Publications

  1. Walsh, P. J.; Hollander, F. J.; Bergman, R. G. Generation, Alkyne Cycloaddition, Arene C-H Activation, N-H Activation, and Dative Ligand Trapping Reactions of the First Monomeric Imidozirconocene (Cp2Zr=NR) Complexes. J. Am Chem. Soc. 1988, 110, 8729.
     
  2. Carney, M. J.; Walsh, P. J.; Hollander, F. J.; Bergman, R. G. A Reactive Organometallic Oxo Intermediate, Cp*2Zr=O: Generation and Subsequent Trapping Reactions Forming Alkyne and Nitrile Addition Products. J. Am Chem. Soc. 1989, 111, 8751.
     
  3. Walsh, P. J.; Hollander, F. J.; Bergman R. G. Generation and Trapping of the Diphenylhydrozido(2-) Complex Cp2Zr(N2Ph2). Insertion of Alkynes into Metal-Nitrogen Bond Leading to 2,3-Diazametallacyclopentenes. J. Am Chem. Soc. 1990, 112, 894.
     
  4. Carney, M. J.; Walsh, P. J.; Hollander, F. J.; Bergman, R. G. Room Temperature Generation of Reactive Intermediates Cp*2Zr=O and Cp*2Zr=S: Trapping Reactions with Unsaturated Organic Molecules and Dative Ligands. J. Am Chem. Soc. 1990, 112, 6426.
     
  5. Walsh, P. J.; Carney, M. J.; Bergman R. G. Generation, Dative Ligand Trapping , and N-N Bond Cleavage Reactions of the First Monomeric h1-Hydrazido Zirconocene Complex, Cp2Zr=NNPh2. A Zirconium-Mediated Synthesis of Indoles. J. Am Chem. Soc. 1991, 113, 6343.
     
  6. Walsh, P. J.; Baranger, A. M.; Bergman, R. G. Stoichiometric and Catalytic Hydroamination of Alkynes and Allene by Zirconium Bisamides Cp2Zr(NHR)2 J. Am Chem. Soc. 1992, 114, 1708.
     
  7. Carney, M. J.; Walsh, P. J.; Hollander, F. J.; Bergman, R. G. Generation of the Highly Reactive Intermediates Cp*2Zr=O and Cp*2Zr=S: Trapping Reactions with Alkynes, Nitriles and Dative Ligands. Organometallics 1992, 11, 761.
     
  8. Walsh, P. J.; Hollander, F. J.; Bergman, R. G. Insertion of Alkynes Into Zirconium-Nitrogen Bonds Leading to 2,3-Diazametallacyclopentenes. Generation and Reactivity of Cp2Zr(N2Ph2). J. Organomet. Chem. 1992, 428, 13.
     
  9. Baranger, A. M.; Walsh, P. J.; Bergman, R. G. Variable Regiochemistry in the Stoichiometric and Catalytic Hydroamination of Alkynes by Imidozirconium Complexes Caused by an Unusual Dependence of the Rate Law on Alkyne Structure and Temperature. J. Am Chem. Soc. 1993, 115, 2753.
     
  10. Walsh, P. J.; Bergman, R. G. Reactions of Monomeric Zirconocene Imido Complexes with Unsaturated Organic Molecules. Organometallics 1993, 12, 3705.
     
  11. Walsh, P. J.; Bennani, Y. L.; Sharpless, K. B. Asymmetric Dihydroxylation (AD)/Cyclization of N-DiBoc Allylic and Homoallylic Amines: Selective Differentiation of the Hydroxyl Groups. Tetrahedron Letters 1993, 34, 5545.
     
  12. Walsh, P. J.; Sharpless, K. B. Asymmetric Dihydroxylation (AD) of a.b-Unsatruated Ketones Syn. Lett. 1993, 605.
     
  13. Arrington, M. P.; Bennani, Y. L.; Gobel, T.; Walsh, P. J.; Sharpless, K. B. Modified Cinchona Alkaloid Ligands: Improved Selectivities in the Osmium Tetroxide Catalyzed Asymmetric Dihydroxylation (AD) of Terminal Olefins. Tetrahedron Letters 1993, 34, 7375.
     
  14. Meyer, K. E.; Walsh, P. J.; Bergman, R. G. Zirconium-Mediated Imine Metathesis. Synthesis of 2,4-Diaza-1-zirocniacyclobutanes and Mechanism of their Reaction with Imines and Alkynes. J. Am Chem. Soc.1994, 116, 2669.
     
