Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
Updated: 5 days 16 hours ago

Activation of cortical somatostatin interneurons prevents the development of neuropathic pain

Mon, 06/26/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4595

Authors: Joseph Cichon, Thomas J J Blanck, Wen-Biao Gan & Guang Yang

Germline Chd8 haploinsufficiency alters brain development in mouse

Mon, 06/26/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4592

Authors: Andrea L Gompers, Linda Su-Feher, Jacob Ellegood, Nycole A Copping, M Asrafuzzaman Riyadh, Tyler W Stradleigh, Michael C Pride, Melanie D Schaffler, A Ayanna Wade, Rinaldo Catta-Preta, Iva Zdilar, Shreya Louis, Gaurav Kaushik, Brandon J Mannion, Ingrid Plajzer-Frick, Veena Afzal, Axel Visel, Len A Pennacchio, Diane E Dickel, Jason P Lerch, Jacqueline N Crawley, Konstantinos S Zarbalis, Jill L Silverman & Alex S Nord

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

Mon, 06/26/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4593

Authors: Ken Y Chan, Min J Jang, Bryan B Yoo, Alon Greenbaum, Namita Ravi, Wei-Li Wu, Luis Sánchez-Guardado, Carlos Lois, Sarkis K Mazmanian, Benjamin E Deverman & Viviana Gradinaru

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders

Mon, 06/26/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4594

Authors: Jing Li, Wangshu Zhang, Hui Yang, Daniel P Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V Evgrafov, Giulio Genovese, Veronica A Clementel, Jennifer C Tudor, Ted Abel, James A Knowles, Benjamin M Neale, Kai Wang, Fengzhu Sun & Marcelo P Coba

Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains

Mon, 06/19/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4589

Authors: Madeleine R Geisheker, Gabriel Heymann, Tianyun Wang, Bradley P Coe, Tychele N Turner, Holly A F Stessman, Kendra Hoekzema, Malin Kvarnung, Marie Shaw, Kathryn Friend, Jan Liebelt, Christopher Barnett, Elizabeth M Thompson, Eric Haan, Hui Guo, Britt-Marie Anderlid, Ann Nordgren, Anna Lindstrand, Geert Vandeweyer, Antonino Alberti, Emanuela Avola, Mirella Vinci, Stefania Giusto, Tiziano Pramparo, Karen Pierce, Srinivasa Nalabolu, Jacob J Michaelson, Zdenek Sedlacek, Gijs W E Santen, Hilde Peeters, Hakon Hakonarson, Eric Courchesne, Corrado Romano, R Frank Kooy, Raphael A Bernier, Magnus Nordenskjöld, Jozef Gecz, Kun Xia, Larry S Zweifel & Evan E Eichler

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

Mon, 06/19/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4587

Authors: Kuan-lin Huang, Edoardo Marcora, Anna A Pimenova, Antonio F Di Narzo, Manav Kapoor, Sheng Chih Jin, Oscar Harari, Sarah Bertelsen, Benjamin P Fairfax, Jake Czajkowski, Vincent Chouraki, Benjamin Grenier-Boley, Céline Bellenguez, Yuetiva Deming, Andrew McKenzie, Towfique Raj, Alan E Renton, John Budde, Albert Smith, Annette Fitzpatrick, Joshua C Bis, Anita DeStefano, Hieab H H Adams, M Arfan Ikram, Sven van der Lee, Jorge L Del-Aguila, Maria Victoria Fernandez, Laura Ibañez, Rebecca Sims, Valentina Escott-Price, Richard Mayeux, Jonathan L Haines, Lindsay A Farrer, Margaret A Pericak-Vance, Jean Charles Lambert, Cornelia van Duijn, Lenore Launer, Sudha Seshadri, Julie Williams, Philippe Amouyel, Gerard D Schellenberg, Bin Zhang, Ingrid Borecki, John S K Kauwe, Carlos Cruchaga, Ke Hao & Alison M Goate

Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1

Mon, 06/19/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4590

Authors: Thomas Rathjen, Xin Yan, Natalia L Kononenko, Min-Chi Ku, Kun Song, Leiron Ferrarese, Valentina Tarallo, Dmytro Puchkov, Gaga Kochlamazashvili, Sebastian Brachs, Luis Varela, Klara Szigeti-Buck, Chun-Xia Yi, Sonja C Schriever, Sudhir Gopal Tattikota, Anne Sophie Carlo, Mirko Moroni, Jan Siemens, Arnd Heuser, Louise van der Weyden, Andreas L Birkenfeld, Thoralf Niendorf, James F A Poulet, Tamas L Horvath, Matthias H Tschöp, Matthias Heinig, Mirko Trajkovski, Volker Haucke & Matthew N Poy

Active dendritic integration as a mechanism for robust and precise grid cell firing

Mon, 06/19/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4582

Authors: Christoph Schmidt-Hieber, Gabija Toleikyte, Laurence Aitchison, Arnd Roth, Beverley A Clark, Tiago Branco & Michael Häusser

Dynamic illumination of spatially restricted or large brain volumes via a single tapered optical fiber

Mon, 06/19/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4591

Authors: Ferruccio Pisanello, Gil Mandelbaum, Marco Pisanello, Ian A Oldenburg, Leonardo Sileo, Jeffrey E Markowitz, Ralph E Peterson, Andrea Della Patria, Trevor M Haynes, Mohamed S Emara, Barbara Spagnolo, Sandeep Robert Datta, Massimo De Vittorio & Bernardo L Sabatini

A TNF–JNK–Axl–ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma

Mon, 06/12/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4584

Authors: Gao Guo, Ke Gong, Sonia Ali, Neha Ali, Shahzad Shallwani, Kimmo J Hatanpaa, Edward Pan, Bruce Mickey, Sandeep Burma, David H Wang, Santosh Kesari, Jann N Sarkaria, Dawen Zhao & Amyn A Habib

Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior

Mon, 06/12/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4580

Authors: Chun Hu, Meike Petersen, Nina Hoyer, Bettina Spitzweck, Federico Tenedini, Denan Wang, Alisa Gruschka, Lara S Burchardt, Emanuela Szpotowicz, Michaela Schweizer, Ananya R Guntur, Chung-Hui Yang & Peter Soba

Neural signatures of dynamic stimulus selection in Drosophila

Mon, 06/12/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4581

Authors: Yi Sun, Aljoscha Nern, Romain Franconville, Hod Dana, Eric R Schreiter, Loren L Looger, Karel Svoboda, Douglas S Kim, Ann M Hermundstad & Vivek Jayaraman

Reinstated episodic context guides sampling-based decisions for reward

Mon, 06/05/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4573

Authors: Aaron M Bornstein & Kenneth A Norman

Cancer-induced anorexia and malaise are mediated by CGRP neurons in the parabrachial nucleus

Mon, 06/05/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4574

Authors: Carlos A Campos, Anna J Bowen, Sung Han, Brent E Wisse, Richard D Palmiter & Michael W Schwartz

Rich cell-type-specific network topology in neocortical microcircuitry

Mon, 06/05/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4576

Authors: Eyal Gal, Michael London, Amir Globerson, Srikanth Ramaswamy, Michael W Reimann, Eilif Muller, Henry Markram & Idan Segev

Attention-related changes in correlated neuronal activity arise from normalization mechanisms

Mon, 05/29/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4572

Authors: Bram-Ernst Verhoef & John H R Maunsell

The cellular mechanism for water detection in the mammalian taste system

Mon, 05/29/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4575

Authors: Dhruv Zocchi, Gunther Wennemuth & Yuki Oka

PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1

Mon, 05/22/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4571

Authors: Gang Chen, Yong Ho Kim, Hui Li, Hao Luo, Da-Lu Liu, Zhi-Jun Zhang, Mark Lay, Wonseok Chang, Yu-Qiu Zhang & Ru-Rong Ji

Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex

Mon, 05/22/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4566

Authors: Daniel Hillier, Michele Fiscella, Antonia Drinnenberg, Stuart Trenholm, Santiago B Rompani, Zoltan Raics, Gergely Katona, Josephine Juettner, Andreas Hierlemann, Balazs Rozsa & Botond Roska

Flexible information routing by transient synchrony

Mon, 05/22/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4569

Authors: Agostina Palmigiano, Theo Geisel, Fred Wolf & Demian Battaglia