Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
Updated: 22 hours 55 min ago

Orbitofrontal activation restores insight lost after cocaine use

Sun, 07/20/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3763

Authors: Federica Lucantonio, Yuji K Takahashi, Alexander F Hoffman, Chun Chang, Sheena Bali-Chaudhary, Yavin Shaham, Carl R Lupica & Geoffrey Schoenbaum

miR-92a regulates expression of synaptic GluA1-containing AMPA receptors during homeostatic scaling

Sun, 07/13/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3762

Authors: Mathieu Letellier, Sara Elramah, Magali Mondin, Anaïs Soula, Andrew Penn, Daniel Choquet, Marc Landry, Olivier Thoumine & Alexandre Favereaux

We investigated whether microRNAs could regulate AMPA receptor expression during activity blockade. miR-92a strongly repressed the translation of GluA1 receptors by binding the 3′ untranslated region of rat GluA1 (also known as Gria1) mRNA and was downregulated in rat hippocampal neurons after treatment with tetrodotoxin and AP5. Deleting the seed region in GluA1 or overexpressing miR-92a blocked homeostatic scaling, indicating that miR-92a regulates the translation and synaptic incorporation of new GluA1-containing AMPA receptors.

Transneuronal propagation of mutant huntingtin contributes to non–cell autonomous pathology in neurons

Sun, 07/13/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3761

Authors: Eline Pecho-Vrieseling, Claus Rieker, Sascha Fuchs, Dorothee Bleckmann, Maria Soledad Esposito, Paolo Botta, Chris Goldstein, Mario Bernhard, Ivan Galimberti, Matthias Müller, Andreas Lüthi, Silvia Arber, Tewis Bouwmeester, Herman van der Putten & Francesco Paolo Di Giorgio

A spinal analog of memory reconsolidation enables reversal of hyperalgesia

Sun, 07/06/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3758

Authors: Robert P Bonin & Yves De Koninck

Hyperalgesia arising from sensitization of pain relays in the spinal dorsal horn shares many mechanistic and phenotypic parallels with memory formation. We discovered that mechanical hyperalgesia could be rendered labile and reversible in mice after reactivation of spinal pain pathways in a process analogous to memory reconsolidation. These findings reveal a previously unknown regulatory mechanism underlying hyperalgesia and demonstrate the existence of reconsolidation-like processes in a sensory system.

Independent control of gamma and theta activity by distinct interneuron networks in the olfactory bulb

Sun, 07/06/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3760

Authors: Izumi Fukunaga, Jan T Herb, Mihaly Kollo, Edward S Boyden & Andreas T Schaefer

Reactivation of emergent task-related ensembles during slow-wave sleep after neuroprosthetic learning

Sun, 07/06/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3759

Authors: Tanuj Gulati, Dhakshin S Ramanathan, Chelsea C Wong & Karunesh Ganguly

Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons

Sun, 07/06/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3757

Authors: Simona Lodato, Bradley J Molyneaux, Emanuela Zuccaro, Loyal A Goff, Hsu-Hsin Chen, Wen Yuan, Alyssa Meleski, Emi Takahashi, Shaun Mahony, John L Rinn, David K Gifford & Paola Arlotta

Noninvasive optical inhibition with a red-shifted microbial rhodopsin

Sun, 07/06/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3752

Authors: Amy S Chuong, Mitra L Miri, Volker Busskamp, Gillian A C Matthews, Leah C Acker, Andreas T Sørensen, Andrew Young, Nathan C Klapoetke, Mike A Henninger, Suhasa B Kodandaramaiah, Masaaki Ogawa, Shreshtha B Ramanlal, Rachel C Bandler, Brian D Allen, Craig R Forest, Brian Y Chow, Xue Han, Yingxi Lin, Kay M Tye, Botond Roska, Jessica A Cardin & Edward S Boyden

Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α

Sun, 06/29/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3754

Authors: Gonzalo Viana Di Prisco, Wei Huang, Shelly A Buffington, Chih-Chun Hsu, Penelope E Bonnen, Andon N Placzek, Carmela Sidrauski, Krešimir Krnjević, Randal J Kaufman, Peter Walter & Mauro Costa-Mattioli

