Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
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Zeb2 recruits HDAC–NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination

Mon, 06/13/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4322

Authors: Lai Man Natalie Wu, Jincheng Wang, Andrea Conidi, Chuntao Zhao, Haibo Wang, Zachary Ford, Liguo Zhang, Christiane Zweier, Brian G Ayee, Patrice Maurel, An Zwijsen, Jonah R Chan, Michael P Jankowski, Danny Huylebroeck & Q Richard Lu

Topographical representation of odor hedonics in the olfactory bulb

Mon, 06/06/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4317

Authors: Florence Kermen, Maëllie Midroit, Nicola Kuczewski, Jérémy Forest, Marc Thévenet, Joëlle Sacquet, Claire Benetollo, Marion Richard, Anne Didier & Nathalie Mandairon

Hedonic value is a dominant aspect of olfactory perception. Using optogenetic manipulation in freely behaving mice paired with immediate early gene mapping, we demonstrate that hedonic information is represented along the antero-posterior axis of the ventral olfactory bulb. Using this representation, we show that the degree of attractiveness of odors can be bidirectionally modulated by local manipulation of the olfactory bulb's neural networks in freely behaving mice.

SHANK3 controls maturation of social reward circuits in the VTA

Mon, 06/06/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4319

Authors: Sebastiano Bariselli, Stamatina Tzanoulinou, Christelle Glangetas, Clément Prévost-Solié, Luca Pucci, Joanna Viguié, Paola Bezzi, Eoin C O'Connor, François Georges, Christian Lüscher & Camilla Bellone

YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells

Mon, 06/06/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4316

Authors: Yannick Poitelon, Camila Lopez-Anido, Kathleen Catignas, Caterina Berti, Marilena Palmisano, Courtney Williamson, Dominique Ameroso, Kansho Abiko, Yoonchan Hwang, Alex Gregorieff, Jeffrey L Wrana, Mohammadnabi Asmani, Ruogang Zhao, Fraser James Sim, Lawrence Wrabetz, John Svaren & Maria Laura Feltri

Decoding subjective decisions from orbitofrontal cortex

Mon, 06/06/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4320

Authors: Erin L Rich & Jonathan D Wallis

Hippocampal global remapping for different sensory modalities in flying bats

Mon, 05/30/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4310

Authors: Maya Geva-Sagiv, Sandro Romani, Liora Las & Nachum Ulanovsky

Opposing mechanisms mediate morphine- and cocaine-induced generation of silent synapses

Mon, 05/30/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4313

Authors: Nicholas M Graziane, Shichao Sun, William J Wright, Daniel Jang, Zheng Liu, Yanhua H Huang, Eric J Nestler, Yu Tian Wang, Oliver M Schlüter & Yan Dong

An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior

Mon, 05/30/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4315

Authors: Yonwoo Jung, Lawrence S Hsieh, Angela M Lee, Zhifeng Zhou, Daniel Coman, Christopher J Heath, Fahmeed Hyder, Yann S Mineur, Qiaoping Yuan, David Goldman, Angelique Bordey & Marina R Picciotto

Silencing CA3 disrupts temporal coding in the CA1 ensemble

Mon, 05/30/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4311

Authors: Steven J Middleton & Thomas J McHugh

Olfactory receptor for prostaglandin F2α mediates male fish courtship behavior

Mon, 05/30/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4314

Authors: Yoichi Yabuki, Tetsuya Koide, Nobuhiko Miyasaka, Noriko Wakisaka, Miwa Masuda, Masamichi Ohkura, Junichi Nakai, Kyoshiro Tsuge, Soken Tsuchiya, Yukihiko Sugimoto & Yoshihiro Yoshihara

Evaluation of ambiguous associations in the amygdala by learning the structure of the environment

Mon, 05/23/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4308

Authors: Tamas J Madarasz, Lorenzo Diaz-Mataix, Omar Akhand, Edgar A Ycu, Joseph E LeDoux & Joshua P Johansen

Hedgehog signaling promotes basal progenitor expansion and the growth and folding of the neocortex

Mon, 05/23/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4307

Authors: Lei Wang, Shirui Hou & Young-Goo Han

Spatially segregated feedforward and feedback neurons support differential odor processing in the lateral entorhinal cortex

Mon, 05/16/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4303

Authors: Frauke C Leitner, Sarah Melzer, Henry Lütcke, Roberta Pinna, Peter H Seeburg, Fritjof Helmchen & Hannah Monyer

Hippocampo-cortical coupling mediates memory consolidation during sleep

Mon, 05/16/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4304

Authors: Nicolas Maingret, Gabrielle Girardeau, Ralitsa Todorova, Marie Goutierre & Michaël Zugaro

Neuronal remapping and circuit persistence in economic decisions

Mon, 05/09/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4300

Authors: Jue Xie & Camillo Padoa-Schioppa

In vivo imaging of dendritic pruning in dentate granule cells

Mon, 05/02/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4301

Authors: J Tiago Gonçalves, Cooper W Bloyd, Matthew Shtrahman, Stephen T Johnston, Simon T Schafer, Sarah L Parylak, Thanh Tran, Tina Chang & Fred H Gage

We longitudinally imaged the developing dendrites of adult-born mouse dentate granule cells (DGCs) in vivo and found that they underwent over-branching and pruning. Exposure to an enriched environment and constraint of dendritic growth by disrupting Wnt signaling led to increased branch addition and accelerated growth, which were, however, counteracted by earlier and more extensive pruning. Our results indicate that pruning is regulated in a homeostatic fashion to oppose excessive branching and promote a similar dendrite structure in DGCs.

Neural pattern similarity reveals the inherent intersection of social categories

Mon, 05/02/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4296

Authors: Ryan M Stolier & Jonathan B Freeman

We provide evidence that neural representations of ostensibly unrelated social categories become bound together by their overlapping stereotype associations. While viewing faces, multi-voxel representations of gender, race, and emotion categories in the fusiform and orbitofrontal cortices were stereotypically biased and correlated with subjective perceptions. The findings suggest that social-conceptual knowledge can systematically alter the representational structure of social categories at multiple levels of cortical processing, reflecting bias in visual perceptions.

A microRNA switch regulates the rise in hypothalamic GnRH production before puberty

Mon, 05/02/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4298

Authors: Andrea Messina, Fanny Langlet, Konstantina Chachlaki, Juan Roa, Sowmyalakshmi Rasika, Nathalie Jouy, Sarah Gallet, Francisco Gaytan, Jyoti Parkash, Manuel Tena-Sempere, Paolo Giacobini & Vincent Prevot

Control of glioblastoma tumorigenesis by feed-forward cytokine signaling

Mon, 04/25/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4295

Authors: Arezu Jahani-Asl, Hang Yin, Vahab D Soleimani, Takrima Haque, H Artee Luchman, Natasha C Chang, Marie-Claude Sincennes, Sidharth V Puram, Andrew M Scott, Ian A J Lorimer, Theodore J Perkins, Keith L Ligon, Samuel Weiss, Michael A Rudnicki & Azad Bonni

Serotonin modulates spike probability in the axon initial segment through HCN channels

Mon, 04/25/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4293

Authors: Kwang Woo Ko, Matthew N Rasband, Victor Meseguer, Richard H Kramer & Nace L Golding