Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
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Delayed stabilization and individualization in connectome development are related to psychiatric disorders

Mon, 02/20/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4511

Authors: Tobias Kaufmann, Dag Alnæs, Nhat Trung Doan, Christine Lycke Brandt, Ole A Andreassen & Lars T Westlye

The brain functional connectome constitutes a unique fingerprint allowing identification of individuals among a pool of people. Here we establish that the connectome develops into a more stable, individual wiring pattern during adolescence and demonstrate that a delay in this network tuning process is associated with reduced mental health in the formative years of late neurodevelopment.

Persistently active neurons in human medial frontal and medial temporal lobe support working memory

Mon, 02/20/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4509

Authors: Jan Kamin´ski, Shannon Sullivan, Jeffrey M Chung, Ian B Ross, Adam N Mamelak & Ueli Rutishauser

Hippocampal awake replay in fear memory retrieval

Mon, 02/20/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4507

Authors: Chun-Ting Wu, Daniel Haggerty, Caleb Kemere & Daoyun Ji

One-step optogenetics with multifunctional flexible polymer fibers

Mon, 02/20/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4510

Authors: Seongjun Park, Yuanyuan Guo, Xiaoting Jia, Han Kyoung Choe, Benjamin Grena, Jeewoo Kang, Jiyeon Park, Chi Lu, Andres Canales, Ritchie Chen, Yeong Shin Yim, Gloria B Choi, Yoel Fink & Polina Anikeeva

Cadherins mediate cocaine-induced synaptic plasticity and behavioral conditioning

Mon, 02/13/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4503

Authors: Fergil Mills, Andrea K Globa, Shuai Liu, Catherine M Cowan, Mahsan Mobasser, Anthony G Phillips, Stephanie L Borgland & Shernaz X Bamji

Metabotropic action of postsynaptic kainate receptors triggers hippocampal long-term potentiation

Mon, 02/13/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4505

Authors: Milos M Petrovic, Silvia Viana da Silva, James P Clement, Ladislav Vyklicky, Christophe Mulle, Inmaculada M González-González & Jeremy M Henley

Retinal origin of direction selectivity in the superior colliculus

Mon, 02/13/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4498

Authors: Xuefeng Shi, Jad Barchini, Hector Acaron Ledesma, David Koren, Yanjiao Jin, Xiaorong Liu, Wei Wei & Jianhua Cang

Nusinersen, an antisense oligonucleotide drug for spinal muscular atrophy

Mon, 02/13/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4508

Author: David R Corey

Nusinersen (Spinraza) is a recently approved drug for treating spinal muscular atrophy. Approval of nusinersen may signal new opportunities for using antisense oligonucleotides as treatments for devastating neurological diseases.

Identification of diverse astrocyte populations and their malignant analogs

Mon, 02/06/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4493

Authors: Chia-Ching John Lin, Kwanha Yu, Asante Hatcher, Teng-Wei Huang, Hyun Kyoung Lee, Jeffrey Carlson, Matthew C Weston, Fengju Chen, Yiqun Zhang, Wenyi Zhu, Carrie A Mohila, Nabil Ahmed, Akash J Patel, Benjamin R Arenkiel, Jeffrey L Noebels, Chad J Creighton & Benjamin Deneen

A molecular census of arcuate hypothalamus and median eminence cell types

Mon, 02/06/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4495

Authors: John N Campbell, Evan Z Macosko, Henning Fenselau, Tune H Pers, Anna Lyubetskaya, Danielle Tenen, Melissa Goldman, Anne M J Verstegen, Jon M Resch, Steven A McCarroll, Evan D Rosen, Bradford B Lowell & Linus T Tsai

Neuronal activity modifies the chromatin accessibility landscape in the adult brain

Mon, 02/06/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4494

Authors: Yijing Su, Jaehoon Shin, Chun Zhong, Sabrina Wang, Prith Roychowdhury, Jongseuk Lim, David Kim, Guo-li Ming & Hongjun Song

Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress

Mon, 01/30/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4491

Authors: Assaf Ramot, Zhiying Jiang, Jin-Bin Tian, Tali Nahum, Yael Kuperman, Nicholas Justice & Alon Chen

The hypothalamic–pituitary–adrenal axis is a pivotal component of an organism's response to stressful challenges, and dysfunction of this neuroendocrine axis is associated with a variety of physiological and psychological pathologies. We found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic–pituitary–adrenal axis regulation that prepares the organism for successive exposure to stressful stimuli.

