Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
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The GABAergic parafacial zone is a medullary slow wave sleep–promoting center

Sun, 08/17/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3789

Authors: Christelle Anaclet, Loris Ferrari, Elda Arrigoni, Caroline E Bass, Clifford B Saper, Jun Lu & Patrick M Fuller

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

Sun, 08/17/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3786

Authors: Philip L De Jager, Gyan Srivastava, Katie Lunnon, Jeremy Burgess, Leonard C Schalkwyk, Lei Yu, Matthew L Eaton, Brendan T Keenan, Jason Ernst, Cristin McCabe, Anna Tang, Towfique Raj, Joseph Replogle, Wendy Brodeur, Stacey Gabriel, High S Chai, Curtis Younkin, Steven G Younkin, Fanggeng Zou, Moshe Szyf, Charles B Epstein, Julie A Schneider, Bradley E Bernstein, Alex Meissner, Nilufer Ertekin-Taner, Lori B Chibnik, Manolis Kellis, Jonathan Mill & David A Bennett

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

Sun, 08/17/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3782

Authors: Katie Lunnon, Rebecca Smith, Eilis Hannon, Philip L De Jager, Gyan Srivastava, Manuela Volta, Claire Troakes, Safa Al-Sarraj, Joe Burrage, Ruby Macdonald, Daniel Condliffe, Lorna W Harries, Pavel Katsel, Vahram Haroutunian, Zachary Kaminsky, Catharine Joachim, John Powell, Simon Lovestone, David A Bennett, Leonard C Schalkwyk & Jonathan Mill

Hippocampal-neocortical functional reorganization underlies children's cognitive development

Sun, 08/17/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3788

Authors: Shaozheng Qin, Soohyun Cho, Tianwen Chen, Miriam Rosenberg-Lee, David C Geary & Vinod Menon

Celsr3 is required in motor neurons to steer their axons in the hindlimb

Sun, 08/10/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3784

Authors: Guoliang Chai, Libing Zhou, Mario Manto, Françoise Helmbacher, Frédéric Clotman, André M Goffinet & Fadel Tissir

Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA

Sun, 08/10/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3787

Authors: Constanza J Cortes, Helen C Miranda, Harald Frankowski, Yakup Batlevi, Jessica E Young, Amy Le, Nishi Ivanov, Bryce L Sopher, Cassiano Carromeu, Alysson R Muotri, Gwenn A Garden & Albert R La Spada

Cocaine exposure reorganizes cell type– and input-specific connectivity in the nucleus accumbens

Sun, 08/10/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3783

Authors: Andrew F MacAskill, John M Cassel & Adam G Carter

Sharp emergence of feature-selective sustained activity along the dorsal visual pathway

Sun, 08/10/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3785

Authors: Diego Mendoza-Halliday, Santiago Torres & Julio C Martinez-Trujillo

Beyond genotype: serotonin transporter epigenetic modification predicts human brain function

Sun, 08/03/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3778

Authors: Yuliya S Nikolova, Karestan C Koenen, Sandro Galea, Chiou-Miin Wang, Marianne L Seney, Etienne Sibille, Douglas E Williamson & Ahmad R Hariri

We examined epigenetic regulation in regards to behaviorally and clinically relevant human brain function. Specifically, we found that increased promoter methylation of the serotonin transporter gene predicted increased threat-related amygdala reactivity and decreased mRNA expression in postmortem amygdala tissue. These patterns were independent of functional genetic variation in the same region. Furthermore, the association with amygdala reactivity was replicated in a second cohort and was robust to both sampling methods and age.

