Feed aggregator

Instrumental learning of traits versus rewards: dissociable neural correlates and effects on choice

Nature Neuroscience - Mon, 08/03/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4080

Authors: Leor M Hackel, Bradley B Doll & David M Amodio

Humans learn about people and objects through positive and negative experiences, yet they can also look beyond the immediate reward of an interaction to encode trait-level attributes. We found that perceivers encoded both reward and trait-level information through feedback in an instrumental learning task, but relied more heavily on trait representations in cross-context decisions. Both learning types implicated ventral striatum, but trait learning also recruited a network associated with social impression formation.

Learning to expect the unexpected: rapid updating in primate cerebellum during voluntary self-motion

Nature Neuroscience - Mon, 08/03/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4077

Authors: Jessica X Brooks, Jerome Carriot & Kathleen E Cullen

Dynamic rewiring of neural circuits in the motor cortex in mouse models of Parkinson's disease

Nature Neuroscience - Mon, 08/03/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4082

Authors: Lili Guo, Huan Xiong, Jae-Ick Kim, Yu-Wei Wu, Rupa R Lalchandani, Yuting Cui, Yu Shu, Tonghui Xu & Jun B Ding

Cellular evidence for efference copy in Drosophila visuomotor processing

Nature Neuroscience - Mon, 08/03/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4083

Authors: Anmo J Kim, Jamie K Fitzgerald & Gaby Maimon

Naturalistic stimulation drives opposing heterosynaptic plasticity at two inputs to songbird cortex

Nature Neuroscience - Mon, 08/03/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4078

Authors: W Hamish Mehaffey & Allison J Doupe

Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome

Nature Neuroscience - Mon, 08/03/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4072

Authors: Jonathan Witton, Ragunathan Padmashri, Larissa E Zinyuk, Victor I Popov, Igor Kraev, Samantha J Line, Thomas P Jensen, Angelo Tedoldi, Damian M Cummings, Victor L J Tybulewicz, Elizabeth M C Fisher, David M Bannerman, Andrew D Randall, Jonathan T Brown, Frances A Edwards, Dmitri A Rusakov, Michael G Stewart & Matt W Jones

Sex, drugs and pain control

Neuroscience in the News - Tue, 07/28/2015 - 12:00am

Nature Neuroscience 18, 1059 (2015). doi:10.1038/nn.4057

Authors: Victoria E Brings & Mark J Zylka

A study finds that pain hypersensitivity in male and female mice is differentially dependent on microglia and T cells, and describes a sex-specific response to microglia-targeted pain treatments. This sex difference will be important to consider when developing treatments for pain and other neurological disorders involving microglia and immune cells.

The binding solution?

Neuroscience in the News - Tue, 07/28/2015 - 12:00am

Nature Neuroscience 18, 1060 (2015). doi:10.1038/nn.4075

Authors: Mark E J Sheffield & Daniel A Dombeck

How do neurons combine distinct information streams and form long-lasting associations? Dendritic plateau potentials may allow the integration and storage of coincident location and contextual information in hippocampal neurons.

Removing synaptic brakes on learning

Neuroscience in the News - Tue, 07/28/2015 - 12:00am

Nature Neuroscience 18, 1062 (2015). doi:10.1038/nn.4073

Authors: Federico W Grillo, Lucien West & Vincenzo De Paola

Imaging experiments in awake mice reveal striking, circuit-specific synaptic structural remodeling of inhibitory axons during learning.

Reassessing VMPFC: full of confidence?

Neuroscience in the News - Tue, 07/28/2015 - 12:00am

Nature Neuroscience 18, 1064 (2015). doi:10.1038/nn.4076

Authors: Helen C Barron, Mona M Garvert & Timothy E J Behrens

The confidence that we place in our decisions can affect the judgments themselves. The BOLD signal in ventromedial prefrontal cortex automatically reflects the relationship between confidence and judgments on a range of tasks.

