Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
Updated: 23 hours 35 min ago

Mesolimbic dopamine signals the value of work

Mon, 11/23/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4173

Authors: Arif A Hamid, Jeffrey R Pettibone, Omar S Mabrouk, Vaughn L Hetrick, Robert Schmidt, Caitlin M Vander Weele, Robert T Kennedy, Brandon J Aragona & Joshua D Berke

Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity

Mon, 11/23/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4176

Authors: Seil Jang, Daeyoung Oh, Yeunkum Lee, Eric Hosy, Hyewon Shin, Christoph van Riesen, Daniel Whitcomb, Julia M Warburton, Jihoon Jo, Doyoun Kim, Sun Gyun Kim, Seung Min Um, Seok-kyu Kwon, Myoung-Hwan Kim, Junyeop Daniel Roh, Jooyeon Woo, Heejung Jun, Dongmin Lee, Won Mah, Hyun Kim, Bong-Kiun Kaang, Kwangwook Cho, Jeong-Seop Rhee, Daniel Choquet & Eunjoon Kim

Stimulus-specific combinatorial functionality of neuronal c-fos enhancers

Mon, 11/23/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4170

Authors: Jae-Yeol Joo, Katie Schaukowitch, Lukas Farbiak, Gokhul Kilaru & Tae-Kyung Kim

A neuromarker of sustained attention from whole-brain functional connectivity

Mon, 11/23/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4179

Authors: Monica D Rosenberg, Emily S Finn, Dustin Scheinost, Xenophon Papademetris, Xilin Shen, R Todd Constable & Marvin M Chun

Task-specific versus generalized mnemonic representations in parietal and prefrontal cortices

Mon, 11/23/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4168

Authors: Arup Sarma, Nicolas Y Masse, Xiao-Jing Wang & David J Freedman

Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects

Mon, 11/16/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4169

Authors: Dennis Mircsof, Maéva Langouët, Marlène Rio, Sébastien Moutton, Karine Siquier-Pernet, Christine Bole-Feysot, Nicolas Cagnard, Patrick Nitschke, Ludmila Gaspar, Matej Žnidarič, Olivier Alibeu, Ann-Kristina Fritz, David P Wolfer, Aileen Schröter, Giovanna Bosshard, Markus Rudin, Christina Koester, Florence Crestani, Petra Seebeck, Nathalie Boddaert, Katrina Prescott, Rochelle Hines, Steven J Moss, Jean-Marc Fritschy, Arnold Munnich, Jeanne Amiel, Steven A Brown, Shiva K Tyagarajan & Laurence Colleaux

The neuronal basis of fear generalization in humans

Mon, 11/16/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4166

Authors: Selim Onat & Christian Büchel

Canonical genetic signatures of the adult human brain

Mon, 11/16/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4171

Authors: Michael Hawrylycz, Jeremy A Miller, Vilas Menon, David Feng, Tim Dolbeare, Angela L Guillozet-Bongaarts, Anil G Jegga, Bruce J Aronow, Chang-Kyu Lee, Amy Bernard, Matthew F Glasser, Donna L Dierker, Jörg Menche, Aaron Szafer, Forrest Collman, Pascal Grange, Kenneth A Berman, Stefan Mihalas, Zizhen Yao, Lance Stewart, Albert-László Barabási, Jay Schulkin, John Phillips, Lydia Ng, Chinh Dang, David R Haynor, Allan Jones, David C Van Essen, Christof Koch & Ed Lein

Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models

Mon, 11/09/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4163

Authors: Marc Aurel Busche, Christine Grienberger, Aylin D Keskin, Beomjong Song, Ulf Neumann, Matthias Staufenbiel, Hans Förstl & Arthur Konnerth

Among the most promising approaches for treating Alzheimer´s disease is immunotherapy with amyloid-β (Aβ)-targeting antibodies. Using in vivo two-photon imaging in mouse models, we found that two different antibodies to Aβ used for treatment were ineffective at repairing neuronal dysfunction and caused an increase in cortical hyperactivity. This unexpected finding provides a possible cellular explanation for the lack of cognitive improvement by immunotherapy in human studies.

