Publications

39.    N. Khan, J.M. Perez-Aguilar, T. Kaufmann, P.A. Hill, O. Taratula, O.-S. Lee, P.J. Carroll, J.G. Saven, I.J. Dmochowski, Synthesis, structure, and simulation of a tribenzylamine hemicryptophane host, Angew. Chem., in preparation.

38.    O. Taratula, P.A. Hill, N.S. Khan, P.J. Carroll, I.J. Dmochowski, Crystallographic observation of ‘induced fit’
in a cryptophane host–guest model system, Nature Communications, (9) 148, 2010.

37.    N.P. Kamat, G.P. Robbins, M.J. Therien, I.J. Dmochowski, D.A. Hammer, A Generalized system for photo-responsive membrane rupture in polymersomes, Adv. Funct. Mater., (16) 2588-2596, 2010.

36.    J. Lampe, Z. Liao, I.J. Dmochowski, P.S. Ayyaswamy, D.M. Eckmann, Imaging macromolecular interactions at an interface, Langmuir, (26) 2452-2459, 2010.

35.    J.L. Richards, G.K. Seward, Y. Huang, I.J. Dmochowski, Turning DNAzymes on and off with light, ChemBioChem, (11) 320-324, 2010.

34.    O. Taratula, I.J. Dmochowski, Functionalized 129Xe contrast agents for magnetic resonance imaging, Curr. Opin. Chem. Biol., (14) 97-104, 2010.

33.    I.J. Dmochowski, Xenon out of its shell, Nature Chemistry, ‘In Your Element’ invited feature article, vol. 1, 250, June 2009.

32.    C.A. Butts, J. Xi, G. Brannigan, M.L. Klein, R.G. Eckenhoff, I.J. Dmochowski, Identification of a fluorescent general anesthetic, 1-aminoanthracene, Proc. Natl. Acad. Sci. U.S.A., (106) 6501-6506, 2009.

31.    J. Swift, C. Butts, J. Cheung-Lau, V. Yerubandi, I.J. Dmochowski, Efficient self-assembly of Archaeoglobus fulgidus ferritin around metallic cores, Langmuir, (25) 5219-5225, 2009.

30.    G.P. Robbins, M. Jimbo, J. Swift, M.J. Therien, D.A. Hammer, I.J. Dmochowski, Photo-initiated destruction of composite porphyrin-protein polymersomes, J. Am. Chem. Soc., (131) 3872-3874, 2009.

29.    P.A. Hill, Q. Wei, T. Troxler, I.J. Dmochowski, Substituent effects on xenon binding affinity and solution behavior of water-soluble cryptophanes, J. Am. Chem. Soc., (131) 3069-3077, 2009.

28.    J.L. Chambers, P.A. Hill, J.A. Aaron, Z. Han, D.W. Christianson, N.N. Kuzma, I.J. Dmochowski, Cryptophane xenon-129 nuclear magnetic resonance biosensors targeting human carbonic anhydrase, J. Am. Chem. Soc. (131) 563-569, 2009.

27.    C. Butts, J. Swift, S.-G. Kang, L. Di Costanzo, D.W. Christianson, J.G. Saven, I.J. Dmochowski, Directing noble metal ion chemistry within a designed ferritin protein, Biochemistry (47) 12729-12739, 2008.

26.    J.L. Richards, X. Tang, A. Turetsky, I.J. Dmochowski, RNA bandages for photomodulating in vitro protein synthesis, Bioorg. Med. Chem. Lett. (18) 6255-6258, 2008.

25.    G.K. Seward, Q. Wei, I.J. Dmochowski, Peptide-mediated cellular uptake of cryptophane, Bioconjug. Chem. (19) 2129-2135, 2008.

24.    J.A. Aaron, J.M. Chambers, K.M. Jude, L. Di Costanzo, I.J. Dmochowski, D.W. Christianson, Structure of a ¹²⁹Xe-cryptophane biosensor complexed with human carbonic anhydrase II, J. Am. Chem. Soc. (130) 6942-6943, 2008.

