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Sugar and Alzheimer's disease: a bittersweet truth

Neuroscience in the News - Thu, 03/26/2015 - 12:00am

Nature Neuroscience 18, 477 (2015). doi:10.1038/nn.3986

Author: Costantino Iadecola

Reductions in brain glucose metabolism have long been associated with Alzheimer's disease. A study now demonstrates that the endothelial glucose transporter GLUT1 is vital for maintaining brain energy metabolism and vascular clearance of amyloid-β.

Cocaine shapes chromatin landscapes via Tet1

Neuroscience in the News - Thu, 03/26/2015 - 12:00am

Nature Neuroscience 18, 478 (2015). doi:10.1038/nn.3985

Author: Anne E West

Chronic cocaine exposure induces long-lasting, transcription-dependent changes in neuronal function. A genome-wide sequencing study shows how cocaine changes the epigenome to exert specific, long-lasting effects on neuronal transcription.

Carrot or stick in motor learning

Neuroscience in the News - Thu, 03/26/2015 - 12:00am

Nature Neuroscience 18, 480 (2015). doi:10.1038/nn.3978

Authors: Dagmar Sternad & Konrad Paul Körding

A study shows that reward and punishment have distinct influences on motor adaptation. Punishing mistakes accelerates adaptation, whereas rewarding good behavior improves retention.

The compass within

Neuroscience in the News - Thu, 03/26/2015 - 12:00am

Nature Neuroscience 18, 482 (2015). doi:10.1038/nn.3977

Authors: Nathan W Schultheiss & A David Redish

Head direction cells have been hypothesized to form representations of an animal's spatial orientation through internal network interactions. New data from mice show the predicted signatures of these internal dynamics.

Forming artificial memories during sleep

Neuroscience in the News - Thu, 03/26/2015 - 12:00am

Nature Neuroscience 18, 483 (2015). doi:10.1038/nn1504-483

Author: Brigitta Gundersen

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

Nature Neuroscience - Tue, 03/24/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4000

Authors: Axel Freischmidt, Thomas Wieland, Benjamin Richter, Wolfgang Ruf, Veronique Schaeffer, Kathrin Müller, Nicolai Marroquin, Frida Nordin, Annemarie Hübers, Patrick Weydt, Susana Pinto, Rayomond Press, Stéphanie Millecamps, Nicolas Molko, Emilien Bernard, Claude Desnuelle, Marie-Hélène Soriani, Johannes Dorst, Elisabeth Graf, Ulrika Nordström, Marisa S Feiler, Stefan Putz, Tobias M Boeckers, Thomas Meyer, Andrea S Winkler, Juliane Winkelman, Mamede de Carvalho, Dietmar R Thal, Markus Otto, Thomas Brännström, Alexander E Volk, Petri Kursula, Karin M Danzer, Peter Lichtner, Ivan Dikic, Thomas Meitinger, Albert C Ludolph, Tim M Strom, Peter M Andersen & Jochen H Weishaupt

Model-based choices involve prospective neural activity

Nature Neuroscience - Mon, 03/23/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3981

Authors: Bradley B Doll, Katherine D Duncan, Dylan A Simon, Daphna Shohamy & Nathaniel D Daw

Global network influences on local functional connectivity

Nature Neuroscience - Mon, 03/23/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3979

Authors: Adam C Snyder, Michael J Morais, Cory M Willis & Matthew A Smith

Role of Tet1 and 5-hydroxymethylcytosine in cocaine action

Neuroscience in the News - Mon, 03/16/2015 - 12:00am

Nature Neuroscience 18, 536 (2015). doi:10.1038/nn.3976

Authors: Jian Feng, Ningyi Shao, Keith E Szulwach, Vincent Vialou, Jimmy Huynh, Chun Zhong, Thuc Le, Deveroux Ferguson, Michael E Cahill, Yujing Li, Ja Wook Koo, Efrain Ribeiro, Benoit Labonte, Benjamin M Laitman, David Estey, Victoria Stockman, Pamela Kennedy, Thomas Couroussé, Isaac Mensah, Gustavo Turecki, Kym F Faull, Guo-li Ming, Hongjun Song, Guoping Fan, Patrizia Casaccia, Li Shen, Peng Jin & Eric J Nestler

Retrieval induces adaptive forgetting of competing memories via cortical pattern suppression

Neuroscience in the News - Mon, 03/16/2015 - 12:00am

Nature Neuroscience 18, 582 (2015). doi:10.1038/nn.3973

Authors: Maria Wimber, Arjen Alink, Ian Charest, Nikolaus Kriegeskorte & Michael C Anderson

Role of Tet1 and 5-hydroxymethylcytosine in cocaine action

Nature Neuroscience - Mon, 03/16/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3976

