Nature Neuroscience 19, 1537 (2016). doi:10.1038/nn.4453
Neuroscientists dedicate themselves to understanding the brain. But what happens when they disagree on experimental outcomes, data interpretation or methodology? Nature Neuroscience debuts a format that invites researchers to debate critical issues in neuroscience.
Nature Neuroscience 19, 1538 (2016). doi:10.1038/nn.4445
Author: David Cesarini
Intellectual disabilities and associated neurodevelopmental disorders may result from rare genetic mutations. Ganna et al. show that these also help explain variability in educational attainment, a proxy for cognitive function.
Nature Neuroscience 19, 1539 (2016). doi:10.1038/nn.4446
Authors: Ravi L Rungta & Serge Charpak
During synaptic activation, the function of astrocyte endfeet depends on the vascular target: at the capillary, but not at the arteriole, a newly described P2X1R–phospholipase D2 pathway modulates prostaglandin E2 release and vessel dilation.
Nature Neuroscience 19, 1541 (2016). doi:10.1038/nn.4440
Authors: Matthew T Kaufman & Anne K Churchland
Humans and animals can collect and maintain information that guides decisions, but how neural circuits achieve this is unknown. It seems neural populations may do so by passing through diverse states in many possible sequences.
Nature Neuroscience 19, 1543 (2016). doi:10.1038/nn.4441
Authors: Jan B Engelmann & Ernst Fehr
Recent experiments suggest that dishonesty can escalate from small levels to ever-larger ones along a 'slippery slope'. Activity in bilateral amygdala tracks this gradual adaptation to repeated acts of self-serving dishonesty.
Nature Neuroscience 19, 1545 (2016). doi:10.1038/nn.4438
Authors: Mauricio R Delgado, Jennifer S Beer, Lesley K Fellows, Scott A Huettel, Michael L Platt, Gregory J Quirk & Daniela Schiller
The ventromedial prefrontal cortex is attributed with various functions during valuation, affect regulation and social cognition. Nature Neuroscience asked a moderator to lead researchers in a dialogue on shared and distinct viewpoints of this region's roles.
Nature Neuroscience 19, 1599 (2016). doi:10.1038/nn.4421
Authors: Makoto Inoue, Po-han Chen, Stephen Siecinski, Qi-jing Li, Chunlei Liu, Lawrence Steinman, Simon G Gregory, Eric Benner & Mari L Shinohara
Nature Neuroscience 19, 1743 (2016). doi:10.1038/nn.4430
Authors: Jordane Dimidschstein, Qian Chen, Robin Tremblay, Stephanie L Rogers, Giuseppe-Antonio Saldi, Lihua Guo, Qing Xu, Runpeng Liu, Congyi Lu, Jianhua Chu, Joshua S Grimley, Anne-Rachel Krostag, Ajamete Kaykas, Michael C Avery, Mohammad S Rashid, Myungin Baek, Amanda L Jacob, Gordon B Smith, Daniel E Wilson, Georg Kosche, Illya Kruglikov, Tomasz Rusielewicz, Vibhakar C Kotak, Todd M Mowery, Stewart A Anderson, Edward M Callaway, Jeremy S Dasen, David Fitzpatrick, Valentina Fossati, Michael A Long, Scott Noggle, John H Reynolds, Dan H Sanes, Bernardo Rudy, Guoping Feng & Gord Fishell
Nature Neuroscience 19, 1381 (2016). doi:10.1038/nn.4434
Nature Neuroscience presents a Focus issue highlighting progress in basic and clinical sciences advancing mental health research.
Nature Neuroscience 19, 1383 (2016). doi:10.1038/nn.4429
Author: Steven E Hyman
Nature Neuroscience 19, 1385 (2016). doi:10.1038/nn.4419
Author: Joshua A Gordon
Nature Neuroscience 19, 1387 (2016). doi:10.1038/nn.4397
Author: Robert M Sapolsky
Nature Neuroscience 19, 1390 (2016). doi:10.1038/nn.4427
Author: James C Harris
Refined social phenotyping of syndromic and idiopathic forms of autism, combined with advances in genetics, animal models of syndromes and brain imaging, may facilitate discovery of shared brain mechanisms that will lead to new treatments. The reversal of social deficits in animal models is promising for eventual translation into therapeutics.
Nature Neuroscience 19, 1392 (2016). doi:10.1038/nn.4411
Authors: Gerome Breen, Qingqin Li, Bryan L Roth, Patricio O'Donnell, Michael Didriksen, Ricardo Dolmetsch, Paul F O'Reilly, Héléna A Gaspar, Husseini Manji, Christopher Huebel, John R Kelsoe, Dheeraj Malhotra, Alessandro Bertolino, Danielle Posthuma, Pamela Sklar, Shitij Kapur, Patrick F Sullivan, David A Collier & Howard J Edenberg
Nature Neuroscience 19, 1397 (2016). doi:10.1038/nn.4409
Authors: Michael J Gandal, Virpi Leppa, Hyejung Won, Neelroop N Parikshak & Daniel H Geschwind
Nature Neuroscience 19, 1408 (2016). doi:10.1038/nn.4420
Authors: Yehezkel Sztainberg & Huda Y Zoghbi
Nature Neuroscience 19, 1418 (2016). doi:10.1038/nn.4413
Authors: Bruno B Averbeck & Matthew V Chafee
Nature Neuroscience 19, 1426 (2016). doi:10.1038/nn.4422
Author: Jacob Gratten
A large DNA sequencing study of schizophrenia finds more evidence that rare inherited coding mutations across many genes contribute to risk of the disorder. This has important implications for geneticists and neuroscientists alike.
Nature Neuroscience 19, 1428 (2016). doi:10.1038/nn.4424
Author: Frank W Albert
Gene expression data from more than 500 human brains shed light on the molecular consequences of genetic variation that contributes to schizophrenia.
Nature Neuroscience 19, 1430 (2016). doi:10.1038/nn.4431
Authors: Martin W Breuss & Joseph G Gleeson
Recent models studying loss of the mouse homolog of the autism-associated gene CHD8 show altered Wnt signaling, cell fate and proliferation. How do these findings shape our understanding of this disease?