Nature Neuroscience. doi:10.1038/nn.3806
Authors: Jeremy A Elman, Hwamee Oh, Cindee M Madison, Suzanne L Baker, Jacob W Vogel, Shawn M Marks, Sam Crowley, James P O'Neil & William J Jagust
Recruitment of extra neural resources may allow people to maintain normal cognition despite amyloid-β (Aβ) plaques. Previous fMRI studies have reported such hyperactivation, but it is unclear whether increases represent compensation or aberrant overexcitation. We found that older adults with Aβ deposition had reduced deactivations in task-negative regions, but increased activation in task-positive regions related to more detailed memory encoding. The association between higher activity and more detailed memories suggests that Aβ-related hyperactivation is compensatory.
Nature Neuroscience. doi:10.1038/nn.3809
Authors: Bogdan Beirowski, Elisabetta Babetto, Judith P Golden, Ying-Jr Chen, Kui Yang, Richard W Gross, Gary J Patti & Jeffrey Milbrandt
Nature Neuroscience. doi:10.1038/nn.3808
Authors: Athar N Malik, Thomas Vierbuchen, Martin Hemberg, Alex A Rubin, Emi Ling, Cameron H Couch, Hume Stroud, Ivo Spiegel, Kyle Kai-How Farh, David A Harmin & Michael E Greenberg
Nature Neuroscience. doi:10.1038/nn.3807
Authors: Rubén Moreno-Bote, Jeffrey Beck, Ingmar Kanitscheider, Xaq Pitkow, Peter Latham & Alexandre Pouget
Nature Neuroscience. doi:10.1038/nn.3805
Authors: Yin Yan, Malte J Rasch, Minggui Chen, Xiaoping Xiang, Min Huang, Si Wu & Wu Li
Nature Neuroscience. doi:10.1038/nn.3798
Authors: Lusha Zhu, Adrianna C Jenkins, Eric Set, Donatella Scabini, Robert T Knight, Pearl H Chiu, Brooks King-Casas & Ming Hsu
Substantial correlational evidence suggests that prefrontal regions are critical to honest and dishonest behavior, but causal evidence specifying the nature of this involvement remains absent. We found that lesions of the human dorsolateral prefrontal cortex (DLPFC) decreased the effect of honesty concerns on behavior in economic games that pit honesty motives against self-interest, but did not affect decisions when honesty concerns were absent. These results point to a causal role for DLPFC in honest behavior.
Nature Neuroscience. doi:10.1038/nn.3803
Authors: Jesse Jackson, Bénédicte Amilhon, Romain Goutagny, Jean-Bastien Bott, Frédéric Manseau, Christian Kortleven, Steven L Bressler & Sylvain Williams
Nature Neuroscience. doi:10.1038/nn.3800
Authors: Il Memming Park, Miriam L R Meister, Alexander C Huk & Jonathan W Pillow
Nature Neuroscience. doi:10.1038/nn.3804
Authors: J Andrew Pruszynski & Roland S Johansson
Nature Neuroscience. doi:10.1038/nn.3801
Authors: Adaikalavan Ramasamy, Daniah Trabzuni, Sebastian Guelfi, Vibin Varghese, Colin Smith, Robert Walker, Tisham De, Lachlan Coin, Rohan de Silva, Mark R Cookson, Andrew B Singleton, John Hardy, Mina Ryten & Michael E Weale
Nature Neuroscience 17, 1137 (2014). doi:10.1038/nn.3802
It is not enough to refute common myths about the brain: scientists need to highlight interesting real science as well.
Nature Neuroscience 17, 1138 (2014). doi:10.1038/nn.3792
Authors: Jenny Lord & Carlos Cruchaga
Two independent epigenome-wide association studies of Alzheimer's disease cohorts have identified overlapping methylation signals in four loci, ANK1, RPL13, RHBDF2 and CDH23, not previously associated with Alzheimer's disease. These studies also suggest that epigenetic changes contribute more to Alzheimer's disease than expected.
Nature Neuroscience 17, 1140 (2014). doi:10.1038/nn.3793
Authors: X William Yang & Ai Yamamoto
Polyglutamine expansion in the androgen receptor, causing X-linked spinal and bulbar muscular atrophy, impairs its function as a transcriptional coactivator regulating an extensive network of proteins involved in protein clearance.
Nature Neuroscience 17, 1142 (2014). doi:10.1038/nn.3795
Authors: Benjamin Y Hayden & Sarah R Heilbronner
In this issue, Shenhav et al. critically evaluate the idea that neural correlates of value actually represent value. They describe how, in many situations, value correlates can reflect other cognitive factors, such as decisional difficulty.
Nature Neuroscience 17, 1144 (2014). doi:10.1038/nn.3796
Author: Timothy E Holy
Olfaction has often been described as a 'synthetic' sense. A study now reveals a surprising capacity to resolve individual odorants in complex mixtures, with implications for how the nervous system recognizes objects.
Nature Neuroscience 17, 1146 (2014). doi:10.1038/nn.3779
Authors: Christophe D Proulx, Okihide Hikosaka & Roberto Malinow
Nature Neuroscience 17, 1286 (2014). doi:10.1038/nn0914-1286a
Author: Shalina S Ousman & Paul Kubes
Addendum: Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder
Nature Neuroscience 17, 1286 (2014). doi:10.1038/nn0914-1286b
Author: Martijn Figee, Judy Luigjes, Ruud Smolders, Carlos-Eduardo Valencia-Alfonso, Guido van Wingen, Bart de Kwaasteniet, Mariska Mantione, Pieter Ooms, Pelle de Koning, Nienke Vulink, Nina Levar, Lukas Droge, Pepijn van den Munckhof, P Richard Schuurman, Aart Nederveen, Wim van den Brink, Ali Mazaheri, Matthijs Vink & Damiaan Denys
Nature Neuroscience 17, 1286 (2014). doi:10.1038/nn0914-1286c
Author: Jiali Li, Ronald P Hart, Elyse M Mallimo, Mavis R Swerdel, Alexander W Kusnecov & Karl Herrup
Corrigendum: Identification of a unique TGF-β–dependent molecular and functional signature in microglia
Nature Neuroscience 17, 1286 (2014). doi:10.1038/nn0914-1286d
Author: Oleg Butovsky, Mark P Jedrychowski, Craig S Moore, Ron Cialic, Amanda J Lanser, Galina Gabriely, Thomas Koeglsperger, Ben Dake, Pauline M Wu, Camille E Doykan, Zain Fanek, LiPing Liu, Zhuoxun Chen, Jeffrey D Rothstein, Richard M Ransohoff, Steven P Gygi, Jack P Antel & Howard L Weiner