Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
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GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

Mon, 03/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3966

Authors: Ethan A Winkler, Yoichiro Nishida, Abhay P Sagare, Sanket V Rege, Robert D Bell, David Perlmutter, Jesse D Sengillo, Sara Hillman, Pan Kong, Amy R Nelson, John S Sullivan, Zhen Zhao, Herbert J Meiselman, Rosalinda B Wenby, Jamie Soto, E Dale Abel, Jacob Makshanoff, Edward Zuniga, Darryl C De Vivo & Berislav V Zlokovic

Mitochondrial control by DRP1 in brain tumor initiating cells

Mon, 03/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3960

Authors: Qi Xie, Qiulian Wu, Craig M Horbinski, William A Flavahan, Kailin Yang, Wenchao Zhou, Stephen M Dombrowski, Zhi Huang, Xiaoguang Fang, Yu Shi, Ashley N Ferguson, David F Kashatus, Shideng Bao & Jeremy N Rich

Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity

Wed, 02/25/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3975

Authors: Xintian You, Irena Vlatkovic, Ana Babic, Tristan Will, Irina Epstein, Georgi Tushev, Güney Akbalik, Mantian Wang, Caspar Glock, Claudia Quedenau, Xi Wang, Jingyi Hou, Hongyu Liu, Wei Sun, Sivakumar Sambandan, Tao Chen, Erin M Schuman & Wei Chen

What does gamma coherence tell us about inter-regional neural communication?

Mon, 02/23/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3952

Authors: György Buzsáki & Erik W Schomburg

Frequency-specific hippocampal-prefrontal interactions during associative learning

Mon, 02/23/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3954

Authors: Scott L Brincat & Earl K Miller

The dissociable effects of punishment and reward on motor learning

Mon, 02/23/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3956

Authors: Joseph M Galea, Elizabeth Mallia, John Rothwell & Jörn Diedrichsen

A subcortical inhibitory signal for behavioral arrest in the thalamus

Mon, 02/23/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3951

Authors: Kristóf Giber, Marco A Diana, Viktor M Plattner, Guillaume P Dugué, Hajnalka Bokor, Charly V Rousseau, Zsófia Maglóczky, László Havas, Balázs Hangya, Hendrik Wildner, Hanns Ulrich Zeilhofer, Stéphane Dieudonné & László Acsády

Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination

Mon, 02/23/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3953

Authors: Jeffery D Haines, Olivier Herbin, Belén de la Hera, Oscar G Vidaurre, Gregory A Moy, Qingxiang Sun, Ho Yee Joyce Fung, Stefanie Albrecht, Konstantina Alexandropoulos, Dilara McCauley, Yuh Min Chook, Tanja Kuhlmann, Grahame J Kidd, Sharon Shacham & Patrizia Casaccia

Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists

Mon, 02/23/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3957

Authors: Zhe Zhang, Valentina Ferretti, İlke Güntan, Alessandro Moro, Eleonora A Steinberg, Zhiwen Ye, Anna Y Zecharia, Xiao Yu, Alexei L Vyssotski, Stephen G Brickley, Raquel Yustos, Zoe E Pillidge, Edward C Harding, William Wisden & Nicholas P Franks

Vernon B. Mountcastle 1918–2015

Mon, 02/16/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3958

Author: Solomon H Snyder

Sensory inputs control the integration of neurogliaform interneurons into cortical circuits

Mon, 02/09/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3946

Authors: Natalia V De Marco García, Rashi Priya, Sebnem N Tuncdemir, Gord Fishell & Theofanis Karayannis

In vivo coincidence detection in mammalian sound localization generates phase delays

Mon, 02/09/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3948

Authors: Tom P Franken, Michael T Roberts, Liting Wei, Nace L Golding & Philip X Joris

Dopaminergic and glutamatergic microdomains in a subset of rodent mesoaccumbens axons

Mon, 02/09/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3945

Authors: Shiliang Zhang, Jia Qi, Xueping Li, Hui-Ling Wang, Jonathan P Britt, Alexander F Hoffman, Antonello Bonci, Carl R Lupica & Marisela Morales

Closed-loop training of attention with real-time brain imaging

Mon, 02/09/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3940

Authors: Megan T deBettencourt, Jonathan D Cohen, Ray F Lee, Kenneth A Norman & Nicholas B Turk-Browne

Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior

Mon, 02/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3937

Authors: Jeff R Jones, Michael C Tackenberg & Douglas G McMahon

To examine the interaction between molecular, electrical and behavioral circadian rhythms, we combined optogenetic manipulation of suprachiasmatic nucleus (SCN) firing rate with bioluminescence imaging and locomotor activity monitoring. Manipulating firing rate reset circadian rhythms both ex vivo and in vivo, and this resetting required spikes and network communication. This suggests that SCN firing rate is fundamental to circadian pacemaking as both an input to and output of the molecular clockworks.

Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula

Mon, 02/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3923

Authors: Frank J Meye, Kristina Valentinova, Salvatore Lecca, Lucile Marion-Poll, Matthieu J Maroteaux, Stefano Musardo, Imane Moutkine, Fabrizio Gardoni, Richard L Huganir, François Georges & Manuel Mameli

Addictive substances mediate positive and negative states promoting persistent drug use. However, substrates for aversive effects of drugs remain elusive. We found that, in mouse lateral habenula (LHb) neurons targeting the rostromedial tegmental nucleus, cocaine enhanced glutamatergic transmission, reduced K+ currents and increased excitability. GluA1 trafficking in LHb was instrumental for these cocaine-evoked modifications and drug-driven aversive behaviors. Altogether, our results suggest that long-lasting adaptations in LHb shape negative symptoms after drug taking.

Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area

Mon, 02/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3932

Authors: Ja Wook Koo, Michelle S Mazei-Robison, Quincey LaPlant, Gabor Egervari, Kevin M Braunscheidel, Danielle N Adank, Deveroux Ferguson, Jian Feng, Haosheng Sun, Kimberly N Scobie, Diane M Damez-Werno, Efrain Ribeiro, Catherine Jensen Peña, Deena Walker, Rosemary C Bagot, Michael E Cahill, Sarah Ann R Anderson, Benoit Labonté, Georgia E Hodes, Heidi Browne, Benjamin Chadwick, Alfred J Robison, Vincent F Vialou, Caroline Dias, Zachary Lorsch, Ezekiell Mouzon, Mary Kay Lobo, David M Dietz, Scott J Russo, Rachael L Neve, Yasmin L Hurd & Eric J Nestler

Optogenetic perturbation of preBötzinger complex inhibitory neurons modulates respiratory pattern

Mon, 02/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3938

Authors: David Sherman, Jason W Worrell, Yan Cui & Jack L Feldman

A neuroprotective role for microRNA miR-1000 mediated by limiting glutamate excitotoxicity

Mon, 02/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3935

Authors: Pushpa Verma, George J Augustine, Mohamed-Raafet Ammar, Ayumu Tashiro & Stephen M Cohen

Visualization of NMDA receptor–dependent AMPA receptor synaptic plasticity in vivo

Mon, 02/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3936

Authors: Yong Zhang, Robert H Cudmore, Da-Ting Lin, David J Linden & Richard L Huganir