Nature Neuroscience. doi:10.1038/nn.4050
Authors: Alexander Borst & Moritz Helmstaedter
Nature Neuroscience. doi:10.1038/nn.4054
Authors: Christian Schachtrup, Jae Kyu Ryu, Könül Mammadzada, Abdullah S Khan, Peter M Carlton, Alex Perez, Frank Christian, Natacha Le Moan, Eirini Vagena, Bernat Baeza-Raja, Victoria Rafalski, Justin P Chan, Roland Nitschke, Miles D Houslay, Mark H Ellisman, Tony Wyss-Coray, Jorge J Palop & Katerina Akassoglou
Astrocytes modulate neuronal activity and inhibit regeneration. We show that cleaved p75 neurotrophin receptor (p75NTR) is a component of the nuclear pore complex (NPC) required for glial scar formation and reduced gamma oscillations in mice via regulation of transforming growth factor (TGF)-β signaling. Cleaved p75NTR interacts with nucleoporins to promote Smad2 nucleocytoplasmic shuttling. Thus, NPC remodeling by regulated intramembrane cleavage of p75NTR controls astrocyte–neuronal communication in response to profibrotic factors.
Nature Neuroscience. doi:10.1038/nn.4053
Authors: Robert E Sorge, Josiane C S Mapplebeck, Sarah Rosen, Simon Beggs, Sarah Taves, Jessica K Alexander, Loren J Martin, Jean-Sebastien Austin, Susana G Sotocinal, Di Chen, Mu Yang, Xiang Qun Shi, Hao Huang, Nicolas J Pillon, Philip J Bilan, YuShan Tu, Amira Klip, Ru-Rong Ji, Ji Zhang, Michael W Salter & Jeffrey S Mogil
A large and rapidly increasing body of evidence indicates that microglia-to-neuron signaling is essential for chronic pain hypersensitivity. Using multiple approaches, we found that microglia are not required for mechanical pain hypersensitivity in female mice; female mice achieved similar levels of pain hypersensitivity using adaptive immune cells, likely T lymphocytes. This sexual dimorphism suggests that male mice cannot be used as proxies for females in pain research.
The medial entorhinal cortex is necessary for temporal organization of hippocampal neuronal activity
Nature Neuroscience. doi:10.1038/nn.4056
Authors: Magdalene I Schlesiger, Christopher C Cannova, Brittney L Boublil, Jena B Hales, Emily A Mankin, Mark P Brandon, Jill K Leutgeb, Christian Leibold & Stefan Leutgeb
Nature Neuroscience. doi:10.1038/nn.4055
Authors: Hang Zhang, Nathaniel D Daw & Laurence T Maloney
Nature Neuroscience. doi:10.1038/nn.4046
Authors: Jerry L Chen, David J Margolis, Atanas Stankov, Lazar T Sumanovski, Bernard L Schneider & Fritjof Helmchen
Nature Neuroscience. doi:10.1038/nn.4049
Authors: Simon X Chen, An Na Kim, Andrew J Peters & Takaki Komiyama
Nature Neuroscience. doi:10.1038/nn.4042
Authors: David Sussillo, Mark M Churchland, Matthew T Kaufman & Krishna V Shenoy
Nature Neuroscience. doi:10.1038/nn.4040
Authors: Robert A Power, Stacy Steinberg, Gyda Bjornsdottir, Cornelius A Rietveld, Abdel Abdellaoui, Michel M Nivard, Magnus Johannesson, Tessel E Galesloot, Jouke J Hottenga, Gonneke Willemsen, David Cesarini, Daniel J Benjamin, Patrik K E Magnusson, Fredrik Ullén, Henning Tiemeier, Albert Hofman, Frank J A van Rooij, G Bragi Walters, Engilbert Sigurdsson, Thorgeir E Thorgeirsson, Andres Ingason, Agnar Helgason, Augustine Kong, Lambertus A Kiemeney, Philipp Koellinger, Dorret I Boomsma, Daniel Gudbjartsson, Hreinn Stefansson & Kari Stefansson
We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10−6 and 3.8 × 10−6 for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.
