Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
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Age-related myelin degradation burdens the clearance function of microglia during aging

Mon, 06/13/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4325

Authors: Shima Safaiyan, Nirmal Kannaiyan, Nicolas Snaidero, Simone Brioschi, Knut Biber, Simon Yona, Aimee L Edinger, Steffen Jung, Moritz J Rossner & Mikael Simons

Myelin is synthesized as a multilamellar membrane, but the mechanisms of membrane turnover are unknown. We found that myelin pieces were gradually released from aging myelin sheaths and were subsequently cleared by microglia. Myelin fragmentation increased with age and led to the formation of insoluble, lipofuscin-like lysosomal inclusions in microglia. Thus, age-related myelin fragmentation is substantial, leading to lysosomal storage and contributing to microglial senescence and immune dysfunction in aging.

A fast pathway for fear in human amygdala

Mon, 06/13/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4324

Authors: Constantino Méndez-Bértolo, Stephan Moratti, Rafael Toledano, Fernando Lopez-Sosa, Roberto Martínez-Alvarez, Yee H Mah, Patrik Vuilleumier, Antonio Gil-Nagel & Bryan A Strange

Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair

Mon, 06/13/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4321

Authors: Susanne Quintes, Bastian G Brinkmann, Madlen Ebert, Franziska Fröb, Theresa Kungl, Friederike A Arlt, Victor Tarabykin, Danny Huylebroeck, Dies Meijer, Ueli Suter, Michael Wegner, Michael W Sereda & Klaus-Armin Nave

Lrp4 in astrocytes modulates glutamatergic transmission

Mon, 06/13/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4326

Authors: Xiang-Dong Sun, Lei Li, Fang Liu, Zhi-Hui Huang, Jonathan C Bean, Hui-Feng Jiao, Arnab Barik, Seon-Myung Kim, Haitao Wu, Chengyong Shen, Yun Tian, Thiri W Lin, Ryan Bates, Anupama Sathyamurthy, Yong-Jun Chen, Dong-Min Yin, Lei Xiong, Hui-Ping Lin, Jin-Xia Hu, Bao-Ming Li, Tian-Ming Gao, Wen-Cheng Xiong & Lin Mei

Orientation selectivity and the functional clustering of synaptic inputs in primary visual cortex

Mon, 06/13/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4323

Authors: Daniel E Wilson, David E Whitney, Benjamin Scholl & David Fitzpatrick

Zeb2 recruits HDAC–NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination

Mon, 06/13/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4322

Authors: Lai Man Natalie Wu, Jincheng Wang, Andrea Conidi, Chuntao Zhao, Haibo Wang, Zachary Ford, Liguo Zhang, Christiane Zweier, Brian G Ayee, Patrice Maurel, An Zwijsen, Jonah R Chan, Michael P Jankowski, Danny Huylebroeck & Q Richard Lu

Topographical representation of odor hedonics in the olfactory bulb

Mon, 06/06/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4317

Authors: Florence Kermen, Maëllie Midroit, Nicola Kuczewski, Jérémy Forest, Marc Thévenet, Joëlle Sacquet, Claire Benetollo, Marion Richard, Anne Didier & Nathalie Mandairon

Hedonic value is a dominant aspect of olfactory perception. Using optogenetic manipulation in freely behaving mice paired with immediate early gene mapping, we demonstrate that hedonic information is represented along the antero-posterior axis of the ventral olfactory bulb. Using this representation, we show that the degree of attractiveness of odors can be bidirectionally modulated by local manipulation of the olfactory bulb's neural networks in freely behaving mice.

SHANK3 controls maturation of social reward circuits in the VTA

Mon, 06/06/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4319

Authors: Sebastiano Bariselli, Stamatina Tzanoulinou, Christelle Glangetas, Clément Prévost-Solié, Luca Pucci, Joanna Viguié, Paola Bezzi, Eoin C O'Connor, François Georges, Christian Lüscher & Camilla Bellone

YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells

Mon, 06/06/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4316

Authors: Yannick Poitelon, Camila Lopez-Anido, Kathleen Catignas, Caterina Berti, Marilena Palmisano, Courtney Williamson, Dominique Ameroso, Kansho Abiko, Yoonchan Hwang, Alex Gregorieff, Jeffrey L Wrana, Mohammadnabi Asmani, Ruogang Zhao, Fraser James Sim, Lawrence Wrabetz, John Svaren & Maria Laura Feltri

Decoding subjective decisions from orbitofrontal cortex

Mon, 06/06/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4320

Authors: Erin L Rich & Jonathan D Wallis