Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
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Dopaminergic and glutamatergic microdomains in a subset of rodent mesoaccumbens axons

Mon, 02/09/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3945

Authors: Shiliang Zhang, Jia Qi, Xueping Li, Hui-Ling Wang, Jonathan P Britt, Alexander F Hoffman, Antonello Bonci, Carl R Lupica & Marisela Morales

Closed-loop training of attention with real-time brain imaging

Mon, 02/09/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3940

Authors: Megan T deBettencourt, Jonathan D Cohen, Ray F Lee, Kenneth A Norman & Nicholas B Turk-Browne

Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior

Mon, 02/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3937

Authors: Jeff R Jones, Michael C Tackenberg & Douglas G McMahon

To examine the interaction between molecular, electrical and behavioral circadian rhythms, we combined optogenetic manipulation of suprachiasmatic nucleus (SCN) firing rate with bioluminescence imaging and locomotor activity monitoring. Manipulating firing rate reset circadian rhythms both ex vivo and in vivo, and this resetting required spikes and network communication. This suggests that SCN firing rate is fundamental to circadian pacemaking as both an input to and output of the molecular clockworks.

Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula

Mon, 02/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3923

Authors: Frank J Meye, Kristina Valentinova, Salvatore Lecca, Lucile Marion-Poll, Matthieu J Maroteaux, Stefano Musardo, Imane Moutkine, Fabrizio Gardoni, Richard L Huganir, François Georges & Manuel Mameli

Addictive substances mediate positive and negative states promoting persistent drug use. However, substrates for aversive effects of drugs remain elusive. We found that, in mouse lateral habenula (LHb) neurons targeting the rostromedial tegmental nucleus, cocaine enhanced glutamatergic transmission, reduced K+ currents and increased excitability. GluA1 trafficking in LHb was instrumental for these cocaine-evoked modifications and drug-driven aversive behaviors. Altogether, our results suggest that long-lasting adaptations in LHb shape negative symptoms after drug taking.

Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area

Mon, 02/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3932

Authors: Ja Wook Koo, Michelle S Mazei-Robison, Quincey LaPlant, Gabor Egervari, Kevin M Braunscheidel, Danielle N Adank, Deveroux Ferguson, Jian Feng, Haosheng Sun, Kimberly N Scobie, Diane M Damez-Werno, Efrain Ribeiro, Catherine Jensen Peña, Deena Walker, Rosemary C Bagot, Michael E Cahill, Sarah Ann R Anderson, Benoit Labonté, Georgia E Hodes, Heidi Browne, Benjamin Chadwick, Alfred J Robison, Vincent F Vialou, Caroline Dias, Zachary Lorsch, Ezekiell Mouzon, Mary Kay Lobo, David M Dietz, Scott J Russo, Rachael L Neve, Yasmin L Hurd & Eric J Nestler

Optogenetic perturbation of preBötzinger complex inhibitory neurons modulates respiratory pattern

Mon, 02/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3938

Authors: David Sherman, Jason W Worrell, Yan Cui & Jack L Feldman

A neuroprotective role for microRNA miR-1000 mediated by limiting glutamate excitotoxicity

Mon, 02/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3935

Authors: Pushpa Verma, George J Augustine, Mohamed-Raafet Ammar, Ayumu Tashiro & Stephen M Cohen

Visualization of NMDA receptor–dependent AMPA receptor synaptic plasticity in vivo

Mon, 02/02/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3936

Authors: Yong Zhang, Robert H Cudmore, Da-Ting Lin, David J Linden & Richard L Huganir

Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression

Mon, 01/26/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3927

Authors: Woosuk Chung, Su Yeon Choi, Eunee Lee, Haram Park, Jaeseung Kang, Hanwool Park, Yeonsoo Choi, Dongsoo Lee, Sae-Geun Park, Ryunhee Kim, Yi Sul Cho, Jeonghoon Choi, Myoung-Hwan Kim, Jong Won Lee, Seungjoon Lee, Issac Rhim, Min Whan Jung, Daesoo Kim, Yong Chul Bae & Eunjoon Kim

