Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
Updated: 7 hours 44 min ago

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

Tue, 03/24/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4000

Authors: Axel Freischmidt, Thomas Wieland, Benjamin Richter, Wolfgang Ruf, Veronique Schaeffer, Kathrin Müller, Nicolai Marroquin, Frida Nordin, Annemarie Hübers, Patrick Weydt, Susana Pinto, Rayomond Press, Stéphanie Millecamps, Nicolas Molko, Emilien Bernard, Claude Desnuelle, Marie-Hélène Soriani, Johannes Dorst, Elisabeth Graf, Ulrika Nordström, Marisa S Feiler, Stefan Putz, Tobias M Boeckers, Thomas Meyer, Andrea S Winkler, Juliane Winkelman, Mamede de Carvalho, Dietmar R Thal, Markus Otto, Thomas Brännström, Alexander E Volk, Petri Kursula, Karin M Danzer, Peter Lichtner, Ivan Dikic, Thomas Meitinger, Albert C Ludolph, Tim M Strom, Peter M Andersen & Jochen H Weishaupt

Model-based choices involve prospective neural activity

Mon, 03/23/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3981

Authors: Bradley B Doll, Katherine D Duncan, Dylan A Simon, Daphna Shohamy & Nathaniel D Daw

Global network influences on local functional connectivity

Mon, 03/23/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3979

Authors: Adam C Snyder, Michael J Morais, Cory M Willis & Matthew A Smith

Role of Tet1 and 5-hydroxymethylcytosine in cocaine action

Mon, 03/16/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3976

Authors: Jian Feng, Ningyi Shao, Keith E Szulwach, Vincent Vialou, Jimmy Huynh, Chun Zhong, Thuc Le, Deveroux Ferguson, Michael E Cahill, Yujing Li, Ja Wook Koo, Efrain Ribeiro, Benoit Labonte, Benjamin M Laitman, David Estey, Victoria Stockman, Pamela Kennedy, Thomas Couroussé, Isaac Mensah, Gustavo Turecki, Kym F Faull, Guo-li Ming, Hongjun Song, Guoping Fan, Patrizia Casaccia, Li Shen, Peng Jin & Eric J Nestler

Retrieval induces adaptive forgetting of competing memories via cortical pattern suppression

Mon, 03/16/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3973

Authors: Maria Wimber, Arjen Alink, Ian Charest, Nikolaus Kriegeskorte & Michael C Anderson

The dorsal posterior insula subserves a fundamental role in human pain

Mon, 03/09/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3969

Authors: Andrew R Segerdahl, Melvin Mezue, Thomas W Okell, John T Farrar & Irene Tracey

Several brain regions have been implicated in human painful experiences, but none have been proven to be specific to pain. We exploited arterial spin-labeling quantitative perfusion imaging and a newly developed procedure to identify a specific role for the dorsal posterior insula (dpIns) in pain. Tract tracing studies in animals identify a similar region as fundamental to nociception, which suggests the dpIns is its human homolog and, as such, a potential therapeutic target.

Explicit memory creation during sleep demonstrates a causal role of place cells in navigation

Mon, 03/09/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3970

Authors: Gaetan de Lavilléon, Marie Masako Lacroix, Laure Rondi-Reig & Karim Benchenane

Hippocampal place cells assemblies are believed to support the cognitive map, and their reactivations during sleep are thought to be involved in spatial memory consolidation. By triggering intracranial rewarding stimulations by place cell spikes during sleep, we induced an explicit memory trace, leading to a goal-directed behavior toward the place field. This demonstrates that place cells' activity during sleep still conveys relevant spatial information and that this activity is functionally significant for navigation.

NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking

Mon, 03/09/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3972

Authors: Kristen E Pleil, Jennifer A Rinker, Emily G Lowery-Gionta, Christopher M Mazzone, Nora M McCall, Alexis M Kendra, David P Olson, Bradford B Lowell, Kathleen A Grant, Todd E Thiele & Thomas L Kash

Somatostatin cells regulate sensory response fidelity via subtractive inhibition in olfactory cortex

Mon, 03/09/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3971

Authors: James F Sturgill & Jeffry S Isaacson

Single-cell analysis reveals transcriptional heterogeneity of neural progenitors in human cortex

Tue, 03/03/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3980

Authors: Matthew B Johnson, Peter P Wang, Kutay D Atabay, Elisabeth A Murphy, Ryan N Doan, Jonathan L Hecht & Christopher A Walsh

Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone

Mon, 03/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3963

Authors: Filippo Calzolari, Julia Michel, Emily Violette Baumgart, Fabian Theis, Magdalena Götz & Jovica Ninkovic

We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.

Attention alters orientation processing in the human lateral geniculate nucleus

Mon, 03/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3967

Authors: Sam Ling, Michael S Pratte & Frank Tong

Orientation selectivity is a cornerstone property of vision, commonly believed to emerge in the primary visual cortex. We found that reliable orientation information could be detected even earlier, in the human lateral geniculate nucleus, and that attentional feedback selectively altered these orientation responses. This attentional modulation may allow the visual system to modify incoming feature-specific signals at the earliest possible processing site.

Anxious individuals have difficulty learning the causal statistics of aversive environments

Mon, 03/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3961

Authors: Michael Browning, Timothy E Behrens, Gerhard Jocham, Jill X O'Reilly & Sonia J Bishop

Internally organized mechanisms of the head direction sense

Mon, 03/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3968

Authors: Adrien Peyrache, Marie M Lacroix, Peter C Petersen & György Buzsáki

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

Mon, 03/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3966

Authors: Ethan A Winkler, Yoichiro Nishida, Abhay P Sagare, Sanket V Rege, Robert D Bell, David Perlmutter, Jesse D Sengillo, Sara Hillman, Pan Kong, Amy R Nelson, John S Sullivan, Zhen Zhao, Herbert J Meiselman, Rosalinda B Wenby, Jamie Soto, E Dale Abel, Jacob Makshanoff, Edward Zuniga, Darryl C De Vivo & Berislav V Zlokovic

Mitochondrial control by DRP1 in brain tumor initiating cells

Mon, 03/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3960

Authors: Qi Xie, Qiulian Wu, Craig M Horbinski, William A Flavahan, Kailin Yang, Wenchao Zhou, Stephen M Dombrowski, Zhi Huang, Xiaoguang Fang, Yu Shi, Ashley N Ferguson, David F Kashatus, Shideng Bao & Jeremy N Rich

Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity

Wed, 02/25/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3975

Authors: Xintian You, Irena Vlatkovic, Ana Babic, Tristan Will, Irina Epstein, Georgi Tushev, Güney Akbalik, Mantian Wang, Caspar Glock, Claudia Quedenau, Xi Wang, Jingyi Hou, Hongyu Liu, Wei Sun, Sivakumar Sambandan, Tao Chen, Erin M Schuman & Wei Chen

What does gamma coherence tell us about inter-regional neural communication?

Mon, 02/23/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3952

Authors: György Buzsáki & Erik W Schomburg

Frequency-specific hippocampal-prefrontal interactions during associative learning

Mon, 02/23/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3954

Authors: Scott L Brincat & Earl K Miller

The dissociable effects of punishment and reward on motor learning

Mon, 02/23/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3956

Authors: Joseph M Galea, Elizabeth Mallia, John Rothwell & Jörn Diedrichsen