Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
Updated: 4 weeks 3 days ago

Necroptosis activation in Alzheimer's disease

Mon, 07/24/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4608

Authors: Antonella Caccamo, Caterina Branca, Ignazio S Piras, Eric Ferreira, Matthew J Huentelman, Winnie S Liang, Ben Readhead, Joel T Dudley, Elizabeth E Spangenberg, Kim N Green, Ramona Belfiore, Wendy Winslow & Salvatore Oddo

Functional dissection of signal and noise in MT and LIP during decision-making

Mon, 07/24/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4611

Authors: Jacob L Yates, Il Memming Park, Leor N Katz, Jonathan W Pillow & Alexander C Huk

High-dimensional, single-cell characterization of the brain's immune compartment

Mon, 07/24/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4610

Authors: Ben Korin, Tamar L Ben-Shaanan, Maya Schiller, Tania Dubovik, Hilla Azulay-Debby, Nadia T Boshnak, Tamar Koren & Asya Rolls

Gut microbiota is critical for the induction of chemotherapy-induced pain

Mon, 07/17/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4606

Authors: Shiqian Shen, Grewo Lim, Zerong You, Weihua Ding, Peigen Huang, Chongzhao Ran, Jason Doheny, Peter Caravan, Samuel Tate, Kun Hu, Hyangin Kim, Michael McCabe, Bo Huang, Zhongcong Xie, Douglas Kwon, Lucy Chen & Jianren Mao

Chemotherapy-induced pain is a dose-limiting condition that affects 30% of patients undergoing chemotherapy. We found that gut microbiota promotes the development of chemotherapy-induced mechanical hyperalgesia. Oxaliplatin-induced mechanical hyperalgesia was reduced in germ-free mice and in mice pretreated with antibiotics. Restoring the microbiota of germ-free mice abrogated this protection. These effects appear to be mediated, in part, by TLR4 expressed on hematopoietic cells, including macrophages.

Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder

Mon, 07/17/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4598

Authors: Elaine T Lim, Mohammed Uddin, Silvia De Rubeis, Yingleong Chan, Anne S Kamumbu, Xiaochang Zhang, Alissa M D'Gama, Sonia N Kim, Robert Sean Hill, Arthur P Goldberg, Christopher Poultney, Nancy J Minshew, Itaru Kushima, Branko Aleksic, Norio Ozaki, Mara Parellada, Celso Arango, Maria J Penzol, Angel Carracedo, Alexander Kolevzon, Christina M Hultman, Lauren A Weiss, Menachem Fromer, Andreas G Chiocchetti, Christine M Freitag, George M Church, Stephen W Scherer, Joseph D Buxbaum & Christopher A Walsh

A circuit-based mechanism underlying familiarity signaling and the preference for novelty

Mon, 07/17/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4607

Authors: Susanna Molas, Rubing Zhao-Shea, Liwang Liu, Steven R DeGroot, Paul D Gardner & Andrew R Tapper

C9orf72 expansion disrupts ATM-mediated chromosomal break repair

Mon, 07/17/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4604

Authors: Callum Walker, Saul Herranz-Martin, Evangelia Karyka, Chunyan Liao, Katherine Lewis, Waheba Elsayed, Vera Lukashchuk, Shih-Chieh Chiang, Swagat Ray, Padraig J Mulcahy, Mateusz Jurga, Ioannis Tsagakis, Tommaso Iannitti, Jayanth Chandran, Ian Coldicott, Kurt J De Vos, Mohamed K Hassan, Adrian Higginbottom, Pamela J Shaw, Guillaume M Hautbergue, Mimoun Azzouz & Sherif F El-Khamisy

Neural reactivations during sleep determine network credit assignment

Mon, 07/10/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4601

Authors: Tanuj Gulati, Ling Guo, Dhakshin S Ramanathan, Anitha Bodepudi & Karunesh Ganguly

A causal account of the brain network computations underlying strategic social behavior

Mon, 07/10/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4602

Authors: Christopher A Hill, Shinsuke Suzuki, Rafael Polania, Marius Moisa, John P O'Doherty & Christian C Ruff

Reorganization of corticospinal output during motor learning

Mon, 07/03/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4596

Authors: Andrew J Peters, Jun Lee, Nathan G Hedrick, Keelin O'Neil & Takaki Komiyama

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

Mon, 07/03/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4597

Authors: Thais F Galatro, Inge R Holtman, Antonio M Lerario, Ilia D Vainchtein, Nieske Brouwer, Paula R Sola, Mariana M Veras, Tulio F Pereira, Renata E P Leite, Thomas Möller, Paul D Wes, Mari C Sogayar, Jon D Laman, Wilfred den Dunnen, Carlos A Pasqualucci, Sueli M Oba-Shinjo, Erik W G M Boddeke, Suely K N Marie & Bart J L Eggen

Activation of cortical somatostatin interneurons prevents the development of neuropathic pain