[18F]FDG PET signal is driven by astroglial glutamate transport

Mon, 01/30/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4492

Authors: Eduardo R Zimmer, Maxime J Parent, Débora G Souza, Antoine Leuzy, Clotilde Lecrux, Hyoung-Ihl Kim, Serge Gauthier, Luc Pellerin, Edith Hamel & Pedro Rosa-Neto

Contributions of glial cells to neuroenergetics have been the focus of extensive debate. Here we provide positron emission tomography evidence that activation of astrocytic glutamate transport via the excitatory amino acid transporter GLT-1 triggers widespread but graded glucose uptake in the rodent brain. Our results highlight the need for a reevaluation of the interpretation of [18F]FDG positron emission tomography data, whereby astrocytes would be recognized as contributing to the [18F]FDG signal.

Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain

Mon, 01/30/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4489

Authors: Kassandra Kisler, Amy R Nelson, Sanket V Rege, Anita Ramanathan, Yaoming Wang, Ashim Ahuja, Divna Lazic, Philbert S Tsai, Zhen Zhao, Yi Zhou, David A Boas, Sava Sakadžić & Berislav V Zlokovic

Hormonal gain control of a medial preoptic area social reward circuit

Mon, 01/30/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4487

Authors: Jenna A McHenry, James M Otis, Mark A Rossi, J Elliott Robinson, Oksana Kosyk, Noah W Miller, Zoe A McElligott, Evgeny A Budygin, David R Rubinow & Garret D Stuber

Overlearning hyperstabilizes a skill by rapidly making neurochemical processing inhibitory-dominant

Mon, 01/30/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4490

Authors: Kazuhisa Shibata, Yuka Sasaki, Ji Won Bang, Edward G Walsh, Maro G Machizawa, Masako Tamaki, Li-Hung Chang & Takeo Watanabe

An inhibitory pull–push circuit in frontal cortex

Mon, 01/23/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4483

Authors: Pablo Garcia-Junco-Clemente, Taruna Ikrar, Elaine Tring, Xiangmin Xu, Dario L Ringach & Joshua T Trachtenberg

Push–pull is a canonical computation of excitatory cortical circuits. By contrast, we identify a pull–push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP)-expressing interneurons. During arousal, VIP cells rapidly and directly inhibit pyramidal neurons; VIP cells also indirectly excite these pyramidal neurons via parallel disinhibition. Thus, arousal exerts a feedback pull–push influence on excitatory neurons—an inversion of the canonical push–pull of feedforward input.

Circuit specificity in the inhibitory architecture of the VTA regulates cocaine-induced behavior

Mon, 01/23/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4482

Authors: Nicholas J Edwards, Hugo A Tejeda, Marco Pignatelli, Shiliang Zhang, Ross A McDevitt, Jocelyn Wu, Caroline E Bass, Bernhard Bettler, Marisela Morales & Antonello Bonci

Inhibitory suppression of heterogeneously tuned excitation enhances spatial coding in CA1 place cells

Mon, 01/23/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4486

Authors: Christine Grienberger, Aaron D Milstein, Katie C Bittner, Sandro Romani & Jeffrey C Magee

An intra-amygdala circuit specifically regulates social fear learning

Mon, 01/23/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4481

Authors: Robert C Twining, Jaime E Vantrease, Skyelar Love, Mallika Padival & J Amiel Rosenkranz