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Extending transparency to code

Neuroscience in the News - Thu, 05/25/2017 - 12:00am

Nature Neuroscience 20, 761 (2017). doi:10.1038/nn.4579

Reproducibility initiatives seek to promote greater transparency and sharing of scientific reagents, procedures and data. Less recognized is the need to share data analysis routines. Nature Neuroscience is launching a pilot project to evaluate the efficacy of sharing code.

Microglial confetti party

Neuroscience in the News - Thu, 05/25/2017 - 12:00am

Nature Neuroscience 20, 762 (2017). doi:10.1038/nn.4570

Authors: Charlotte Madore, Caroline Baufeld & Oleg Butovsky

Microglia are highly heterogeneous and plastic. However, the dynamics of their turnover have been difficult to visualize. A new multicolor reporter system reveals a plastic but stable network of microglia during health and disease.

A cell-type-specific jolt for motor disorders

Neuroscience in the News - Thu, 05/25/2017 - 12:00am

Nature Neuroscience 20, 763 (2017). doi:10.1038/nn.4565

Authors: Yu-Wei Wu & Jun B Ding

Manipulating the activity of a subpopulation of external globus pallidus neurons with optogenetic deep brain stimulation ameliorates motor deficits in a mouse model of Parkinson's disease.

Fear from the bottom up

Neuroscience in the News - Thu, 05/25/2017 - 12:00am

Nature Neuroscience 20, 765 (2017). doi:10.1038/nn.4578

Authors: Joseph M Stujenske & Ekaterina Likhtik

Two groups demonstrate the importance of inputs from the amygdala to the medial prefrontal cortex for signaling aversion across a range of behaviors and motivational drives.

Pinging the brain to reveal hidden memories

Neuroscience in the News - Thu, 05/25/2017 - 12:00am

Nature Neuroscience 20, 767 (2017). doi:10.1038/nn.4560

Authors: Rosanne L Rademaker & John T Serences

Keeping a picture in mind requires many brain cells to actively communicate ... or does it? There might be more to working memory than neuronal chatter, and silent processes could be hiding right beneath the surface.

Toward standard practices for sharing computer code and programs in neuroscience

Neuroscience in the News - Thu, 05/25/2017 - 12:00am

Nature Neuroscience 20, 770 (2017). doi:10.1038/nn.4550

Authors: Stephen J Eglen, Ben Marwick, Yaroslav O Halchenko, Michael Hanke, Shoaib Sufi, Padraig Gleeson, R Angus Silver, Andrew P Davison, Linda Lanyon, Mathew Abrams, Thomas Wachtler, David J Willshaw, Christophe Pouzat & Jean-Baptiste Poline

Computational techniques are central in many areas of neuroscience and are relatively easy to share. This paper describes why computer programs underlying scientific publications should be shared and lists simple steps for sharing. Together with ongoing efforts in data sharing, this should aid reproducibility of research.

Corrigendum: Brain feminization requires active repression of masculinization via DNA methylation

Neuroscience in the News - Thu, 05/25/2017 - 12:00am

Nature Neuroscience 20, 896 (2017). doi:10.1038/nn0617-896a

Author: Bridget M Nugent, Christopher L Wright, Amol C Shetty, Georgia E Hodes, Kathryn M Lenz, Anup Mahurkar, Scott J Russo, Scott E Devine & Margaret M McCarthy

Erratum: Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ

Neuroscience in the News - Thu, 05/25/2017 - 12:00am

Nature Neuroscience 20, 896 (2017). doi:10.1038/nn0617-896b

Author: Takashi Matsuda, Takeshi Y Hiyama, Fumio Niimura, Taiji Matsusaka, Akiyoshi Fukamizu, Kenta Kobayashi, Kazuto Kobayashi & Masaharu Noda

PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1

Nature Neuroscience - Mon, 05/22/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4571