An olfactory cocktail party: figure-ground segregation of odorants in rodents

Sun, 08/03/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3775

Authors: Dan Rokni, Vivian Hemmelder, Vikrant Kapoor & Venkatesh N Murthy

LKB1 and AMPK regulate synaptic remodeling in old age

Sun, 08/03/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3772

Authors: Melanie A Samuel, P Emanuela Voinescu, Brendan N Lilley, Rafa de Cabo, Marc Foretz, Benoit Viollet, Basil Pawlyk, Michael A Sandberg, Demetrios G Vavvas & Joshua R Sanes

Corticolimbic gating of emotion-driven punishment

Sun, 08/03/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3781

Authors: Michael T Treadway, Joshua W Buckholtz, Justin W Martin, Katharine Jan, Christopher L Asplund, Matthew R Ginther, Owen D Jones & René Marois

A comprehensive thalamocortical projection map at the mesoscopic level

Sun, 08/03/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3780

Authors: Barbara J Hunnicutt, Brian R Long, Deniz Kusefoglu, Katrina J Gertz, Haining Zhong & Tianyi Mao

'Silent' mitral cells dominate odor responses in the olfactory bulb of awake mice

Sun, 07/27/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3768

Authors: Mihaly Kollo, Anja Schmaltz, Mostafa Abdelhamid, Izumi Fukunaga & Andreas T Schaefer

How wakefulness shapes neural activity is a topic of intense discussion. In the awake olfactory bulb, high activity with weak sensory-evoked responses has been reported in mitral/tufted cells (M/TCs). Using blind whole-cell recordings, we found 33% of M/TCs to be 'silent', yet still show strong sensory responses, with weak or inhibitory responses in 'active' neurons. Thus, a previously missed M/TC subpopulation can exert powerful influence over the olfactory bulb.

Central amygdala PKC-δ+ neurons mediate the influence of multiple anorexigenic signals

Sun, 07/27/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3767

Authors: Haijiang Cai, Wulf Haubensak, Todd E Anthony & David J Anderson

Cerebellum involvement in cortical sensorimotor circuits for the control of voluntary movements

Sun, 07/27/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3773

Authors: Rémi D Proville, Maria Spolidoro, Nicolas Guyon, Guillaume P Dugué, Fekrije Selimi, Philippe Isope, Daniela Popa & Clément Léna

Anterior cingulate engagement in a foraging context reflects choice difficulty, not foraging value

Sun, 07/27/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3771

Authors: Amitai Shenhav, Mark A Straccia, Jonathan D Cohen & Matthew M Botvinick

Orbitofrontal activation restores insight lost after cocaine use

Sun, 07/20/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3763

Authors: Federica Lucantonio, Yuji K Takahashi, Alexander F Hoffman, Chun Chang, Sheena Bali-Chaudhary, Yavin Shaham, Carl R Lupica & Geoffrey Schoenbaum

miR-92a regulates expression of synaptic GluA1-containing AMPA receptors during homeostatic scaling

Sun, 07/13/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3762

Authors: Mathieu Letellier, Sara Elramah, Magali Mondin, Anaïs Soula, Andrew Penn, Daniel Choquet, Marc Landry, Olivier Thoumine & Alexandre Favereaux

We investigated whether microRNAs could regulate AMPA receptor expression during activity blockade. miR-92a strongly repressed the translation of GluA1 receptors by binding the 3′ untranslated region of rat GluA1 (also known as Gria1) mRNA and was downregulated in rat hippocampal neurons after treatment with tetrodotoxin and AP5. Deleting the seed region in GluA1 or overexpressing miR-92a blocked homeostatic scaling, indicating that miR-92a regulates the translation and synaptic incorporation of new GluA1-containing AMPA receptors.

Transneuronal propagation of mutant huntingtin contributes to non–cell autonomous pathology in neurons

Sun, 07/13/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3761

Authors: Eline Pecho-Vrieseling, Claus Rieker, Sascha Fuchs, Dorothee Bleckmann, Maria Soledad Esposito, Paolo Botta, Chris Goldstein, Mario Bernhard, Ivan Galimberti, Matthias Müller, Andreas Lüthi, Silvia Arber, Tewis Bouwmeester, Herman van der Putten & Francesco Paolo Di Giorgio