Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
Updated: 44 min 20 sec ago

Control of glioblastoma tumorigenesis by feed-forward cytokine signaling

Mon, 04/25/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4295

Authors: Arezu Jahani-Asl, Hang Yin, Vahab D Soleimani, Takrima Haque, H Artee Luchman, Natasha C Chang, Marie-Claude Sincennes, Sidharth V Puram, Andrew M Scott, Ian A J Lorimer, Theodore J Perkins, Keith L Ligon, Samuel Weiss, Michael A Rudnicki & Azad Bonni

Serotonin modulates spike probability in the axon initial segment through HCN channels

Mon, 04/25/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4293

Authors: Kwang Woo Ko, Matthew N Rasband, Victor Meseguer, Richard H Kramer & Nace L Golding

Reward and choice encoding in terminals of midbrain dopamine neurons depends on striatal target

Mon, 04/25/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4287

Authors: Nathan F Parker, Courtney M Cameron, Joshua P Taliaferro, Junuk Lee, Jung Yoon Choi, Thomas J Davidson, Nathaniel D Daw & Ilana B Witten

Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells

Mon, 04/25/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4297

Authors: Yuanchao Xue, Hao Qian, Jing Hu, Bing Zhou, Yu Zhou, Xihao Hu, Aziz Karakhanyan, Zhiping Pang & Xiang-Dong Fu

Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury

Mon, 04/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4289

Authors: Masaki Ueno, Yuka Ueno-Nakamura, Jesse Niehaus, Phillip G Popovich & Yutaka Yoshida

Spinal cord injury (SCI) at high spinal levels (e.g., above thoracic level 5) causes systemic immune suppression; however, the underlying mechanisms are unknown. Here we show that profound plasticity develops within spinal autonomic circuitry below the injury, creating a sympathetic anti-inflammatory reflex, and that chemogenetic silencing of this reflex circuitry blocks post-SCI immune suppression. These data provide new insights and potential therapeutic options for limiting the devastating consequences of post-traumatic autonomic hyperreflexia and post-injury immune suppression.

Coordinated grid and place cell replay during rest

Mon, 04/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4291

Authors: H Freyja Ólafsdóttir, Francis Carpenter & Caswell Barry

Hippocampal replay has been hypothesized to underlie memory consolidation and navigational planning, yet the involvement of grid cells in replay is unknown. During replay we found grid cells to be spatially coherent with place cells, encoding locations 11 ms delayed relative to the hippocampus, with directionally modulated grid cells and forward replay exhibiting the greatest coherence with the CA1 area of the hippocampus. This suggests grid cells are engaged during the consolidation of spatial memories to the neocortex.

Dense EM-based reconstruction of the interglomerular projectome in the zebrafish olfactory bulb

Mon, 04/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4290

Authors: Adrian A Wanner, Christel Genoud, Tafheem Masudi, Léa Siksou & Rainer W Friedrich

Linking pattern completion in the hippocampus to predictive coding in visual cortex

Mon, 04/11/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4284

Authors: Nicholas C Hindy, Felicia Y Ng & Nicholas B Turk-Browne

Models of predictive coding frame perception as a generative process in which expectations constrain sensory representations. These models account for expectations about how a stimulus will move or change from moment to moment, but do not address expectations about what other, distinct stimuli are likely to appear based on prior experience. We show that such memory-based expectations in human visual cortex are related to the hippocampal mechanism of pattern completion.

Is cortical connectivity optimized for storing information?

Mon, 04/11/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4286

Author: Nicolas Brunel

Ryk controls remapping of motor cortex during functional recovery after spinal cord injury

Mon, 04/11/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4282

Authors: Edmund R Hollis, Nao Ishiko, Ting Yu, Chin-Chun Lu, Ariela Haimovich, Kristine Tolentino, Alisha Richman, Anna Tury, Shih-Hsiu Wang, Maysam Pessian, Euna Jo, Alex Kolodkin & Yimin Zou

A GABAergic nigrotectal pathway for coordination of drinking behavior

Mon, 04/04/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4285

Authors: Mark A Rossi, Haofang E Li, Dongye Lu, Il Hwan Kim, Ryan A Bartholomew, Erin Gaidis, Joseph W Barter, Namsoo Kim, Min Tong Cai, Scott H Soderling & Henry H Yin

The RNA-binding protein SFPQ orchestrates an RNA regulon to promote axon viability

Mon, 03/28/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4280

Authors: Katharina E Cosker, Sara J Fenstermacher, Maria F Pazyra-Murphy, Hunter L Elliott & Rosalind A Segal

Agouti-related peptide neural circuits mediate adaptive behaviors in the starved state