Authors: Gang Chen, Yong Ho Kim, Hui Li, Hao Luo, Da-Lu Liu, Zhi-Jun Zhang, Mark Lay, Wonseok Chang, Yu-Qiu Zhang & Ru-Rong Ji

Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex

Nature Neuroscience - Mon, 05/22/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4566

Authors: Daniel Hillier, Michele Fiscella, Antonia Drinnenberg, Stuart Trenholm, Santiago B Rompani, Zoltan Raics, Gergely Katona, Josephine Juettner, Andreas Hierlemann, Balazs Rozsa & Botond Roska

Flexible information routing by transient synchrony

Nature Neuroscience - Mon, 05/22/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4569

Authors: Agostina Palmigiano, Theo Geisel, Fred Wolf & Demian Battaglia

A cerebellum-like circuit in the auditory system cancels responses to self-generated sounds

Nature Neuroscience - Mon, 05/22/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4567

Authors: Shobhit Singla, Conor Dempsey, Richard Warren, Armen G Enikolopov & Nathaniel B Sawtell

Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy

Nature Neuroscience - Mon, 05/15/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4561

Authors: Emily V Fletcher, Christian M Simon, John G Pagiazitis, Joshua I Chalif, Aleksandra Vukojicic, Estelle Drobac, Xiaojian Wang & George Z Mentis

Identification of a motor-to-auditory pathway important for vocal learning

Nature Neuroscience - Mon, 05/15/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4563

Authors: Todd F Roberts, Erin Hisey, Masashi Tanaka, Matthew G Kearney, Gaurav Chattree, Cindy F Yang, Nirao M Shah & Richard Mooney

A fluoro-Nissl dye identifies pericytes as distinct vascular mural cells during in vivo brain imaging

Nature Neuroscience - Mon, 05/15/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4564

Authors: Eyiyemisi C Damisah, Robert A Hill, Lei Tong, Katie N Murray & Jaime Grutzendler

Cell-specific pallidal intervention induces long-lasting motor recovery in dopamine-depleted mice

Neuroscience in the News - Mon, 05/08/2017 - 12:00am

Nature Neuroscience 20, 815 (2017). doi:10.1038/nn.4559

Authors: Kevin J Mastro, Kevin T Zitelli, Amanda M Willard, Kimberly H Leblanc, Alexxai V Kravitz & Aryn H Gittis

Cell-specific pallidal intervention induces long-lasting motor recovery in dopamine-depleted mice

Nature Neuroscience - Mon, 05/08/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4559

Authors: Kevin J Mastro, Kevin T Zitelli, Amanda M Willard, Kimberly H Leblanc, Alexxai V Kravitz & Aryn H Gittis

Cortical gamma band synchronization through somatostatin interneurons

Nature Neuroscience - Mon, 05/08/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4562

Authors: Julia Veit, Richard Hakim, Monika P Jadi, Terrence J Sejnowski & Hillel Adesnik

Thalamic projections sustain prefrontal activity during working memory maintenance

Nature Neuroscience - Wed, 05/03/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4568

Authors: Scott S Bolkan, Joseph M Stujenske, Sebastien Parnaudeau, Timothy J Spellman, Caroline Rauffenbart, Atheir I Abbas, Alexander Z Harris, Joshua A Gordon & Christoph Kellendonk

Mural lymphatic endothelial cells regulate meningeal angiogenesis in the zebrafish

Neuroscience in the News - Mon, 05/01/2017 - 12:00am

Nature Neuroscience 20, 774 (2017). doi:10.1038/nn.4558

Authors: Neil I Bower, Katarzyna Koltowska, Cathy Pichol-Thievend, Isaac Virshup, Scott Paterson, Anne K Lagendijk, Weili Wang, Benjamin W Lindsey, Stephen J Bent, Sungmin Baek, Maria Rondon-Galeano, Daniel G Hurley, Naoki Mochizuki, Cas Simons, Mathias Francois, Christine A Wells, Jan Kaslin & Benjamin M Hogan

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