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Research in the
Dmochowski lab encompasses
many
areas of Bioinorganic, Bioorganic, and Biophysical Chemistry, as well as Chemical Biology.
Our lab
is comprised of people with backgrounds spanning these disciplines. We
are
developing
small molecules, proteins, and spectroscopic techniques for
studying complex biomolecular systems. Our approach
involves cycles of molecular design, synthesis, and measurement.
 We are synthesizing light-activated oligonucleotides and
Xe-129
MRI contrast agents to elucidate
protein interactions involved in vertebrate development,
limb regeneration, and the progression of many diseases, including
cancer. We are also developing novel nano/biomaterials using
proteins for the synthesis and assembly of
metal nanoparticles.
Useful Links Ivan@UPenn Chemistry UPenn Department of Chemistry American Chemical Society |
Recent
Highlights 2009 July Congratulations to Anna! She graduated and will be pursuing a PhD in Biophysics at Harvard. June Ivan’s piece “Xenon out of its shell” highlights the element xenon in Nature Chemistry. April Chris’s PNAS paper reports the discovery of the first fluorescent general anesthetic. February Masaya’s
light-activated
polymersomes appear online as JACS comm.
Aru’s new
higher-Xe-affinity water-soluble cryptophane appears online in JACS.
Joe’s ferritin-encapsulated gold nanoparticles appear online in Langmuir. Chris successfully defends Ph.D. thesis! January Jenny’s xenon
biosensors targeting carbonic anhydrase are published in
JACS.
This work was highlighted on Nature Chemistry homepage, “Biosensors: The Xe-Factor”. |