Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
Updated: 2 hours 53 min ago

Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo

Mon, 04/06/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3991

Authors: Sigrid Mensch, Marion Baraban, Rafael Almeida, Tim Czopka, Jessica Ausborn, Abdeljabbar El Manira & David A Lyons

The myelination of axons by oligodendrocytes markedly affects CNS function, but how this is regulated by neuronal activity in vivo is not known. We found that blocking synaptic vesicle release impaired CNS myelination by reducing the number of myelin sheaths made by individual oligodendrocytes during their short period of formation. We also found that stimulating neuronal activity increased myelin sheath formation by individual oligodendrocytes. These data indicate that neuronal activity regulates the myelinating capacity of single oligodendrocytes.

Learning-induced autonomy of sensorimotor systems

Mon, 04/06/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3993

Authors: Danielle S Bassett, Muzhi Yang, Nicholas F Wymbs & Scott T Grafton

Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum

Mon, 04/06/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3995

Authors: Christopher L Frank, Fang Liu, Ranjula Wijayatunge, Lingyun Song, Matthew T Biegler, Marty G Yang, Christopher M Vockley, Alexias Safi, Charles A Gersbach, Gregory E Crawford & Anne E West

Neuronal activity biases axon selection for myelination in vivo

Mon, 04/06/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3992

Authors: Jacob H Hines, Andrew M Ravanelli, Rani Schwindt, Ethan K Scott & Bruce Appel

Medial prefrontal cortical activity reflects dynamic re-evaluation during voluntary persistence

Mon, 04/06/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3994

Authors: Joseph T McGuire & Joseph W Kable

Synaptic diversity enables temporal coding of coincident multisensory inputs in single neurons

Mon, 03/30/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3974

Authors: François P Chabrol, Alexander Arenz, Martin T Wiechert, Troy W Margrie & David A DiGregorio

Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells

Mon, 03/30/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3989

Authors: Shohei Furutachi, Hiroaki Miya, Tomoyuki Watanabe, Hiroki Kawai, Norihiko Yamasaki, Yujin Harada, Itaru Imayoshi, Mark Nelson, Keiichi I Nakayama, Yusuke Hirabayashi & Yukiko Gotoh

Family income, parental education and brain structure in children and adolescents

Mon, 03/30/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3983

Authors: Kimberly G Noble, Suzanne M Houston, Natalie H Brito, Hauke Bartsch, Eric Kan, Joshua M Kuperman, Natacha Akshoomoff, David G Amaral, Cinnamon S Bloss, Ondrej Libiger, Nicholas J Schork, Sarah S Murray, B J Casey, Linda Chang, Thomas M Ernst, Jean A Frazier, Jeffrey R Gruen, David N Kennedy, Peter Van Zijl, Stewart Mostofsky, Walter E Kaufmann, Tal Kenet, Anders M Dale, Terry L Jernigan & Elizabeth R Sowell

Brain feminization requires active repression of masculinization via DNA methylation

Mon, 03/30/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3988

Authors: Bridget M Nugent, Christopher L Wright, Amol C Shetty, Georgia E Hodes, Kathryn M Lenz, Anup Mahurkar, Scott J Russo, Scott E Devine & Margaret M McCarthy

Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity

Mon, 03/30/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3984

Authors: Daisuke Tsuboi, Keisuke Kuroda, Motoki Tanaka, Takashi Namba, Yukihiko Iizuka, Shinichiro Taya, Tomoyasu Shinoda, Takao Hikita, Shinsuke Muraoka, Michiro Iizuka, Ai Nimura, Akira Mizoguchi, Nobuyuki Shiina, Masahiro Sokabe, Hideyuki Okano, Katsuhiko Mikoshiba & Kozo Kaibuchi

GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury

Mon, 03/30/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3990

Authors: Marzieh Zonouzi, Joseph Scafidi, Peijun Li, Brian McEllin, Jorge Edwards, Jeffrey L Dupree, Lloyd Harvey, Dandan Sun, Christian A Hübner, Stuart G Cull-Candy, Mark Farrant & Vittorio Gallo

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

Tue, 03/24/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4000

Authors: Axel Freischmidt, Thomas Wieland, Benjamin Richter, Wolfgang Ruf, Veronique Schaeffer, Kathrin Müller, Nicolai Marroquin, Frida Nordin, Annemarie Hübers, Patrick Weydt, Susana Pinto, Rayomond Press, Stéphanie Millecamps, Nicolas Molko, Emilien Bernard, Claude Desnuelle, Marie-Hélène Soriani, Johannes Dorst, Elisabeth Graf, Ulrika Nordström, Marisa S Feiler, Stefan Putz, Tobias M Boeckers, Thomas Meyer, Andrea S Winkler, Juliane Winkelman, Mamede de Carvalho, Dietmar R Thal, Markus Otto, Thomas Brännström, Alexander E Volk, Petri Kursula, Karin M Danzer, Peter Lichtner, Ivan Dikic, Thomas Meitinger, Albert C Ludolph, Tim M Strom, Peter M Andersen & Jochen H Weishaupt

Model-based choices involve prospective neural activity

Mon, 03/23/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3981

Authors: Bradley B Doll, Katherine D Duncan, Dylan A Simon, Daphna Shohamy & Nathaniel D Daw

Global network influences on local functional connectivity

Mon, 03/23/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3979

Authors: Adam C Snyder, Michael J Morais, Cory M Willis & Matthew A Smith

Role of Tet1 and 5-hydroxymethylcytosine in cocaine action

Mon, 03/16/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3976

Authors: Jian Feng, Ningyi Shao, Keith E Szulwach, Vincent Vialou, Jimmy Huynh, Chun Zhong, Thuc Le, Deveroux Ferguson, Michael E Cahill, Yujing Li, Ja Wook Koo, Efrain Ribeiro, Benoit Labonte, Benjamin M Laitman, David Estey, Victoria Stockman, Pamela Kennedy, Thomas Couroussé, Isaac Mensah, Gustavo Turecki, Kym F Faull, Guo-li Ming, Hongjun Song, Guoping Fan, Patrizia Casaccia, Li Shen, Peng Jin & Eric J Nestler

Retrieval induces adaptive forgetting of competing memories via cortical pattern suppression

Mon, 03/16/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.3973

Authors: Maria Wimber, Arjen Alink, Ian Charest, Nikolaus Kriegeskorte & Michael C Anderson