Planning activity for internally generated reward goals in monkey amygdala neurons

Mon, 01/26/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3925

Authors: István Hernádi, Fabian Grabenhorst & Wolfram Schultz

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory

Mon, 01/26/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3930

Authors: Anna G Orr, Edward C Hsiao, Max M Wang, Kaitlyn Ho, Daniel H Kim, Xin Wang, Weikun Guo, Jing Kang, Gui-Qiu Yu, Anthony Adame, Nino Devidze, Dena B Dubal, Eliezer Masliah, Bruce R Conklin & Lennart Mucke

The striatum multiplexes contextual and kinematic information to constrain motor habits execution

Mon, 01/26/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3924

Authors: Pavel E Rueda-Orozco & David Robbe

Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1

Mon, 01/19/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3920

Authors: Sam F Cooke, Robert W Komorowski, Eitan S Kaplan, Jeffrey P Gavornik & Mark F Bear

The idiosyncratic brain: distortion of spontaneous connectivity patterns in autism spectrum disorder

Mon, 01/19/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3919

Authors: Avital Hahamy, Marlene Behrmann & Rafael Malach

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

Mon, 01/19/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3922

Authors: Colm O'Dushlaine, Lizzy Rossin, Phil H Lee, Laramie Duncan, Neelroop N Parikshak, Stephen Newhouse, Stephan Ripke, Benjamin M Neale, Shaun M Purcell, Danielle Posthuma, John I Nurnberger, S Hong Lee, Stephen V Faraone, Roy H Perlis, Bryan J Mowry, Anita Thapar, Michael E Goddard, John S Witte, Devin Absher, Ingrid Agartz, Huda Akil, Farooq Amin, Ole A Andreassen, Adebayo Anjorin, Richard Anney, Verneri Anttila, Dan E Arking, Philip Asherson, Maria H Azevedo, Lena Backlund, Judith A Badner, Anthony J Bailey, Tobias Banaschewski, Jack D Barchas, Michael R Barnes, Thomas B Barrett, Nicholas Bass, Agatino Battaglia, Michael Bauer, Mònica Bayés, Frank Bellivier, Sarah E Bergen, Wade Berrettini, Catalina Betancur, Thomas Bettecken, Joseph Biederman, Elisabeth B Binder, Donald W Black, Douglas H R Blackwood, Cinnamon S Bloss, Michael Boehnke, Dorret I Boomsma, René Breuer, Richard Bruggeman, Paul Cormican, Nancy G Buccola, Jan K Buitelaar, William E Bunney, Joseph D Buxbaum, William F Byerley, Enda M Byrne, Sian Caesar, Wiepke Cahn, Rita M Cantor, Miguel Casas, Aravinda Chakravarti, Kimberly Chambert, Khalid Choudhury, Sven Cichon, Manuel Mattheisen, C Robert Cloninger, David A Collier, Edwin H Cook, Hilary Coon, Bru Cormand, Aiden Corvin, William H Coryell, David W Craig, Ian W Craig, Jennifer Crosbie, Michael L Cuccaro, David Curtis, Darina Czamara, Susmita Datta, Geraldine Dawson, Richard Day, Eco J De Geus, Franziska Degenhardt, Srdjan Djurovic, Gary J Donohoe, Alysa E Doyle, Jubao Duan, Frank Dudbridge, Eftichia Duketis, Richard P Ebstein, Howard J Edenberg, Josephine Elia, Sean Ennis, Bruno Etain, Ayman Fanous, Anne E Farmer, I Nicol Ferrier, Matthew Flickinger, Eric Fombonne, Tatiana Foroud, Josef Frank, Barbara Franke, Christine Fraser, Robert Freedman, Nelson B Freimer, Christine M Freitag, Marion Friedl, Louise Frisén, Louise Gallagher, Pablo V Gejman, Lyudmila Georgieva, Elliot S Gershon, Ina Giegling, Michael Gill, Scott D Gordon, Katherine Gordon-Smith, Elaine K Green, Tiffany A Greenwood, Dorothy E Grice, Magdalena Gross, Detelina Grozeva, Weihua Guan, Hugh Gurling, Lieuwe De Haan, Jonathan L Haines, Hakon Hakonarson, Joachim Hallmayer, Steven P Hamilton, Marian L Hamshere, Thomas F Hansen, Annette M Hartmann, Martin Hautzinger, Andrew C Heath, Anjali K Henders, Stefan Herms, Ian B Hickie, Maria Hipolito, Susanne Hoefels, Florian Holsboer, Witte J Hoogendijk, Jouke-Jan Hottenga, Christina M Hultman, Vanessa Hus, Andrés Ingason, Marcus