  15. Walsh, P. J.; Ho, T. P.; King, S. B.; Sharpless, K. B. Asymmetric Dihydroxylation of Olefins Containing Sulfur: Chemoselective Oxidation of C-C Double Bonds in the Presence of Sulfides, 1,3-dithaines and Disulfides. Tetrahedron Letters 1994, 35, 5129.
     
  16. Hanna, T. A.; Baranger, A. M.; Walsh, P. J.; Bergman, R. G. Formation of a.b -Unsaturated Imines and the Successful Trapping of Oxozirconocene in a [4+2] Azaoxometallacyclehexene. J. Am Chem. Soc. 1995, 117, 3292.
     
  17. Meyer, K. E.; Walsh, P. J.; Bergman, R. G. A Mechanistic Study of the Cycloaddition-Cycloreversion Reactions of Zirconium Imido Complexes Cp2Zr(N-t-Bu)(THF) with Organic Imines and Organic Azides. J. Am Chem. Soc. 1995, 117, 974-985.

Independent Publications

  1. Walsh, P. J. Bis(cyclopentadienyl)bis(2,6-dimethylphenylamino)-zirconium, Vol. 1, pg. 459, Contribution to Encyclopedia of Reagents for Organic Synthesis. Ed. Leo A Paquette, John Wiley & Sons, New York, 1995.
     
  2. Guo, C.; Qiu, J.; Zhang, X.; Verdugo, D.; Larter, M. L.; Christie, R.; Kenney, P.; Walsh, P. J. Enantioselective Addition of Diethylzinc to Benzaldehyde Catalyzed by Chiral Titanate Complexes with Helical Ligands Tetrahedorn. 1997, 53, 4145.
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  3. Ho, D. E.; Betancort, J. M.; Woodmansee, D. H.; Larter, M. L.; Walsh, P. J. Synthesis of New chiral Tetradentate Sulfonamide Based Ligands. Tetrahedron Letters. 1997, 38, 3867.
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  4. Pritchett, S.; Gantzel, P.; Walsh. P. J. Synthesis and Crystal Structures of Chiral Bissulfonamido Titanium Bisamide Complexes: Differences in Ligand Hapticity caused by Crystal Packing Forces Organometallics 1997, 16, 5130-5132.
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  5. Diltz, S.; Aguirre, G.; Ortega, F.; Walsh, P. J. Synthesis of Chiral Heteroaromatic Tetradentate Sulfonamide Based Ligands. Tetrahedron: Asymmetry 1997, 8, 3559-3562.
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  6. Pritchett, S.; Woodmansee, D. H.; Gantzel, P.; Walsh. P. J. Synthesis and Crystal Structures of Bissulfonamido Titanium Bisalkoxide Complexes: Mechanistic Implications in the Bissulfonamide Catalyzed Asymmetric Addition of Dialkylzinc Reagents to Aldehydes. J. Am. Chem. Soc. 1998, 120, 6423-6424.
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  7. Larter, M. L.; Phillips, M.; Ortega, F.; Aguirre, G.; Somanathan, R.; Walsh P. J. Synthesis of cis and trans 2,4,5-Tripyridylimidazolines Tetrahedron Letters. 1998, 39, 4785-4788.
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  8. Gantzel, P.; Walsh, P. J. Synthesis and Structure of Lithium and Potassium Triazenide Complexes Inorganic Chemistry 1998, 37, 3450-3451.
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  9. Pritchett, S.; Woodmansee, D. H.; Davis, T. J.; Walsh, P. J. Improved Methodology for the Asymmetric Alkylation of Aldehydes Employing Bis(sulfonamide) Complexes,Tetrahedron Letters. 1998, 39, 5941-5944.
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  10. Walsh, P. J.; Smith, D. K.; Costello, C.; Resolution of trans-1,2-Diaminocyclohexane, an Undergraduate Experiment J. Chem. Ed.1998, 75, 1459-1462.
     
