Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
Updated: 12 hours 11 min ago

Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases

Sat, 10/18/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3846

Authors: Alexander C W Smith, Yonatan M Kupchik, Michael D Scofield, Cassandra D Gipson, Armina Wiggins, Charles A Thomas & Peter W Kalivas

Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administered cocaine and transient increases in MMP-9 during cue-induced cocaine relapse. Cue-induced heroin and nicotine relapse increased MMP activity, and increased MMP activity was required for both cocaine relapse and relapse-associated synaptic plasticity.

Mind matters: placebo enhances reward learning in Parkinson's disease

Sat, 10/18/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3842

Authors: Liane Schmidt, Erin Kendall Braun, Tor D Wager & Daphna Shohamy

Hierarchical competitions subserving multi-attribute choice

Sat, 10/11/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3836

Authors: Laurence T Hunt, Raymond J Dolan & Timothy E J Behrens

Attention can either increase or decrease spike count correlations in visual cortex

Sat, 10/11/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3835

Authors: Douglas A Ruff & Marlene R Cohen

Cortical neurogenesis in the absence of centrioles

Sat, 10/04/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3831

Authors: Ryan Insolera, Hisham Bazzi, Wei Shao, Kathryn V Anderson & Song-Hai Shi

Anchoring the neural compass: coding of local spatial reference frames in human medial parietal lobe

Sat, 10/04/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3834

Authors: Steven A Marchette, Lindsay K Vass, Jack Ryan & Russell A Epstein

Representation of aversive prediction errors in the human periaqueductal gray

Sat, 10/04/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3832

Authors: Mathieu Roy, Daphna Shohamy, Nathaniel Daw, Marieke Jepma, G Elliott Wimmer & Tor D Wager

Modulation of oligodendrocyte generation during a critical temporal window after NG2 cell division

Sat, 09/27/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3815

Authors: Robert A Hill, Kiran D Patel, Christopher M Goncalves, Jaime Grutzendler & Akiko Nishiyama

Neural correlates of water reward in thirsty Drosophila

Sat, 09/27/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3827

Authors: Suewei Lin, David Owald, Vikram Chandra, Clifford Talbot, Wolf Huetteroth & Scott Waddell

A somatosensory circuit for cooling perception in mice

Sat, 09/27/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3828

Authors: Nevena Milenkovic, Wen-Jie Zhao, Jan Walcher, Tobias Albert, Jan Siemens, Gary R Lewin & James F A Poulet

Neural antecedents of self-initiated actions in secondary motor cortex

Sat, 09/27/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3826

Authors: Masayoshi Murakami, M Inês Vicente, Gil M Costa & Zachary F Mainen

Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase

Sat, 09/20/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3822

Authors: Andrei I Molosh, Philip L Johnson, John P Spence, David Arendt, Lauren M Federici, Cristian Bernabe, Steven P Janasik, Zaneer M Segu, Rajesh Khanna, Chirayu Goswami, Weiguo Zhu, Su-Jung Park, Lang Li, Yehia S Mechref, D Wade Clapp & Anantha Shekhar

Tactile frequency discrimination is enhanced by circumventing neocortical adaptation

Sat, 09/20/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3821

Authors: Simon Musall, Wolfger von der Behrens, Johannes M Mayrhofer, Bruno Weber, Fritjof Helmchen & Florent Haiss

Single rodent mesohabenular axons release glutamate and GABA

Sat, 09/20/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3823

Authors: David H Root, Carlos A Mejias-Aponte, Shiliang Zhang, Hui-Ling Wang, Alexander F Hoffman, Carl R Lupica & Marisela Morales

Visualizing an emotional valence map in the limbic forebrain by TAI-FISH

Sat, 09/20/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3813

Authors: Jianbo Xiu, Qi Zhang, Tao Zhou, Ting-ting Zhou, Yang Chen & Hailan Hu

Neural compensation in older people with brain amyloid-β deposition

Sat, 09/13/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3806

Authors: Jeremy A Elman, Hwamee Oh, Cindee M Madison, Suzanne L Baker, Jacob W Vogel, Shawn M Marks, Sam Crowley, James P O'Neil & William J Jagust

Recruitment of extra neural resources may allow people to maintain normal cognition despite amyloid-β (Aβ) plaques. Previous fMRI studies have reported such hyperactivation, but it is unclear whether increases represent compensation or aberrant overexcitation. We found that older adults with Aβ deposition had reduced deactivations in task-negative regions, but increased activation in task-positive regions related to more detailed memory encoding. The association between higher activity and more detailed memories suggests that Aβ-related hyperactivation is compensatory.

Metabolic regulator LKB1 is crucial for Schwann cell–mediated axon maintenance

Sat, 09/06/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3809

Authors: Bogdan Beirowski, Elisabetta Babetto, Judith P Golden, Ying-Jr Chen, Kui Yang, Richard W Gross, Gary J Patti & Jeffrey Milbrandt

Genome-wide identification and characterization of functional neuronal activity–dependent enhancers

Sat, 09/06/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3808

Authors: Athar N Malik, Thomas Vierbuchen, Martin Hemberg, Alex A Rubin, Emi Ling, Cameron H Couch, Hume Stroud, Ivo Spiegel, Kyle Kai-How Farh, David A Harmin & Michael E Greenberg

Information-limiting correlations

Sat, 09/06/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3807

Authors: Rubén Moreno-Bote, Jeffrey Beck, Ingmar Kanitscheider, Xaq Pitkow, Peter Latham & Alexandre Pouget

Perceptual training continuously refines neuronal population codes in primary visual cortex

Sat, 09/06/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3805

Authors: Yin Yan, Malte J Rasch, Minggui Chen, Xiaoping Xiang, Min Huang, Si Wu & Wu Li