Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
Updated: 15 hours 23 min ago

Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors

Mon, 10/27/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3871

Authors: Elizabeth A Heller, Hannah M Cates, Catherine J Peña, Haosheng Sun, Ningyi Shao, Jian Feng, Sam A Golden, James P Herman, Jessica J Walsh, Michelle Mazei-Robison, Deveroux Ferguson, Scott Knight, Mark A Gerber, Christian Nievera, Ming-Hu Han, Scott J Russo, Carol S Tamminga, Rachael L Neve, Li Shen, H Steve Zhang, Feng Zhang & Eric J Nestler

Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults

Sun, 10/26/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3850

Authors: Adam M Brickman, Usman A Khan, Frank A Provenzano, Lok-Kin Yeung, Wendy Suzuki, Hagen Schroeter, Melanie Wall, Richard P Sloan & Scott A Small

An α2-Na/K ATPase/α-adducin complex in astrocytes triggers non–cell autonomous neurodegeneration

Sun, 10/26/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3853

Authors: Gilbert Gallardo, Jessica Barowski, John Ravits, Teepu Siddique, Jerry B Lingrel, Janice Robertson, Hanno Steen & Azad Bonni

Rods in daylight act as relay cells for cone-driven horizontal cell–mediated surround inhibition

Sun, 10/26/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3852

Authors: Tamas Szikra, Stuart Trenholm, Antonia Drinnenberg, Josephine Jüttner, Zoltan Raics, Karl Farrow, Martin Biel, Gautam Awatramani, Damon A Clark, José-Alain Sahel, Rava Azeredo da Silveira & Botond Roska

Nonlinear dendritic integration of electrical and chemical synaptic inputs drives fine-scale correlations

Sun, 10/26/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3851

Authors: Stuart Trenholm, Amanda J McLaughlin, David J Schwab, Maxwell H Turner, Robert G Smith, Fred Rieke & Gautam B Awatramani

Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence

Sun, 10/19/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3843

Authors: Colin G McNamara, Álvaro Tejero-Cantero, Stéphanie Trouche, Natalia Campo-Urriza & David Dupret

We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest. When applied during spatial learning of new goal locations, dopaminergic photostimulation improved the later recall of neural representations of space and stabilized memory performance. These findings reveal that midbrain dopaminergic neurons promote hippocampal network dynamics associated with memory persistence.

Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases

Sun, 10/19/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3846

Authors: Alexander C W Smith, Yonatan M Kupchik, Michael D Scofield, Cassandra D Gipson, Armina Wiggins, Charles A Thomas & Peter W Kalivas

Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administered cocaine and transient increases in MMP-9 during cue-induced cocaine relapse. Cue-induced heroin and nicotine relapse increased MMP activity, and increased MMP activity was required for both cocaine relapse and relapse-associated synaptic plasticity.

Mind matters: placebo enhances reward learning in Parkinson's disease

Sun, 10/19/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3842

Authors: Liane Schmidt, Erin Kendall Braun, Tor D Wager & Daphna Shohamy

Hierarchical competitions subserving multi-attribute choice

Sun, 10/12/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3836

Authors: Laurence T Hunt, Raymond J Dolan & Timothy E J Behrens

Attention can either increase or decrease spike count correlations in visual cortex

Sun, 10/12/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3835

Authors: Douglas A Ruff & Marlene R Cohen

Cortical neurogenesis in the absence of centrioles

Sun, 10/05/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3831

Authors: Ryan Insolera, Hisham Bazzi, Wei Shao, Kathryn V Anderson & Song-Hai Shi

Anchoring the neural compass: coding of local spatial reference frames in human medial parietal lobe

Sun, 10/05/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3834

Authors: Steven A Marchette, Lindsay K Vass, Jack Ryan & Russell A Epstein

Representation of aversive prediction errors in the human periaqueductal gray

Sun, 10/05/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3832

Authors: Mathieu Roy, Daphna Shohamy, Nathaniel Daw, Marieke Jepma, G Elliott Wimmer & Tor D Wager

Modulation of oligodendrocyte generation during a critical temporal window after NG2 cell division

Sun, 09/28/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3815

Authors: Robert A Hill, Kiran D Patel, Christopher M Goncalves, Jaime Grutzendler & Akiko Nishiyama

Neural correlates of water reward in thirsty Drosophila

Sun, 09/28/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3827

Authors: Suewei Lin, David Owald, Vikram Chandra, Clifford Talbot, Wolf Huetteroth & Scott Waddell

A somatosensory circuit for cooling perception in mice

Sun, 09/28/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3828

Authors: Nevena Milenkovic, Wen-Jie Zhao, Jan Walcher, Tobias Albert, Jan Siemens, Gary R Lewin & James F A Poulet

Neural antecedents of self-initiated actions in secondary motor cortex

Sun, 09/28/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3826

Authors: Masayoshi Murakami, M Inês Vicente, Gil M Costa & Zachary F Mainen

Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase

Sun, 09/21/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3822

Authors: Andrei I Molosh, Philip L Johnson, John P Spence, David Arendt, Lauren M Federici, Cristian Bernabe, Steven P Janasik, Zaneer M Segu, Rajesh Khanna, Chirayu Goswami, Weiguo Zhu, Su-Jung Park, Lang Li, Yehia S Mechref, D Wade Clapp & Anantha Shekhar

Tactile frequency discrimination is enhanced by circumventing neocortical adaptation

Sun, 09/21/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3821

Authors: Simon Musall, Wolfger von der Behrens, Johannes M Mayrhofer, Bruno Weber, Fritjof Helmchen & Florent Haiss

Single rodent mesohabenular axons release glutamate and GABA

Sun, 09/21/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3823

Authors: David H Root, Carlos A Mejias-Aponte, Shiliang Zhang, Hui-Ling Wang, Alexander F Hoffman, Carl R Lupica & Marisela Morales