Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
Updated: 1 day 16 hours ago

Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α

Sun, 06/29/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3754

Authors: Gonzalo Viana Di Prisco, Wei Huang, Shelly A Buffington, Chih-Chun Hsu, Penelope E Bonnen, Andon N Placzek, Carmela Sidrauski, Krešimir Krnjević, Randal J Kaufman, Peter Walter & Mauro Costa-Mattioli

Differences in the emergent coding properties of cortical and striatal ensembles

Sun, 06/29/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3753

Authors: Liya Ma, James M Hyman, Adrian J Lindsay, Anthony G Phillips & Jeremy K Seamans

Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates

Sun, 06/29/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3751

Authors: Jerel K Mueller, Erinn M Grigsby, Vincent Prevosto, Frank W Petraglia, Hrishikesh Rao, Zhi-De Deng, Angel V Peterchev, Marc A Sommer, Tobias Egner, Michael L Platt & Warren M Grill

Population coding of affect across stimuli, modalities and individuals

Sun, 06/22/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3749

Authors: Junichi Chikazoe, Daniel H Lee, Nikolaus Kriegeskorte & Adam K Anderson

Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity

Sun, 06/22/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3750

Authors: Collin J Kreple, Yuan Lu, Rebecca J Taugher, Andrea L Schwager-Gutman, Jianyang Du, Madeliene Stump, Yimo Wang, Ali Ghobbeh, Rong Fan, Caitlin V Cosme, Levi P Sowers, Michael J Welsh, Jason J Radley, Ryan T LaLumiere & John A Wemmie

Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling

Sun, 06/22/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3744

Authors: Boxing Li, Wei Jie, Lianyan Huang, Peng Wei, Shuji Li, Zhengyi Luo, Allyson K Friedman, Andrea L Meredith, Ming-Hu Han, Xin-Hong Zhu & Tian-Ming Gao

Maintenance of postmitotic neuronal cell identity

Sun, 06/15/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3731

Authors: Evan S Deneris & Oliver Hobert

Lesions of prefrontal cortex reduce attentional modulation of neuronal responses and synchrony in V4

Sun, 06/15/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3742

Authors: Georgia G Gregoriou, Andrew F Rossi, Leslie G Ungerleider & Robert Desimone

Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia

Sun, 06/08/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3737

Authors: Eric D Berglund, Tiemin Liu, Xingxing Kong, Jong-Woo Sohn, Linh Vong, Zhuo Deng, Charlotte E Lee, Syann Lee, Kevin W Williams, David P Olson, Philipp E Scherer, Bradford B Lowell & Joel K Elmquist

Whether melanocortin 4 receptors (MC4Rs) in extra-hypothalamic neurons, including cholinergic autonomic pre-ganglionic neurons, are required to control energy and glucose homeostasis is unclear. We found that MC4Rs in sympathetic, but not parasympathetic, pre-ganglionic neurons were required to regulate energy expenditure and body weight, including thermogenic responses to diet and cold exposure and 'beiging' of white adipose tissue. Deletion of Mc4r genes in both sympathetic and parasympathetic cholinergic neurons impaired glucose homeostasis.

Behavioral and neurophysiological correlates of regret in rat decision-making on a neuroeconomic task

Sun, 06/08/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3740

Authors: Adam P Steiner & A David Redish

A spike-timing mechanism for action selection

Sun, 06/08/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3741

Authors: Catherine R von Reyn, Patrick Breads, Martin Y Peek, Grace Zhiyu Zheng, W Ryan Williamson, Alyson L Yee, Anthony Leonardo & Gwyneth M Card

Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding

Sun, 06/01/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3725

Authors: Jae Geun Kim, Shigetomo Suyama, Marco Koch, Sungho Jin, Pilar Argente-Arizon, Jesús Argente, Zhong-Wu Liu, Marcelo R Zimmer, Jin Kwon Jeong, Klara Szigeti-Buck, Yuanqing Gao, Cristina Garcia-Caceres, Chun-Xia Yi, Natalina Salmaso, Flora M Vaccarino, Julie Chowen, Sabrina Diano, Marcelo O Dietrich, Matthias H Tschöp & Tamas L Horvath

We found that leptin receptors were expressed in hypothalamic astrocytes and that their conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic neurons involved in feeding control. Leptin-regulated feeding was diminished, whereas feeding after fasting or ghrelin administration was elevated in mice with astrocyte-specific leptin receptor deficiency. These data reveal an active role of glial cells in hypothalamic synaptic remodeling and control of feeding by leptin.

Functional organization of glomerular maps in the mouse accessory olfactory bulb

Sun, 06/01/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3738

Authors: Gary F Hammen, Diwakar Turaga, Timothy E Holy & Julian P Meeks

Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task

Sun, 06/01/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3739

Authors: Yoshito Masamizu, Yasuhiro R Tanaka, Yasuyo H Tanaka, Riichiro Hira, Fuki Ohkubo, Kazuo Kitamura, Yoshikazu Isomura, Takashi Okada & Masanori Matsuzaki

Identification of distinct ChAT+ neurons and activity-dependent control of postnatal SVZ neurogenesis

Sun, 06/01/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3734

Authors: Patricia Paez-Gonzalez, Brent Asrican, Erica Rodriguez & Chay T Kuo

Patterns across multiple memories are identified over time

Sun, 06/01/2014 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3736

Authors: Blake A Richards, Frances Xia, Adam Santoro, Jana Husse, Melanie A Woodin, Sheena A Josselyn & Paul W Frankland