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Reactivations of emotional memory in the hippocampus–amygdala system during sleep

Nature Neuroscience - Mon, 09/11/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4637

Authors: Gabrielle Girardeau, Ingrid Inema & György Buzsáki

Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis

Nature Neuroscience - Mon, 09/11/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4638

Authors: Stacey M Glasgow, Jeffrey C Carlson, Wenyi Zhu, Lesley S Chaboub, Peng Kang, Hyun Kyoung Lee, Yoanne M Clovis, Brittney E Lozzi, Robert J McEvilly, Michael G Rosenfeld, Chad J Creighton, Soo-Kyung Lee, Carrie A Mohila & Benjamin Deneen

Seeing faces is necessary for face-domain formation

Nature Neuroscience - Mon, 09/04/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4635

Authors: Michael J Arcaro, Peter F Schade, Justin L Vincent, Carlos R Ponce & Margaret S Livingstone

Parallel encoding of recent visual experience and self-motion during navigation in Drosophila

Nature Neuroscience - Mon, 09/04/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4628

Authors: Hiroshi M Shiozaki & Hokto Kazama

Impaired hippocampal place cell dynamics in a mouse model of the 22q11.2 deletion

Nature Neuroscience - Mon, 09/04/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4634

Authors: Jeffrey D Zaremba, Anastasia Diamantopoulou, Nathan B Danielson, Andres D Grosmark, Patrick W Kaifosh, John C Bowler, Zhenrui Liao, Fraser T Sparks, Joseph A Gogos & Attila Losonczy

An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome

Nature Neuroscience - Mon, 09/04/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4632

Authors: Bernard Ng, Charles C White, Hans-Ulrich Klein, Solveig K Sieberts, Cristin McCabe, Ellis Patrick, Jishu Xu, Lei Yu, Chris Gaiteri, David A Bennett, Sara Mostafavi & Philip L De Jager

The Zika threat to the periphery

Neuroscience in the News - Tue, 08/29/2017 - 12:00am

Nature Neuroscience 20, 1191 (2017). doi:10.1038/nn.4633

Authors: Themasap A. Khan & Sergiu P. Paşca

Zika virus infection is associated with birth defects, including microcephaly, but also with disorders of peripheral nerves. Oh et al. use rodent and human cell models to explore how the virus affects the peripheral nervous system.

Loopholes in the DNA contract kill neurons

Neuroscience in the News - Tue, 08/29/2017 - 12:00am

Nature Neuroscience 20, 1192 (2017). doi:10.1038/nn.4626

Authors: Karl Herrup, Kai-Hei Tse & Hei-Man Chow

Hexanucleotide repeat expansions in C9orf72 gene locus create double jeopardy, first by leading to DNA–RNA R-loops that spawn double-strand breaks and second by the synthesis of dipeptide repeats that hinder DNA repair. This two-pronged mechanism may explain neurodegeneration in amyotrophic lateral sclerosis and frontotemporal dementia.

Jamais vu all over again

Neuroscience in the News - Tue, 08/29/2017 - 12:00am

Nature Neuroscience 20, 1194 (2017). doi:10.1038/nn.4625

Authors: Rebecca D Burwell & Victoria L Templer

What is the basis for the feeling that someplace or someone is familiar? Molas et al. have identified brain structures involved in signaling familiarity, a necessary element for the expression of preference for novelty.

Is population activity more than the sum of its parts?

Neuroscience in the News - Tue, 08/29/2017 - 12:00am

Nature Neuroscience 20, 1196 (2017). doi:10.1038/nn.4627

Authors: Jonathan W Pillow & Mikio C Aoi

A study introduces innovative ways to test whether neural population activity exhibits structure above and beyond that of its basic components.

Functions and dysfunctions of neocortical inhibitory neuron subtypes

Neuroscience in the News - Tue, 08/29/2017 - 12:00am

Nature Neuroscience 20, 1199 (2017). doi:10.1038/nn.4619

Authors: Ryoma Hattori, Kishore V Kuchibhotla, Robert C Froemke & Takaki Komiyama

Memory reactivation improves visual perception

Nature Neuroscience - Mon, 08/28/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4629

Authors: Rotem Amar-Halpert, Rony Laor-Maayany, Shlomi Nemni, Jonathan D Rosenblatt & Nitzan Censor

Human perception thresholds can improve through learning. Here we report findings challenging the fundamental 'practice makes perfect' basis of procedural learning theory, showing that brief reactivations of encoded visual memories are sufficient to improve perceptual discrimination thresholds. Learning was comparable to standard practice-induced learning and was not due to short training per se, nor to an epiphenomenon of primed retrieval enhancement. The results demonstrate that basic perceptual functions can be substantially improved by memory reactivation, supporting a new account of perceptual learning dynamics.

Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging

Nature Neuroscience - Mon, 08/28/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4631

Authors: Petra Füger, Jasmin K Hefendehl, Karthik Veeraraghavalu, Ann-Christin Wendeln, Christine Schlosser, Ulrike Obermüller, Bettina M Wegenast-Braun, Jonas J Neher, Peter Martus, Shinichi Kohsaka, Martin Thunemann, Robert Feil, Sangram S Sisodia, Angelos Skodras & Mathias Jucker

Glia initiate brain assembly through noncanonical Chimaerin–Furin axon guidance in C. elegans

Nature Neuroscience - Mon, 08/28/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4630

Authors: Georgia Rapti, Chang Li, Alan Shan, Yun Lu & Shai Shaham

Central amygdala circuits modulate food consumption through a positive-valence mechanism

Nature Neuroscience - Mon, 08/21/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4623

Authors: Amelia M Douglass, Hakan Kucukdereli, Marion Ponserre, Milica Markovic, Jan Gründemann, Cornelia Strobel, Pilar L Alcala Morales, Karl-Klaus Conzelmann, Andreas Lüthi & Rüdiger Klein

Selective inhibitory control of pyramidal neuron ensembles and cortical subnetworks by chandelier cells

Nature Neuroscience - Mon, 08/21/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4624

Authors: Jiangteng Lu, Jason Tucciarone, Nancy Padilla-Coreano, Miao He, Joshua A Gordon & Z Josh Huang

AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma

Nature Neuroscience - Mon, 08/14/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4620

Authors: Ryan D Chow, Christopher D Guzman, Guangchuan Wang, Florian Schmidt, Mark W Youngblood, Lupeng Ye, Youssef Errami, Matthew B Dong, Michael A Martinez, Sensen Zhang, Paul Renauer, Kaya Bilguvar, Murat Gunel, Phillip A Sharp, Feng Zhang, Randall J Platt & Sidi Chen

Selective attention within the foveola

Nature Neuroscience - Mon, 08/14/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4622

Authors: Martina Poletti, Michele Rucci & Marisa Carrasco

Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry

Nature Neuroscience - Mon, 08/14/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4618

Authors: Hon-Cheong So, Carlos Kwan-Long Chau, Wan-To Chiu, Kin-Sang Ho, Cho-Pong Lo, Stephanie Ho-Yue Yim & Pak-Chung Sham

Cerebellar granule cell replenishment postinjury by adaptive reprogramming of Nestin+ progenitors

Nature Neuroscience - Mon, 08/14/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4621

Authors: Alexandre Wojcinski, Andrew K Lawton, N Sumru Bayin, Zhimin Lao, Daniel N Stephen & Alexandra L Joyner

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