Delayed stabilization and individualization in connectome development are related to psychiatric disorders
Nature Neuroscience. doi:10.1038/nn.4511
Authors: Tobias Kaufmann, Dag Alnæs, Nhat Trung Doan, Christine Lycke Brandt, Ole A Andreassen & Lars T Westlye
The brain functional connectome constitutes a unique fingerprint allowing identification of individuals among a pool of people. Here we establish that the connectome develops into a more stable, individual wiring pattern during adolescence and demonstrate that a delay in this network tuning process is associated with reduced mental health in the formative years of late neurodevelopment.
Nature Neuroscience. doi:10.1038/nn.4509
Authors: Jan Kamin´ski, Shannon Sullivan, Jeffrey M Chung, Ian B Ross, Adam N Mamelak & Ueli Rutishauser
Nature Neuroscience. doi:10.1038/nn.4507
Authors: Chun-Ting Wu, Daniel Haggerty, Caleb Kemere & Daoyun Ji
Nature Neuroscience. doi:10.1038/nn.4510
Authors: Seongjun Park, Yuanyuan Guo, Xiaoting Jia, Han Kyoung Choe, Benjamin Grena, Jeewoo Kang, Jiyeon Park, Chi Lu, Andres Canales, Ritchie Chen, Yeong Shin Yim, Gloria B Choi, Yoel Fink & Polina Anikeeva
Nature Neuroscience. doi:10.1038/nn.4503
Authors: Fergil Mills, Andrea K Globa, Shuai Liu, Catherine M Cowan, Mahsan Mobasser, Anthony G Phillips, Stephanie L Borgland & Shernaz X Bamji
Nature Neuroscience. doi:10.1038/nn.4505
Authors: Milos M Petrovic, Silvia Viana da Silva, James P Clement, Ladislav Vyklicky, Christophe Mulle, Inmaculada M González-González & Jeremy M Henley
Nature Neuroscience. doi:10.1038/nn.4498
Authors: Xuefeng Shi, Jad Barchini, Hector Acaron Ledesma, David Koren, Yanjiao Jin, Xiaorong Liu, Wei Wei & Jianhua Cang
Nature Neuroscience. doi:10.1038/nn.4508
Author: David R Corey
Nusinersen (Spinraza) is a recently approved drug for treating spinal muscular atrophy. Approval of nusinersen may signal new opportunities for using antisense oligonucleotides as treatments for devastating neurological diseases.
Nature Neuroscience. doi:10.1038/nn.4493
Authors: Chia-Ching John Lin, Kwanha Yu, Asante Hatcher, Teng-Wei Huang, Hyun Kyoung Lee, Jeffrey Carlson, Matthew C Weston, Fengju Chen, Yiqun Zhang, Wenyi Zhu, Carrie A Mohila, Nabil Ahmed, Akash J Patel, Benjamin R Arenkiel, Jeffrey L Noebels, Chad J Creighton & Benjamin Deneen
Nature Neuroscience. doi:10.1038/nn.4495
Authors: John N Campbell, Evan Z Macosko, Henning Fenselau, Tune H Pers, Anna Lyubetskaya, Danielle Tenen, Melissa Goldman, Anne M J Verstegen, Jon M Resch, Steven A McCarroll, Evan D Rosen, Bradford B Lowell & Linus T Tsai
Nature Neuroscience. doi:10.1038/nn.4494
Authors: Yijing Su, Jaehoon Shin, Chun Zhong, Sabrina Wang, Prith Roychowdhury, Jongseuk Lim, David Kim, Guo-li Ming & Hongjun Song
Nature Neuroscience. doi:10.1038/nn.4491
Authors: Assaf Ramot, Zhiying Jiang, Jin-Bin Tian, Tali Nahum, Yael Kuperman, Nicholas Justice & Alon Chen
The hypothalamic–pituitary–adrenal axis is a pivotal component of an organism's response to stressful challenges, and dysfunction of this neuroendocrine axis is associated with a variety of physiological and psychological pathologies. We found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic–pituitary–adrenal axis regulation that prepares the organism for successive exposure to stressful stimuli.
Nature Neuroscience. doi:10.1038/nn.4492
Authors: Eduardo R Zimmer, Maxime J Parent, Débora G Souza, Antoine Leuzy, Clotilde Lecrux, Hyoung-Ihl Kim, Serge Gauthier, Luc Pellerin, Edith Hamel & Pedro Rosa-Neto
Contributions of glial cells to neuroenergetics have been the focus of extensive debate. Here we provide positron emission tomography evidence that activation of astrocytic glutamate transport via the excitatory amino acid transporter GLT-1 triggers widespread but graded glucose uptake in the rodent brain. Our results highlight the need for a reevaluation of the interpretation of [18F]FDG positron emission tomography data, whereby astrocytes would be recognized as contributing to the [18F]FDG signal.
Nature Neuroscience. doi:10.1038/nn.4489
Authors: Kassandra Kisler, Amy R Nelson, Sanket V Rege, Anita Ramanathan, Yaoming Wang, Ashim Ahuja, Divna Lazic, Philbert S Tsai, Zhen Zhao, Yi Zhou, David A Boas, Sava Sakadžić & Berislav V Zlokovic
Nature Neuroscience. doi:10.1038/nn.4487
Authors: Jenna A McHenry, James M Otis, Mark A Rossi, J Elliott Robinson, Oksana Kosyk, Noah W Miller, Zoe A McElligott, Evgeny A Budygin, David R Rubinow & Garret D Stuber
Nature Neuroscience. doi:10.1038/nn.4490
Authors: Kazuhisa Shibata, Yuka Sasaki, Ji Won Bang, Edward G Walsh, Maro G Machizawa, Masako Tamaki, Li-Hung Chang & Takeo Watanabe
Nature Neuroscience 20, 128 (2017). doi:10.1038/nn.4484
Authors: Tobias Ackels & Andreas T Schaefer
Representations in excitatory neurons generally narrow as they are refined. Odor representations in interneurons, however, broaden with maturation and learning, as connections between interneurons and projection neurons expand.
Nature Neuroscience 20, 130 (2017). doi:10.1038/nn.4485
Authors: Amber L Alhadeff & J Nicholas Betley
The biological drive to consume salt ensures that we consume adequate sodium for survival. In this issue of Nature Neuroscience, two articles provide insight into the neurons and circuits that regulate sodium appetite.
Nature Neuroscience 20, 131 (2017). doi:10.1038/nn.4480
Author: Jeffrey S Taube
Many spatial correlates have been identified that form the neural basis for navigation. Two studies have now uncovered a new cell type: bidirectional cells, which fire when the head is pointing in one of two opposing directions.
Nature Neuroscience 20, 134 (2017). doi:10.1038/nn.4473
Authors: Cindy K Barha & Liisa A M Galea
Pregnancy results in changes to maternal physiology and brain that may extend into older age. New results show that pregnancy-induced reductions in gray matter volume remain 2 years after childbirth in humans.