Mon, 03/28/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4274

Authors: Stephanie L Padilla, Jian Qiu, Marta E Soden, Elisenda Sanz, Casey C Nestor, Forrest D Barker, Albert Quintana, Larry S Zweifel, Oline K Rønnekleiv, Martin J Kelly & Richard D Palmiter

VTA glutamatergic inputs to nucleus accumbens drive aversion by acting on GABAergic interneurons

Mon, 03/28/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4281

Authors: Jia Qi, Shiliang Zhang, Hui-Ling Wang, David J Barker, Jorge Miranda-Barrientos & Marisela Morales

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

Mon, 03/21/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4272

Authors: Yong-Jie Zhang, Tania F Gendron, Jonathan C Grima, Hiroki Sasaguri, Karen Jansen-West, Ya-Fei Xu, Rebecca B Katzman, Jennifer Gass, Melissa E Murray, Mitsuru Shinohara, Wen-Lang Lin, Aliesha Garrett, Jeannette N Stankowski, Lillian Daughrity, Jimei Tong, Emilie A Perkerson, Mei Yue, Jeannie Chew, Monica Castanedes-Casey, Aishe Kurti, Zizhao S Wang, Amanda M Liesinger, Jeremy D Baker, Jie Jiang, Clotilde Lagier-Tourenne, Dieter Edbauer, Don W Cleveland, Rosa Rademakers, Kevin B Boylan, Guojun Bu, Christopher D Link, Chad A Dickey, Jeffrey D Rothstein, Dennis W Dickson, John D Fryer & Leonard Petrucelli

Schizophrenia genetics complements its mechanistic understanding

Mon, 03/21/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4277

Authors: Elizabeth K Ruzzo & Daniel H Geschwind

Refinement of genetic variants within the major histocompatibility complex reveals three distinct genetic influences on schizophrenia risk and sheds light on the disease's neurobiology.

Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders

Mon, 03/14/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4267

Authors: Tarjinder Singh, Mitja I Kurki, David Curtis, Shaun M Purcell, Lucy Crooks, Jeremy McRae, Jaana Suvisaari, Himanshu Chheda, Douglas Blackwood, Gerome Breen, Olli Pietiläinen, Sebastian S Gerety, Muhammad Ayub, Moira Blyth, Trevor Cole, David Collier, Eve L Coomber, Nick Craddock, Mark J Daly, John Danesh, Marta DiForti, Alison Foster, Nelson B Freimer, Daniel Geschwind, Mandy Johnstone, Shelagh Joss, Georg Kirov, Jarmo Körkkö, Outi Kuismin, Peter Holmans, Christina M Hultman, Conrad Iyegbe, Jouko Lönnqvist, Minna Männikkö, Steve A McCarroll, Peter McGuffin, Andrew M McIntosh, Andrew McQuillin, Jukka S Moilanen, Carmel Moore, Robin M Murray, Ruth Newbury-Ecob, Willem Ouwehand, Tiina Paunio, Elena Prigmore, Elliott Rees, David Roberts, Jennifer Sambrook, Pamela Sklar, David St Clair, Juha Veijola, James T R Walters, Hywel Williams, Patrick F Sullivan, Matthew E Hurles, Michael C O'Donovan, Aarno Palotie, Michael J Owen & Jeffrey C Barrett

Spike sorting for large, dense electrode arrays

Mon, 03/14/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4268

Authors: Cyrille Rossant, Shabnam N Kadir, Dan F M Goodman, John Schulman, Maximilian L D Hunter, Aman B Saleem, Andres Grosmark, Mariano Belluscio, George H Denfield, Alexander S Ecker, Andreas S Tolias, Samuel Solomon, György Buzsáki, Matteo Carandini & Kenneth D Harris

Biophysical constraints of optogenetic inhibition at presynaptic terminals

Mon, 03/07/2016 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4266

Authors: Mathias Mahn, Matthias Prigge, Shiri Ron, Rivka Levy & Ofer Yizhar

We investigated the efficacy of optogenetic inhibition at presynaptic terminals using halorhodopsin, archaerhodopsin and chloride-conducting channelrhodopsins. Precisely timed activation of both archaerhodopsin and halorhodpsin at presynaptic terminals attenuated evoked release. However, sustained archaerhodopsin activation was paradoxically associated with increased spontaneous release. Activation of chloride-conducting channelrhodopsins triggered neurotransmitter release upon light onset. Thus, the biophysical properties of presynaptic terminals dictate unique boundary conditions for optogenetic manipulation.

Hypothalamic control of male aggression-seeking behavior

Mon, 03/07/2016 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4264

Authors: Annegret L Falkner, Logan Grosenick, Thomas J Davidson, Karl Deisseroth & Dayu Lin