Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
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The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain

Mon, 12/21/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4199

Authors: Wenjie Ren, Maria Virginia Centeno, Sara Berger, Ying Wu, Xiaodong Na, Xianguo Liu, Jyothisri Kondapalli, A Vania Apkarian, Marco Martina & D James Surmeier

We examined adaptations in nucleus accumbens (NAc) neurons in mouse and rat peripheral nerve injury models of neuropathic pain. Injury selectively increased excitability of NAc shell indirect pathway spiny projection neurons (iSPNs) and altered their synaptic connectivity. Moreover, injury-induced tactile allodynia was reversed by inhibiting and exacerbated by exciting iSPNs, indicating that they not only participated in the central representation of pain, but gated activity in ascending nociceptive pathways.

Hypothalamic feedforward inhibition of thalamocortical network controls arousal and consciousness

Mon, 12/21/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4209

Authors: Carolina Gutierrez Herrera, Marta Carus Cadavieco, Sonia Jego, Alexey Ponomarenko, Tatiana Korotkova & Antoine Adamantidis

Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease

Mon, 12/21/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4205

Authors: Michael R Johnson, Kirill Shkura, Sarah R Langley, Andree Delahaye-Duriez, Prashant Srivastava, W David Hill, Owen J L Rackham, Gail Davies, Sarah E Harris, Aida Moreno-Moral, Maxime Rotival, Doug Speed, Slavé Petrovski, Anaïs Katz, Caroline Hayward, David J Porteous, Blair H Smith, Sandosh Padmanabhan, Lynne J Hocking, John M Starr, David C Liewald, Alessia Visconti, Mario Falchi, Leonardo Bottolo, Tiziana Rossetti, Bénédicte Danis, Manuela Mazzuferi, Patrik Foerch, Alexander Grote, Christoph Helmstaedter, Albert J Becker, Rafal M Kaminski, Ian J Deary & Enrico Petretto

Laminar differences in the orientation selectivity of geniculate afferents in mouse primary visual cortex

Mon, 12/21/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4215

Authors: Satoru Kondo & Kenichi Ohki

Thalamic nuclei convey diverse contextual information to layer 1 of visual cortex

Mon, 12/21/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4197

Authors: Morgane M Roth, Johannes C Dahmen, Dylan R Muir, Fabia Imhof, Francisco J Martini & Sonja B Hofer

Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomics

Mon, 12/21/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4198

Authors: Jochen Schwenk, Enrique Pérez-Garci, Andy Schneider, Astrid Kollewe, Anne Gauthier-Kemper, Thorsten Fritzius, Adi Raveh, Margarita C Dinamarca, Alexander Hanuschkin, Wolfgang Bildl, Jürgen Klingauf, Martin Gassmann, Uwe Schulte, Bernhard Bettler & Bernd Fakler

Thalamus provides layer 4 of primary visual cortex with orientation- and direction-tuned inputs

Mon, 12/21/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4196

Authors: Wenzhi Sun, Zhongchao Tan, Brett D Mensh & Na Ji

Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value

Mon, 12/14/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4192

Authors: Mark A G Eldridge, Walter Lerchner, Richard C Saunders, Hiroyuki Kaneko, Kristopher W Krausz, Frank J Gonzalez, Bin Ji, Makoto Higuchi, Takafumi Minamimoto & Barry J Richmond

To study how the interaction between orbitofrontal (OFC) and rhinal (Rh) cortices influences the judgment of reward size, we reversibly disconnected these regions using hM4Di-DREADD (designer receptor exclusively activated by designer drug). Repeated inactivation reduced sensitivity to differences in reward size in two monkeys. These results suggest that retrieval of relative stimulus values from memory depends on the interaction between Rh and OFC.

DNA methylation changes in plasticity genes accompany the formation and maintenance of memory

Mon, 12/14/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4194

Authors: Rashi Halder, Magali Hennion, Ramon O Vidal, Orr Shomroni, Raza-Ur Rahman, Ashish Rajput, Tonatiuh Pena Centeno, Frauke van Bebber, Vincenzo Capece, Julio C Garcia Vizcaino, Anna-Lena Schuetz, Susanne Burkhardt, Eva Benito, Magdalena Navarro Sala, Sanaz Bahari Javan, Christian Haass, Bettina Schmid, Andre Fischer & Stefan Bonn

Oligodendrocyte death results in immune-mediated CNS demyelination

Mon, 12/14/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4193

Authors: Maria Traka, Joseph R Podojil, Derrick P McCarthy, Stephen D Miller & Brian Popko

Causal contribution of primate auditory cortex to auditory perceptual decision-making

Mon, 12/14/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4195

Authors: Joji Tsunada, Andrew S K Liu, Joshua I Gold & Yale E Cohen

Action initiation shapes mesolimbic dopamine encoding of future rewards

Mon, 12/07/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4187

Authors: Emilie C J Syed, Laura L Grima, Peter J Magill, Rafal Bogacz, Peter Brown & Mark E Walton

It is widely held that dopamine signaling encodes predictions of future rewards and such predictions are regularly used to drive behavior, but the relationship between these two is poorly defined. We found in rats that nucleus accumbens dopamine following a reward-predicting cue was attenuated unless movement was correctly initiated. Our results indicate that dopamine release in this region is contingent on correct action initiation and not just reward prediction.

Brief optogenetic inhibition of dopamine neurons mimics endogenous negative reward prediction errors

Mon, 12/07/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4191

Authors: Chun Yun Chang, Guillem R Esber, Yasmin Marrero-Garcia, Hau-Jie Yau, Antonello Bonci & Geoffrey Schoenbaum

Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway

Mon, 12/07/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4188

Authors: Utpal Das, Lina Wang, Archan Ganguly, Junmi M Saikia, Steven L Wagner, Edward H Koo & Subhojit Roy

Cortical tracking of hierarchical linguistic structures in connected speech

Mon, 12/07/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4186

Authors: Nai Ding, Lucia Melloni, Hang Zhang, Xing Tian & David Poeppel

Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain

Mon, 12/07/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4189

Authors: Zhonghui Guan, Julia A Kuhn, Xidao Wang, Bradley Colquitt, Carlos Solorzano, Smitha Vaman, Andrew K Guan, Zoe Evans-Reinsch, Joao Braz, Marshall Devor, Sherry L Abboud-Werner, Lewis L Lanier, Stavros Lomvardas & Allan I Basbaum

Origins of choice-related activity in mouse somatosensory cortex

Mon, 12/07/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4183

Authors: Hongdian Yang, Sung E Kwon, Kyle S Severson & Daniel H O'Connor

Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci

Mon, 11/30/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4182

Authors: Eilis Hannon, Helen Spiers, Joana Viana, Ruth Pidsley, Joe Burrage, Therese M Murphy, Claire Troakes, Gustavo Turecki, Michael C O'Donovan, Leonard C Schalkwyk, Nicholas J Bray & Jonathan Mill

Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex

Mon, 11/30/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4181

Authors: Andrew E Jaffe, Yuan Gao, Amy Deep-Soboslay, Ran Tao, Thomas M Hyde, Daniel R Weinberger & Joel E Kleinman

Decoding the content of visual short-term memory under distraction in occipital and parietal areas

Mon, 11/23/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4174

Authors: Katherine C Bettencourt & Yaoda Xu