Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
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Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia

Sun, 06/08/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3737

Authors: Eric D Berglund, Tiemin Liu, Xingxing Kong, Jong-Woo Sohn, Linh Vong, Zhuo Deng, Charlotte E Lee, Syann Lee, Kevin W Williams, David P Olson, Philipp E Scherer, Bradford B Lowell & Joel K Elmquist

Whether melanocortin 4 receptors (MC4Rs) in extra-hypothalamic neurons, including cholinergic autonomic pre-ganglionic neurons, are required to control energy and glucose homeostasis is unclear. We found that MC4Rs in sympathetic, but not parasympathetic, pre-ganglionic neurons were required to regulate energy expenditure and body weight, including thermogenic responses to diet and cold exposure and 'beiging' of white adipose tissue. Deletion of Mc4r genes in both sympathetic and parasympathetic cholinergic neurons impaired glucose homeostasis.

Behavioral and neurophysiological correlates of regret in rat decision-making on a neuroeconomic task

Sun, 06/08/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3740

Authors: Adam P Steiner & A David Redish

A spike-timing mechanism for action selection

Sun, 06/08/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3741

Authors: Catherine R von Reyn, Patrick Breads, Martin Y Peek, Grace Zhiyu Zheng, W Ryan Williamson, Alyson L Yee, Anthony Leonardo & Gwyneth M Card

Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding

Sun, 06/01/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3725

Authors: Jae Geun Kim, Shigetomo Suyama, Marco Koch, Sungho Jin, Pilar Argente-Arizon, Jesús Argente, Zhong-Wu Liu, Marcelo R Zimmer, Jin Kwon Jeong, Klara Szigeti-Buck, Yuanqing Gao, Cristina Garcia-Caceres, Chun-Xia Yi, Natalina Salmaso, Flora M Vaccarino, Julie Chowen, Sabrina Diano, Marcelo O Dietrich, Matthias H Tschöp & Tamas L Horvath

We found that leptin receptors were expressed in hypothalamic astrocytes and that their conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic neurons involved in feeding control. Leptin-regulated feeding was diminished, whereas feeding after fasting or ghrelin administration was elevated in mice with astrocyte-specific leptin receptor deficiency. These data reveal an active role of glial cells in hypothalamic synaptic remodeling and control of feeding by leptin.

Functional organization of glomerular maps in the mouse accessory olfactory bulb

Sun, 06/01/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3738

Authors: Gary F Hammen, Diwakar Turaga, Timothy E Holy & Julian P Meeks

Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task

Sun, 06/01/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3739

Authors: Yoshito Masamizu, Yasuhiro R Tanaka, Yasuyo H Tanaka, Riichiro Hira, Fuki Ohkubo, Kazuo Kitamura, Yoshikazu Isomura, Takashi Okada & Masanori Matsuzaki

Identification of distinct ChAT+ neurons and activity-dependent control of postnatal SVZ neurogenesis

Sun, 06/01/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3734

Authors: Patricia Paez-Gonzalez, Brent Asrican, Erica Rodriguez & Chay T Kuo

Patterns across multiple memories are identified over time

Sun, 06/01/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3736

Authors: Blake A Richards, Frances Xia, Adam Santoro, Jana Husse, Melanie A Woodin, Sheena A Josselyn & Paul W Frankland

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

Sun, 05/25/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3728

Authors: Nitai C Hait, Laura E Wise, Jeremy C Allegood, Megan O'Brien, Dorit Avni, Thomas M Reeves, Pamela E Knapp, Junyan Lu, Cheng Luo, Michael F Miles, Sheldon Milstien, Aron H Lichtman & Sarah Spiegel

ALK5-dependent TGF-β signaling is a major determinant of late-stage adult neurogenesis

Sun, 05/25/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3732

Authors: Yingbo He, Hui Zhang, Andrea Yung, Saul A Villeda, Philipp A Jaeger, Oluwatobi Olayiwola, Nina Fainberg & Tony Wyss-Coray