Differences in the emergent coding properties of cortical and striatal ensembles

Sun, 06/29/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3753

Authors: Liya Ma, James M Hyman, Adrian J Lindsay, Anthony G Phillips & Jeremy K Seamans

Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates

Sun, 06/29/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3751

Authors: Jerel K Mueller, Erinn M Grigsby, Vincent Prevosto, Frank W Petraglia, Hrishikesh Rao, Zhi-De Deng, Angel V Peterchev, Marc A Sommer, Tobias Egner, Michael L Platt & Warren M Grill

Population coding of affect across stimuli, modalities and individuals

Sun, 06/22/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3749

Authors: Junichi Chikazoe, Daniel H Lee, Nikolaus Kriegeskorte & Adam K Anderson

Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity

Sun, 06/22/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3750

Authors: Collin J Kreple, Yuan Lu, Rebecca J Taugher, Andrea L Schwager-Gutman, Jianyang Du, Madeliene Stump, Yimo Wang, Ali Ghobbeh, Rong Fan, Caitlin V Cosme, Levi P Sowers, Michael J Welsh, Jason J Radley, Ryan T LaLumiere & John A Wemmie

Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling

Sun, 06/22/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3744

Authors: Boxing Li, Wei Jie, Lianyan Huang, Peng Wei, Shuji Li, Zhengyi Luo, Allyson K Friedman, Andrea L Meredith, Ming-Hu Han, Xin-Hong Zhu & Tian-Ming Gao

Maintenance of postmitotic neuronal cell identity

Sun, 06/15/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3731

Authors: Evan S Deneris & Oliver Hobert

Lesions of prefrontal cortex reduce attentional modulation of neuronal responses and synchrony in V4

Sun, 06/15/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3742

Authors: Georgia G Gregoriou, Andrew F Rossi, Leslie G Ungerleider & Robert Desimone

Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia

Sun, 06/08/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3737

Authors: Eric D Berglund, Tiemin Liu, Xingxing Kong, Jong-Woo Sohn, Linh Vong, Zhuo Deng, Charlotte E Lee, Syann Lee, Kevin W Williams, David P Olson, Philipp E Scherer, Bradford B Lowell & Joel K Elmquist

Whether melanocortin 4 receptors (MC4Rs) in extra-hypothalamic neurons, including cholinergic autonomic pre-ganglionic neurons, are required to control energy and glucose homeostasis is unclear. We found that MC4Rs in sympathetic, but not parasympathetic, pre-ganglionic neurons were required to regulate energy expenditure and body weight, including thermogenic responses to diet and cold exposure and 'beiging' of white adipose tissue. Deletion of Mc4r genes in both sympathetic and parasympathetic cholinergic neurons impaired glucose homeostasis.

Behavioral and neurophysiological correlates of regret in rat decision-making on a neuroeconomic task

Sun, 06/08/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3740

Authors: Adam P Steiner & A David Redish

A spike-timing mechanism for action selection

Sun, 06/08/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3741

Authors: Catherine R von Reyn, Patrick Breads, Martin Y Peek, Grace Zhiyu Zheng, W Ryan Williamson, Alyson L Yee, Anthony Leonardo & Gwyneth M Card

Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding

Sun, 06/01/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3725

Authors: Jae Geun Kim, Shigetomo Suyama, Marco Koch, Sungho Jin, Pilar Argente-Arizon, Jesús Argente, Zhong-Wu Liu, Marcelo R Zimmer, Jin Kwon Jeong, Klara Szigeti-Buck, Yuanqing Gao, Cristina Garcia-Caceres, Chun-Xia Yi, Natalina Salmaso, Flora M Vaccarino, Julie Chowen, Sabrina Diano, Marcelo O Dietrich, Matthias H Tschöp & Tamas L Horvath

We found that leptin receptors were expressed in hypothalamic astrocytes and that their conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic neurons involved in feeding control. Leptin-regulated feeding was diminished, whereas feeding after fasting or ghrelin administration was elevated in mice with astrocyte-specific leptin receptor deficiency. These data reveal an active role of glial cells in hypothalamic synaptic remodeling and control of feeding by leptin.