Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
Updated: 15 hours 5 min ago

CD33 modulates TREM2: convergence of Alzheimer loci

Sun, 09/27/2015 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.4126

Authors: Gail Chan, Charles C White, Phoebe A Winn, Maria Cimpean, Joseph M Replogle, Laura R Glick, Nicole E Cuerdon, Katie J Ryan, Keith A Johnson, Julie A Schneider, David A Bennett, Lori B Chibnik, Reisa A Sperling, Elizabeth M Bradshaw & Philip L De Jager

We used a protein quantitative trait analysis in monocytes from 226 individuals to evaluate cross-talk between Alzheimer loci. The NME8 locus influenced PTK2B and the CD33 risk allele led to greater TREM2 expression. There was also a decreased TREM1/TREM2 ratio with a TREM1 risk allele, decreased TREM2 expression with CD33 suppression and elevated cortical TREM2 mRNA expression with amyloid pathology.

A positive-negative mode of population covariation links brain connectivity, demographics and behavior

Sun, 09/27/2015 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.4125

Authors: Stephen M Smith, Thomas E Nichols, Diego Vidaurre, Anderson M Winkler, Timothy E J Behrens, Matthew F Glasser, Kamil Ugurbil, Deanna M Barch, David C Van Essen & Karla L Miller

We investigated the relationship between individual subjects' functional connectomes and 280 behavioral and demographic measures in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of population co-variation: subjects were predominantly spread along a single 'positive-negative' axis linking lifestyle, demographic and psychometric measures to each other and to a specific pattern of brain connectivity.

A direct translaminar inhibitory circuit tunes cortical output

Sun, 09/27/2015 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.4123

Authors: Scott Pluta, Alexander Naka, Julia Veit, Gregory Telian, Lucille Yao, Richard Hakim, David Taylor & Hillel Adesnik

Physical basis of apparent pore dilation of ATP-activated P2X receptor channels

Sun, 09/20/2015 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.4120

Authors: Mufeng Li, Gilman E S Toombes, Shai D Silberberg & Kenton J Swartz

5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response

Sun, 09/20/2015 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.4116

Authors: Benjamin Adam Samuels, Christoph Anacker, Alice Hu, Marjorie R Levinstein, Anouchka Pickenhagen, Theodore Tsetsenis, Noelia Madroñal, Zoe R Donaldson, Liam John Drew, Alex Dranovsky, Cornelius T Gross, Kenji F Tanaka & René Hen

Hierarchical nesting of slow oscillations, spindles and ripples in the human hippocampus during sleep

Sun, 09/20/2015 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.4119

Authors: Bernhard P Staresina, Til Ole Bergmann, Mathilde Bonnefond, Roemer van der Meij, Ole Jensen, Lorena Deuker, Christian E Elger, Nikolai Axmacher & Juergen Fell

Basal forebrain neuronal inhibition enables rapid behavioral stopping

Sun, 09/13/2015 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.4110

Authors: Jeffrey D Mayse, Geoffrey M Nelson, Irene Avila, Michela Gallagher & Shih-Chieh Lin

ScaleS: an optical clearing palette for biological imaging

Sun, 09/13/2015 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.4107

Authors: Hiroshi Hama, Hiroyuki Hioki, Kana Namiki, Tetsushi Hoshida, Hiroshi Kurokawa, Fumiyoshi Ishidate, Takeshi Kaneko, Takumi Akagi, Takashi Saito, Takaomi Saido & Atsushi Miyawaki

Persistence of Aβ seeds in APP null mouse brain

Tue, 09/08/2015 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.4117

Authors: Lan Ye, Sarah K Fritschi, Juliane Schelle, Ulrike Obermüller, Karoline Degenhardt, Stephan A Kaeser, Yvonne S Eisele, Lary C Walker, Frank Baumann, Matthias Staufenbiel & Mathias Jucker

Cerebral β-amyloidosis is induced by inoculation of Aβ seeds into APP transgenic mice, but not into App−/− (APP null) mice. We found that brain extracts from APP null mice that had been inoculated with Aβ seeds up to 6 months previously still induced β-amyloidosis in APP transgenic hosts following secondary transmission. Thus, Aβ seeds can persist in the brain for months, and they regain propagative and pathogenic activity in the presence of host Aβ.

A Bayesian observer model constrained by efficient coding can explain 'anti-Bayesian' percepts

Sun, 09/06/2015 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.4105

Authors: Xue-Xin Wei & Alan A Stocker

Regulating anxiety with extrasynaptic inhibition

Sun, 08/30/2015 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.4102

Authors: Paolo Botta, Lynda Demmou, Yu Kasugai, Milica Markovic, Chun Xu, Jonathan P Fadok, Tingjia Lu, Michael M Poe, Li Xu, James M Cook, Uwe Rudolph, Pankaj Sah, Francesco Ferraguti & Andreas Lüthi

Molecular profiling of activated olfactory neurons identifies odorant receptors for odors in vivo

Sun, 08/30/2015 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.4104

Authors: Yue Jiang, Naihua Natalie Gong, Xiaoyang Serene Hu, Mengjue Jessica Ni, Radhika Pasi & Hiroaki Matsunami

Centrosomin represses dendrite branching by orienting microtubule nucleation

Sun, 08/30/2015 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.4099

Authors: Cagri Yalgin, Saman Ebrahimi, Caroline Delandre, Li Foong Yoong, Saori Akimoto, Heidi Tran, Reiko Amikura, Rebecca Spokony, Benjamin Torben-Nielsen, Kevin P White & Adrian W Moore

Large-scale transcriptional profiling of chemosensory neurons identifies receptor-ligand pairs in vivo

Sun, 08/30/2015 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.4100

Authors: Benoît von der Weid, Daniel Rossier, Matti Lindup, Joël Tuberosa, Alexandre Widmer, Julien Dal Col, Chenda Kan, Alan Carleton & Ivan Rodriguez

Neuronal pattern separation in the olfactory bulb improves odor discrimination learning

Sun, 08/23/2015 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.4089

Authors: Olivier Gschwend, Nixon M Abraham, Samuel Lagier, Frédéric Begnaud, Ivan Rodriguez & Alan Carleton

BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice

Sun, 08/23/2015 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.4095

Authors: Erica Korb, Margo Herre, Ilana Zucker-Scharff, Robert B Darnell & C David Allis

Coordinated forms of noradrenergic plasticity in the locus coeruleus and primary auditory cortex

Sun, 08/23/2015 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.4090

Authors: Ana Raquel O Martins & Robert C Froemke

GABAergic mechanisms regulated by miR-33 encode state-dependent fear

Sun, 08/16/2015 - 11:00pm

Nature Neuroscience. doi:10.1038/nn.4084

Authors: Vladimir Jovasevic, Kevin A Corcoran, Katherine Leaderbrand, Naoki Yamawaki, Anita L Guedea, Helen J Chen, Gordon M G Shepherd & Jelena Radulovic