Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
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Impaired spatial selectivity and intact phase precession in two-dimensional virtual reality

Mon, 11/24/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3884

Authors: Zahra M Aghajan, Lavanya Acharya, Jason J Moore, Jesse D Cushman, Cliff Vuong & Mayank R Mehta

Selective conversion of fibroblasts into peripheral sensory neurons

Mon, 11/24/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3887

Authors: Joel W Blanchard, Kevin T Eade, Attila Szűcs, Valentina Lo Sardo, Rachel K Tsunemoto, Daniel Williams, Pietro Paolo Sanna & Kristin K Baldwin

A learning-based approach to artificial sensory feedback leads to optimal integration

Mon, 11/24/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3883

Authors: Maria C Dadarlat, Joseph E O'Doherty & Philip N Sabes

Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts

Mon, 11/24/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3886

Authors: Brian J Wainger, Elizabeth D Buttermore, Julia T Oliveira, Cassidy Mellin, Seungkyu Lee, Wardiya Afshar Saber, Amy J Wang, Justin K Ichida, Isaac M Chiu, Lee Barrett, Eric A Huebner, Canan Bilgin, Naomi Tsujimoto, Christian Brenneis, Kush Kapur, Lee L Rubin, Kevin Eggan & Clifford J Woolf

Columnar organization of spatial phase in visual cortex

Mon, 11/24/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3878

Authors: Yushi Wang, Jianzhong Jin, Jens Kremkow, Reza Lashgari, Stanley J Komban & Jose M Alonso

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

Mon, 11/24/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3881

Authors: Dmitry Usoskin, Alessandro Furlan, Saiful Islam, Hind Abdo, Peter Lönnerberg, Daohua Lou, Jens Hjerling-Leffler, Jesper Haeggström, Olga Kharchenko, Peter V Kharchenko, Sten Linnarsson & Patrik Ernfors

Pathological circuit function underlying addiction and anxiety disorders

Mon, 11/17/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3849

Authors: Andreas Lüthi & Christian Lüscher

Short latency cerebellar modulation of the basal ganglia

Mon, 11/17/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3868

Authors: Christopher H Chen, Rachel Fremont, Eduardo E Arteaga-Bracho & Kamran Khodakhah

VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation

Mon, 11/17/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3872

Authors: Taryn E Grieder, Melissa A Herman, Candice Contet, Laura A Tan, Hector Vargas-Perez, Ami Cohen, Michal Chwalek, Geith Maal-Bared, John Freiling, Joel E Schlosburg, Laura Clarke, Elena Crawford, Pascale Koebel, Vez Repunte-Canonigo, Pietro P Sanna, Andrew R Tapper, Marisa Roberto, Brigitte L Kieffer, Paul E Sawchenko, George F Koob, Derek van der Kooy & Olivier George

FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry

Mon, 11/17/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3870

Authors: Giorgio La Fata, Annette Gärtner, Nuria Domínguez-Iturza, Tom Dresselaers, Julia Dawitz, Rogier B Poorthuis, Michele Averna, Uwe Himmelreich, Rhiannon M Meredith, Tilmann Achsel, Carlos G Dotti & Claudia Bagni

Visualizing mammalian brain area interactions by dual-axis two-photon calcium imaging

Mon, 11/17/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3867

Authors: Jérôme Lecoq, Joan Savall, Dejan Vučinić, Benjamin F Grewe, Hyun Kim, Jin Zhong Li, Lacey J Kitch & Mark J Schnitzer

Simultaneous cellular-resolution optical perturbation and imaging of place cell firing fields

Mon, 11/17/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3866

Authors: John Peter Rickgauer, Karl Deisseroth & David W Tank

A hierarchy of intrinsic timescales across primate cortex

Mon, 11/10/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3862

Authors: John D Murray, Alberto Bernacchia, David J Freedman, Ranulfo Romo, Jonathan D Wallis, Xinying Cai, Camillo Padoa-Schioppa, Tatiana Pasternak, Hyojung Seo, Daeyeol Lee & Xiao-Jing Wang

Specialization and hierarchy are organizing principles for primate cortex, yet there is little direct evidence for how cortical areas are specialized in the temporal domain. We measured timescales of intrinsic fluctuations in spiking activity across areas and found a hierarchical ordering, with sensory and prefrontal areas exhibiting shorter and longer timescales, respectively. On the basis of our findings, we suggest that intrinsic timescales reflect areal specialization for task-relevant computations over multiple temporal ranges.

Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance

Mon, 11/10/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3861

Authors: Jonathan N Flak, Christa M Patterson, Alastair S Garfield, Giuseppe D'Agostino, Paulette B Goforth, Amy K Sutton, Paige A Malec, Jenny-Marie T Wong, Mark Germani, Justin C Jones, Michael Rajala, Leslie Satin, Christopher J Rhodes, David P Olson, Robert T Kennedy, Lora K Heisler & Martin G Myers

Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome

Mon, 11/10/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3863

Authors: Yong-Seok Lee, Dan Ehninger, Miou Zhou, Jun-Young Oh, Minkyung Kang, Chuljung Kwak, Hyun-Hee Ryu, Delana Butz, Toshiyuki Araki, Ying Cai, J Balaji, Yoshitake Sano, Christine I Nam, Hyong Kyu Kim, Bong-Kiun Kaang, Corinna Burger, Benjamin G Neel & Alcino J Silva

A category-free neural population supports evolving demands during decision-making

Mon, 11/10/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3865

Authors: David Raposo, Matthew T Kaufman & Anne K Churchland

Dendritic channelopathies contribute to neocortical and sensory hyperexcitability in Fmr1−/y mice

Mon, 11/10/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3864

Authors: Yu Zhang, Audrey Bonnan, Guillaume Bony, Isabelle Ferezou, Susanna Pietropaolo, Melanie Ginger, Nathalie Sans, Jean Rossier, Ben Oostra, Gwen LeMasson & Andreas Frick

Molecular and functional definition of the developing human striatum

Mon, 11/10/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3860

Authors: Marco Onorati, Valentina Castiglioni, Daniele Biasci, Elisabetta Cesana, Ramesh Menon, Romina Vuono, Francesca Talpo, Rocio Laguna Goya, Paul A Lyons, Gaetano P Bulfamante, Luca Muzio, Gianvito Martino, Mauro Toselli, Cinthia Farina, Roger A Barker, Gerardo Biella & Elena Cattaneo

Glial ankyrins facilitate paranodal axoglial junction assembly

Sat, 11/01/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3858

Authors: Kae-Jiun Chang, Daniel R Zollinger, Keiichiro Susuki, Diane L Sherman, Michael A Makara, Peter J Brophy, Edward C Cooper, Vann Bennett, Peter J Mohler & Matthew N Rasband

A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier

Sat, 11/01/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3859

Authors: Tammy Szu-Yu Ho, Daniel R Zollinger, Kae-Jiun Chang, Mingxuan Xu, Edward C Cooper, Michael C Stankewich, Vann Bennett & Matthew N Rasband