Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
Updated: 7 hours 35 min ago

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

Mon, 05/25/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4025

Authors: Zhen Zhao, Abhay P Sagare, Qingyi Ma, Matthew R Halliday, Pan Kong, Kassandra Kisler, Ethan A Winkler, Anita Ramanathan, Takahisa Kanekiyo, Guojun Bu, Nelly Chuqui Owens, Sanket V Rege, Gabriel Si, Ashim Ahuja, Donghui Zhu, Carol A Miller, Julie A Schneider, Manami Maeda, Takahiro Maeda, Tohru Sugawara, Justin K Ichida & Berislav V Zlokovic

The cortical analysis of speech-specific temporal structure revealed by responses to sound quilts

Mon, 05/18/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4021

Authors: Tobias Overath, Josh H McDermott, Jean Mary Zarate & David Poeppel

Social signals of safety and risk confer utility and have asymmetric effects on observers' choices

Mon, 05/18/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4022

Authors: Dongil Chung, George I Christopoulos, Brooks King-Casas, Sheryl B Ball & Pearl H Chiu

Inhumane treatment of nonhuman primate researchers

Mon, 05/18/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4039

Animal rights extremists are threatening nonhuman primate research by harassing scientists. We cannot tolerate these tactics, and we must rally individual, institutional and governmental support to protect scientists.

Function and developmental origin of a mesocortical inhibitory circuit

Mon, 05/11/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4020

Authors: Anna Kabanova, Milan Pabst, Markus Lorkowski, Oliver Braganza, Anne Boehlen, Negar Nikbakht, Leonie Pothmann, Ankita R Vaswani, Ruth Musgrove, Donato A Di Monte, Magdalena Sauvage, Heinz Beck & Sandra Blaess

Regulation of axon regeneration by the RNA repair and splicing pathway

Mon, 05/11/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4019

Authors: Yuanquan Song, David Sretavan, Ernesto A Salegio, Jim Berg, Xi Huang, Tong Cheng, Xin Xiong, Shan Meltzer, Chun Han, Trong-Tuong Nguyen, Jacqueline C Bresnahan, Michael S Beattie, Lily Yeh Jan & Yuh Nung Jan

A transcriptional reporter of intracellular Ca2+ in Drosophila

Mon, 05/11/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4016

Authors: Xiaojing J Gao, Olena Riabinina, Jiefu Li, Christopher J Potter, Thomas R Clandinin & Liqun Luo

A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease

Mon, 05/04/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4014

Authors: Kristina Bečanović, Anne Nørremølle, Scott J Neal, Chris Kay, Jennifer A Collins, David Arenillas, Tobias Lilja, Giulia Gaudenzi, Shiana Manoharan, Crystal N Doty, Jessalyn Beck, Nayana Lahiri, Elodie Portales-Casamar, Simon C Warby, Colúm Connolly, Rebecca A G De Souza, Sarah J Tabrizi, Ola Hermanson, Douglas R Langbehn, Michael R Hayden, Wyeth W Wasserman & Blair R Leavitt

Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine

Mon, 05/04/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4015

Authors: Il Hwan Kim, Mark A Rossi, Dipendra K Aryal, Bence Racz, Namsoo Kim, Akiyoshi Uezu, Fan Wang, William C Wetsel, Richard J Weinberg, Henry Yin & Scott H Soderling

An astrocyte-dependent mechanism for neuronal rhythmogenesis

Mon, 05/04/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4013

Authors: Philippe Morquette, Dorly Verdier, Aklesso Kadala, James Féthière, Antony G Philippe, Richard Robitaille & Arlette Kolta

Light-regulated translational control of circadian behavior by eIF4E phosphorylation

Mon, 04/27/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4010

Authors: Ruifeng Cao, Christos G Gkogkas, Nuria de Zavalia, Ian D Blum, Akiko Yanagiya, Yoshinori Tsukumo, Haiyan Xu, Choogon Lee, Kai-Florian Storch, Andrew C Liu, Shimon Amir & Nahum Sonenberg

An acetylcholine-activated microcircuit drives temporal dynamics of cortical activity

Mon, 04/27/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4002

Authors: Naiyan Chen, Hiroki Sugihara & Mriganka Sur

A neural basis for melanocortin-4 receptor–regulated appetite

Mon, 04/27/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4011

Authors: Alastair S Garfield, Chia Li, Joseph C Madara, Bhavik P Shah, Emily Webber, Jennifer S Steger, John N Campbell, Oksana Gavrilova, Charlotte E Lee, David P Olson, Joel K Elmquist, Bakhos A Tannous, Michael J Krashes & Bradford B Lowell

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease

Mon, 04/27/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4004

Authors: Ariadna Laguna, Nicoletta Schintu, André Nobre, Alexandra Alvarsson, Nikolaos Volakakis, Jesper Kjaer Jacobsen, Marta Gómez-Galán, Elena Sopova, Eliza Joodmardi, Takashi Yoshitake, Qiaolin Deng, Jan Kehr, Johan Ericson, Per Svenningsson, Oleg Shupliakov & Thomas Perlmann

Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair

Mon, 04/27/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4008

Authors: Huimei Yu, Yijing Su, Jaehoon Shin, Chun Zhong, Junjie U Guo, Yi-Lan Weng, Fuying Gao, Daniel H Geschwind, Giovanni Coppola, Guo-li Ming & Hongjun Song

Ca2+ signaling in astrocytes from Ip3r2−/− mice in brain slices and during startle responses in vivo

Mon, 04/20/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4001

Authors: Rahul Srinivasan, Ben S Huang, Sharmila Venugopal, April D Johnston, Hua Chai, Hongkui Zeng, Peyman Golshani & Baljit S Khakh

Neural encoding of opposing strategy values in anterior and posterior cingulate cortex

Mon, 04/20/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3999

Authors: Xiaohong Wan, Kang Cheng & Keiji Tanaka

A coding-independent function of an alternative Ube3a transcript during neuronal development

Mon, 04/13/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3996

Authors: Jeremy Valluy, Silvia Bicker, Ayla Aksoy-Aksel, Martin Lackinger, Simon Sumer, Roberto Fiore, Tatjana Wüst, Dominik Seffer, Franziska Metge, Christoph Dieterich, Markus Wöhr, Rainer Schwarting & Gerhard Schratt

Mesopontine median raphe regulates hippocampal ripple oscillation and memory consolidation

Mon, 04/13/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3998

Authors: Dong V Wang, Hau-Jie Yau, Carl J Broker, Jen-Hui Tsou, Antonello Bonci & Satoshi Ikemoto

Therapeutic deep brain stimulation reduces cortical phase-amplitude coupling in Parkinson's disease

Mon, 04/13/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3997

Authors: Coralie de Hemptinne, Nicole C Swann, Jill L Ostrem, Elena S Ryapolova-Webb, Marta San Luciano, Nicholas B Galifianakis & Philip A Starr