Authors: Jian Feng, Ningyi Shao, Keith E Szulwach, Vincent Vialou, Jimmy Huynh, Chun Zhong, Thuc Le, Deveroux Ferguson, Michael E Cahill, Yujing Li, Ja Wook Koo, Efrain Ribeiro, Benoit Labonte, Benjamin M Laitman, David Estey, Victoria Stockman, Pamela Kennedy, Thomas Couroussé, Isaac Mensah, Gustavo Turecki, Kym F Faull, Guo-li Ming, Hongjun Song, Guoping Fan, Patrizia Casaccia, Li Shen, Peng Jin & Eric J Nestler

Retrieval induces adaptive forgetting of competing memories via cortical pattern suppression

Nature Neuroscience - Mon, 03/16/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3973

Authors: Maria Wimber, Arjen Alink, Ian Charest, Nikolaus Kriegeskorte & Michael C Anderson

Explicit memory creation during sleep demonstrates a causal role of place cells in navigation

Neuroscience in the News - Mon, 03/09/2015 - 12:00am

Nature Neuroscience 18, 493 (2015). doi:10.1038/nn.3970

Authors: Gaetan de Lavilléon, Marie Masako Lacroix, Laure Rondi-Reig & Karim Benchenane

Hippocampal place cells assemblies are believed to support the cognitive map, and their reactivations during sleep are thought to be involved in spatial memory consolidation. By triggering intracranial rewarding stimulations by place cell spikes during sleep, we induced an explicit memory trace, leading to a goal-directed behavior toward the place field. This demonstrates that place cells' activity during sleep still conveys relevant spatial information and that this activity is functionally significant for navigation.

The dorsal posterior insula subserves a fundamental role in human pain

Neuroscience in the News - Mon, 03/09/2015 - 12:00am

Nature Neuroscience 18, 499 (2015). doi:10.1038/nn.3969

Authors: Andrew R Segerdahl, Melvin Mezue, Thomas W Okell, John T Farrar & Irene Tracey

Several brain regions have been implicated in human painful experiences, but none have been proven to be specific to pain. We exploited arterial spin-labeling quantitative perfusion imaging and a newly developed procedure to identify a specific role for the dorsal posterior insula (dpIns) in pain. Tract tracing studies in animals identify a similar region as fundamental to nociception, which suggests the dpIns is its human homolog and, as such, a potential therapeutic target.

Somatostatin cells regulate sensory response fidelity via subtractive inhibition in olfactory cortex

Neuroscience in the News - Mon, 03/09/2015 - 12:00am

Nature Neuroscience 18, 531 (2015). doi:10.1038/nn.3971

Authors: James F Sturgill & Jeffry S Isaacson

NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking

Neuroscience in the News - Mon, 03/09/2015 - 12:00am

Nature Neuroscience 18, 545 (2015). doi:10.1038/nn.3972

Authors: Kristen E Pleil, Jennifer A Rinker, Emily G Lowery-Gionta, Christopher M Mazzone, Nora M McCall, Alexis M Kendra, David P Olson, Bradford B Lowell, Kathleen A Grant, Todd E Thiele & Thomas L Kash

The dorsal posterior insula subserves a fundamental role in human pain

Nature Neuroscience - Mon, 03/09/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3969

Authors: Andrew R Segerdahl, Melvin Mezue, Thomas W Okell, John T Farrar & Irene Tracey

Several brain regions have been implicated in human painful experiences, but none have been proven to be specific to pain. We exploited arterial spin-labeling quantitative perfusion imaging and a newly developed procedure to identify a specific role for the dorsal posterior insula (dpIns) in pain. Tract tracing studies in animals identify a similar region as fundamental to nociception, which suggests the dpIns is its human homolog and, as such, a potential therapeutic target.

Explicit memory creation during sleep demonstrates a causal role of place cells in navigation

Nature Neuroscience - Mon, 03/09/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3970

Authors: Gaetan de Lavilléon, Marie Masako Lacroix, Laure Rondi-Reig & Karim Benchenane

Hippocampal place cells assemblies are believed to support the cognitive map, and their reactivations during sleep are thought to be involved in spatial memory consolidation. By triggering intracranial rewarding stimulations by place cell spikes during sleep, we induced an explicit memory trace, leading to a goal-directed behavior toward the place field. This demonstrates that place cells' activity during sleep still conveys relevant spatial information and that this activity is functionally significant for navigation.

NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking

Nature Neuroscience - Mon, 03/09/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3972

Authors: Kristen E Pleil, Jennifer A Rinker, Emily G Lowery-Gionta, Christopher M Mazzone, Nora M McCall, Alexis M Kendra, David P Olson, Bradford B Lowell, Kathleen A Grant, Todd E Thiele & Thomas L Kash

Somatostatin cells regulate sensory response fidelity via subtractive inhibition in olfactory cortex

Nature Neuroscience - Mon, 03/09/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3971

Authors: James F Sturgill & Jeffry S Isaacson

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