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Imagine a journey through time and space

Neuroscience in the News - Tue, 01/27/2015 - 12:00am

Nature Neuroscience 18, 163 (2015). doi:10.1038/nn.3926

Author: Lisa M Giocomo

The hippocampus, a structure critical for memory and navigation, contains both place and episodic cell assemblies. Synchronous input from the medial septum is crucial for inducing spatial and temporal neural sequences. These sequences are, in turn, necessary for constructing episodic cells and, in the absence of sensory input, place cells.

Neddylation is needed for synapse maturation

Neuroscience in the News - Tue, 01/27/2015 - 12:00am

Nature Neuroscience 18, 164 (2015). doi:10.1038/nn.3929

Authors: Amy K Fu & Nancy Y Ip

A study reports for the first time on the importance of post-translational modification by neddylation in postnatal brain development. In particular, it is critical to synapse maturation and stability, and thus to cognition.

Mobile binding sites regulate glutamate clearance

Neuroscience in the News - Tue, 01/27/2015 - 12:00am

Nature Neuroscience 18, 166 (2015). doi:10.1038/nn.3931

Author: Robert H Edwards

Glutamate transporters influence the kinetics of synaptic transmission by acutely buffering synaptically released glutamate. In addition to high synaptic density of EAAT2, the transporter's high mobility contributes to function.

A convergent tale of two species

Neuroscience in the News - Tue, 01/27/2015 - 12:00am

Nature Neuroscience 18, 168 (2015). doi:10.1038/nn.3928

Author: Shihab A Shamma

Spatial hearing in birds and mammals is more alike than previously thought in its patterns of developmental plasticity, physiological responses, and the computations employed to interpret binaural cues and map the environment.

The neocortical circuit: themes and variations

Neuroscience in the News - Tue, 01/27/2015 - 12:00am

Nature Neuroscience 18, 170 (2015). doi:10.1038/nn.3917

Authors: Kenneth D Harris & Gordon M G Shepherd

Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression

Nature Neuroscience - Mon, 01/26/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3927

Authors: Woosuk Chung, Su Yeon Choi, Eunee Lee, Haram Park, Jaeseung Kang, Hanwool Park, Yeonsoo Choi, Dongsoo Lee, Sae-Geun Park, Ryunhee Kim, Yi Sul Cho, Jeonghoon Choi, Myoung-Hwan Kim, Jong Won Lee, Seungjoon Lee, Issac Rhim, Min Whan Jung, Daesoo Kim, Yong Chul Bae & Eunjoon Kim

Planning activity for internally generated reward goals in monkey amygdala neurons

Nature Neuroscience - Mon, 01/26/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3925

Authors: István Hernádi, Fabian Grabenhorst & Wolfram Schultz

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory

Nature Neuroscience - Mon, 01/26/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3930

Authors: Anna G Orr, Edward C Hsiao, Max M Wang, Kaitlyn Ho, Daniel H Kim, Xin Wang, Weikun Guo, Jing Kang, Gui-Qiu Yu, Anthony Adame, Nino Devidze, Dena B Dubal, Eliezer Masliah, Bruce R Conklin & Lennart Mucke

The striatum multiplexes contextual and kinematic information to constrain motor habits execution

Nature Neuroscience - Mon, 01/26/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3924

Authors: Pavel E Rueda-Orozco & David Robbe

The development of cortical circuits for motion discrimination

Neuroscience in the News - Mon, 01/19/2015 - 12:00am

Nature Neuroscience 18, 252 (2015). doi:10.1038/nn.3921

Authors: Gordon B Smith, Audrey Sederberg, Yishai M Elyada, Stephen D Van Hooser, Matthias Kaschube & David Fitzpatrick

Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1

Neuroscience in the News - Mon, 01/19/2015 - 12:00am

Nature Neuroscience 18, 262 (2015). doi:10.1038/nn.3920

Authors: Sam F Cooke, Robert W Komorowski, Eitan S Kaplan, Jeffrey P Gavornik & Mark F Bear

