Sept. 12, 2005: Chemical and Engineering News features our organometallic kinase inhibitors.
586K PDF

June 15, 2005: New Penn Center for Molecular Discovery
The University of Pennsylvania receives $9.5 million grant from NIH as part of a national screening network to discover active molecules. Our group is involved in this center with the design of bioactive organometallic compounds.

March 21, 2005: Chemical and Engineering News features our discovery of a simplified nucleic acid...

H. Bregman, D. S. Williams, G. E. Atilla, P. J. Carroll, E. Meggers, "An Organometallic Inhibitor for Glycogen Synthase Kinase 3" J. Am. Chem. Soc. 2004,126, 13594-13595 112K PDF

Zhang, L.; Peritz, A.; Meggers, E. "A Simple Glycol Nucleic Acid", J. Am. Chem. Soc. 2005, 127, 4174-4175112K PDF

Williams, D. S.; Atilla, G. E.; Bregman, H.; Arzoumanian, A.; Klein, P. S.; Meggers, E. "Switching on a Signaling Pathway with an Organometallic Ruthenium Complex", Angew. Chem. Int. Ed. 2005, 44, 1984-1987 223K PDF

J. É. Debreczeni, A. N. Bullock, G. E. Atilla, D. S. Williams, H. Bregman, S. Knapp, E. Meggers, "Ruthenium Half-Sandwich Complexes Bound to Protein Kinase Pim-1", Angew. Chem. Int. Ed. 2006, 45, 1580-1585 902K PDF

Streu, C.; Meggers, E. "Ruthenium-Induced Allylcarbamate Cleavage in Living Cells", Angew. Chem. Int. Ed. 2006,45, 5645-5648 642K PDF

Atilla, G. A.; Williams, D. S.; Bregman, H.; Pagano, N.; Meggers, E. "Organometallic Compounds with Biological Activity: A Very Selective and Highly Potent Cellular Inhibitor for Glycogen Synthase Kinase 3", ChemBioChem. 2006, 7, 1443-1450 270K PDF

N. Pagano, J. Maksimoska, H. Bregman, D. S. Williams, R. D. Webster, F. Xue and E. Meggers "Ruthenium Half-Sandwich Complexes as Protein Kinase Inhibitors: Derivatization of the Pyridocarbazole Pharmacophore Ligand", Org. Biomol. Chem. 2007, 5, 1218-1227338K PDF