23.    X. Tang, J. Swaminathin, A.M. Gewirtz, I.J. Dmochowski, Regulating gene expression in human leukemia cells using light-activated oligodeoxynucleotides, Nucl. Acids Res. (36) 559-569, 2008.

22.    X. Tang, S. Maegawa, E.S. Weinberg, I.J. Dmochowski, Regulating gene expression in zebrafish embryos using light-activated, negatively charged peptide nucleic acids, J. Am. Chem. Soc. (129) 11000-11001, 2007.

21.    L. Zhang, J. Swift, C. Butts, V. Yerubandi, I.J. Dmochowski, Structure and activity of apoferritin-stabilized gold nanoparticles, J. Inorg. Biochem., Ed Stiefel Special Issue (101) 1719-1729, 2007.

20.    I.J. Dmochowski, X. Tang, Taking control of gene expression with light-activated oligonucleotides, Biotechniques (43) 161-171, 2007.

19.    P.A. Hill, Q. Wei, R. Eckenhoff, I.J. Dmochowski, Thermodynamics of xenon binding to cryptophane in water and human plasma, J. Am. Chem. Soc. (129) 9262-9263, 2007.

18.    X. Tang, I.J. Dmochowski, Synthesis of light-activated antisense oligodeoxynucleotide, Nature Protocols (1) 3041-3048, 2007.

17.    X. Tang, I.J. Dmochowski, Probing expression, Chemical Biology, invited feature highlighting Mol. Biosystems article, (2) B15, 2007.

16.    X. Tang, I.J. Dmochowski, Regulating gene expression with light-activated oligonucleotides, Mol. BioSystems (3) 100-110, 2007.

15.    Q. Wei, G.K. Seward, P.A. Hill, B. Patton, I. Dimitrov, N.N. Kuzma, I.J. Dmochowski, Designing ¹²⁹Xe NMR biosensors for matrix metalloproteinase detection, J. Am. Chem. Soc. (128) 13274-13283, 2006.

14.    X. Tang, I.J. Dmochowski, Controlling RNA digestion by RNase H with a light-activated DNA hairpin, Angew. Chem. Int. Ed. (45) 3523-3526, 2006.

13.    J. Swift, W.A. Wehbi, B.D. Kelly, X. Fu Stowell, J.G. Saven, I.J. Dmochowski, Design of functional ferritin-like proteins with hydrophobic cavities, J. Am. Chem. Soc. (128) 6611-6619, 2006.

12.    X. Tang, J.L. Richards, A.E. Peritz, I.J. Dmochowski, Photoregulation of DNA polymerase I (Klenow) with caged fluorescent oligodeoxynucleotides, Bioorg. Med. Chem. Lett. (15) 5303-5306, 2005.

11.    X. Tang, I.J. Dmochowski, Phototriggering of caged fluorescent oligodeoxynucleotides, Org. Lett. (7) 279-282, 2005.

10.    H. Agadjanian, J. Weaver, I.J. Dmochowski, J. Kim, R. Margalit, H.B. Gray, Z. Gross, and L.K. Medina-Kauwe, Specific delivery of corroles to cells via noncovalent conjugates with viral proteins,  Pharmaceutical Res. (23) 367-377, 2006.

9.    A.R. Dunn, I.J. Dmochowski, J.R. Winkler, H.B. Gray, Nanosecond photoreduction of cytochrome P450cam by channel-specific Ru-diimine electron tunneling wires, J. Am. Chem. Soc. (125) 12450-12456, 2003.

8.    I.J. Dmochowski, J.E. Dmochowski, P. Oliveri, E.H. Davidson, S.E. Fraser, Quantitative imaging of cis-regulatory reporters in living embryos, Proc. Natl. Acad. Sci. USA (20) 12895-12900, 2002.

7.    I.J. Dmochowski, A.R. Dunn, J.J. Wilker, B.R. Crane, M. Green, J.H. Dawson, S.G. Sligar, J.R. Winkler, H.B. Gray, Ruthenium probes of P450 structure and mechanism, Meth. Enzym. (357) 120-133, 2002.