The idiosyncratic brain: distortion of spontaneous connectivity patterns in autism spectrum disorder

Neuroscience in the News - Mon, 01/19/2015 - 12:00am

Nature Neuroscience 18, 302 (2015). doi:10.1038/nn.3919

Authors: Avital Hahamy, Marlene Behrmann & Rafael Malach

Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1

Nature Neuroscience - Mon, 01/19/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3920

Authors: Sam F Cooke, Robert W Komorowski, Eitan S Kaplan, Jeffrey P Gavornik & Mark F Bear

The idiosyncratic brain: distortion of spontaneous connectivity patterns in autism spectrum disorder

Nature Neuroscience - Mon, 01/19/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3919

Authors: Avital Hahamy, Marlene Behrmann & Rafael Malach

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

Nature Neuroscience - Mon, 01/19/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3922

Authors: Colm O'Dushlaine, Lizzy Rossin, Phil H Lee, Laramie Duncan, Neelroop N Parikshak, Stephen Newhouse, Stephan Ripke, Benjamin M Neale, Shaun M Purcell, Danielle Posthuma, John I Nurnberger, S Hong Lee, Stephen V Faraone, Roy H Perlis, Bryan J Mowry, Anita Thapar, Michael E Goddard, John S Witte, Devin Absher, Ingrid Agartz, Huda Akil, Farooq Amin, Ole A Andreassen, Adebayo Anjorin, Richard Anney, Verneri Anttila, Dan E Arking, Philip Asherson, Maria H Azevedo, Lena Backlund, Judith A Badner, Anthony J Bailey, Tobias Banaschewski, Jack D Barchas, Michael R Barnes, Thomas B Barrett, Nicholas Bass, Agatino Battaglia, Michael Bauer, Mònica Bayés, Frank Bellivier, Sarah E Bergen, Wade Berrettini, Catalina Betancur, Thomas Bettecken, Joseph Biederman, Elisabeth B Binder, Donald W Black, Douglas H R Blackwood, Cinnamon S Bloss, Michael Boehnke, Dorret I Boomsma, René Breuer, Richard Bruggeman, Paul Cormican, Nancy G Buccola, Jan K Buitelaar, William E Bunney, Joseph D Buxbaum, William F Byerley, Enda M Byrne, Sian Caesar, Wiepke Cahn, Rita M Cantor, Miguel Casas, Aravinda Chakravarti, Kimberly Chambert, Khalid Choudhury, Sven Cichon, Manuel Mattheisen, C Robert Cloninger, David A Collier, Edwin H Cook, Hilary Coon, Bru Cormand, Aiden Corvin, William H Coryell, David W Craig, Ian W Craig, Jennifer Crosbie, Michael L Cuccaro, David Curtis, Darina Czamara, Susmita Datta, Geraldine Dawson, Richard Day, Eco J De Geus, Franziska Degenhardt, Srdjan Djurovic, Gary J Donohoe, Alysa E Doyle, Jubao Duan, Frank Dudbridge, Eftichia Duketis, Richard P Ebstein, Howard J Edenberg, Josephine Elia, Sean Ennis, Bruno Etain, Ayman Fanous, Anne E Farmer, I Nicol Ferrier, Matthew Flickinger, Eric Fombonne, Tatiana Foroud, Josef Frank, Barbara Franke, Christine Fraser, Robert Freedman, Nelson B Freimer, Christine M Freitag, Marion Friedl, Louise Frisén, Louise Gallagher, Pablo V Gejman, Lyudmila Georgieva, Elliot S Gershon, Ina Giegling, Michael Gill, Scott D Gordon, Katherine Gordon-Smith, Elaine K Green, Tiffany A Greenwood, Dorothy E Grice, Magdalena Gross, Detelina Grozeva, Weihua Guan, Hugh Gurling, Lieuwe De Haan, Jonathan L Haines, Hakon Hakonarson, Joachim Hallmayer, Steven P Hamilton, Marian L Hamshere, Thomas F Hansen, Annette M Hartmann, Martin Hautzinger, Andrew C Heath, Anjali K Henders, Stefan Herms, Ian B Hickie, Maria Hipolito, Susanne Hoefels, Florian Holsboer, Witte J Hoogendijk, Jouke-Jan Hottenga, Christina M Hultman, Vanessa Hus, Andrés Ingason, Marcus Ising, Stéphane Jamain, Edward G Jones, Ian Jones, Lisa Jones, Jung-Ying Tzeng, Anna K Kähler, René S Kahn, Radhika Kandaswamy, Matthew C Keller, James L Kennedy, Elaine Kenny, Lindsey Kent, Yunjung Kim, George