Carlo Ballatore
Research Assistant Professor of Pathology and Laboratory Medicine
Pathology and Laboratory Medicine
Contact information
University of Pennsylvania Medical School Phialdelphia, PA 19104
Email: bcarlo@sas.upenn.edu
Education
Ph.D. (Medicinal Chemistry)
University of Wales , 2001.
Selected Publications
C. Ballatore, K. R. Brunden, F. Piscitelli, M. James, A. Crowe, M. Yao, E. Hyde, J. Q. Trojanowski, V. M.-Y. Lee, A. B. Smith, III: Discovery of brain-penetrant and orally bioavailable aminothienopyridazine inhibitors of tau aggregation. Journal of Medicinal Chemistry. ACS, 53: 3739–3747, 2010.
Francesco Piscitelli, Carlo Ballatore, Amos B. Smith III: Solid phase synthesis of 2-aminobenzothiazoles Bioorganic & Medicinal Chemistry Letters 20: 644, 2010.
Alex Crowe, Wenwei Huang, Carlo Ballatore, Ronald L. Johnson, Anne-Marie L. Hogan, Ruili Huang, Jennifer Wichtermann, Joshua McCoy, Donna Huryn, Douglas S. Auld, Amos B. Smith, III , James Inglese, John Q. Trojanowski, Christopher P.Austin, Kurt R. Brunden and Virginia M.-Y. Lee: The Identification of Aminothienopyridazine Inhibitors of Tau Assembly by Quantitative High-Throughput Screening. Biochemistry 2009.
Ballatore, C., Zhang, B., Trojanowski, J. Q., Lee, V. M., Smith, A. B., 3rd: In situ blood-brain barrier permeability of a C-10 paclitaxel carbamate. Bioorg Med Chem Lett 18(23): 6119-21, 2008.
Ballatore, C., Hyde, E., Deiches, R. F., Lee, V. M., Trojanowski, J. Q., Huryn, D., Smith, A. B., 3rd: Paclitaxel C-10 carbamates: potential candidates for the treatment of neurodegenerative tauopathies. Bioorg Med Chem Lett 17(13): 3642-6, 2007.
Crowe, A., Ballatore, C., Hyde, E., Trojanowski, J. Q., Lee, V. M.: High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation. Biochem Biophys Res Commun 358(1): 1-6, 2007.
Aspland, S. E., Ballatore, C., Castillo, R., Desharnais, J., Eustaquio, T., Goelet, P., Guo, Z., Li, Q., Nelson, D., Sun, C., Castellino, A. J., Newman, M. J.: Kinase-mediated trapping of bi-functional conjugates of paclitaxel or vinblastine with thymidine in cancer cells. Bioorg Med Chem Lett 16(19): 5194-8, 2006.
Sun, C., Aspland, S. E., Ballatore, C., Castillo, R., Smith, A. B., 3rd, Castellino, A. J.: The design, synthesis, and evaluation of two universal doxorubicin-linkers: preparation of conjugates that retain topoisomerase II activity. Bioorg Med Chem Lett 16(1): 104-7, 2006.
Kim, Y., Lillo, A. M., Steiniger, S. C., Liu, Y., Ballatore, C., Anichini, A., Mortarini, R., Kaufmann, G. F., Zhou, B., Felding-Habermann, B., Janda, K. D.: Targeting heat shock proteins on cancer cells: selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand. Biochemistry 45(31): 9434-44, 2006.
Ballatore, C., Aspland, S. E., Castillo, R., Desharnais, J., Eustaquio, T., Sun, C., Castellino, A. J., Smith, A. B., 3rd: A facile route to paclitaxel C-10 carbamates. Bioorg Med Chem Lett 15(10): 2477-80, 2005.
