Nature Neuroscience. doi:10.1038/nn.3712
Authors: Kelly B Clancy, Aaron C Koralek, Rui M Costa, Daniel E Feldman & Jose M Carmena
Nature Neuroscience. doi:10.1038/nn.3695
Authors: Katharina Gapp, Ali Jawaid, Peter Sarkies, Johannes Bohacek, Pawel Pelczar, Julien Prados, Laurent Farinelli, Eric Miska & Isabelle M Mansuy
Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.
Nature Neuroscience. doi:10.1038/nn.3697
Authors: Takashi Saito, Yukio Matsuba, Naomi Mihira, Jiro Takano, Per Nilsson, Shigeyoshi Itohara, Nobuhisa Iwata & Takaomi C Saido
Experimental studies of Alzheimer's disease have largely depended on transgenic mice overexpressing amyloid precursor protein (APP). These mice, however, suffer from artificial phenotypes because, in addition to amyloid β peptide (Aβ), they overproduce other APP fragments. We generated knock-in mice that harbor Swedish and Beyreuther/Iberian mutations with and without the Arctic mutation in the APP gene. The mice showed typical Aβ pathology, neuroinflammation and memory impairment in an age-dependent manner.
Parvalbumin interneurons provide grid cell–driven recurrent inhibition in the medial entorhinal cortex
Nature Neuroscience. doi:10.1038/nn.3696
Authors: Christina Buetfering, Kevin Allen & Hannah Monyer
Nature Neuroscience. doi:10.1038/nn.3694
Authors: Ingo Willuhn, Lauren M Burgeno, Peter A Groblewski & Paul E M Phillips