Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
Updated: 17 hours 45 min ago

A hierarchy of intrinsic timescales across primate cortex

Mon, 11/10/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3862

Authors: John D Murray, Alberto Bernacchia, David J Freedman, Ranulfo Romo, Jonathan D Wallis, Xinying Cai, Camillo Padoa-Schioppa, Tatiana Pasternak, Hyojung Seo, Daeyeol Lee & Xiao-Jing Wang

Specialization and hierarchy are organizing principles for primate cortex, yet there is little direct evidence for how cortical areas are specialized in the temporal domain. We measured timescales of intrinsic fluctuations in spiking activity across areas and found a hierarchical ordering, with sensory and prefrontal areas exhibiting shorter and longer timescales, respectively. On the basis of our findings, we suggest that intrinsic timescales reflect areal specialization for task-relevant computations over multiple temporal ranges.

Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance

Mon, 11/10/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3861

Authors: Jonathan N Flak, Christa M Patterson, Alastair S Garfield, Giuseppe D'Agostino, Paulette B Goforth, Amy K Sutton, Paige A Malec, Jenny-Marie T Wong, Mark Germani, Justin C Jones, Michael Rajala, Leslie Satin, Christopher J Rhodes, David P Olson, Robert T Kennedy, Lora K Heisler & Martin G Myers

Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome

Mon, 11/10/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3863

Authors: Yong-Seok Lee, Dan Ehninger, Miou Zhou, Jun-Young Oh, Minkyung Kang, Chuljung Kwak, Hyun-Hee Ryu, Delana Butz, Toshiyuki Araki, Ying Cai, J Balaji, Yoshitake Sano, Christine I Nam, Hyong Kyu Kim, Bong-Kiun Kaang, Corinna Burger, Benjamin G Neel & Alcino J Silva

A category-free neural population supports evolving demands during decision-making

Mon, 11/10/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3865

Authors: David Raposo, Matthew T Kaufman & Anne K Churchland

Dendritic channelopathies contribute to neocortical and sensory hyperexcitability in Fmr1−/y mice

Mon, 11/10/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3864

Authors: Yu Zhang, Audrey Bonnan, Guillaume Bony, Isabelle Ferezou, Susanna Pietropaolo, Melanie Ginger, Nathalie Sans, Jean Rossier, Ben Oostra, Gwen LeMasson & Andreas Frick

Molecular and functional definition of the developing human striatum

Mon, 11/10/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3860

Authors: Marco Onorati, Valentina Castiglioni, Daniele Biasci, Elisabetta Cesana, Ramesh Menon, Romina Vuono, Francesca Talpo, Rocio Laguna Goya, Paul A Lyons, Gaetano P Bulfamante, Luca Muzio, Gianvito Martino, Mauro Toselli, Cinthia Farina, Roger A Barker, Gerardo Biella & Elena Cattaneo

Glial ankyrins facilitate paranodal axoglial junction assembly

Sat, 11/01/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3858

Authors: Kae-Jiun Chang, Daniel R Zollinger, Keiichiro Susuki, Diane L Sherman, Michael A Makara, Peter J Brophy, Edward C Cooper, Vann Bennett, Peter J Mohler & Matthew N Rasband

A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier

Sat, 11/01/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3859

Authors: Tammy Szu-Yu Ho, Daniel R Zollinger, Kae-Jiun Chang, Mingxuan Xu, Edward C Cooper, Michael C Stankewich, Vann Bennett & Matthew N Rasband

Novel domain formation reveals proto-architecture in inferotemporal cortex

Sat, 11/01/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3855

Authors: Krishna Srihasam, Justin L Vincent & Margaret S Livingstone

Prostaglandin D2 synthase/GPR44: a signaling axis in PNS myelination

Sat, 11/01/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3857

Authors: Amelia Trimarco, Maria Grazia Forese, Valentina Alfieri, Alessandra Lucente, Paola Brambilla, Giorgia Dina, Damiana Pieragostino, Paolo Sacchetta, Yoshihiro Urade, Brigitte Boizet-Bonhoure, Filippo Martinelli Boneschi, Angelo Quattrini & Carla Taveggia

A genetically specified connectomics approach applied to long-range feeding regulatory circuits

Sat, 11/01/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3854

Authors: Deniz Atasoy, J Nicholas Betley, Wei-Ping Li, Helen H Su, Sinem M Sertel, Louis K Scheffer, Julie H Simpson, Richard D Fetter & Scott M Sternson

Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors

Sun, 10/26/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3871

Authors: Elizabeth A Heller, Hannah M Cates, Catherine J Peña, Haosheng Sun, Ningyi Shao, Jian Feng, Sam A Golden, James P Herman, Jessica J Walsh, Michelle Mazei-Robison, Deveroux Ferguson, Scott Knight, Mark A Gerber, Christian Nievera, Ming-Hu Han, Scott J Russo, Carol S Tamminga, Rachael L Neve, Li Shen, H Steve Zhang, Feng Zhang & Eric J Nestler

Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults

Sat, 10/25/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3850

Authors: Adam M Brickman, Usman A Khan, Frank A Provenzano, Lok-Kin Yeung, Wendy Suzuki, Hagen Schroeter, Melanie Wall, Richard P Sloan & Scott A Small

An α2-Na/K ATPase/α-adducin complex in astrocytes triggers non–cell autonomous neurodegeneration

Sat, 10/25/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3853

Authors: Gilbert Gallardo, Jessica Barowski, John Ravits, Teepu Siddique, Jerry B Lingrel, Janice Robertson, Hanno Steen & Azad Bonni

Rods in daylight act as relay cells for cone-driven horizontal cell–mediated surround inhibition

Sat, 10/25/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3852

Authors: Tamas Szikra, Stuart Trenholm, Antonia Drinnenberg, Josephine Jüttner, Zoltan Raics, Karl Farrow, Martin Biel, Gautam Awatramani, Damon A Clark, José-Alain Sahel, Rava Azeredo da Silveira & Botond Roska

Nonlinear dendritic integration of electrical and chemical synaptic inputs drives fine-scale correlations

Sat, 10/25/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3851

Authors: Stuart Trenholm, Amanda J McLaughlin, David J Schwab, Maxwell H Turner, Robert G Smith, Fred Rieke & Gautam B Awatramani

Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence

Sat, 10/18/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3843

Authors: Colin G McNamara, Álvaro Tejero-Cantero, Stéphanie Trouche, Natalia Campo-Urriza & David Dupret

We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest. When applied during spatial learning of new goal locations, dopaminergic photostimulation improved the later recall of neural representations of space and stabilized memory performance. These findings reveal that midbrain dopaminergic neurons promote hippocampal network dynamics associated with memory persistence.

Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases

Sat, 10/18/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3846

Authors: Alexander C W Smith, Yonatan M Kupchik, Michael D Scofield, Cassandra D Gipson, Armina Wiggins, Charles A Thomas & Peter W Kalivas

Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administered cocaine and transient increases in MMP-9 during cue-induced cocaine relapse. Cue-induced heroin and nicotine relapse increased MMP activity, and increased MMP activity was required for both cocaine relapse and relapse-associated synaptic plasticity.

Mind matters: placebo enhances reward learning in Parkinson's disease

Sat, 10/18/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3842

Authors: Liane Schmidt, Erin Kendall Braun, Tor D Wager & Daphna Shohamy

Hierarchical competitions subserving multi-attribute choice

Sat, 10/11/2014 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.3836

Authors: Laurence T Hunt, Raymond J Dolan & Timothy E J Behrens