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Focus on big data

Neuroscience in the News - Tue, 10/28/2014 - 12:00am

Nature Neuroscience 17, 1429 (2014). doi:10.1038/nn.3856

Nature Neuroscience presents a special focus issue highlighting big data efforts under way in the field.

Converting Drosophobia into Drosophila

Neuroscience in the News - Tue, 10/28/2014 - 12:00am

Nature Neuroscience 17, 1430 (2014). doi:10.1038/nn.3845

Authors: Meng-Fu Maxwell Shih & Josh Dubnau

Fruit flies seek water, but only when they are thirsty. And imbibing is rewarding only to water-deprived individuals. The effects of thirst on water seeking and on formation of associative memories of drinking water each are mediated by distinct sets of dopamine neurons that innervate restricted zones of the mushroom bodies in the fly brain.

Bilingual neurons release glutamate and GABA

Neuroscience in the News - Tue, 10/28/2014 - 12:00am

Nature Neuroscience 17, 1432 (2014). doi:10.1038/nn.3840

Author: Naoshige Uchida

A study finds evidence supporting co-release of glutamate and GABA, excitatory and inhibitory fast neurotransmitters, from a single axon terminal in neurons of the ventral tegmental area that project to the lateral habenula.

Cortical adaptation and tactile perception

Neuroscience in the News - Tue, 10/28/2014 - 12:00am

Nature Neuroscience 17, 1434 (2014). doi:10.1038/nn.3847

Authors: Hongdian Yang & Daniel H O'Connor

Cortical neurons reduce spiking responses to repetitive sensory stimulation, but the perceptual impact of this adaptation has been difficult to assess. Work now shows that it has profound consequences for tactile perception.

A local anchor for the brain's compass

Neuroscience in the News - Tue, 10/28/2014 - 12:00am

Nature Neuroscience 17, 1436 (2014). doi:10.1038/nn.3841

Authors: Martin J Chadwick & Hugo J Spiers

Retrosplenial cortex neurons provide a signal akin to a compass readout. Evidence in humans now demonstrates that these neurons anchor their representations locally, locking to the geometry of a room rather than to the city beyond.

Pain and the PAG: learning from painful mistakes

Neuroscience in the News - Tue, 10/28/2014 - 12:00am

Nature Neuroscience 17, 1438 (2014). doi:10.1038/nn.3844

Authors: Falk Eippert & Irene Tracey

Jeremy Bentham distilled animal behavior as avoiding pain and seeking pleasure. Now, using a combination of different methodological approaches, Roy et al. identify a neural mechanism relevant for learning to avoid pain.

Putting big data to good use in neuroscience

Neuroscience in the News - Tue, 10/28/2014 - 12:00am

Nature Neuroscience 17, 1440 (2014). doi:10.1038/nn.3839

Authors: Terrence J Sejnowski, Patricia S Churchland & J Anthony Movshon

Big data from small data: data-sharing in the 'long tail' of neuroscience

Neuroscience in the News - Tue, 10/28/2014 - 12:00am

Nature Neuroscience 17, 1442 (2014). doi:10.1038/nn.3838

Authors: Adam R Ferguson, Jessica L Nielson, Melissa H Cragin, Anita E Bandrowski & Maryann E Martone

The big data challenges of connectomics

Neuroscience in the News - Tue, 10/28/2014 - 12:00am

Nature Neuroscience 17, 1448 (2014). doi:10.1038/nn.3837

Authors: Jeff W Lichtman, Hanspeter Pfister & Nir Shavit

Big behavioral data: psychology, ethology and the foundations of neuroscience

Neuroscience in the News - Tue, 10/28/2014 - 12:00am

Nature Neuroscience 17, 1455 (2014). doi:10.1038/nn.3812

Authors: Alex Gomez-Marin, Joseph J Paton, Adam R Kampff, Rui M Costa & Zachary F Mainen

Decoding neural transcriptomes and epigenomes via high-throughput sequencing

Neuroscience in the News - Tue, 10/28/2014 - 12:00am

Nature Neuroscience 17, 1463 (2014). doi:10.1038/nn.3814

Authors: Jaehoon Shin, Guo-li Ming & Hongjun Song

Analytical tools and current challenges in the modern era of neuroepigenomics

Neuroscience in the News - Tue, 10/28/2014 - 12:00am

Nature Neuroscience 17, 1476 (2014). doi:10.1038/nn.3816

Authors: Ian Maze, Li Shen, Bin Zhang, Benjamin A Garcia, Ningyi Shao, Amanda Mitchell, HaoSheng Sun, Schahram Akbarian, C David Allis & Eric J Nestler

Decoding neuroproteomics: integrating the genome, translatome and functional anatomy

Neuroscience in the News - Tue, 10/28/2014 - 12:00am

Nature Neuroscience 17, 1491 (2014). doi:10.1038/nn.3829

Authors: Robert R Kitchen, Joel S Rozowsky, Mark B Gerstein & Angus C Nairn

Making big data open: data sharing in neuroimaging

Neuroscience in the News - Tue, 10/28/2014 - 12:00am

Nature Neuroscience 17, 1510 (2014). doi:10.1038/nn.3818

Authors: Russell A Poldrack & Krzysztof J Gorgolewski

Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors

Nature Neuroscience - Mon, 10/27/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3871

Authors: Elizabeth A Heller, Hannah M Cates, Catherine J Peña, Haosheng Sun, Ningyi Shao, Jian Feng, Sam A Golden, James P Herman, Jessica J Walsh, Michelle Mazei-Robison, Deveroux Ferguson, Scott Knight, Mark A Gerber, Christian Nievera, Ming-Hu Han, Scott J Russo, Carol S Tamminga, Rachael L Neve, Li Shen, H Steve Zhang, Feng Zhang & Eric J Nestler

Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults

Nature Neuroscience - Sun, 10/26/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3850

Authors: Adam M Brickman, Usman A Khan, Frank A Provenzano, Lok-Kin Yeung, Wendy Suzuki, Hagen Schroeter, Melanie Wall, Richard P Sloan & Scott A Small

An α2-Na/K ATPase/α-adducin complex in astrocytes triggers non–cell autonomous neurodegeneration

Nature Neuroscience - Sun, 10/26/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3853

Authors: Gilbert Gallardo, Jessica Barowski, John Ravits, Teepu Siddique, Jerry B Lingrel, Janice Robertson, Hanno Steen & Azad Bonni

Rods in daylight act as relay cells for cone-driven horizontal cell–mediated surround inhibition

Nature Neuroscience - Sun, 10/26/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3852

Authors: Tamas Szikra, Stuart Trenholm, Antonia Drinnenberg, Josephine Jüttner, Zoltan Raics, Karl Farrow, Martin Biel, Gautam Awatramani, Damon A Clark, José-Alain Sahel, Rava Azeredo da Silveira & Botond Roska

Nonlinear dendritic integration of electrical and chemical synaptic inputs drives fine-scale correlations

Nature Neuroscience - Sun, 10/26/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3851

Authors: Stuart Trenholm, Amanda J McLaughlin, David J Schwab, Maxwell H Turner, Robert G Smith, Fred Rieke & Gautam B Awatramani

Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence

Nature Neuroscience - Sun, 10/19/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3843

Authors: Colin G McNamara, Álvaro Tejero-Cantero, Stéphanie Trouche, Natalia Campo-Urriza & David Dupret

We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest. When applied during spatial learning of new goal locations, dopaminergic photostimulation improved the later recall of neural representations of space and stabilized memory performance. These findings reveal that midbrain dopaminergic neurons promote hippocampal network dynamics associated with memory persistence.

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