Ising, Stéphane Jamain, Edward G Jones, Ian Jones, Lisa Jones, Jung-Ying Tzeng, Anna K Kähler, René S Kahn, Radhika Kandaswamy, Matthew C Keller, James L Kennedy, Elaine Kenny, Lindsey Kent, Yunjung Kim, George K Kirov, Sabine M Klauck, Lambertus Klei, James A Knowles, Martin A Kohli, Daniel L Koller, Bettina Konte, Ania Korszun, Lydia Krabbendam, Robert Krasucki, Jonna Kuntsi, Phoenix Kwan, Mikael Landén, Niklas Längström, Mark Lathrop, Jacob Lawrence, William B Lawson, Marion Leboyer, David H Ledbetter, Todd Lencz, Klaus-Peter Lesch, Douglas F Levinson, Cathryn M Lewis, Jun Li, Paul Lichtenstein, Jeffrey A Lieberman, Dan-Yu Lin, Don H Linszen, Chunyu Liu, Falk W Lohoff, Sandra K Loo, Catherine Lord, Jennifer K Lowe, Susanne Lucae, Donald J MacIntyre, Pamela A F Madden, Elena Maestrini, Patrik K E Magnusson, Pamela B Mahon, Wolfgang Maier, Anil K Malhotra, Shrikant M Mane, Christa L Martin, Nicholas G Martin, Keith Matthews, Morten Mattingsdal, Steven A McCarroll, Kevin A McGhee, James J McGough, Patrick J McGrath, Peter McGuffin, Melvin G McInnis, Andrew McIntosh, Rebecca McKinney, Alan W McLean, Francis J McMahon, William M McMahon, Andrew McQuillin, Helena Medeiros, Sarah E Medland, Sandra Meier, Ingrid Melle, Fan Meng, Jobst Meyer, Christel M Middeldorp, Lefkos Middleton, Vihra Milanova, Ana Miranda, Anthony P Monaco, Grant W Montgomery, Jennifer L Moran, Daniel Moreno-De-Luca, Gunnar Morken, Derek W Morris, Eric M Morrow, Valentina Moskvina, Pierandrea Muglia, Thomas W Mühleisen, Walter J Muir, Bertram Müller-Myhsok, Michael Murtha, Richard M Myers, Inez Myin-Germeys, Michael C Neale, Stan F Nelson, Caroline M Nievergelt, Ivan Nikolov, Vishwajit Nimgaonkar, Willem A Nolen, Markus M Nöthen, Evaristus A Nwulia, Dale R Nyholt, Robert D Oades, Ann Olincy, Guiomar Oliveira, Line Olsen, Roel A Ophoff, Urban Osby, Michael J Owen, Aarno Palotie, Jeremy R Parr, Andrew D Paterson, Carlos N Pato, Michele T Pato, Brenda W Penninx, Michele L Pergadia, Margaret A Pericak-Vance, Benjamin S Pickard, Jonathan Pimm, Joseph Piven, James B Potash, Fritz Poustka, Peter Propping, Vinay Puri, Digby J Quested, Emma M Quinn, Josep Antoni Ramos-Quiroga, Henrik B Rasmussen, Soumya Raychaudhuri, Karola Rehnström, Andreas Reif, Marta Ribasés, John P Rice, Marcella Rietschel, Kathryn Roeder, Herbert Roeyers, Aribert Rothenberger, Guy Rouleau, Douglas Ruderfer, Dan Rujescu, Alan R Sanders, Stephan J Sanders, Susan L Santangelo, Joseph A Sergeant, Russell Schachar, Martin Schalling, Alan F Schatzberg, William A Scheftner, Gerard D Schellenberg, Stephen W Scherer, Nicholas J Schork, Thomas G Schulze, Johannes Schumacher, Markus Schwarz, Edward Scolnick, Laura J Scott, Jianxin Shi, Paul D Shilling, Stanley I Shyn, Jeremy M Silverman, Susan L Slager, Susan L Smalley, Johannes H Smit, Erin N Smith, Edmund J S Sonuga-Barke, David St. Clair, Matthew State, Michael Steffens, Hans-Christoph Steinhausen, John S Strauss, Jana Strohmaier, T Scott Stroup, James S Sutcliffe, Peter Szatmari, Szabocls Szelinger, Srinivasa Thirumalai, Robert C Thompson, Alexandre A Todorov, Federica Tozzi, Jens Treutlein, Manfred Uhr, Edwin J C G van den Oord, Gerard Van Grootheest, Jim Van Os, Astrid M Vicente, Veronica J Vieland, John B Vincent, Peter M Visscher, Christopher A Walsh, Thomas H Wassink, Stanley J Watson, Myrna M Weissman, Thomas Werge, Thomas F Wienker, Ellen M Wijsman, Gonneke Willemsen, Nigel Williams, A Jeremy Willsey, Stephanie H Witt, Wei Xu, Allan H Young, Timothy W Yu, Stanley Zammit, Peter P Zandi, Peng Zhang, Frans G Zitman, Sebastian Zöllner, Bernie Devlin, John R Kelsoe, Pamela Sklar, Mark J Daly, Michael C O'Donovan, Nicholas Craddock, Kenneth S Kendler, Lauren A Weiss, Naomi R Wray, Zhaoming Zhao, Daniel H Geschwind, Patrick F Sullivan, Jordan W Smoller, Peter A Holmans & Gerome Breen

