andreas Meyer-Lindenberg, Manuel Mattheisen, Ole A Andreassen, Oliver Gruber, Perminder S Sachdev, Roberto Roiz-Santiañez, Andrew J Saykin, Stefan Ehrlich, Karen A Mather, Jessica A Turner, Emanuel Schwarz, Anbupalam Thalamuthu, Yin Yao, Yvonne Y W Ho, Nicholas G Martin, Margaret J Wright, Michael C O'Donovan, Paul M Thompson, Benjamin M Neale, Sarah E Medland & Patrick F Sullivan

Engineering microdeletions and microduplications by targeting segmental duplications with CRISPR

Nature Neuroscience - Mon, 02/01/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4235

Authors: Derek J C Tai, Ashok Ragavendran, Poornima Manavalan, Alexei Stortchevoi, Catarina M Seabra, Serkan Erdin, Ryan L Collins, Ian Blumenthal, Xiaoli Chen, Yiping Shen, Mustafa Sahin, Chengsheng Zhang, Charles Lee, James F Gusella & Michael E Talkowski

Gene coexpression modules in human cognition

Neuroscience in the News - Wed, 01/27/2016 - 12:00am

Nature Neuroscience 19, 173 (2016). doi:10.1038/nn.4226

Authors: Donna M Werling & Stephan J Sanders

Analysis of human hippocampus identifies two modules of coexpressed genes that are conserved throughout the human cortex and in mouse hippocampi. These modules are enriched for genetic variants associated with both cognitive phenotypes and neuropsychiatric disorders.

Natural killers in the brain's nursery

Neuroscience in the News - Wed, 01/27/2016 - 12:00am

Nature Neuroscience 19, 176 (2016). doi:10.1038/nn.4227

Authors: Sachin P Gadani & Jonathan Kipnis

A previously unknown mechanism contributes to dysfunction of the neurogenic niche during CNS autoimmunity. Natural killer cells are retained specifically in the subventricular zone in chronic disease, killing stem cells and promoting pathology.

Life goes by: a visual circuit signals perceptual-motor mismatch

Neuroscience in the News - Wed, 01/27/2016 - 12:00am

Nature Neuroscience 19, 177 (2016). doi:10.1038/nn.4233

Authors: Nao Ishiko & Andrew D Huberman

Connections between a specific thalamic structure and the neocortex convey mismatches between internal perceptions and external events. These findings help to define the circuits controlling contextual modulation of visual-motor processing.

Seq-ing the cortex one neuron at a time

Neuroscience in the News - Wed, 01/27/2016 - 12:00am

Nature Neuroscience 19, 179 (2016). doi:10.1038/nn.4230

Authors: Hsu-Hsin Chen & Paola Arlotta

The most complete single-neuron transcriptome database of the mouse visual cortex was performed using a large collection of reporter mouse lines. Results highlight the unmatched neuronal diversity of the cerebral cortex.

Rapid control of olfaction

Neuroscience in the News - Wed, 01/27/2016 - 12:00am

Nature Neuroscience 19, 181 (2016). doi:10.1038/nn0216-181

Author: Sasha Devore

Astrocyte calcium signaling: the third wave

Neuroscience in the News - Wed, 01/27/2016 - 12:00am

Nature Neuroscience 19, 182 (2016). doi:10.1038/nn.4201

Authors: Narges Bazargani & David Attwell

Remodeling myelination: implications for mechanisms of neural plasticity

Neuroscience in the News - Wed, 01/27/2016 - 12:00am

Nature Neuroscience 19, 190 (2016). doi:10.1038/nn.4200

Authors: Kae-Jiun Chang, Stephanie A Redmond & Jonah R Chan

Lateral hypothalamic circuits for feeding and reward

Neuroscience in the News - Wed, 01/27/2016 - 12:00am

Nature Neuroscience 19, 198 (2016). doi:10.1038/nn.4220

Authors: Garret D Stuber & Roy A Wise

Melanocortin-4 receptor–regulated energy homeostasis

Neuroscience in the News - Wed, 01/27/2016 - 12:00am

Nature Neuroscience 19, 206 (2016). doi:10.1038/nn.4202

Authors: Michael J Krashes, Bradford B Lowell & Alastair S Garfield

PV plasticity sustained through D1/5 dopamine signaling required for long-term memory consolidation

Nature Neuroscience - Mon, 01/25/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4231

Authors: Smitha Karunakaran, Ananya Chowdhury, Flavio Donato, Charles Quairiaux, Christoph M Michel & Pico Caroni

Separate circuitries encode the hedonic and nutritional values of sugar

Nature Neuroscience - Mon, 01/25/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4224

Authors: Luis A Tellez, Wenfei Han, Xiaobing Zhang, Tatiana L Ferreira, Isaac O Perez, Sara J Shammah-Lagnado, Anthony N van den Pol & Ivan E de Araujo

Epigenomic annotation of gene regulatory alterations during evolution of the primate brain

Nature Neuroscience - Mon, 01/25/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4229

Authors: Marit W Vermunt, Sander C Tan, Bas Castelijns, Geert Geeven, Peter Reinink, Ewart de Bruijn, Ivanela Kondova, Stephan Persengiev, Ronald Bontrop, Edwin Cuppen, Wouter de Laat & Menno P Creyghton

PTEN recruitment controls synaptic and cognitive function in Alzheimer's models

Nature Neuroscience - Mon, 01/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4225

Authors: Shira Knafo, Cristina Sánchez-Puelles, Ernest Palomer, Igotz Delgado, Jonathan E Draffin, Janire Mingo, Tina Wahle, Kanwardeep Kaleka, Liping Mou, Inmaculada Pereda-Perez, Edvin Klosi, Erik B Faber, Heidi M Chapman, Laura Lozano-Montes, Ana Ortega-Molina, Lara Ordóñez-Gutiérrez, Francisco Wandosell, Jose Viña, Carlos G Dotti, Randy A Hall, Rafael Pulido, Nashaat Z Gerges, Andrew M Chan, Mark R Spaller, Manuel Serrano, César Venero & José A Esteban

Nicotinic receptors in the ventral tegmental area promote uncertainty-seeking

Nature Neuroscience - Mon, 01/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4223

Authors: Jérémie Naudé, Stefania Tolu, Malou Dongelmans, Nicolas Torquet, Sébastien Valverde, Guillaume Rodriguez, Stéphanie Pons, Uwe Maskos, Alexandre Mourot, Fabio Marti & Philippe Faure

On-going computation of whisking phase by mechanoreceptors

Nature Neuroscience - Mon, 01/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4221

Authors: Avner Wallach, Knarik Bagdasarian & Ehud Ahissar

Illuminating next-generation brain therapies

Nature Neuroscience - Mon, 01/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4232

Authors: Emily Ferenczi & Karl Deisseroth

A clinical trial inspired and guided by optogenetics experiments in rodents reports the outcome of targeted transcranial magnetic stimulation in patients suffering from cocaine addiction.

Microglial brain region−dependent diversity and selective regional sensitivities to aging

Nature Neuroscience - Mon, 01/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4222

Authors: Kathleen Grabert, Tom Michoel, Michail H Karavolos, Sara Clohisey, J Kenneth Baillie, Mark P Stevens, Tom C Freeman, Kim M Summers & Barry W McColl

Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation

Neuroscience in the News - Mon, 01/11/2016 - 12:00am

Nature Neuroscience 19, 243 (2016). doi:10.1038/nn.4211

Authors: Qiang Liu, Nader Sanai, Wei-Na Jin, Antonio La Cava, Luc Van Kaer & Fu-Dong Shi

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