K Kirov, Sabine M Klauck, Lambertus Klei, James A Knowles, Martin A Kohli, Daniel L Koller, Bettina Konte, Ania Korszun, Lydia Krabbendam, Robert Krasucki, Jonna Kuntsi, Phoenix Kwan, Mikael Landén, Niklas Längström, Mark Lathrop, Jacob Lawrence, William B Lawson, Marion Leboyer, David H Ledbetter, Todd Lencz, Klaus-Peter Lesch, Douglas F Levinson, Cathryn M Lewis, Jun Li, Paul Lichtenstein, Jeffrey A Lieberman, Dan-Yu Lin, Don H Linszen, Chunyu Liu, Falk W Lohoff, Sandra K Loo, Catherine Lord, Jennifer K Lowe, Susanne Lucae, Donald J MacIntyre, Pamela A F Madden, Elena Maestrini, Patrik K E Magnusson, Pamela B Mahon, Wolfgang Maier, Anil K Malhotra, Shrikant M Mane, Christa L Martin, Nicholas G Martin, Keith Matthews, Morten Mattingsdal, Steven A McCarroll, Kevin A McGhee, James J McGough, Patrick J McGrath, Peter McGuffin, Melvin G McInnis, Andrew McIntosh, Rebecca McKinney, Alan W McLean, Francis J McMahon, William M McMahon, Andrew McQuillin, Helena Medeiros, Sarah E Medland, Sandra Meier, Ingrid Melle, Fan Meng, Jobst Meyer, Christel M Middeldorp, Lefkos Middleton, Vihra Milanova, Ana Miranda, Anthony P Monaco, Grant W Montgomery, Jennifer L Moran, Daniel Moreno-De-Luca, Gunnar Morken, Derek W Morris, Eric M Morrow, Valentina Moskvina, Pierandrea Muglia, Thomas W Mühleisen, Walter J Muir, Bertram Müller-Myhsok, Michael Murtha, Richard M Myers, Inez Myin-Germeys, Michael C Neale, Stan F Nelson, Caroline M Nievergelt, Ivan Nikolov, Vishwajit Nimgaonkar, Willem A Nolen, Markus M Nöthen, Evaristus A Nwulia, Dale R Nyholt, Robert D Oades, Ann Olincy, Guiomar Oliveira, Line Olsen, Roel A Ophoff, Urban Osby, Michael J Owen, Aarno Palotie, Jeremy R Parr, Andrew D Paterson, Carlos N Pato, Michele T Pato, Brenda W Penninx, Michele L Pergadia, Margaret A Pericak-Vance, Benjamin S Pickard, Jonathan Pimm, Joseph Piven, James B Potash, Fritz Poustka, Peter Propping, Vinay Puri, Digby J Quested, Emma M Quinn, Josep Antoni Ramos-Quiroga, Henrik B Rasmussen, Soumya Raychaudhuri, Karola Rehnström, Andreas Reif, Marta Ribasés, John P Rice, Marcella Rietschel, Kathryn Roeder, Herbert Roeyers, Aribert Rothenberger, Guy Rouleau, Douglas Ruderfer, Dan Rujescu, Alan R Sanders, Stephan J Sanders, Susan L Santangelo, Joseph A Sergeant, Russell Schachar, Martin Schalling, Alan F Schatzberg, William A Scheftner, Gerard D Schellenberg, Stephen W Scherer, Nicholas J Schork, Thomas G Schulze, Johannes Schumacher, Markus Schwarz, Edward Scolnick, Laura J Scott, Jianxin Shi, Paul D Shilling, Stanley I Shyn, Jeremy M Silverman, Susan L Slager, Susan L Smalley, Johannes H Smit, Erin N Smith, Edmund J S Sonuga-Barke, David St. Clair, Matthew State, Michael Steffens, Hans-Christoph Steinhausen, John S Strauss, Jana Strohmaier, T Scott Stroup, James S Sutcliffe, Peter Szatmari, Szabocls Szelinger, Srinivasa Thirumalai, Robert C Thompson, Alexandre A Todorov, Federica Tozzi, Jens Treutlein, Manfred Uhr, Edwin J C G van den Oord, Gerard Van Grootheest, Jim Van Os, Astrid M Vicente, Veronica J Vieland, John B Vincent, Peter M Visscher, Christopher A Walsh, Thomas H Wassink, Stanley J Watson, Myrna M Weissman, Thomas Werge, Thomas F Wienker, Ellen M Wijsman, Gonneke Willemsen, Nigel Williams, A Jeremy Willsey, Stephanie H Witt, Wei Xu, Allan H Young, Timothy W Yu, Stanley Zammit, Peter P Zandi, Peng Zhang, Frans G Zitman, Sebastian Zöllner, Bernie Devlin, John R Kelsoe, Pamela Sklar, Mark J Daly, Michael C O'Donovan, Nicholas Craddock, Kenneth S Kendler, Lauren A Weiss, Naomi R Wray, Zhaoming Zhao, Daniel H Geschwind, Patrick F Sullivan, Jordan W Smoller, Peter A Holmans & Gerome Breen

