Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
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Volitional modulation of optically recorded calcium signals during neuroprosthetic learning

Sun, 04/13/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3712

Authors: Kelly B Clancy, Aaron C Koralek, Rui M Costa, Daniel E Feldman & Jose M Carmena

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

Sun, 04/13/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3695

Authors: Katharina Gapp, Ali Jawaid, Peter Sarkies, Johannes Bohacek, Pawel Pelczar, Julien Prados, Laurent Farinelli, Eric Miska & Isabelle M Mansuy

Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.

Single App knock-in mouse models of Alzheimer's disease

Sun, 04/13/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3697

Authors: Takashi Saito, Yukio Matsuba, Naomi Mihira, Jiro Takano, Per Nilsson, Shigeyoshi Itohara, Nobuhisa Iwata & Takaomi C Saido

Experimental studies of Alzheimer's disease have largely depended on transgenic mice overexpressing amyloid precursor protein (APP). These mice, however, suffer from artificial phenotypes because, in addition to amyloid β peptide (Aβ), they overproduce other APP fragments. We generated knock-in mice that harbor Swedish and Beyreuther/Iberian mutations with and without the Arctic mutation in the APP gene. The mice showed typical Aβ pathology, neuroinflammation and memory impairment in an age-dependent manner.

Parvalbumin interneurons provide grid cell–driven recurrent inhibition in the medial entorhinal cortex

Sun, 04/06/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3696

Authors: Christina Buetfering, Kevin Allen & Hannah Monyer

Excessive cocaine use results from decreased phasic dopamine signaling in the striatum

Sun, 04/06/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3694

Authors: Ingo Willuhn, Lauren M Burgeno, Peter A Groblewski & Paul E M Phillips

Contributions and challenges for network models in cognitive neuroscience

Sun, 03/30/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3690

Author: Olaf Sporns

Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis

Sun, 03/30/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3688

Authors: Janel O Johnson, Erik P Pioro, Ashley Boehringer, Ruth Chia, Howard Feit, Alan E Renton, Hannah A Pliner, Yevgeniya Abramzon, Giuseppe Marangi, Brett J Winborn, J Raphael Gibbs, Michael A Nalls, Sarah Morgan, Maryam Shoai, John Hardy, Alan Pittman, Richard W Orrell, Andrea Malaspina, Katie C Sidle, Pietro Fratta, Matthew B Harms, Robert H Baloh, Alan Pestronk, Conrad C Weihl, Ekaterina Rogaeva, Lorne Zinman, Vivian E Drory, Giuseppe Borghero, Gabriele Mora, Andrea Calvo, Jeffrey D Rothstein, Carsten Drepper, Michael Sendtner, Andrew B Singleton, J Paul Taylor, Mark R Cookson, Gabriella Restagno, Mario Sabatelli, Robert Bowser, Adriano Chiò & Bryan J Traynor

MATR3 is an RNA- and DNA-binding protein that interacts with TDP-43, a disease protein linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Using exome sequencing, we identified mutations in MATR3 in ALS kindreds. We also observed MATR3 pathology in ALS-affected spinal cords with and without MATR3 mutations. Our data provide more evidence supporting the role of aberrant RNA processing in motor neuron degeneration.

Serial dependence in visual perception

Sun, 03/30/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3689

Authors: Jason Fischer & David Whitney

Attentive scanning behavior drives one-trial potentiation of hippocampal place fields

Sun, 03/30/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3687

Authors: Joseph D Monaco, Geeta Rao, Eric D Roth & James J Knierim

Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

Sun, 03/30/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3691

Authors: Xiaoping Tong, Yan Ao, Guido C Faas, Sinifunanya E Nwaobi, Ji Xu, Martin D Haustein, Mark A Anderson, Istvan Mody, Michelle L Olsen, Michael V Sofroniew & Baljit S Khakh

Reversed theta sequences of hippocampal cell assemblies during backward travel

Tue, 03/25/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3698

Authors: Anne Cei, Gabrielle Girardeau, Céline Drieu, Karim El Kanbi & Michaël Zugaro

Learned spatiotemporal sequence recognition and prediction in primary visual cortex

Sun, 03/23/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3683

Authors: Jeffrey P Gavornik & Mark F Bear

A supercritical density of Na+ channels ensures fast signaling in GABAergic interneuron axons

Sun, 03/23/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3678

Authors: Hua Hu & Peter Jonas

Linker mutations reveal the complexity of synaptotagmin 1 action during synaptic transmission

Sun, 03/23/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3681

Authors: Huisheng Liu, Hua Bai, Renhao Xue, Hirohide Takahashi, J Michael Edwardson & Edwin R Chapman

Spine neck plasticity regulates compartmentalization of synapses

Sun, 03/23/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3682

Authors: Jan Tønnesen, Gergely Katona, Balázs Rózsa & U Valentin Nägerl

Unbalanced excitability underlies offline reactivation of behaviorally activated neurons

Sun, 03/16/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3674

Authors: Mika Mizunuma, Hiroaki Norimoto, Kentaro Tao, Takahiro Egawa, Kenjiro Hanaoka, Tetsuya Sakaguchi, Hiroyuki Hioki, Takeshi Kaneko, Shun Yamaguchi, Tetsuo Nagano, Norio Matsuki & Yuji Ikegaya

Hippocampal sharp waves (SWs)/ripples represent the reactivation of neurons involved in recently acquired memory and are crucial for memory consolidation. By labeling active cells with fluorescent protein under the control of an immediate-early gene promoter, we found that neurons that had been activated while mice explored a novel environment were preferentially reactivated during spontaneous SWs in hippocampal slices in vitro. During SWs, the reactivated neurons received strong excitatory synaptic inputs as opposed to a globally tuned network balance between excitation and inhibition.

Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer

Sun, 03/09/2014 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3676

Authors: Stephen P J Fancy, Emily P Harrington, Sergio E Baranzini, John C Silbereis, Lawrence R Shiow, Tracy J Yuen, Eric J Huang, Stavros Lomvardas & David H Rowitch

Identification of a cellular node for motor control pathways

Sun, 03/09/2014 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3675

Authors: Ariel J Levine, Christopher A Hinckley, Kathryn L Hilde, Shawn P Driscoll, Tiffany H Poon, Jessica M Montgomery & Samuel L Pfaff

Spontaneous fluctuations in neural responses to heartbeats predict visual detection

Sun, 03/09/2014 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3671

Authors: Hyeong-Dong Park, Stéphanie Correia, Antoine Ducorps & Catherine Tallon-Baudry

Changing value through cued approach: an automatic mechanism of behavior change

Sun, 03/09/2014 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3673

Authors: Tom Schonberg, Akram Bakkour, Ashleigh M Hover, Jeanette A Mumford, Lakshya Nagar, Jacob Perez & Russell A Poldrack