Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
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Explicit memory creation during sleep demonstrates a causal role of place cells in navigation

Mon, 03/09/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3970

Authors: Gaetan de Lavilléon, Marie Masako Lacroix, Laure Rondi-Reig & Karim Benchenane

Hippocampal place cells assemblies are believed to support the cognitive map, and their reactivations during sleep are thought to be involved in spatial memory consolidation. By triggering intracranial rewarding stimulations by place cell spikes during sleep, we induced an explicit memory trace, leading to a goal-directed behavior toward the place field. This demonstrates that place cells' activity during sleep still conveys relevant spatial information and that this activity is functionally significant for navigation.

NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking

Mon, 03/09/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3972

Authors: Kristen E Pleil, Jennifer A Rinker, Emily G Lowery-Gionta, Christopher M Mazzone, Nora M McCall, Alexis M Kendra, David P Olson, Bradford B Lowell, Kathleen A Grant, Todd E Thiele & Thomas L Kash

Somatostatin cells regulate sensory response fidelity via subtractive inhibition in olfactory cortex

Mon, 03/09/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3971

Authors: James F Sturgill & Jeffry S Isaacson

Single-cell analysis reveals transcriptional heterogeneity of neural progenitors in human cortex

Tue, 03/03/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3980

Authors: Matthew B Johnson, Peter P Wang, Kutay D Atabay, Elisabeth A Murphy, Ryan N Doan, Jonathan L Hecht & Christopher A Walsh

Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone

Mon, 03/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3963

Authors: Filippo Calzolari, Julia Michel, Emily Violette Baumgart, Fabian Theis, Magdalena Götz & Jovica Ninkovic

We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.

Attention alters orientation processing in the human lateral geniculate nucleus

Mon, 03/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3967

Authors: Sam Ling, Michael S Pratte & Frank Tong

Orientation selectivity is a cornerstone property of vision, commonly believed to emerge in the primary visual cortex. We found that reliable orientation information could be detected even earlier, in the human lateral geniculate nucleus, and that attentional feedback selectively altered these orientation responses. This attentional modulation may allow the visual system to modify incoming feature-specific signals at the earliest possible processing site.

Anxious individuals have difficulty learning the causal statistics of aversive environments

Mon, 03/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3961

Authors: Michael Browning, Timothy E Behrens, Gerhard Jocham, Jill X O'Reilly & Sonia J Bishop

Internally organized mechanisms of the head direction sense

Mon, 03/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3968

Authors: Adrien Peyrache, Marie M Lacroix, Peter C Petersen & György Buzsáki

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

Mon, 03/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3966

Authors: Ethan A Winkler, Yoichiro Nishida, Abhay P Sagare, Sanket V Rege, Robert D Bell, David Perlmutter, Jesse D Sengillo, Sara Hillman, Pan Kong, Amy R Nelson, John S Sullivan, Zhen Zhao, Herbert J Meiselman, Rosalinda B Wenby, Jamie Soto, E Dale Abel, Jacob Makshanoff, Edward Zuniga, Darryl C De Vivo & Berislav V Zlokovic

Mitochondrial control by DRP1 in brain tumor initiating cells

Mon, 03/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3960

Authors: Qi Xie, Qiulian Wu, Craig M Horbinski, William A Flavahan, Kailin Yang, Wenchao Zhou, Stephen M Dombrowski, Zhi Huang, Xiaoguang Fang, Yu Shi, Ashley N Ferguson, David F Kashatus, Shideng Bao & Jeremy N Rich

Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity

Wed, 02/25/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3975

Authors: Xintian You, Irena Vlatkovic, Ana Babic, Tristan Will, Irina Epstein, Georgi Tushev, Güney Akbalik, Mantian Wang, Caspar Glock, Claudia Quedenau, Xi Wang, Jingyi Hou, Hongyu Liu, Wei Sun, Sivakumar Sambandan, Tao Chen, Erin M Schuman & Wei Chen

What does gamma coherence tell us about inter-regional neural communication?

Mon, 02/23/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3952

Authors: György Buzsáki & Erik W Schomburg

Frequency-specific hippocampal-prefrontal interactions during associative learning

Mon, 02/23/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3954

Authors: Scott L Brincat & Earl K Miller

The dissociable effects of punishment and reward on motor learning

Mon, 02/23/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3956

Authors: Joseph M Galea, Elizabeth Mallia, John Rothwell & Jörn Diedrichsen

A subcortical inhibitory signal for behavioral arrest in the thalamus

Mon, 02/23/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3951

Authors: Kristóf Giber, Marco A Diana, Viktor M Plattner, Guillaume P Dugué, Hajnalka Bokor, Charly V Rousseau, Zsófia Maglóczky, László Havas, Balázs Hangya, Hendrik Wildner, Hanns Ulrich Zeilhofer, Stéphane Dieudonné & László Acsády

Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination

Mon, 02/23/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3953

Authors: Jeffery D Haines, Olivier Herbin, Belén de la Hera, Oscar G Vidaurre, Gregory A Moy, Qingxiang Sun, Ho Yee Joyce Fung, Stefanie Albrecht, Konstantina Alexandropoulos, Dilara McCauley, Yuh Min Chook, Tanja Kuhlmann, Grahame J Kidd, Sharon Shacham & Patrizia Casaccia

Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists

Mon, 02/23/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3957

Authors: Zhe Zhang, Valentina Ferretti, İlke Güntan, Alessandro Moro, Eleonora A Steinberg, Zhiwen Ye, Anna Y Zecharia, Xiao Yu, Alexei L Vyssotski, Stephen G Brickley, Raquel Yustos, Zoe E Pillidge, Edward C Harding, William Wisden & Nicholas P Franks

Vernon B. Mountcastle 1918–2015

Mon, 02/16/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3958

Author: Solomon H Snyder

Sensory inputs control the integration of neurogliaform interneurons into cortical circuits

Mon, 02/09/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3946

Authors: Natalia V De Marco García, Rashi Priya, Sebnem N Tuncdemir, Gord Fishell & Theofanis Karayannis

In vivo coincidence detection in mammalian sound localization generates phase delays

Mon, 02/09/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3948

Authors: Tom P Franken, Michael T Roberts, Liting Wei, Nace L Golding & Philip X Joris