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The cortical analysis of speech-specific temporal structure revealed by responses to sound quilts

Nature Neuroscience - Tue, 08/18/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4021

Authors: Tobias Overath, Josh H McDermott, Jean Mary Zarate & David Poeppel

Social signals of safety and risk confer utility and have asymmetric effects on observers' choices

Nature Neuroscience - Mon, 05/18/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4022

Authors: Dongil Chung, George I Christopoulos, Brooks King-Casas, Sheryl B Ball & Pearl H Chiu

Inhumane treatment of nonhuman primate researchers

Nature Neuroscience - Mon, 05/18/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4039

Animal rights extremists are threatening nonhuman primate research by harassing scientists. We cannot tolerate these tactics, and we must rally individual, institutional and governmental support to protect scientists.

Function and developmental origin of a mesocortical inhibitory circuit

Nature Neuroscience - Mon, 05/11/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4020

Authors: Anna Kabanova, Milan Pabst, Markus Lorkowski, Oliver Braganza, Anne Boehlen, Negar Nikbakht, Leonie Pothmann, Ankita R Vaswani, Ruth Musgrove, Donato A Di Monte, Magdalena Sauvage, Heinz Beck & Sandra Blaess

Regulation of axon regeneration by the RNA repair and splicing pathway

Nature Neuroscience - Mon, 05/11/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4019

Authors: Yuanquan Song, David Sretavan, Ernesto A Salegio, Jim Berg, Xi Huang, Tong Cheng, Xin Xiong, Shan Meltzer, Chun Han, Trong-Tuong Nguyen, Jacqueline C Bresnahan, Michael S Beattie, Lily Yeh Jan & Yuh Nung Jan

A transcriptional reporter of intracellular Ca2+ in Drosophila

Nature Neuroscience - Mon, 05/11/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4016

Authors: Xiaojing J Gao, Olena Riabinina, Jiefu Li, Christopher J Potter, Thomas R Clandinin & Liqun Luo

A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease

Nature Neuroscience - Mon, 05/04/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4014

Authors: Kristina Bečanović, Anne Nørremølle, Scott J Neal, Chris Kay, Jennifer A Collins, David Arenillas, Tobias Lilja, Giulia Gaudenzi, Shiana Manoharan, Crystal N Doty, Jessalyn Beck, Nayana Lahiri, Elodie Portales-Casamar, Simon C Warby, Colúm Connolly, Rebecca A G De Souza, Sarah J Tabrizi, Ola Hermanson, Douglas R Langbehn, Michael R Hayden, Wyeth W Wasserman & Blair R Leavitt

Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine

Nature Neuroscience - Mon, 05/04/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4015

Authors: Il Hwan Kim, Mark A Rossi, Dipendra K Aryal, Bence Racz, Namsoo Kim, Akiyoshi Uezu, Fan Wang, William C Wetsel, Richard J Weinberg, Henry Yin & Scott H Soderling

An astrocyte-dependent mechanism for neuronal rhythmogenesis

Nature Neuroscience - Mon, 05/04/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4013

Authors: Philippe Morquette, Dorly Verdier, Aklesso Kadala, James Féthière, Antony G Philippe, Richard Robitaille & Arlette Kolta

Exome sequencing uncovers hidden pathways in familial and sporadic ALS

Neuroscience in the News - Tue, 04/28/2015 - 12:00am

Nature Neuroscience 18, 611 (2015). doi:10.1038/nn.4012

Authors: Conceição Bettencourt & Henry Houlden

Amyotrophic lateral sclerosis (ALS) is a complex and as yet untreatable neurodegenerative disorder. We discuss two examples of exome sequencing in large international collections of familial and sporadic ALS cases that are revealing new and potentially treatable pathways, such as those involving autophagy and neuroinflammation.

Stem cells: slow and steady wins the race

Neuroscience in the News - Tue, 04/28/2015 - 12:00am

Nature Neuroscience 18, 613 (2015). doi:10.1038/nn.4009

Author: Wieland B Huttner

How are quiescent adult neural stem cells (NSCs) generated during development? A study now identifies a reserve population of p57-expressing, slowly dividing embryonic neural progenitors that later give rise to adult NSCs.

Strength in more than numbers

Neuroscience in the News - Tue, 04/28/2015 - 12:00am

Nature Neuroscience 18, 614 (2015). doi:10.1038/nn.4006

Authors: Nathaniel B Sawtell & L F Abbott

Theory suggests that cerebellar granule cells combine sensory and motor signals originating from different sources. An unexpected logic governing how granule cells process different input sources may enhance computational power.

Divide and conquer: strategic decision areas

Neuroscience in the News - Tue, 04/28/2015 - 12:00am

Nature Neuroscience 18, 616 (2015). doi:10.1038/nn.4005

Authors: Nils Kolling & Laurence T Hunt

Strategic decisions can prove difficult to study. The board game shogi is used to investigate the functional neuroanatomy of strategic decisions, revealing different brain areas from those engaged by other forms of choice.

Good vibrations with deep brain stimulation

Neuroscience in the News - Tue, 04/28/2015 - 12:00am

Nature Neuroscience 18, 618 (2015). doi:10.1038/nn.4007

Author: Ziv M Williams

Insight into the mechanism by which deep brain stimulation exerts its therapeutic effects comes from recording in motor cortical regions of neurosurgical subjects undergoing subthalamic nucleus deep brain stimulation.

The cost of brain structure

Neuroscience in the News - Tue, 04/28/2015 - 12:00am

Nature Neuroscience 18, 619 (2015). doi:10.1038/nn0515-619

Author: Jean Mary Zarate

What the orbitofrontal cortex does not do

Neuroscience in the News - Tue, 04/28/2015 - 12:00am

Nature Neuroscience 18, 620 (2015). doi:10.1038/nn.3982

Authors: Thomas A Stalnaker, Nisha K Cooch & Geoffrey Schoenbaum

Light-regulated translational control of circadian behavior by eIF4E phosphorylation

Nature Neuroscience - Mon, 04/27/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4010

Authors: Ruifeng Cao, Christos G Gkogkas, Nuria de Zavalia, Ian D Blum, Akiko Yanagiya, Yoshinori Tsukumo, Haiyan Xu, Choogon Lee, Kai-Florian Storch, Andrew C Liu, Shimon Amir & Nahum Sonenberg

An acetylcholine-activated microcircuit drives temporal dynamics of cortical activity

Nature Neuroscience - Mon, 04/27/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4002

Authors: Naiyan Chen, Hiroki Sugihara & Mriganka Sur

A neural basis for melanocortin-4 receptor–regulated appetite

Nature Neuroscience - Mon, 04/27/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4011

Authors: Alastair S Garfield, Chia Li, Joseph C Madara, Bhavik P Shah, Emily Webber, Jennifer S Steger, John N Campbell, Oksana Gavrilova, Charlotte E Lee, David P Olson, Joel K Elmquist, Bakhos A Tannous, Michael J Krashes & Bradford B Lowell

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease

Nature Neuroscience - Mon, 04/27/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4004

Authors: Ariadna Laguna, Nicoletta Schintu, André Nobre, Alexandra Alvarsson, Nikolaos Volakakis, Jesper Kjaer Jacobsen, Marta Gómez-Galán, Elena Sopova, Eliza Joodmardi, Takashi Yoshitake, Qiaolin Deng, Jan Kehr, Johan Ericson, Per Svenningsson, Oleg Shupliakov & Thomas Perlmann

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