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Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence

Nature Neuroscience - Sun, 10/19/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3843

Authors: Colin G McNamara, Álvaro Tejero-Cantero, Stéphanie Trouche, Natalia Campo-Urriza & David Dupret

We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest. When applied during spatial learning of new goal locations, dopaminergic photostimulation improved the later recall of neural representations of space and stabilized memory performance. These findings reveal that midbrain dopaminergic neurons promote hippocampal network dynamics associated with memory persistence.

Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases

Nature Neuroscience - Sun, 10/19/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3846

Authors: Alexander C W Smith, Yonatan M Kupchik, Michael D Scofield, Cassandra D Gipson, Armina Wiggins, Charles A Thomas & Peter W Kalivas

Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administered cocaine and transient increases in MMP-9 during cue-induced cocaine relapse. Cue-induced heroin and nicotine relapse increased MMP activity, and increased MMP activity was required for both cocaine relapse and relapse-associated synaptic plasticity.

Mind matters: placebo enhances reward learning in Parkinson's disease

Nature Neuroscience - Sun, 10/19/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3842

Authors: Liane Schmidt, Erin Kendall Braun, Tor D Wager & Daphna Shohamy

Hierarchical competitions subserving multi-attribute choice

Nature Neuroscience - Sun, 10/12/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3836

Authors: Laurence T Hunt, Raymond J Dolan & Timothy E J Behrens

Attention can either increase or decrease spike count correlations in visual cortex

Nature Neuroscience - Sun, 10/12/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3835

Authors: Douglas A Ruff & Marlene R Cohen

Cortical neurogenesis in the absence of centrioles

Nature Neuroscience - Sun, 10/05/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3831

Authors: Ryan Insolera, Hisham Bazzi, Wei Shao, Kathryn V Anderson & Song-Hai Shi

Anchoring the neural compass: coding of local spatial reference frames in human medial parietal lobe

Nature Neuroscience - Sun, 10/05/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3834

Authors: Steven A Marchette, Lindsay K Vass, Jack Ryan & Russell A Epstein

Representation of aversive prediction errors in the human periaqueductal gray

Nature Neuroscience - Sun, 10/05/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3832

Authors: Mathieu Roy, Daphna Shohamy, Nathaniel Daw, Marieke Jepma, G Elliott Wimmer & Tor D Wager

Modulation of oligodendrocyte generation during a critical temporal window after NG2 cell division

Nature Neuroscience - Sun, 09/28/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3815

Authors: Robert A Hill, Kiran D Patel, Christopher M Goncalves, Jaime Grutzendler & Akiko Nishiyama

Neural correlates of water reward in thirsty Drosophila

Nature Neuroscience - Sun, 09/28/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3827

Authors: Suewei Lin, David Owald, Vikram Chandra, Clifford Talbot, Wolf Huetteroth & Scott Waddell

A somatosensory circuit for cooling perception in mice

Nature Neuroscience - Sun, 09/28/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3828

Authors: Nevena Milenkovic, Wen-Jie Zhao, Jan Walcher, Tobias Albert, Jan Siemens, Gary R Lewin & James F A Poulet

Neural antecedents of self-initiated actions in secondary motor cortex

Nature Neuroscience - Sun, 09/28/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3826

Authors: Masayoshi Murakami, M Inês Vicente, Gil M Costa & Zachary F Mainen

Consorting with big science

Neuroscience in the News - Thu, 09/25/2014 - 12:00am

Nature Neuroscience 17, 1289 (2014). doi:10.1038/nn.3830

Large-scale consortia have benefited many fields chasing big data. In the face of new projects, neuroscientists should consider banding together.

A touching tale: point sensor or pattern detector?

Neuroscience in the News - Thu, 09/25/2014 - 12:00am

Nature Neuroscience 17, 1290 (2014). doi:10.1038/nn.3820

Author: David T Blake

The tactile sensors in our fingers have variable sensitivity across the skin. Does this variability harm or help the CNS in touch perception? Work now shows that this variability may provide the CNS with more information about micropositioning and stimulus orientation.

Promoting FOS to an enhanced position

Neuroscience in the News - Thu, 09/25/2014 - 12:00am

Nature Neuroscience 17, 1291 (2014). doi:10.1038/nn.3819

Authors: Sietse Jonkman & Paul J Kenny

How do enhancers facilitate transcription of plasticity-related genes in response to synaptic stimulation? A study implicates a specific histone modification and suggests that FOS regulates enhancer function.

Axons hooked to Schwann cell metabolism

Neuroscience in the News - Thu, 09/25/2014 - 12:00am

Nature Neuroscience 17, 1293 (2014). doi:10.1038/nn.3825

Authors: Iva D Tzvetanova & Klaus-Armin Nave

Long axonal projections seem to be metabolically coupled to ensheathing glial cells. Targeting LKB1, a regulator of energy homeostasis, specifically in Schwann cells causes a loss of predominantly small unmyelinated fibers.

Practice makes perfect

Neuroscience in the News - Thu, 09/25/2014 - 12:00am

Nature Neuroscience 17, 1295 (2014). doi:10.1038/nn.3817

Author: Aniruddha Das

As we learn through visual experience, where does that memory form? A study now shows that neural responses at even the earliest stage of visual cortex get reshaped in a way that faithfully reflects ongoing learning.

A two-way street

Neuroscience in the News - Thu, 09/25/2014 - 12:00am

Nature Neuroscience 17, 1297 (2014). doi:10.1038/nn1014-1297

Author: Sébastien Thuault

Motivational activation: a unifying hypothesis of orexin/hypocretin function

Neuroscience in the News - Thu, 09/25/2014 - 12:00am

Nature Neuroscience 17, 1298 (2014). doi:10.1038/nn.3810

Authors: Stephen V Mahler, David E Moorman, Rachel J Smith, Morgan H James & Gary Aston-Jones

Reward and motivation in pain and pain relief

Neuroscience in the News - Thu, 09/25/2014 - 12:00am

Nature Neuroscience 17, 1304 (2014). doi:10.1038/nn.3811

Authors: Edita Navratilova & Frank Porreca

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