Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
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Volitional modulation of optically recorded calcium signals during neuroprosthetic learning

Sun, 04/13/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3712

Authors: Kelly B Clancy, Aaron C Koralek, Rui M Costa, Daniel E Feldman & Jose M Carmena

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

Sun, 04/13/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3695

Authors: Katharina Gapp, Ali Jawaid, Peter Sarkies, Johannes Bohacek, Pawel Pelczar, Julien Prados, Laurent Farinelli, Eric Miska & Isabelle M Mansuy

Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.

Single App knock-in mouse models of Alzheimer's disease

Sun, 04/13/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3697

Authors: Takashi Saito, Yukio Matsuba, Naomi Mihira, Jiro Takano, Per Nilsson, Shigeyoshi Itohara, Nobuhisa Iwata & Takaomi C Saido

Experimental studies of Alzheimer's disease have largely depended on transgenic mice overexpressing amyloid precursor protein (APP). These mice, however, suffer from artificial phenotypes because, in addition to amyloid β peptide (Aβ), they overproduce other APP fragments. We generated knock-in mice that harbor Swedish and Beyreuther/Iberian mutations with and without the Arctic mutation in the APP gene. The mice showed typical Aβ pathology, neuroinflammation and memory impairment in an age-dependent manner.

Parvalbumin interneurons provide grid cell–driven recurrent inhibition in the medial entorhinal cortex

Sun, 04/06/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3696

Authors: Christina Buetfering, Kevin Allen & Hannah Monyer

Excessive cocaine use results from decreased phasic dopamine signaling in the striatum

Sun, 04/06/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3694

Authors: Ingo Willuhn, Lauren M Burgeno, Peter A Groblewski & Paul E M Phillips