6.    A.R. Dunn, I.J. Dmochowski, A.M. Bilwes, H.B. Gray, B.R. Crane, Probing the open state of cytochrome P450cam with ruthenium-linker substrates, Proc. Natl. Acad. Sci. USA (22) 12420-12425, 2001.

5.    J. Bendix, I.J. Dmochowski, H.B. Gray, A. Mahammed, L. Simkhovich, Z. Gross, Structural, electrochemical, and photophysical properties of gallium (III) 5,10,15-tris(pentafluorophenyl)corrole, Angew. Chem. Int. Ed. (22) 4048-4051, 2000.

4.    I.J. Dmochowski, J.R. Winkler, H.B. Gray, Enantiomeric discrimination of Ru-substrates by cytochrome P450cam, J. Inorg. Biochem. (3) 221-228, 2000.

3.    I.J. Dmochowski, B.R. Crane, J.J. Wilker, J.R. Winkler, H.B. Gray, Optical detection of cytochrome P450 by sensitizer-linked substrates. Proc. Natl. Acad. Sci. USA (23) 12987-12990, 1999.

2.    J.J. Wilker, I.J. Dmochowski, J.H. Dawson, J.R. Winkler, H.B. Gray, Substrates for rapid delivery of electrons and holes to buried active sites in proteins. Angew. Chem. Int. Ed. (1-2) 90-92, 1999.

1.    J.A. Rego, S. Kumar, I.J. Dmochowski, H. Ringsdorf, Synthesis of novel mixed tail triphenylene discotic liquid crystals - The search for higher order. Chem. Comm. (9) 1031-1032, 1996.

Undergraduate contributors are underlined.

Invited Book Chapters

M.I. Arnone, I.J. Dmochowski, C. Gache, Using reporter genes to study cis-regulatory elements, Meth. Cell Biol. (74) 621-652, 2004.

Patents

I.J. Dmochowski, B.R. Crane, A.R. Dunn, H.B. Gray, J.J. Wilker, J.R. Winkler, Detection of biomolecules by sensitizer-linked substrates, serial number 10/031,532; patent number 7,105,310, issued 9/12/06.

I.J. Dmochowski, P.A. Hill, Q. Wei, N.N. Kuzma, 129Xe biosensors and their use, P-9049-USP, provisional filed 08/27/06, U.S. patent application filed 8/6/07. 

I.J. Dmochowski, X. Tang, Photocleavable oligonucleotide and uses thereof, filed 12/04/06, provisional filed 11/27/07, U.S. patent application filed 11/08.

I.J. Dmochowski, P.A. Hill, Q. Wei, J.L. Chambers, Tri-functionalized cryptophanes and their use, provisional filed 07/07/08, U.S. patent application filed 7/07/09.

M. Jimbo, G. Robbins, N. Kamat, I.J. Dmochowski, M.J. Therien, D. Hammer, Polymer vesicles for selective electromagnetic energy-induced delivery, U.S. patent application #12/548,801 filed 8/27/09.

Prominent Citations of Research

University of Pennsylvania Gazette, highlight featuring annual research accomplishments at UPenn, citing fluorescent anesthetic studies, ref. 32.

In Science Daily, April 8, 2009, “New model for drug discovery with fluorescent anesthetic demonstrated” featuring ref. 32.

In Nature Chemistry, Jan. 2009 “Research Highlight” on homepage, “Biosensors: The Xe-Factor”, article by Gavin Armstrong featuring ref. 28.

On ACS home page, “News and Research” during week of Nov. 1, 2008, highlighted work on xenon biosensors published in ref. 25.

In ACS Chemical Biology, 2, 646-648, Oct. 2007 “Point of View” titled “Yin-Yang Ways of Controlling Gene Expression Are Now in Our Hands” by Hitoshi Okamoto featuring ref. 22.

Faculty of 1000 Biology recognition from Edward Stiefel, June 2006, featuring ref. 13.