Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
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Neural compensation in older people with brain amyloid-β deposition

Sun, 09/14/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3806

Authors: Jeremy A Elman, Hwamee Oh, Cindee M Madison, Suzanne L Baker, Jacob W Vogel, Shawn M Marks, Sam Crowley, James P O'Neil & William J Jagust

Recruitment of extra neural resources may allow people to maintain normal cognition despite amyloid-β (Aβ) plaques. Previous fMRI studies have reported such hyperactivation, but it is unclear whether increases represent compensation or aberrant overexcitation. We found that older adults with Aβ deposition had reduced deactivations in task-negative regions, but increased activation in task-positive regions related to more detailed memory encoding. The association between higher activity and more detailed memories suggests that Aβ-related hyperactivation is compensatory.

Metabolic regulator LKB1 is crucial for Schwann cell–mediated axon maintenance

Sun, 09/07/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3809

Authors: Bogdan Beirowski, Elisabetta Babetto, Judith P Golden, Ying-Jr Chen, Kui Yang, Richard W Gross, Gary J Patti & Jeffrey Milbrandt

Genome-wide identification and characterization of functional neuronal activity–dependent enhancers

Sun, 09/07/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3808

Authors: Athar N Malik, Thomas Vierbuchen, Martin Hemberg, Alex A Rubin, Emi Ling, Cameron H Couch, Hume Stroud, Ivo Spiegel, Kyle Kai-How Farh, David A Harmin & Michael E Greenberg

Information-limiting correlations

Sun, 09/07/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3807

Authors: Rubén Moreno-Bote, Jeffrey Beck, Ingmar Kanitscheider, Xaq Pitkow, Peter Latham & Alexandre Pouget

Perceptual training continuously refines neuronal population codes in primary visual cortex

Sun, 09/07/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3805

Authors: Yin Yan, Malte J Rasch, Minggui Chen, Xiaoping Xiang, Min Huang, Si Wu & Wu Li

Damage to dorsolateral prefrontal cortex affects tradeoffs between honesty and self-interest

Sun, 08/31/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3798

Authors: Lusha Zhu, Adrianna C Jenkins, Eric Set, Donatella Scabini, Robert T Knight, Pearl H Chiu, Brooks King-Casas & Ming Hsu

Substantial correlational evidence suggests that prefrontal regions are critical to honest and dishonest behavior, but causal evidence specifying the nature of this involvement remains absent. We found that lesions of the human dorsolateral prefrontal cortex (DLPFC) decreased the effect of honesty concerns on behavior in economic games that pit honesty motives against self-interest, but did not affect decisions when honesty concerns were absent. These results point to a causal role for DLPFC in honest behavior.

Reversal of theta rhythm flow through intact hippocampal circuits

Sun, 08/31/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3803

Authors: Jesse Jackson, Bénédicte Amilhon, Romain Goutagny, Jean-Bastien Bott, Frédéric Manseau, Christian Kortleven, Steven L Bressler & Sylvain Williams

Encoding and decoding in parietal cortex during sensorimotor decision-making

Sun, 08/31/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3800

Authors: Il Memming Park, Miriam L R Meister, Alexander C Huk & Jonathan W Pillow

Edge-orientation processing in first-order tactile neurons

Sun, 08/31/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3804

Authors: J Andrew Pruszynski & Roland S Johansson

Genetic variability in the regulation of gene expression in ten regions of the human brain

Sun, 08/31/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3801

Authors: Adaikalavan Ramasamy, Daniah Trabzuni, Sebastian Guelfi, Vibin Varghese, Colin Smith, Robert Walker, Tisham De, Lachlan Coin, Rohan de Silva, Mark R Cookson, Andrew B Singleton, John Hardy, Mina Ryten & Michael E Weale

Dimensionality reduction for large-scale neural recordings

Sun, 08/24/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3776

Authors: John P Cunningham & Byron M Yu

Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes

Sun, 08/24/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3790

Authors: Stacey M Glasgow, Wenyi Zhu, C Claus Stolt, Teng-Wei Huang, Fuyi Chen, Joseph J LoTurco, Jeffrey L Neul, Michael Wegner, Carrie Mohila & Benjamin Deneen

Image familiarization sharpens response dynamics of neurons in inferotemporal cortex

Sun, 08/24/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3794

Authors: Travis Meyer, Christopher Walker, Raymond Y Cho & Carl R Olson

Activity-dependent regulation of astrocyte GAT levels during synaptogenesis

Sun, 08/24/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3791

Authors: Allie K Muthukumar, Tobias Stork & Marc R Freeman

Gamma-range synchronization of fast-spiking interneurons can enhance detection of tactile stimuli

Sun, 08/24/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3797

Authors: Joshua H Siegle, Dominique L Pritchett & Christopher I Moore

The GABAergic parafacial zone is a medullary slow wave sleep–promoting center

Sun, 08/17/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3789

Authors: Christelle Anaclet, Loris Ferrari, Elda Arrigoni, Caroline E Bass, Clifford B Saper, Jun Lu & Patrick M Fuller

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

Sun, 08/17/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3786

Authors: Philip L De Jager, Gyan Srivastava, Katie Lunnon, Jeremy Burgess, Leonard C Schalkwyk, Lei Yu, Matthew L Eaton, Brendan T Keenan, Jason Ernst, Cristin McCabe, Anna Tang, Towfique Raj, Joseph Replogle, Wendy Brodeur, Stacey Gabriel, High S Chai, Curtis Younkin, Steven G Younkin, Fanggeng Zou, Moshe Szyf, Charles B Epstein, Julie A Schneider, Bradley E Bernstein, Alex Meissner, Nilufer Ertekin-Taner, Lori B Chibnik, Manolis Kellis, Jonathan Mill & David A Bennett

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

Sun, 08/17/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3782

Authors: Katie Lunnon, Rebecca Smith, Eilis Hannon, Philip L De Jager, Gyan Srivastava, Manuela Volta, Claire Troakes, Safa Al-Sarraj, Joe Burrage, Ruby Macdonald, Daniel Condliffe, Lorna W Harries, Pavel Katsel, Vahram Haroutunian, Zachary Kaminsky, Catharine Joachim, John Powell, Simon Lovestone, David A Bennett, Leonard C Schalkwyk & Jonathan Mill

Hippocampal-neocortical functional reorganization underlies children's cognitive development

Sun, 08/17/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3788

Authors: Shaozheng Qin, Soohyun Cho, Tianwen Chen, Miriam Rosenberg-Lee, David C Geary & Vinod Menon

Celsr3 is required in motor neurons to steer their axons in the hindlimb

Sun, 08/10/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3784

Authors: Guoliang Chai, Libing Zhou, Mario Manto, Françoise Helmbacher, Frédéric Clotman, André M Goffinet & Fadel Tissir