Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
Updated: 14 hours 51 min ago

Agouti-related peptide neural circuits mediate adaptive behaviors in the starved state

Mon, 03/28/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4274

Authors: Stephanie L Padilla, Jian Qiu, Marta E Soden, Elisenda Sanz, Casey C Nestor, Forrest D Barker, Albert Quintana, Larry S Zweifel, Oline K Rønnekleiv, Martin J Kelly & Richard D Palmiter

VTA glutamatergic inputs to nucleus accumbens drive aversion by acting on GABAergic interneurons

Mon, 03/28/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4281

Authors: Jia Qi, Shiliang Zhang, Hui-Ling Wang, David J Barker, Jorge Miranda-Barrientos & Marisela Morales

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

Mon, 03/21/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4272

Authors: Yong-Jie Zhang, Tania F Gendron, Jonathan C Grima, Hiroki Sasaguri, Karen Jansen-West, Ya-Fei Xu, Rebecca B Katzman, Jennifer Gass, Melissa E Murray, Mitsuru Shinohara, Wen-Lang Lin, Aliesha Garrett, Jeannette N Stankowski, Lillian Daughrity, Jimei Tong, Emilie A Perkerson, Mei Yue, Jeannie Chew, Monica Castanedes-Casey, Aishe Kurti, Zizhao S Wang, Amanda M Liesinger, Jeremy D Baker, Jie Jiang, Clotilde Lagier-Tourenne, Dieter Edbauer, Don W Cleveland, Rosa Rademakers, Kevin B Boylan, Guojun Bu, Christopher D Link, Chad A Dickey, Jeffrey D Rothstein, Dennis W Dickson, John D Fryer & Leonard Petrucelli

Schizophrenia genetics complements its mechanistic understanding

Mon, 03/21/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4277

Authors: Elizabeth K Ruzzo & Daniel H Geschwind

Refinement of genetic variants within the major histocompatibility complex reveals three distinct genetic influences on schizophrenia risk and sheds light on the disease's neurobiology.

Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders

Mon, 03/14/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4267

Authors: Tarjinder Singh, Mitja I Kurki, David Curtis, Shaun M Purcell, Lucy Crooks, Jeremy McRae, Jaana Suvisaari, Himanshu Chheda, Douglas Blackwood, Gerome Breen, Olli Pietiläinen, Sebastian S Gerety, Muhammad Ayub, Moira Blyth, Trevor Cole, David Collier, Eve L Coomber, Nick Craddock, Mark J Daly, John Danesh, Marta DiForti, Alison Foster, Nelson B Freimer, Daniel Geschwind, Mandy Johnstone, Shelagh Joss, Georg Kirov, Jarmo Körkkö, Outi Kuismin, Peter Holmans, Christina M Hultman, Conrad Iyegbe, Jouko Lönnqvist, Minna Männikkö, Steve A McCarroll, Peter McGuffin, Andrew M McIntosh, Andrew McQuillin, Jukka S Moilanen, Carmel Moore, Robin M Murray, Ruth Newbury-Ecob, Willem Ouwehand, Tiina Paunio, Elena Prigmore, Elliott Rees, David Roberts, Jennifer Sambrook, Pamela Sklar, David St Clair, Juha Veijola, James T R Walters, Hywel Williams, Patrick F Sullivan, Matthew E Hurles, Michael C O'Donovan, Aarno Palotie, Michael J Owen & Jeffrey C Barrett

Spike sorting for large, dense electrode arrays

Mon, 03/14/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4268

Authors: Cyrille Rossant, Shabnam N Kadir, Dan F M Goodman, John Schulman, Maximilian L D Hunter, Aman B Saleem, Andres Grosmark, Mariano Belluscio, George H Denfield, Alexander S Ecker, Andreas S Tolias, Samuel Solomon, György Buzsáki, Matteo Carandini & Kenneth D Harris

Biophysical constraints of optogenetic inhibition at presynaptic terminals

Mon, 03/07/2016 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4266

Authors: Mathias Mahn, Matthias Prigge, Shiri Ron, Rivka Levy & Ofer Yizhar

We investigated the efficacy of optogenetic inhibition at presynaptic terminals using halorhodopsin, archaerhodopsin and chloride-conducting channelrhodopsins. Precisely timed activation of both archaerhodopsin and halorhodpsin at presynaptic terminals attenuated evoked release. However, sustained archaerhodopsin activation was paradoxically associated with increased spontaneous release. Activation of chloride-conducting channelrhodopsins triggered neurotransmitter release upon light onset. Thus, the biophysical properties of presynaptic terminals dictate unique boundary conditions for optogenetic manipulation.