G9a is essential for epigenetic silencing of K+ channel genes in acute-to-chronic pain transition

Mon, 11/09/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4165

Authors: Geoffroy Laumet, Judit Garriga, Shao-Rui Chen, Yuhao Zhang, De-Pei Li, Trevor M Smith, Yingchun Dong, Jaroslav Jelinek, Matteo Cesaroni, Jean-Pierre Issa & Hui-Lin Pan

Climbing fibers encode a temporal-difference prediction error during cerebellar learning in mice

Mon, 11/09/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4167

Authors: Shogo Ohmae & Javier F Medina

Piezo2 is the principal mechanotransduction channel for proprioception

Mon, 11/09/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4162

Authors: Seung-Hyun Woo, Viktor Lukacs, Joriene C de Nooij, Dasha Zaytseva, Connor R Criddle, Allain Francisco, Thomas M Jessell, Katherine A Wilkinson & Ardem Patapoutian

Optogenetic acidification of synaptic vesicles and lysosomes

Mon, 11/09/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4161

Authors: Benjamin R Rost, Franziska Schneider, M Katharina Grauel, Christian Wozny, Claudia G Bentz, Anja Blessing, Tanja Rosenmund, Thomas J Jentsch, Dietmar Schmitz, Peter Hegemann & Christian Rosenmund

Parcellating cortical functional networks in individuals

Mon, 11/09/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4164

Authors: Danhong Wang, Randy L Buckner, Michael D Fox, Daphne J Holt, Avram J Holmes, Sophia Stoecklein, Georg Langs, Ruiqi Pan, Tianyi Qian, Kuncheng Li, Justin T Baker, Steven M Stufflebeam, Kai Wang, Xiaomin Wang, Bo Hong & Hesheng Liu

Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation

Mon, 11/02/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4159

Authors: Gerald J Sun, Yi Zhou, Shiori Ito, Michael A Bonaguidi, Genevieve Stein-O'Brien, Nicholas K Kawasaki, Nikhil Modak, Yuan Zhu, Guo-li Ming & Hongjun Song

Endogenous neural stem cells (NSCs) in the adult hippocampus are considered to be bi-potent, as they only produce neurons and astrocytes in vivo. In mouse, we found that inactivation of neurofibromin 1 (Nf1), a gene mutated in neurofibromatosis type 1, unlocked a latent oligodendrocyte lineage potential to produce all three lineages from NSCs in vivo. Our results suggest an avenue for promoting stem cell plasticity by targeting barriers of latent lineage potential.

Neuronal activity is not required for the initial formation and maturation of visual selectivity

Mon, 11/02/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4155

Authors: Kenta M Hagihara, Tomonari Murakami, Takashi Yoshida, Yoshiaki Tagawa & Kenichi Ohki

Inferring learning rules from distributions of firing rates in cortical neurons

Mon, 11/02/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4158

Authors: Sukbin Lim, Jillian L McKee, Luke Woloszyn, Yali Amit, David J Freedman, David L Sheinberg & Nicolas Brunel

Midbrain dopamine neurons bidirectionally regulate CA3-CA1 synaptic drive

Mon, 11/02/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4152

Authors: Zev B Rosen, Stephanie Cheung & Steven A Siegelbaum

Cell type– and brain region–resolved mouse brain proteome

Mon, 11/02/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4160

Authors: Kirti Sharma, Sebastian Schmitt, Caroline G Bergner, Stefka Tyanova, Nirmal Kannaiyan, Natalia Manrique-Hoyos, Karina Kongi, Ludovico Cantuti, Uwe-Karsten Hanisch, Mari-Anne Philips, Moritz J Rossner, Matthias Mann & Mikael Simons

Sensory uncertainty decoded from visual cortex predicts behavior

Sun, 10/25/2015 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.4150

Authors: Ruben S van Bergen, Wei Ji Ma, Michael S Pratte & Janneke F M Jehee

Bayesian theories of neural coding propose that sensory uncertainty is represented by a probability distribution encoded in neural population activity, but direct neural evidence supporting this hypothesis is currently lacking. Using fMRI in combination with a generative model-based analysis, we found that probability distributions reflecting sensory uncertainty could reliably be estimated from human visual cortex and, moreover, that observers appeared to use knowledge of this uncertainty in their perceptual decisions.