Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
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MeCP2 and histone deacetylases 1 and 2 in dorsal striatum collectively suppress repetitive behaviors

Mon, 09/26/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4395

Authors: Melissa Mahgoub, Megumi Adachi, Kanzo Suzuki, Xihui Liu, Ege T Kavalali, Maria H Chahrour & Lisa M Monteggia

Neural substrate of dynamic Bayesian inference in the cerebral cortex

Mon, 09/19/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4390

Authors: Akihiro Funamizu, Bernd Kuhn & Kenji Doya

Dynamic GABAergic afferent modulation of AgRP neurons

Mon, 09/19/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4392

Authors: Alastair S Garfield, Bhavik P Shah, Christian R Burgess, Monica M Li, Chia Li, Jennifer S Steger, Joseph C Madara, John N Campbell, Daniel Kroeger, Thomas E Scammell, Bakhos A Tannous, Martin G Myers, Mark L Andermann, Michael J Krashes & Bradford B Lowell

Mechanosensing is critical for axon growth in the developing brain

Mon, 09/19/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4394

Authors: David E Koser, Amelia J Thompson, Sarah K Foster, Asha Dwivedy, Eva K Pillai, Graham K Sheridan, Hanno Svoboda, Matheus Viana, Luciano da F Costa, Jochen Guck, Christine E Holt & Kristian Franze

Multimodal population brain imaging in the UK Biobank prospective epidemiological study

Mon, 09/19/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4393

Authors: Karla L Miller, Fidel Alfaro-Almagro, Neal K Bangerter, David L Thomas, Essa Yacoub, Junqian Xu, Andreas J Bartsch, Saad Jbabdi, Stamatios N Sotiropoulos, Jesper L R Andersson, Ludovica Griffanti, Gwenaëlle Douaud, Thomas W Okell, Peter Weale, Iulius Dragonu, Steve Garratt, Sarah Hudson, Rory Collins, Mark Jenkinson, Paul M Matthews & Stephen M Smith

L1-associated genomic regions are deleted in somatic cells of the healthy human brain

Mon, 09/12/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4388

Authors: Jennifer A Erwin, Apuã C M Paquola, Tatjana Singer, Iryna Gallina, Mark Novotny, Carolina Quayle, Tracy A Bedrosian, Francisco I A Alves, Cheyenne R Butcher, Joseph R Herdy, Anindita Sarkar, Roger S Lasken, Alysson R Muotri & Fred H Gage

Experience-dependent spatial expectations in mouse visual cortex

Mon, 09/12/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4385

Authors: Aris Fiser, David Mahringer, Hassana K Oyibo, Anders V Petersen, Marcus Leinweber & Georg B Keller

Global dynamics of selective attention and its lapses in primary auditory cortex

Mon, 09/12/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4386

Authors: Peter Lakatos, Annamaria Barczak, Samuel A Neymotin, Tammy McGinnis, Deborah Ross, Daniel C Javitt & Monica Noelle O'Connell

Foxp2 controls synaptic wiring of corticostriatal circuits and vocal communication by opposing Mef2c

Mon, 09/05/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4380

Authors: Yi-Chuan Chen, Hsiao-Ying Kuo, Ulrich Bornschein, Hiroshi Takahashi, Shih-Yun Chen, Kuan-Ming Lu, Hao-Yu Yang, Gui-May Chen, Jing-Ruei Lin, Yi-Hsin Lee, Yun-Chia Chou, Sin-Jhong Cheng, Cheng-Ting Chien, Wolfgang Enard, Wulf Hevers, Svante Pääbo, Ann M Graybiel & Fu-Chin Liu

VTA dopaminergic neurons regulate ethologically relevant sleep–wake behaviors

Mon, 09/05/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4377

Authors: Ada Eban-Rothschild, Gideon Rothschild, William J Giardino, Jeff R Jones & Luis de Lecea

Selective synaptic remodeling of amygdalocortical connections associated with fear memory

Mon, 09/05/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4370

Authors: Yang Yang, Dan-qian Liu, Wei Huang, Juan Deng, Yangang Sun, Yi Zuo & Mu-ming Poo

The opposite lane: a path to memories?

Mon, 09/05/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4381

Author: Bo Li

Sound information travels from auditory cortex to lateral amygdala, but a newly identified pathway runs in the opposite direction. It undergoes plasticity and is required for memory recall during auditory fear conditioning.

Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control

Mon, 08/29/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4376

Authors: Alessandro Furlan, Gioele La Manno, Moritz Lübke, Martin Häring, Hind Abdo, Hannah Hochgerner, Jussi Kupari, Dmitry Usoskin, Matti S Airaksinen, Guillermo Oliver, Sten Linnarsson & Patrik Ernfors

Episodic sequence memory is supported by a theta–gamma phase code

Mon, 08/29/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4374

Authors: Andrew C Heusser, David Poeppel, Youssef Ezzyat & Lila Davachi

Genome-wide, integrative analysis implicates microRNA dysregulation in autism spectrum disorder

Mon, 08/29/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4373

Authors: Ye E Wu, Neelroop N Parikshak, T Grant Belgard & Daniel H Geschwind

Hypothalamic arcuate nucleus tyrosine hydroxylase neurons play orexigenic role in energy homeostasis

Mon, 08/22/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4372

Authors: Xiaobing Zhang & Anthony N van den Pol

Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca2+ channel–vesicle coupling

Mon, 08/15/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4364

Authors: Mathias A Böhme, Christina Beis, Suneel Reddy-Alla, Eric Reynolds, Malou M Mampell, Andreas T Grasskamp, Janine Lützkendorf, Dominique Dufour Bergeron, Jan H Driller, Husam Babikir, Fabian Göttfert, Iain M Robinson, Cahir J O'Kane, Stefan W Hell, Markus C Wahl, Ulrich Stelzl, Bernhard Loll, Alexander M Walter & Stephan J Sigrist

Representation of egomotion in rat's trident and E-row whisker cortices

Mon, 08/15/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4363

Authors: Edith Chorev, Patricia Preston-Ferrer & Michael Brecht

Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration

Mon, 08/15/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4360

Authors: Melanie von Schimmelmann, Philip A Feinberg, Josefa M Sullivan, Stacy M Ku, Ana Badimon, Mary Kaye Duff, Zichen Wang, Alexander Lachmann, Scott Dewell, Avi Ma'ayan, Ming-Hu Han, Alexander Tarakhovsky & Anne Schaefer

Diminished KCC2 confounds synapse specificity of LTP during senescence

Mon, 08/08/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4357

Authors: Isabella Ferando, Guido C Faas & Istvan Mody

The synapse specificity of long-term potentiation (LTP) ensures that no interference arises from inputs irrelevant to the memory to be encoded. In hippocampi of aged (21–28 months) mice, LTP was relayed to unstimulated synapses, blemishing its synapse specificity. Diminished levels of the K+/Cl− cotransporter KCC2 and a depolarizing GABAA receptor-mediated synaptic component following LTP were the most likely causes for the spreading of potentiation, unveiling mechanisms hindering information storage in the aged brain and identifying KCC2 as a potential target for intervention.