Hypothalamic control of male aggression-seeking behavior

Mon, 03/07/2016 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4264

Authors: Annegret L Falkner, Logan Grosenick, Thomas J Davidson, Karl Deisseroth & Dayu Lin

Genetically targeted magnetic control of the nervous system

Mon, 03/07/2016 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4265

Authors: Michael A Wheeler, Cody J Smith, Matteo Ottolini, Bryan S Barker, Aarti M Purohit, Ryan M Grippo, Ronald P Gaykema, Anthony J Spano, Mark P Beenhakker, Sarah Kucenas, Manoj K Patel, Christopher D Deppmann & Ali D Güler

Circadian rhythms in neuronal activity propagate through output circuits

Mon, 02/29/2016 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4263

Authors: Matthieu Cavey, Ben Collins, Claire Bertet & Justin Blau

Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination

Mon, 02/29/2016 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4258

Authors: Danyang He, Corentine Marie, Chuntao Zhao, Bongwoo Kim, Jincheng Wang, Yaqi Deng, Adrien Clavairoly, Magali Frah, Haibo Wang, Xuelian He, Hatem Hmidan, Blaise V Jones, David Witte, Bernard Zalc, Xin Zhou, Daniel I Choo, Donna M Martin, Carlos Parras & Q Richard Lu

Asymmetry of Drosophila ON and OFF motion detectors enhances real-world velocity estimation

Mon, 02/29/2016 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4262

Authors: Aljoscha Leonhardt, Georg Ammer, Matthias Meier, Etienne Serbe, Armin Bahl & Alexander Borst

Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B−/− mice

Mon, 02/29/2016 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4260

Authors: Rui T Peixoto, Wengang Wang, Donyell M Croney, Yevgenia Kozorovitskiy & Bernardo L Sabatini

Recoding a cocaine-place memory engram to a neutral engram in the hippocampus

Mon, 02/22/2016 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4250

Authors: Stéphanie Trouche, Pavel V Perestenko, Gido M van de Ven, Claire T Bratley, Colin G McNamara, Natalia Campo-Urriza, S Lucas Black, Leon G Reijmers & David Dupret

The hippocampus provides the brain's memory system with a subset of neurons holding a map-like representation of each environment experienced. We found in mice that optogenetic silencing those neurons active in an environment unmasked a subset of quiet neurons, enabling the emergence of an alternative map. When applied in a cocaine-paired environment, this intervention neutralized an otherwise long-lasting drug-place preference, showing that recoding a spatial memory engram can alleviate associated maladaptive behavior.

Hyperactive somatostatin interneurons contribute to excitotoxicity in neurodegenerative disorders

Mon, 02/22/2016 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4257

Authors: Wen Zhang, Lifeng Zhang, Bo Liang, David Schroeder, Zhong-wei Zhang, Gregory A Cox, Yun Li & Da-Ting Lin

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are overlapping neurodegenerative disorders whose pathogenesis remains largely unknown. Using TDP-43A315T mice, an ALS and FTD model with marked cortical pathology, we found that hyperactive somatostatin interneurons disinhibited layer 5 pyramidal neurons (L5-PNs) and contributed to their excitotoxicity. Focal ablation of somatostatin interneurons efficiently restored normal excitability of L5-PNs and alleviated neurodegeneration, suggesting a new therapeutic target for ALS and FTD.

Explicit information for category-orthogonal object properties increases along the ventral stream

Mon, 02/22/2016 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4247

Authors: Ha Hong, Daniel L K Yamins, Najib J Majaj & James J DiCarlo

Fluorescent false neurotransmitter reveals functionally silent dopamine vesicle clusters in the striatum

Mon, 02/22/2016 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4252

Authors: Daniela B Pereira, Yvonne Schmitz, József Mészáros, Paolomi Merchant, Gang Hu, Shu Li, Adam Henke, José E Lizardi-Ortiz, Richard J Karpowicz, Travis J Morgenstern, Mark S Sonders, Ellen Kanter, Pamela C Rodriguez, Eugene V Mosharov, Dalibor Sames & David Sulzer

Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice

Mon, 02/22/2016 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4256

Authors: Peter Langfelder, Jeffrey P Cantle, Doxa Chatzopoulou, Nan Wang, Fuying Gao, Ismael Al-Ramahi, Xiao-Hong Lu, Eliana Marisa Ramos, Karla El-Zein, Yining Zhao, Sandeep Deverasetty, Andreas Tebbe, Christoph Schaab, Daniel J Lavery, David Howland, Seung Kwak, Juan Botas, Jeffrey S Aaronson, Jim Rosinski, Giovanni Coppola, Steve Horvath & X William Yang

Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons

Mon, 02/15/2016 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4245

Authors: Elsa Isingrini, Léa Perret, Quentin Rainer, Bénédicte Amilhon, Elisa Guma, Arnaud Tanti, Garance Martin, Jennifer Robinson, Luc Moquin, Fabio Marti, Naguib Mechawar, Sylvain Williams, Alain Gratton & Bruno Giros

Dopamine (DA) neurons in the ventral tegmental area (VTA) help mediate stress susceptibility and resilience. However, upstream mechanisms controlling these neurons remain unknown. Noradrenergic (NE) neurons in the locus coeruleus, implicated in the pathophysiology of depression, have direct connections within the VTA. Here we demonstrate that NE neurons regulate vulnerability to social defeat through inhibitory control of VTA DA neurons.

An excitatory basis for divisive normalization in visual cortex

Mon, 02/15/2016 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4249

Authors: Tatsuo K Sato, Bilal Haider, Michael Häusser & Matteo Carandini

Neurons in visual cortex are connected not only locally, but also through networks of distal connectivity. These distal networks recruit both excitatory and inhibitory synapses and result in divisive normalization. Normalization is traditionally thought to result from increases in synaptic inhibition. By combining optogenetic stimulation and intracellular recordings in mouse visual cortex, we found that, on the contrary, normalization is a result of a decrease in synaptic excitation.