Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
Updated: 13 hours 35 min ago

VTA glutamatergic inputs to nucleus accumbens drive aversion by acting on GABAergic interneurons

Mon, 03/28/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4281

Authors: Jia Qi, Shiliang Zhang, Hui-Ling Wang, David J Barker, Jorge Miranda-Barrientos & Marisela Morales

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

Mon, 03/21/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4272

Authors: Yong-Jie Zhang, Tania F Gendron, Jonathan C Grima, Hiroki Sasaguri, Karen Jansen-West, Ya-Fei Xu, Rebecca B Katzman, Jennifer Gass, Melissa E Murray, Mitsuru Shinohara, Wen-Lang Lin, Aliesha Garrett, Jeannette N Stankowski, Lillian Daughrity, Jimei Tong, Emilie A Perkerson, Mei Yue, Jeannie Chew, Monica Castanedes-Casey, Aishe Kurti, Zizhao S Wang, Amanda M Liesinger, Jeremy D Baker, Jie Jiang, Clotilde Lagier-Tourenne, Dieter Edbauer, Don W Cleveland, Rosa Rademakers, Kevin B Boylan, Guojun Bu, Christopher D Link, Chad A Dickey, Jeffrey D Rothstein, Dennis W Dickson, John D Fryer & Leonard Petrucelli

Schizophrenia genetics complements its mechanistic understanding

Mon, 03/21/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4277

Authors: Elizabeth K Ruzzo & Daniel H Geschwind

Refinement of genetic variants within the major histocompatibility complex reveals three distinct genetic influences on schizophrenia risk and sheds light on the disease's neurobiology.

Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders

Mon, 03/14/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4267

Authors: Tarjinder Singh, Mitja I Kurki, David Curtis, Shaun M Purcell, Lucy Crooks, Jeremy McRae, Jaana Suvisaari, Himanshu Chheda, Douglas Blackwood, Gerome Breen, Olli Pietiläinen, Sebastian S Gerety, Muhammad Ayub, Moira Blyth, Trevor Cole, David Collier, Eve L Coomber, Nick Craddock, Mark J Daly, John Danesh, Marta DiForti, Alison Foster, Nelson B Freimer, Daniel Geschwind, Mandy Johnstone, Shelagh Joss, Georg Kirov, Jarmo Körkkö, Outi Kuismin, Peter Holmans, Christina M Hultman, Conrad Iyegbe, Jouko Lönnqvist, Minna Männikkö, Steve A McCarroll, Peter McGuffin, Andrew M McIntosh, Andrew McQuillin, Jukka S Moilanen, Carmel Moore, Robin M Murray, Ruth Newbury-Ecob, Willem Ouwehand, Tiina Paunio, Elena Prigmore, Elliott Rees, David Roberts, Jennifer Sambrook, Pamela Sklar, David St Clair, Juha Veijola, James T R Walters, Hywel Williams, Patrick F Sullivan, Matthew E Hurles, Michael C O'Donovan, Aarno Palotie, Michael J Owen & Jeffrey C Barrett

Spike sorting for large, dense electrode arrays

Mon, 03/14/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4268

Authors: Cyrille Rossant, Shabnam N Kadir, Dan F M Goodman, John Schulman, Maximilian L D Hunter, Aman B Saleem, Andres Grosmark, Mariano Belluscio, George H Denfield, Alexander S Ecker, Andreas S Tolias, Samuel Solomon, György Buzsáki, Matteo Carandini & Kenneth D Harris

Biophysical constraints of optogenetic inhibition at presynaptic terminals

Mon, 03/07/2016 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4266

Authors: Mathias Mahn, Matthias Prigge, Shiri Ron, Rivka Levy & Ofer Yizhar

We investigated the efficacy of optogenetic inhibition at presynaptic terminals using halorhodopsin, archaerhodopsin and chloride-conducting channelrhodopsins. Precisely timed activation of both archaerhodopsin and halorhodpsin at presynaptic terminals attenuated evoked release. However, sustained archaerhodopsin activation was paradoxically associated with increased spontaneous release. Activation of chloride-conducting channelrhodopsins triggered neurotransmitter release upon light onset. Thus, the biophysical properties of presynaptic terminals dictate unique boundary conditions for optogenetic manipulation.

Hypothalamic control of male aggression-seeking behavior

Mon, 03/07/2016 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4264

Authors: Annegret L Falkner, Logan Grosenick, Thomas J Davidson, Karl Deisseroth & Dayu Lin

Genetically targeted magnetic control of the nervous system

Mon, 03/07/2016 - 1:00am

Nature Neuroscience. doi:10.1038/nn.4265

Authors: Michael A Wheeler, Cody J Smith, Matteo Ottolini, Bryan S Barker, Aarti M Purohit, Ryan M Grippo, Ronald P Gaykema, Anthony J Spano, Mark P Beenhakker, Sarah Kucenas, Manoj K Patel, Christopher D Deppmann & Ali D Güler