Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
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Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning

Mon, 12/05/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4452

Authors: Nagendran Muthusamy, Xuying Zhang, Caroline A Johnson, Prem N Yadav & H Troy Ghashghaei

Postnatal and adult neurogenesis are region- and modality-specific, but the significance of developmentally distinct neuronal populations remains unclear. We demonstrate that chemogenetic inactivation of a subset of forebrain and olfactory neurons generated at birth disrupts responses to an aversive odor. In contrast, novel appetitive odor learning is sensitive to inactivation of adult-born neurons, revealing that developmentally defined sets of neurons may differentially participate in hedonic aspects of sensory learning.

Shared memories reveal shared structure in neural activity across individuals

Mon, 12/05/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4450

Authors: Janice Chen, Yuan Chang Leong, Christopher J Honey, Chung H Yong, Kenneth A Norman & Uri Hasson

A probabilistic approach to demixing odors

Mon, 12/05/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4444

Authors: Agnieszka Grabska-Barwińska, Simon Barthelmé, Jeff Beck, Zachary F Mainen, Alexandre Pouget & Peter E Latham

Glutamatergic synaptic integration of locomotion speed via septoentorhinal projections

Mon, 11/28/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4447

Authors: Daniel Justus, Dennis Dalügge, Stefanie Bothe, Falko Fuhrmann, Christian Hannes, Hiroshi Kaneko, Detlef Friedrichs, Liudmila Sosulina, Inna Schwarz, David Anthony Elliott, Susanne Schoch, Frank Bradke, Martin Karl Schwarz & Stefan Remy

The medial septum and diagonal band of Broca (MSDB) send glutamatergic axons to medial entorhinal cortex (MEC). We found that this pathway provides speed-correlated input to several MEC cell-types in layer 2/3. The speed signal is integrated most effectively by pyramidal cells but also excites stellate cells and interneurons. Thus, the MSDB conveys speed information that can be used by MEC neurons for spatial representation of self-location.

Mechanosensory hair cells express two molecularly distinct mechanotransduction channels

Mon, 11/28/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4449

Authors: Zizhen Wu, Nicolas Grillet, Bo Zhao, Christopher Cunningham, Sarah Harkins-Perry, Bertrand Coste, Sanjeev Ranade, Navid Zebarjadi, Maryline Beurg, Robert Fettiplace, Ardem Patapoutian & Ulrich Müller

A rapidly acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH

Mon, 11/21/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4442

Authors: Henning Fenselau, John N Campbell, Anne M J Verstegen, Joseph C Madara, Jie Xu, Bhavik P Shah, Jon M Resch, Zongfang Yang, Yael Mandelblat-Cerf, Yoav Livneh & Bradford B Lowell

Direct dorsal hippocampal–prelimbic cortex connections strengthen fear memories

Mon, 11/21/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4443

Authors: Xiaojing Ye, Dana Kapeller-Libermann, Alessio Travaglia, M Carmen Inda & Cristina M Alberini

A feedback neural circuit for calibrating aversive memory strength

Mon, 11/14/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4439

Authors: Takaaki Ozawa, Edgar A Ycu, Ashwani Kumar, Li-Feng Yeh, Touqeer Ahmed, Jenny Koivumaa & Joshua P Johansen