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Gut microbiota is critical for the induction of chemotherapy-induced pain

Nature Neuroscience - Mon, 07/17/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4606

Authors: Shiqian Shen, Grewo Lim, Zerong You, Weihua Ding, Peigen Huang, Chongzhao Ran, Jason Doheny, Peter Caravan, Samuel Tate, Kun Hu, Hyangin Kim, Michael McCabe, Bo Huang, Zhongcong Xie, Douglas Kwon, Lucy Chen & Jianren Mao

Chemotherapy-induced pain is a dose-limiting condition that affects 30% of patients undergoing chemotherapy. We found that gut microbiota promotes the development of chemotherapy-induced mechanical hyperalgesia. Oxaliplatin-induced mechanical hyperalgesia was reduced in germ-free mice and in mice pretreated with antibiotics. Restoring the microbiota of germ-free mice abrogated this protection. These effects appear to be mediated, in part, by TLR4 expressed on hematopoietic cells, including macrophages.

Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder

Nature Neuroscience - Mon, 07/17/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4598

Authors: Elaine T Lim, Mohammed Uddin, Silvia De Rubeis, Yingleong Chan, Anne S Kamumbu, Xiaochang Zhang, Alissa M D'Gama, Sonia N Kim, Robert Sean Hill, Arthur P Goldberg, Christopher Poultney, Nancy J Minshew, Itaru Kushima, Branko Aleksic, Norio Ozaki, Mara Parellada, Celso Arango, Maria J Penzol, Angel Carracedo, Alexander Kolevzon, Christina M Hultman, Lauren A Weiss, Menachem Fromer, Andreas G Chiocchetti, Christine M Freitag, George M Church, Stephen W Scherer, Joseph D Buxbaum & Christopher A Walsh

A circuit-based mechanism underlying familiarity signaling and the preference for novelty

Nature Neuroscience - Mon, 07/17/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4607

Authors: Susanna Molas, Rubing Zhao-Shea, Liwang Liu, Steven R DeGroot, Paul D Gardner & Andrew R Tapper

C9orf72 expansion disrupts ATM-mediated chromosomal break repair

Nature Neuroscience - Mon, 07/17/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4604

Authors: Callum Walker, Saul Herranz-Martin, Evangelia Karyka, Chunyan Liao, Katherine Lewis, Waheba Elsayed, Vera Lukashchuk, Shih-Chieh Chiang, Swagat Ray, Padraig J Mulcahy, Mateusz Jurga, Ioannis Tsagakis, Tommaso Iannitti, Jayanth Chandran, Ian Coldicott, Kurt J De Vos, Mohamed K Hassan, Adrian Higginbottom, Pamela J Shaw, Guillaume M Hautbergue, Mimoun Azzouz & Sherif F El-Khamisy

Neural reactivations during sleep determine network credit assignment

Nature Neuroscience - Mon, 07/10/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4601

Authors: Tanuj Gulati, Ling Guo, Dhakshin S Ramanathan, Anitha Bodepudi & Karunesh Ganguly

A causal account of the brain network computations underlying strategic social behavior

Nature Neuroscience - Mon, 07/10/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4602

Authors: Christopher A Hill, Shinsuke Suzuki, Rafael Polania, Marius Moisa, John P O'Doherty & Christian C Ruff

Reorganization of corticospinal output during motor learning

Nature Neuroscience - Mon, 07/03/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4596

Authors: Andrew J Peters, Jun Lee, Nathan G Hedrick, Keelin O'Neil & Takaki Komiyama

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

Nature Neuroscience - Mon, 07/03/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4597

Authors: Thais F Galatro, Inge R Holtman, Antonio M Lerario, Ilia D Vainchtein, Nieske Brouwer, Paula R Sola, Mariana M Veras, Tulio F Pereira, Renata E P Leite, Thomas Möller, Paul D Wes, Mari C Sogayar, Jon D Laman, Wilfred den Dunnen, Carlos A Pasqualucci, Sueli M Oba-Shinjo, Erik W G M Boddeke, Suely K N Marie & Bart J L Eggen

A checkpoint to pain

Neuroscience in the News - Tue, 06/27/2017 - 12:00am

Nature Neuroscience 20, 897 (2017). doi:10.1038/nn.4586

Authors: Michael Hirth, Jagadeesh Gandla & Rohini Kuner

The checkpoint pathway consisting of programmed death ligand 1 (PD-L1) and its receptor, PD-1, modulates immune function in cancer and infection, but unexpectedly, it also silences pain signals in nerves.

Direction selectivity starts early

Neuroscience in the News - Tue, 06/27/2017 - 12:00am

Nature Neuroscience 20, 899 (2017). doi:10.1038/nn.4585

Authors: Qi Fang & Huizhong W Tao

Disruption of retinal direction selectivity reveals both peripheral and central computations contributing to direction selectivity in mouse visual cortex. These mechanisms work together to better encode motion directions and speeds.

The thalamic paradox

Neuroscience in the News - Tue, 06/27/2017 - 12:00am

Nature Neuroscience 20, 901 (2017). doi:10.1038/nn.4583

Author: László Acsády

Most thalamic research has focused on sensory transmission. Now three independent groups reveal the thalamus to be critical in behaviors linked to frontal cortex and the maintenance of persistent cortical activity during delays.