The development of cortical circuits for motion discrimination

Mon, 01/19/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3921

Authors: Gordon B Smith, Audrey Sederberg, Yishai M Elyada, Stephen D Van Hooser, Matthias Kaschube & David Fitzpatrick

Complementary adaptive processes contribute to the developmental plasticity of spatial hearing

Mon, 01/12/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3914

Authors: Peter Keating, Johannes C Dahmen & Andrew J King

Spatial hearing evolved independently in mammals and birds and is thought to adapt to altered developmental input in different ways. We found, however, that ferrets possess multiple forms of plasticity that are expressed according to which spatial cues are available, suggesting that the basis for adaptation may be similar across species. Our results also provide insight into the way sound source location is represented by populations of cortical neurons.

Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion

Mon, 01/12/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3911

Authors: Di Tian, Laura J Stoppel, Arnold J Heynen, Lothar Lindemann, Georg Jaeschke, Alea A Mills & Mark F Bear

Human chromosome 16p11.2 microdeletion is the most common gene copy number variation in autism, but the synaptic pathophysiology caused by this mutation is largely unknown. Using a mouse with the same genetic deficiency, we found that metabotropic glutamate receptor 5 (mGluR5)-dependent synaptic plasticity and protein synthesis was altered in the hippocampus and that hippocampus-dependent memory was impaired. Notably, chronic treatment with a negative allosteric modulator of mGluR5 reversed the cognitive deficit.

Dynamic routing of task-relevant signals for decision making in dorsolateral prefrontal cortex

Mon, 01/12/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3918

Authors: Christopher H Donahue & Daeyeol Lee

Olfactory bulb coding of odors, mixtures and sniffs is a linear sum of odor time profiles

Mon, 01/12/2015 - 1:00am

Nature Neuroscience. doi:10.1038/nn.3913

Authors: Priyanka Gupta, Dinu F Albeanu & Upinder S Bhalla