Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
Updated: 14 hours 22 min ago

Instrumental learning of traits versus rewards: dissociable neural correlates and effects on choice

Mon, 08/03/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4080

Authors: Leor M Hackel, Bradley B Doll & David M Amodio

Humans learn about people and objects through positive and negative experiences, yet they can also look beyond the immediate reward of an interaction to encode trait-level attributes. We found that perceivers encoded both reward and trait-level information through feedback in an instrumental learning task, but relied more heavily on trait representations in cross-context decisions. Both learning types implicated ventral striatum, but trait learning also recruited a network associated with social impression formation.

Learning to expect the unexpected: rapid updating in primate cerebellum during voluntary self-motion

Mon, 08/03/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4077

Authors: Jessica X Brooks, Jerome Carriot & Kathleen E Cullen

Dynamic rewiring of neural circuits in the motor cortex in mouse models of Parkinson's disease

Mon, 08/03/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4082

Authors: Lili Guo, Huan Xiong, Jae-Ick Kim, Yu-Wei Wu, Rupa R Lalchandani, Yuting Cui, Yu Shu, Tonghui Xu & Jun B Ding

Cellular evidence for efference copy in Drosophila visuomotor processing

Mon, 08/03/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4083

Authors: Anmo J Kim, Jamie K Fitzgerald & Gaby Maimon

Naturalistic stimulation drives opposing heterosynaptic plasticity at two inputs to songbird cortex

Mon, 08/03/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4078

Authors: W Hamish Mehaffey & Allison J Doupe

Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome

Mon, 08/03/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4072

Authors: Jonathan Witton, Ragunathan Padmashri, Larissa E Zinyuk, Victor I Popov, Igor Kraev, Samantha J Line, Thomas P Jensen, Angelo Tedoldi, Damian M Cummings, Victor L J Tybulewicz, Elizabeth M C Fisher, David M Bannerman, Andrew D Randall, Jonathan T Brown, Frances A Edwards, Dmitri A Rusakov, Michael G Stewart & Matt W Jones

Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections

Mon, 07/27/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4068

Authors: Yonatan M Kupchik, Robyn M Brown, Jasper A Heinsbroek, Mary Kay Lobo, Danielle J Schwartz & Peter W Kalivas

It is widely accepted that D1 dopamine receptor–expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to mouse nucleus accumbens projections to the ventral pallidum. Thus, current thinking attributing D1 and D2 selectivity to accumbens projections akin to dorsal striatal pathways needs to be reconsidered.

Determinants of different deep and superficial CA1 pyramidal cell dynamics during sharp-wave ripples

Mon, 07/27/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4074

Authors: Manuel Valero, Elena Cid, Robert G Averkin, Juan Aguilar, Alberto Sanchez-Aguilera, Tim J Viney, Daniel Gomez-Dominguez, Elisa Bellistri & Liset Menendez de la Prida

Oscillatory dynamics coordinating human frontal networks in support of goal maintenance

Mon, 07/27/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4071

Authors: Bradley Voytek, Andrew S Kayser, David Badre, David Fegen, Edward F Chang, Nathan E Crone, Josef Parvizi, Robert T Knight & Mark D'Esposito

LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control

Mon, 07/27/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4069

Authors: Jianxun Wang, Francesca Telese, Yuliang Tan, Wenbo Li, Chunyu Jin, Xin He, Harihar Basnet, Qi Ma, Daria Merkurjev, Xiaoyan Zhu, Zhijie Liu, Jie Zhang, Kenny Ohgi, Havilah Taylor, Ryan R White, Cagdas Tazearsalan, Yousin Suh, Todd S Macfarlan, Samuel L Pfaff & Michael G Rosenfeld

Identification of neurodegenerative factors using translatome–regulatory network analysis

Mon, 07/27/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4070

Authors: Lars Brichta, William Shin, Vernice Jackson-Lewis, Javier Blesa, Ee-Lynn Yap, Zachary Walker, Jack Zhang, Jean-Pierre Roussarie, Mariano J Alvarez, Andrea Califano, Serge Przedborski & Paul Greengard

Automatic integration of confidence in the brain valuation signal

Mon, 07/20/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4064

Authors: Maël Lebreton, Raphaëlle Abitbol, Jean Daunizeau & Mathias Pessiglione

The role of ventral striatal cAMP signaling in stress-induced behaviors

Mon, 07/20/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4066

Authors: Florian Plattner, Kanehiro Hayashi, Adan Hernández, David R Benavides, Tara C Tassin, Chunfeng Tan, Jonathan Day, Maggy W Fina, Eunice Y Yuen, Zhen Yan, Matthew S Goldberg, Angus C Nairn, Paul Greengard, Eric J Nestler, Ronald Taussig, Akinori Nishi, Miles D Houslay & James A Bibb

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

Mon, 07/20/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4067

Authors: Meaghan Morris, Giselle M Knudsen, Sumihiro Maeda, Jonathan C Trinidad, Alexandra Ioanoviciu, Alma L Burlingame & Lennart Mucke

Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS

Mon, 07/20/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4065

Authors: Mercedes Prudencio, Veronique V Belzil, Ranjan Batra, Christian A Ross, Tania F Gendron, Luc J Pregent, Melissa E Murray, Karen K Overstreet, Amelia E Piazza-Johnston, Pamela Desaro, Kevin F Bieniek, Michael DeTure, Wing C Lee, Sherri M Biendarra, Mary D Davis, Matthew C Baker, Ralph B Perkerson, Marka van Blitterswijk, Caroline T Stetler, Rosa Rademakers, Christopher D Link, Dennis W Dickson, Kevin B Boylan, Hu Li & Leonard Petrucelli

Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons

Mon, 07/13/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4062

Authors: Katie C Bittner, Christine Grienberger, Sachin P Vaidya, Aaron D Milstein, John J Macklin, Junghyup Suh, Susumu Tonegawa & Jeffrey C Magee

Learning enhances the relative impact of top-down processing in the visual cortex

Mon, 07/13/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4061

Authors: Hiroshi Makino & Takaki Komiyama

Coexpression networks identify brain region–specific enhancer RNAs in the human brain

Mon, 07/13/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4063

Authors: Pu Yao, Peijie Lin, Akira Gokoolparsadh, Amelia Assareh, Mike W C Thang & Irina Voineagu

Retrosplenial cortex maps the conjunction of internal and external spaces

Mon, 07/06/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4058

Authors: Andrew S Alexander & Douglas A Nitz

Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking

Mon, 07/06/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4060

Authors: Shuyong Zhu, Chengjiang Zhao, Yingying Wu, Qiaoqiao Yang, Aiyun Shao, Tiepeng Wang, Jianfu Wu, Yanqing Yin, Yandong Li, Jincan Hou, Xinhua Zhang, Guomin Zhou, Xiaosong Gu, Xiaomin Wang, Xosé R Bustelo & Jiawei Zhou