Sampling memory to make profitable choices

Neuroscience in the News - Tue, 06/27/2017 - 12:00am

Nature Neuroscience 20, 903 (2017). doi:10.1038/nn.4588

Authors: Brice A Kuhl & Nicole M Long

A computational model explains how memories of past rewards guide value-based choices. Incorporating behavioral and functional MRI evidence, the findings indicate that 'sampling' from individual memories of past rewards influences choices.

Erratum: Infantile amnesia reflects a developmental critical period for hippocampal learning

Neuroscience in the News - Tue, 06/27/2017 - 12:00am

Nature Neuroscience 20, 1033 (2017). doi:10.1038/nn0717-1033a

Author: Alessio Travaglia, Reto Bisaz, Eric S Sweet, Robert D Blitzer & Cristina M Alberini

Corrigendum: Opportunities and challenges in modeling human brain disorders in transgenic primates

Neuroscience in the News - Tue, 06/27/2017 - 12:00am

Nature Neuroscience 20, 1033 (2017). doi:10.1038/nn0717-1033b

Author: Charles Jennings, Rogier Landman, Yang Zhou, Jitendra Sharma, Julia Hyman, J Anthony Movshon, Zilong Qiu, Angela Roberts, Anna Wang Roe, Xiaoqin Wang, Huihui Zhou, Liping Wang, Feng Zhang, Robert Desimone & Guoping Feng

Corrigendum: A viral strategy for targeting and manipulating interneurons across vertebrate species

Neuroscience in the News - Tue, 06/27/2017 - 12:00am

Nature Neuroscience 20, 1033 (2017). doi:10.1038/nn0717-1033c

Author: Jordane Dimidschstein, Qian Chen, Robin Tremblay, Stephanie L Rogers, Giuseppe-Antonio Saldi, Lihua Guo, Qing Xu, Runpeng Liu, Congyi Lu, Jianhua Chu, Michael C Avery, Mohammad S Rashid, Myungin Baek, Amanda L Jacob, Gordon B Smith, Daniel E Wilson, Georg Kosche, Illya Kruglikov, Tomasz Rusielewicz, Vibhakar C Kotak, Todd M Mowery, Stewart A Anderson, Edward M Callaway, Jeremy S Dasen, David Fitzpatrick, Valentina Fossati, Michael A Long, Scott Noggle, John H Reynolds, Dan H Sanes, Bernardo Rudy, Guoping Feng & Gord Fishell

Addendum: A viral strategy for targeting and manipulating interneurons across vertebrate species

Neuroscience in the News - Tue, 06/27/2017 - 12:00am

Nature Neuroscience 20, 1033 (2017). doi:10.1038/nn0717-1033d

Author: Jordane Dimidschstein, Qian Chen, Robin Tremblay, Stephanie L Rogers, Giuseppe-Antonio Saldi, Lihua Guo, Qing Xu, Runpeng Liu, Congyi Lu, Jianhua Chu, Michael C Avery, Mohammad S Rashid, Myungin Baek, Amanda L Jacob, Gordon B Smith, Daniel E Wilson, Georg Kosche, Illya Kruglikov, Tomasz Rusielewicz, Vibhakar C Kotak, Todd M Mowery, Stewart A Anderson, Edward M Callaway, Jeremy S Dasen, David Fitzpatrick, Valentina Fossati, Michael A Long, Scott Noggle, John H Reynolds, Dan H Sanes, Bernardo Rudy, Guoping Feng & Gord Fishell

Activation of cortical somatostatin interneurons prevents the development of neuropathic pain

Nature Neuroscience - Mon, 06/26/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4595

Authors: Joseph Cichon, Thomas J J Blanck, Wen-Biao Gan & Guang Yang

Germline Chd8 haploinsufficiency alters brain development in mouse

Nature Neuroscience - Mon, 06/26/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4592

Authors: Andrea L Gompers, Linda Su-Feher, Jacob Ellegood, Nycole A Copping, M Asrafuzzaman Riyadh, Tyler W Stradleigh, Michael C Pride, Melanie D Schaffler, A Ayanna Wade, Rinaldo Catta-Preta, Iva Zdilar, Shreya Louis, Gaurav Kaushik, Brandon J Mannion, Ingrid Plajzer-Frick, Veena Afzal, Axel Visel, Len A Pennacchio, Diane E Dickel, Jason P Lerch, Jacqueline N Crawley, Konstantinos S Zarbalis, Jill L Silverman & Alex S Nord

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

Nature Neuroscience - Mon, 06/26/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4593

Authors: Ken Y Chan, Min J Jang, Bryan B Yoo, Alon Greenbaum, Namita Ravi, Wei-Li Wu, Luis Sánchez-Guardado, Carlos Lois, Sarkis K Mazmanian, Benjamin E Deverman & Viviana Gradinaru

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders

Nature Neuroscience - Mon, 06/26/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4594

Authors: Jing Li, Wangshu Zhang, Hui Yang, Daniel P Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V Evgrafov, Giulio Genovese, Veronica A Clementel, Jennifer C Tudor, Ted Abel, James A Knowles, Benjamin M Neale, Kai Wang, Fengzhu Sun & Marcelo P Coba

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