Nature Neuroscience. doi:10.1038/nn.4041
Authors: Ueli Rutishauser, Shengxuan Ye, Matthieu Koroma, Oana Tudusciuc, Ian B Ross, Jeffrey M Chung & Adam N Mamelak
Nature Neuroscience. doi:10.1038/nn.4034
Authors: Daniel J Christoffel, Sam A Golden, Jessica J Walsh, Kevin G Guise, Mitra Heshmati, Allyson K Friedman, Aditi Dey, Milo Smith, Nicole Rebusi, Madeline Pfau, Jessica L Ables, Hossein Aleyasin, Lena A Khibnik, Georgia E Hodes, Gabriel A Ben-Dor, Karl Deisseroth, Matthew L Shapiro, Robert C Malenka, Ines Ibanez-Tallon, Ming-Hu Han & Scott J Russo
Postsynaptic remodeling of glutamatergic synapses on ventral striatum (vSTR) medium spiny neurons (MSNs) is critical for shaping stress responses. However, it is unclear which presynaptic inputs are involved. Susceptible mice exhibited increased synaptic strength at intralaminar thalamus (ILT), but not prefrontal cortex (PFC), inputs to vSTR MSNs following chronic social stress. Modulation of ILT-vSTR versus PFC-vSTR neuronal activity differentially regulated dendritic spine plasticity and social avoidance.
Nature Neuroscience. doi:10.1038/nn.4036
Authors: Amy M Gancarz, Zi-Jun Wang, Gabrielle L Schroeder, Diane Damez-Werno, Kevin M Braunscheidel, Lauren E Mueller, Monica S Humby, Aaron Caccamise, Jennifer A Martin, Karen C Dietz, Rachael L Neve & David M Dietz
Activin receptor signaling, including the transcription factor Smad3, was upregulated in the rat nucleus accumbens (NAc) shell following withdrawal from cocaine. Direct genetic and pharmacological manipulations of this pathway bidirectionally altered cocaine seeking while governing morphological plasticity in NAc neurons. Thus, Activin/Smad3 signaling is induced following withdrawal from cocaine, and such regulation may be a key molecular mechanism underlying behavioral and cellular plasticity in the brain following cocaine self-administration.
Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses
Nature Neuroscience. doi:10.1038/nn.4037
Authors: Jason Aoto, Csaba Földy, Silviana Maria Ciurea Ilcus, Katsuhiko Tabuchi & Thomas C Südhof
Nature Neuroscience. doi:10.1038/nn.4038
Authors: Naveed Ejaz, Masashi Hamada & Jörn Diedrichsen
Nature Neuroscience. doi:10.1038/nn.4030
Authors: Daniel Erny, Anna Lena Hrabě de Angelis, Diego Jaitin, Peter Wieghofer, Ori Staszewski, Eyal David, Hadas Keren-Shaul, Tanel Mahlakoiv, Kristin Jakobshagen, Thorsten Buch, Vera Schwierzeck, Olaf Utermöhlen, Eunyoung Chun, Wendy S Garrett, Kathy D McCoy, Andreas Diefenbach, Peter Staeheli, Bärbel Stecher, Ido Amit & Marco Prinz
Nature Neuroscience. doi:10.1038/nn.4035
Authors: Bryce A Mander, Shawn M Marks, Jacob W Vogel, Vikram Rao, Brandon Lu, Jared M Saletin, Sonia Ancoli-Israel, William J Jagust & Matthew P Walker
Nature Neuroscience. doi:10.1038/nn.4026
Authors: Paola Tognini, Debora Napoli, Jonida Tola, Davide Silingardi, Floriana Della Ragione, Maurizio D'Esposito & Tommaso Pizzorusso
DNA methylation is an epigenetic repressor mark for transcription dynamically regulated in neurons. We analyzed visual experience regulation of DNA methylation in mice and its involvement in ocular dominance plasticity of the developing visual cortex. Monocular deprivation modulated the expression of factors controlling DNA methylation and exerted opposite effects on DNA methylation and hydroxymethylation in specific plasticity genes. Inhibition of DNA methyltrasferase (DNMT) blocked molecular and functional effects of monocular deprivation, partially reversing the monocular deprivation transcriptional program.
Nature Neuroscience. doi:10.1038/nn.4024
Authors: Jing-Qiong Kang, Wangzhen Shen, Chengwen Zhou, Dong Xu & Robert L Macdonald
Nature Neuroscience. doi:10.1038/nn.4028
Authors: Sora Shin, Obin Kwon, Jee In Kang, Somin Kwon, Sora Oh, Jiwon Choi, Chul Hoon Kim & Dong Goo Kim
Nature Neuroscience. doi:10.1038/nn.4023
Authors: Sandra Siegert, Jinsoo Seo, Ester J Kwon, Andrii Rudenko, Sukhee Cho, Wenyuan Wang, Zachary Flood, Anthony J Martorell, Maria Ericsson, Alison E Mungenast & Li-Huei Tsai