Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
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Diminished KCC2 confounds synapse specificity of LTP during senescence

Mon, 08/08/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4357

Authors: Isabella Ferando, Guido C Faas & Istvan Mody

The synapse specificity of long-term potentiation (LTP) ensures that no interference arises from inputs irrelevant to the memory to be encoded. In hippocampi of aged (21–28 months) mice, LTP was relayed to unstimulated synapses, blemishing its synapse specificity. Diminished levels of the K+/Cl− cotransporter KCC2 and a depolarizing GABAA receptor-mediated synaptic component following LTP were the most likely causes for the spreading of potentiation, unveiling mechanisms hindering information storage in the aged brain and identifying KCC2 as a potential target for intervention.

Connectivity precedes function in the development of the visual word form area

Mon, 08/08/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4354

Authors: Zeynep M Saygin, David E Osher, Elizabeth S Norton, Deanna A Youssoufian, Sara D Beach, Jenelle Feather, Nadine Gaab, John D E Gabrieli & Nancy Kanwisher

Meta-analysis of 2,104 trios provides support for 10 new genes for intellectual disability

Mon, 08/01/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4352

Authors: Stefan H Lelieveld, Margot R F Reijnders, Rolph Pfundt, Helger G Yntema, Erik-Jan Kamsteeg, Petra de Vries, Bert B A de Vries, Marjolein H Willemsen, Tjitske Kleefstra, Katharina Löhner, Maaike Vreeburg, Servi J C Stevens, Ineke van der Burgt, Ernie M H F Bongers, Alexander P A Stegmann, Patrick Rump, Tuula Rinne, Marcel R Nelen, Joris A Veltman, Lisenka E L M Vissers, Han G Brunner & Christian Gilissen

To identify candidate genes for intellectual disability, we performed a meta-analysis on 2,637 de novo mutations, identified from the exomes of 2,104 patient–parent trios. Statistical analyses identified 10 new candidate ID genes: DLG4, PPM1D, RAC1, SMAD6, SON, SOX5, SYNCRIP, TCF20, TLK2 and TRIP12. In addition, we show that these genes are intolerant to nonsynonymous variation and that mutations in these genes are associated with specific clinical ID phenotypes.

Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder

Mon, 08/01/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4353

Authors: Arjun Krishnan, Ran Zhang, Victoria Yao, Chandra L Theesfeld, Aaron K Wong, Alicja Tadych, Natalia Volfovsky, Alan Packer, Alex Lash & Olga G Troyanskaya

The coding of cutaneous temperature in the spinal cord

Mon, 07/25/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4350

Authors: Chen Ran, Mark A Hoon & Xiaoke Chen

Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning

Mon, 07/25/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4351

Authors: Lin Xiao, David Ohayon, Ian A McKenzie, Alexander Sinclair-Wilson, Jordan L Wright, Alexander D Fudge, Ben Emery, Huiliang Li & William D Richardson

Sensory and decision-related activity propagate in a cortical feedback loop during touch perception

Wed, 07/20/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4356

Authors: Sung Eun Kwon, Hongdian Yang, Genki Minamisawa & Daniel H O'Connor

Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior

Mon, 07/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4347

Authors: Alexi Nott, Jemmie Cheng, Fan Gao, Yuan-Ta Lin, Elizabeta Gjoneska, Tak Ko, Paras Minhas, Alicia Viridiana Zamudio, Jia Meng, Feiran Zhang, Peng Jin & Li-Huei Tsai

Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics

Mon, 07/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4346

Authors: Yair Shemesh, Oren Forkosh, Mathias Mahn, Sergey Anpilov, Yehezkel Sztainberg, Sharon Manashirov, Tamar Shlapobersky, Evan Elliott, Laure Tabouy, Gili Ezra, Elaine S Adler, Yair J Ben-Efraim, Shosh Gil, Yael Kuperman, Sharon Haramati, Julien Dine, Matthias Eder, Jan M Deussing, Elad Schneidman, Ofer Yizhar & Alon Chen

