Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
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Interactions between the microbiota, immune and nervous systems in health and disease

Mon, 01/16/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4476

Authors: Thomas C Fung, Christine A Olson & Elaine Y Hsiao

Neural regulation of immunity: molecular mechanisms and clinical translation

Mon, 01/16/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4477

Authors: Valentin A Pavlov & Kevin J Tracey

The role of peripheral immune cells in the CNS in steady state and disease

Mon, 01/16/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4475

Authors: Marco Prinz & Josef Priller

REM sleep selectively prunes and maintains new synapses in development and learning

Mon, 01/16/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4479

Authors: Wei Li, Lei Ma, Guang Yang & Wen-Biao Gan

Neuroimmune communication

Mon, 01/16/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4496

We present a special set of Review articles on neuroimmune communication that highlight how the immune system and nervous system are anatomically connected, mechanistically communicate and reciprocally influence the other's function.

Separate elements of episodic memory subserved by distinct hippocampal–prefrontal connections

Mon, 01/09/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4472

Authors: Gareth R I Barker, Paul J Banks, Hannah Scott, G Scott Ralph, Kyriacos A Mitrophanous, Liang-Fong Wong, Zafar I Bashir, James B Uney & E Clea Warburton

Prefrontal cortical control of a brainstem social behavior circuit

Mon, 01/09/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4470

Authors: Tamara B Franklin, Bianca A Silva, Zinaida Perova, Livia Marrone, Maria E Masferrer, Yang Zhan, Angie Kaplan, Louise Greetham, Violaine Verrechia, Andreas Halman, Sara Pagella, Alexei L Vyssotski, Anna Illarionova, Valery Grinevich, Tiago Branco & Cornelius T Gross

Modulation of excitation on parvalbumin interneurons by neuroligin-3 regulates the hippocampal network

Mon, 01/09/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4471

Authors: Jai S Polepalli, Hemmings Wu, Debanjan Goswami, Casey H Halpern, Thomas C Südhof & Robert C Malenka

Stream-dependent development of higher visual cortical areas

Mon, 01/09/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4469

Authors: Ikuko T Smith, Leah B Townsend, Ruth Huh, Hongtu Zhu & Spencer L Smith

Developmental broadening of inhibitory sensory maps

Mon, 12/26/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4467

Authors: Kathleen B Quast, Kevin Ung, Emmanouil Froudarakis, Longwen Huang, Isabella Herman, Angela P Addison, Joshua Ortiz-Guzman, Keith Cordiner, Peter Saggau, Andreas S Tolias & Benjamin R Arenkiel

Emotional brain states carry over and enhance future memory formation

Mon, 12/26/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4468

Authors: Arielle Tambini, Ulrike Rimmele, Elizabeth A Phelps & Lila Davachi

An independent, landmark-dominated head-direction signal in dysgranular retrosplenial cortex

Mon, 12/19/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4465

Authors: Pierre-Yves Jacob, Giulio Casali, Laure Spieser, Hector Page, Dorothy Overington & Kate Jeffery

We investigated how landmarks influence the brain's computation of head direction and found that in a bidirectionally symmetrical environment, some neurons in dysgranular retrosplenial cortex showed bidirectional firing patterns. This indicates dominance of neural activity by local environmental cues even when these conflicted with the global head direction signal. It suggests a mechanism for associating landmarks to or dissociating them from the head direction signal, according to their directional stability and/or utility.

Subiculum neurons map the current axis of travel

Mon, 12/19/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4464

Authors: Jacob M Olson, Kanyanat Tongprasearth & Douglas A Nitz

Flexible navigation demands knowledge of boundaries, routes and their relationships. Within a multi-path environment, a subpopulation of subiculum neurons robustly encoded the axis of travel. The firing of axis-tuned neurons peaked bimodally, at head orientations 180° apart. Environmental manipulations showed these neurons to be anchored to environmental boundaries but to lack axis tuning in an open arena. Axis-tuned neurons thus provide a powerful mechanism for mapping relationships between routes and the larger environmental context.

Pregnancy leads to long-lasting changes in human brain structure

Mon, 12/19/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4458

Authors: Elseline Hoekzema, Erika Barba-Müller, Cristina Pozzobon, Marisol Picado, Florencio Lucco, David García-García, Juan Carlos Soliva, Adolf Tobeña, Manuel Desco, Eveline A Crone, Agustín Ballesteros, Susanna Carmona & Oscar Vilarroya

Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ

Mon, 12/19/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4463

Authors: Takashi Matsuda, Takeshi Y Hiyama, Fumio Niimura, Taiji Matsusaka, Akiyoshi Fukamizu, Kenta Kobayashi, Kazuto Kobayashi & Masaharu Noda

Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes

Mon, 12/19/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4462

Authors: Roman A Romanov, Amit Zeisel, Joanne Bakker, Fatima Girach, Arash Hellysaz, Raju Tomer, Alán Alpár, Jan Mulder, Frédéric Clotman, Erik Keimpema, Brian Hsueh, Ailey K Crow, Henrik Martens, Christian Schwindling, Daniela Calvigioni, Jaideep S Bains, Zoltán Máté, Gábor Szabó, Yuchio Yanagawa, Ming-Dong Zhang, Andre Rendeiro, Matthias Farlik, Mathias Uhlén, Peer Wulff, Christoph Bock, Christian Broberger, Karl Deisseroth, Tomas Hökfelt, Sten Linnarsson, Tamas L Horvath & Tibor Harkany

Manipulating stored phonological input during verbal working memory

Mon, 12/12/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4459

Authors: Gregory B Cogan, Asha Iyer, Lucia Melloni, Thomas Thesen, Daniel Friedman, Werner Doyle, Orrin Devinsky & Bijan Pesaran

A cortical–hippocampal–cortical loop of information processing during memory consolidation

Mon, 12/12/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4457

Authors: Gideon Rothschild, Elad Eban & Loren M Frank

Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity

Mon, 12/12/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4454

Authors: Christiane Wetzel, Simone Pifferi, Cristina Picci, Caglar Gök, Diana Hoffmann, Kiran K Bali, André Lampe, Liudmila Lapatsina, Raluca Fleischer, Ewan St John Smith, Valérie Bégay, Mirko Moroni, Luc Estebanez, Johannes Kühnemund, Jan Walcher, Edgar Specker, Martin Neuenschwander, Jens Peter von Kries, Volker Haucke, Rohini Kuner, James F A Poulet, Jan Schmoranzer, Kate Poole & Gary R Lewin

HSD2 neurons in the hindbrain drive sodium appetite

Mon, 12/05/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4451

Authors: Brooke C Jarvie & Richard D Palmiter

Sodium-depleted animals develop an appetite for aversive concentrations of sodium. Here we show that chemogenetic activation of aldosterone-sensitive neurons that express 11β-hydroxysteroid dehydrogenase type 2 (HSD2) in the nucleus of the solitary tract is sufficient to drive consumption of sodium-containing solutions in mice, independently of thirst or hunger. These HSD2-positive neurons are necessary for full expression of sodium appetite and have distinct downstream targets that are activated during sodium depletion.