Mechanical coupling maintains the fidelity of NMDA receptor–mediated currents

Sun, 05/25/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3724

Authors: Rashek Kazi, Jian Dai, Cameron Sweeney, Huan-Xiang Zhou & Lonnie P Wollmuth

Mutations in Eml1 lead to ectopic progenitors and neuronal heterotopia in mouse and human

Sun, 05/25/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3729

Authors: Michel Kielar, Françoise Phan Dinh Tuy, Sara Bizzotto, Cécile Lebrand, Camino de Juan Romero, Karine Poirier, Renske Oegema, Grazia Maria Mancini, Nadia Bahi-Buisson, Robert Olaso, Anne-Gaëlle Le Moing, Katia Boutourlinsky, Dominique Boucher, Wassila Carpentier, Patrick Berquin, Jean-François Deleuze, Richard Belvindrah, Victor Borrell, Egbert Welker, Jamel Chelly, Alexandre Croquelois & Fiona Francis

Spatiotemporal receptive fields of barrel cortex revealed by reverse correlation of synaptic input

Sun, 05/18/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3720

Authors: Alejandro Ramirez, Eftychios A Pnevmatikakis, Josh Merel, Liam Paninski, Kenneth D Miller & Randy M Bruno

Inhibition of mitochondrial protein import by mutant huntingtin

Sun, 05/18/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3721

Authors: Hiroko Yano, Sergei V Baranov, Oxana V Baranova, Jinho Kim, Yanchun Pan, Svitlana Yablonska, Diane L Carlisle, Robert J Ferrante, Albert H Kim & Robert M Friedlander

Induction of self awareness in dreams through frontal low current stimulation of gamma activity

Sun, 05/11/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3719

Authors: Ursula Voss, Romain Holzmann, Allan Hobson, Walter Paulus, Judith Koppehele-Gossel, Ansgar Klimke & Michael A Nitsche

Recent findings link fronto-temporal gamma electroencephalographic (EEG) activity to conscious awareness in dreams, but a causal relationship has not yet been established. We found that current stimulation in the lower gamma band during REM sleep influences ongoing brain activity and induces self-reflective awareness in dreams. Other stimulation frequencies were not effective, suggesting that higher order consciousness is indeed related to synchronous oscillations around 25 and 40 Hz.

Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase

Sun, 05/11/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3717

Authors: Javier Sanchez-Padilla, Jaime N Guzman, Ema Ilijic, Jyothisri Kondapalli, Daniel J Galtieri, Ben Yang, Simon Schieber, Wolfgang Oertel, David Wokosin, Paul T Schumacker & D James Surmeier

Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes

Sun, 05/04/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3715

Authors: Sachin Katyal, Youngsoo Lee, Karin C Nitiss, Susanna M Downing, Yang Li, Mikio Shimada, Jingfeng Zhao, Helen R Russell, John H J Petrini, John L Nitiss & Peter J McKinnon

Cellular origins of auditory event-related potential deficits in Rett syndrome

Mon, 04/28/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3710

Authors: Darren Goffin, Edward S Brodkin, Julie A Blendy, Steve J Siegel & Zhaolan Zhou

Dysfunction in sensory information processing is a hallmark of many neurological disorders, including autism spectrum disorders, schizophrenia and Rett syndrome (RTT). Using mouse models of RTT, a monogenic disorder caused by mutations in MECP2, we found that the large-scale loss of MeCP2 from forebrain GABAergic interneurons led to deficits in auditory event-related potentials and seizure manifestation, whereas the restoration of MeCP2 in specific classes of interneurons ameliorated these deficits.

Partitioning neuronal variability

Mon, 04/28/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3711

Authors: Robbe L T Goris, J Anthony Movshon & Eero P Simoncelli

High-fidelity optical reporting of neuronal electrical activity with an ultrafast fluorescent voltage sensor

Tue, 04/22/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3709

Authors: François St-Pierre, Jesse D Marshall, Ying Yang, Yiyang Gong, Mark J Schnitzer & Michael Z Lin