Infantile amnesia reflects a developmental critical period for hippocampal learning

Mon, 07/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4348

Authors: Alessio Travaglia, Reto Bisaz, Eric S Sweet, Robert D Blitzer & Cristina M Alberini

ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks

Mon, 07/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4345

Authors: Ritchie Ho, Samuel Sances, Genevieve Gowing, Mackenzie Weygandt Amoroso, Jacqueline G O'Rourke, Anais Sahabian, Hynek Wichterle, Robert H Baloh, Dhruv Sareen & Clive N Svendsen

Postsynaptic, not presynaptic NMDA receptors are required for spike-timing-dependent LTD induction

Mon, 07/11/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4343

Authors: Brett C Carter & Craig E Jahr

Neural activity promotes long-distance, target-specific regeneration of adult retinal axons

Mon, 07/11/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4340

Authors: Jung-Hwan A Lim, Benjamin K Stafford, Phong L Nguyen, Brian V Lien, Chen Wang, Katherine Zukor, Zhigang He & Andrew D Huberman

Fast and slow transitions in frontal ensemble activity during flexible sensorimotor behavior

Mon, 07/11/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4342

Authors: Michael J Siniscalchi, Victoria Phoumthipphavong, Farhan Ali, Marc Lozano & Alex C Kwan

Multilaminar networks of cortical neurons integrate common inputs from sensory thalamus

Mon, 07/04/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4339

Authors: Nicolás A Morgenstern, Jacques Bourg & Leopoldo Petreanu

Segregated cholinergic transmission modulates dopamine neurons integrated in distinct functional circuits

Mon, 06/27/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4335

Authors: Daniel Dautan, Albert S Souza, Icnelia Huerta-Ocampo, Miguel Valencia, Maxime Assous, Ilana B Witten, Karl Deisseroth, James M Tepper, J Paul Bolam, Todor V Gerdjikov & Juan Mena-Segovia

Shifted pallidal co-release of GABA and glutamate in habenula drives cocaine withdrawal and relapse

Mon, 06/27/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4334

Authors: Frank J Meye, Mariano Soiza-Reilly, Tamar Smit, Marco A Diana, Martin K Schwarz & Manuel Mameli

Dynamic regulation of RNA editing in human brain development and disease

Mon, 06/27/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4337

Authors: Taeyoung Hwang, Chul-Kee Park, Anthony K L Leung, Yuan Gao, Thomas M Hyde, Joel E Kleinman, Anandita Rajpurohit, Ran Tao, Joo Heon Shin & Daniel R Weinberger

Glucose-responsive neurons of the paraventricular thalamus control sucrose-seeking behavior

Mon, 06/20/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4331

Authors: Gwenaël Labouèbe, Benjamin Boutrel, David Tarussio & Bernard Thorens

Feeding behavior is governed by homeostatic needs and motivational drive to obtain palatable foods. Here, we identify a population of glutamatergic neurons in the paraventricular thalamus of mice that express the glucose transporter Glut2 (encoded by Slc2a2) and project to the nucleus accumbens. These neurons are activated by hypoglycemia and, in freely moving mice, their activation by optogenetics or Slc2a2 inactivation increases motivated sucrose-seeking but not saccharin-seeking behavior. These neurons may control sugar overconsumption in obesity and diabetes.

Bidirectional prefrontal-hippocampal interactions support context-guided memory

Mon, 06/20/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4327

Authors: Ryan Place, Anja Farovik, Marco Brockmann & Howard Eichenbaum

We compared the dynamics of hippocampal and prefrontal interactions in rats as they used spatial contexts to guide the retrieval of object memories. Functional connectivity analysis indicated a flow of contextual information from the hippocampus to prefrontal cortex upon the rat's entry into the spatial context. Conversely, upon the onset of object sampling, the direction of information flow reversed, consistent with prefrontal control over the retrieval of context-appropriate hippocampal memory representations.