Mon, 06/26/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4595

Authors: Joseph Cichon, Thomas J J Blanck, Wen-Biao Gan & Guang Yang

Germline Chd8 haploinsufficiency alters brain development in mouse

Mon, 06/26/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4592

Authors: Andrea L Gompers, Linda Su-Feher, Jacob Ellegood, Nycole A Copping, M Asrafuzzaman Riyadh, Tyler W Stradleigh, Michael C Pride, Melanie D Schaffler, A Ayanna Wade, Rinaldo Catta-Preta, Iva Zdilar, Shreya Louis, Gaurav Kaushik, Brandon J Mannion, Ingrid Plajzer-Frick, Veena Afzal, Axel Visel, Len A Pennacchio, Diane E Dickel, Jason P Lerch, Jacqueline N Crawley, Konstantinos S Zarbalis, Jill L Silverman & Alex S Nord

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

Mon, 06/26/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4593

Authors: Ken Y Chan, Min J Jang, Bryan B Yoo, Alon Greenbaum, Namita Ravi, Wei-Li Wu, Luis Sánchez-Guardado, Carlos Lois, Sarkis K Mazmanian, Benjamin E Deverman & Viviana Gradinaru

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders

Mon, 06/26/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4594

Authors: Jing Li, Wangshu Zhang, Hui Yang, Daniel P Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V Evgrafov, Giulio Genovese, Veronica A Clementel, Jennifer C Tudor, Ted Abel, James A Knowles, Benjamin M Neale, Kai Wang, Fengzhu Sun & Marcelo P Coba

Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains

Mon, 06/19/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4589

Authors: Madeleine R Geisheker, Gabriel Heymann, Tianyun Wang, Bradley P Coe, Tychele N Turner, Holly A F Stessman, Kendra Hoekzema, Malin Kvarnung, Marie Shaw, Kathryn Friend, Jan Liebelt, Christopher Barnett, Elizabeth M Thompson, Eric Haan, Hui Guo, Britt-Marie Anderlid, Ann Nordgren, Anna Lindstrand, Geert Vandeweyer, Antonino Alberti, Emanuela Avola, Mirella Vinci, Stefania Giusto, Tiziano Pramparo, Karen Pierce, Srinivasa Nalabolu, Jacob J Michaelson, Zdenek Sedlacek, Gijs W E Santen, Hilde Peeters, Hakon Hakonarson, Eric Courchesne, Corrado Romano, R Frank Kooy, Raphael A Bernier, Magnus Nordenskjöld, Jozef Gecz, Kun Xia, Larry S Zweifel & Evan E Eichler

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

Mon, 06/19/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4587

Authors: Kuan-lin Huang, Edoardo Marcora, Anna A Pimenova, Antonio F Di Narzo, Manav Kapoor, Sheng Chih Jin, Oscar Harari, Sarah Bertelsen, Benjamin P Fairfax, Jake Czajkowski, Vincent Chouraki, Benjamin Grenier-Boley, Céline Bellenguez, Yuetiva Deming, Andrew McKenzie, Towfique Raj, Alan E Renton, John Budde, Albert Smith, Annette Fitzpatrick, Joshua C Bis, Anita DeStefano, Hieab H H Adams, M Arfan Ikram, Sven van der Lee, Jorge L Del-Aguila, Maria Victoria Fernandez, Laura Ibañez, Rebecca Sims, Valentina Escott-Price, Richard Mayeux, Jonathan L Haines, Lindsay A Farrer, Margaret A Pericak-Vance, Jean Charles Lambert, Cornelia van Duijn, Lenore Launer, Sudha Seshadri, Julie Williams, Philippe Amouyel, Gerard D Schellenberg, Bin Zhang, Ingrid Borecki, John S K Kauwe, Carlos Cruchaga, Ke Hao & Alison M Goate

Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1

Mon, 06/19/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4590

Authors: Thomas Rathjen, Xin Yan, Natalia L Kononenko, Min-Chi Ku, Kun Song, Leiron Ferrarese, Valentina Tarallo, Dmytro Puchkov, Gaga Kochlamazashvili, Sebastian Brachs, Luis Varela, Klara Szigeti-Buck, Chun-Xia Yi, Sonja C Schriever, Sudhir Gopal Tattikota, Anne Sophie Carlo, Mirko Moroni, Jan Siemens, Arnd Heuser, Louise van der Weyden, Andreas L Birkenfeld, Thoralf Niendorf, James F A Poulet, Tamas L Horvath, Matthias H Tschöp, Matthias Heinig, Mirko Trajkovski, Volker Haucke & Matthew N Poy

Active dendritic integration as a mechanism for robust and precise grid cell firing

Mon, 06/19/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4582

Authors: Christoph Schmidt-Hieber, Gabija Toleikyte, Laurence Aitchison, Arnd Roth, Beverley A Clark, Tiago Branco & Michael Häusser

Dynamic illumination of spatially restricted or large brain volumes via a single tapered optical fiber

Mon, 06/19/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4591

Authors: Ferruccio Pisanello, Gil Mandelbaum, Marco Pisanello, Ian A Oldenburg, Leonardo Sileo, Jeffrey E Markowitz, Ralph E Peterson, Andrea Della Patria, Trevor M Haynes, Mohamed S Emara, Barbara Spagnolo, Sandeep Robert Datta, Massimo De Vittorio & Bernardo L Sabatini