Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
Updated: 13 hours 16 min ago

Neuronal activity modifies the chromatin accessibility landscape in the adult brain

Mon, 02/06/2017 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4494

Authors: Yijing Su, Jaehoon Shin, Chun Zhong, Sabrina Wang, Prith Roychowdhury, Jongseuk Lim, David Kim, Guo-li Ming & Hongjun Song

Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress

Mon, 01/30/2017 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4491

Authors: Assaf Ramot, Zhiying Jiang, Jin-Bin Tian, Tali Nahum, Yael Kuperman, Nicholas Justice & Alon Chen

The hypothalamic–pituitary–adrenal axis is a pivotal component of an organism's response to stressful challenges, and dysfunction of this neuroendocrine axis is associated with a variety of physiological and psychological pathologies. We found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic–pituitary–adrenal axis regulation that prepares the organism for successive exposure to stressful stimuli.

[18F]FDG PET signal is driven by astroglial glutamate transport

Mon, 01/30/2017 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4492

Authors: Eduardo R Zimmer, Maxime J Parent, Débora G Souza, Antoine Leuzy, Clotilde Lecrux, Hyoung-Ihl Kim, Serge Gauthier, Luc Pellerin, Edith Hamel & Pedro Rosa-Neto

Contributions of glial cells to neuroenergetics have been the focus of extensive debate. Here we provide positron emission tomography evidence that activation of astrocytic glutamate transport via the excitatory amino acid transporter GLT-1 triggers widespread but graded glucose uptake in the rodent brain. Our results highlight the need for a reevaluation of the interpretation of [18F]FDG positron emission tomography data, whereby astrocytes would be recognized as contributing to the [18F]FDG signal.

Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain

Mon, 01/30/2017 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4489

Authors: Kassandra Kisler, Amy R Nelson, Sanket V Rege, Anita Ramanathan, Yaoming Wang, Ashim Ahuja, Divna Lazic, Philbert S Tsai, Zhen Zhao, Yi Zhou, David A Boas, Sava Sakadžić & Berislav V Zlokovic

Hormonal gain control of a medial preoptic area social reward circuit

Mon, 01/30/2017 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4487

Authors: Jenna A McHenry, James M Otis, Mark A Rossi, J Elliott Robinson, Oksana Kosyk, Noah W Miller, Zoe A McElligott, Evgeny A Budygin, David R Rubinow & Garret D Stuber

Overlearning hyperstabilizes a skill by rapidly making neurochemical processing inhibitory-dominant

Mon, 01/30/2017 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4490

Authors: Kazuhisa Shibata, Yuka Sasaki, Ji Won Bang, Edward G Walsh, Maro G Machizawa, Masako Tamaki, Li-Hung Chang & Takeo Watanabe