The RNAs of ALS

Neuroscience in the News - Tue, 07/28/2015 - 12:00am

Nature Neuroscience 18, 1066 (2015). doi:10.1038/nn0815-1066

Author: Sébastien Thuault

Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections

Nature Neuroscience - Mon, 07/27/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4068

Authors: Yonatan M Kupchik, Robyn M Brown, Jasper A Heinsbroek, Mary Kay Lobo, Danielle J Schwartz & Peter W Kalivas

It is widely accepted that D1 dopamine receptor–expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to mouse nucleus accumbens projections to the ventral pallidum. Thus, current thinking attributing D1 and D2 selectivity to accumbens projections akin to dorsal striatal pathways needs to be reconsidered.

Determinants of different deep and superficial CA1 pyramidal cell dynamics during sharp-wave ripples

Nature Neuroscience - Mon, 07/27/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4074

Authors: Manuel Valero, Elena Cid, Robert G Averkin, Juan Aguilar, Alberto Sanchez-Aguilera, Tim J Viney, Daniel Gomez-Dominguez, Elisa Bellistri & Liset Menendez de la Prida

Oscillatory dynamics coordinating human frontal networks in support of goal maintenance

Nature Neuroscience - Mon, 07/27/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4071

Authors: Bradley Voytek, Andrew S Kayser, David Badre, David Fegen, Edward F Chang, Nathan E Crone, Josef Parvizi, Robert T Knight & Mark D'Esposito

LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control

Nature Neuroscience - Mon, 07/27/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4069

Authors: Jianxun Wang, Francesca Telese, Yuliang Tan, Wenbo Li, Chunyu Jin, Xin He, Harihar Basnet, Qi Ma, Daria Merkurjev, Xiaoyan Zhu, Zhijie Liu, Jie Zhang, Kenny Ohgi, Havilah Taylor, Ryan R White, Cagdas Tazearsalan, Yousin Suh, Todd S Macfarlan, Samuel L Pfaff & Michael G Rosenfeld

Identification of neurodegenerative factors using translatome–regulatory network analysis

Nature Neuroscience - Mon, 07/27/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4070

Authors: Lars Brichta, William Shin, Vernice Jackson-Lewis, Javier Blesa, Ee-Lynn Yap, Zachary Walker, Jack Zhang, Jean-Pierre Roussarie, Mariano J Alvarez, Andrea Califano, Serge Przedborski & Paul Greengard

The role of ventral striatal cAMP signaling in stress-induced behaviors

Neuroscience in the News - Mon, 07/20/2015 - 12:00am

Nature Neuroscience 18, 1094 (2015). doi:10.1038/nn.4066

Authors: Florian Plattner, Kanehiro Hayashi, Adan Hernández, David R Benavides, Tara C Tassin, Chunfeng Tan, Jonathan Day, Maggy W Fina, Eunice Y Yuen, Zhen Yan, Matthew S Goldberg, Angus C Nairn, Paul Greengard, Eric J Nestler, Ronald Taussig, Akinori Nishi, Miles D Houslay & James A Bibb

Automatic integration of confidence in the brain valuation signal

Neuroscience in the News - Mon, 07/20/2015 - 12:00am

Nature Neuroscience 18, 1159 (2015). doi:10.1038/nn.4064

Authors: Maël Lebreton, Raphaëlle Abitbol, Jean Daunizeau & Mathias Pessiglione

Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS

Neuroscience in the News - Mon, 07/20/2015 - 12:00am

Nature Neuroscience 18, 1175 (2015). doi:10.1038/nn.4065

Authors: Mercedes Prudencio, Veronique V Belzil, Ranjan Batra, Christian A Ross, Tania F Gendron, Luc J Pregent, Melissa E Murray, Karen K Overstreet, Amelia E Piazza-Johnston, Pamela Desaro, Kevin F Bieniek, Michael DeTure, Wing C Lee, Sherri M Biendarra, Mary D Davis, Matthew C Baker, Ralph B Perkerson, Marka van Blitterswijk, Caroline T Stetler, Rosa Rademakers, Christopher D Link, Dennis W Dickson, Kevin B Boylan, Hu Li & Leonard Petrucelli

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

Neuroscience in the News - Mon, 07/20/2015 - 12:00am

Nature Neuroscience 18, 1183 (2015). doi:10.1038/nn.4067

Authors: Meaghan Morris, Giselle M Knudsen, Sumihiro Maeda, Jonathan C Trinidad, Alexandra Ioanoviciu, Alma L Burlingame & Lennart Mucke

Syndicate content