The development of cortical circuits for motion discrimination

Nature Neuroscience - Mon, 01/19/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3921

Authors: Gordon B Smith, Audrey Sederberg, Yishai M Elyada, Stephen D Van Hooser, Matthias Kaschube & David Fitzpatrick

Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion

Neuroscience in the News - Mon, 01/12/2015 - 12:00am

Nature Neuroscience 18, 182 (2015). doi:10.1038/nn.3911

Authors: Di Tian, Laura J Stoppel, Arnold J Heynen, Lothar Lindemann, Georg Jaeschke, Alea A Mills & Mark F Bear

Human chromosome 16p11.2 microdeletion is the most common gene copy number variation in autism, but the synaptic pathophysiology caused by this mutation is largely unknown. Using a mouse with the same genetic deficiency, we found that metabotropic glutamate receptor 5 (mGluR5)-dependent synaptic plasticity and protein synthesis was altered in the hippocampus and that hippocampus-dependent memory was impaired. Notably, chronic treatment with a negative allosteric modulator of mGluR5 reversed the cognitive deficit.

Complementary adaptive processes contribute to the developmental plasticity of spatial hearing

Neuroscience in the News - Mon, 01/12/2015 - 12:00am

Nature Neuroscience 18, 185 (2015). doi:10.1038/nn.3914

Authors: Peter Keating, Johannes C Dahmen & Andrew J King

Spatial hearing evolved independently in mammals and birds and is thought to adapt to altered developmental input in different ways. We found, however, that ferrets possess multiple forms of plasticity that are expressed according to which spatial cues are available, suggesting that the basis for adaptation may be similar across species. Our results also provide insight into the way sound source location is represented by populations of cortical neurons.

Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission

Neuroscience in the News - Mon, 01/12/2015 - 12:00am

Nature Neuroscience 18, 219 (2015). doi:10.1038/nn.3901

Authors: Ciaran Murphy-Royal, Julien P Dupuis, Juan A Varela, Aude Panatier, Benoît Pinson, Jérôme Baufreton, Laurent Groc & Stéphane H R Oliet

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