  11. Westhusin, S.; Gantzel, P.; Walsh, P. J. Synthesis and Crystal Structures of Magnesium and Calcium Triazenide Complexes Inorganic Chemistry.1998, 37, 5956-5959.
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  12. Nanthakumar, A.; Miura, J.; Diltz, S.; Lee, C. -K.; Aguirre, G.; Ortega, F.; Ziller, J. W.; Walsh, P. J. Synthesis and Structure of Asymmetric Bis(sulfonamide) Based Copper(II) Complexes: Influence of Diastereometic Interactions in the Solid State. Inorganic Chemistry 1999, 38, 3010-3013.
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  13. Balsells, J.; Mejorado, L.; Phillips, M.; Ortega, F.; Aguirre, G.; Somanathan, R.; Walsh, P.J. Synthesis of Chiral Sulfonamide / Schiff Base Ligands. Tetrahedron: Asymmetry 1998, 9, 4135-4142.
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  14. Pritchett, S.; Gantzel, P.; Walsh, P. J. Synthesis and Structural Study of Titanium Bis(sulfonamido) Bis(amide) Complexes Organometallics.1999, 18, 823-831.
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  15. Meprathu, B. V.; Diltz,S.; Walsh, P J. and Protasiewicz, J. D. Hypervalent Iodine Nitrene Precursors Bearing N-Heterocyclic Rings Tetrahedron Letters 1999, 40, 5459-5460.
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  16. Rodr?uez, J. G.; Parra-Hake, M.; Aguirre, G.; Ortega, F.; Walsh, P. J. Synthesis and Structure of a Dinuclear Copper Complex of a Bis(bidentate) Triazenide Ligand Polyhedron 1999, 18, 3051.
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  17. Balsells, J. and Walsh, P. J. The Use of Achiral Ligands to Convey Asymmetry: Chiral Environment Amplification J. Am. Chem. Soc. 2000, 122, 1802.
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  18. Balsells, J. and Walsh, P. J Design of Diastereomeric Self-Inhibiting Catalysts for Control of Turnover Frequency and Enantioselectivity J. Am. Chem. Soc. 2000, 122, 3250-3251.
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  19. Flores-Lopez, L. Z.; Parra-Hake, M.; Somanathan, R.; Walsh, P. J., Enantioselective Addition of Trimethylsilylcyanide to Aldehydes Catalyzed by Ti(IV) Complexes Derived from cis-1-Amino-2-Indanol: A Reactivity/Enantioselectivity Study, Organometallics 2000, 19, 2153-2160.
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  20. Balsells, J. and Walsh, P. J., Asymmetric Cyclopropanation of Allylic Alcohols Employing Sulfonamide/Salen Ligands, J. Org. Chem. 2000, 65, 5005-5008.
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  21. Balsells, J.; Betancort, J. M.; Walsh, P. J., Probing the Conformation of Flexible Catalysts in Solution, Angew. Chem. Int. Ed. 2000, 39, 3428-3430.
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  22. Parra-Hake, M.; Larter, M. L.; Gantzel, P.; Aguirre, G.; Ortega, F.; Somanathan, R.; Walsh, P. J., Synthesis and Structure of Dimeric [(cis-Py3Im)M]2 Complexes [M = Ni, Cu, Zn; (cis-Py3Im) = cis-2,4,5-Tri(2-pyridyl)imidazoline], Inorg. Chem. 2000, 39, 5400-5403.
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  23. Royo, E.; Betancort, J. M.; Davis, T. J.; Walsh, P. J., Synthesis, Structure and Catalytic Properties of Bis[bis(sulfonamido)] Titanium Complexes, Organometallics 2000, 19, 4840-4851.
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  24. Davis, T. J.; Balsells, J.; Carroll, P.; Walsh, P. J., Snapshots of Titanium BINOLate Complexes with Diverse Solid State Structures, Org. Lett. 2001, 3, 699-702.
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  25. Chen, Y. K.; Costa, A. M.; Walsh, P. J., Substrate Dependence of Non-Linear Effects: Mechanistic Probe and Practical Applications, J. Am. Chem. Soc. 2001, 123, 5378-5379.
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  26. Davis, T. J.; Balsells, J.; Carroll, P. J.; Walsh, P. J., Metal Geometry-Induced Ligand Asymmetry: An Application to Asymmetric Catalysis, Org. Lett. 2001, 3, 2161-2164.
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  27. Ng, K.; Somanathan, R.; Walsh, P. J., Synthesis of Chiral Resolved Pentadentate Sulfonamide-Based Ligands, Tetrahedron: Asymmetry 2001, 12, 1719.
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  28. Balsells, J.; Carroll, P.; Walsh, P. J., Achiral Tetrahydrosalen Ligands for the Synthesis of C2-Symmetric Titanium Complexes: A Structure and Diastereoselectivity Study, Inorg. Chem. 2001, 40; 5568-5574.
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  29. Balsells, J.; Costa, A. M.; Walsh, P.J., Temperature-Dependent Nonlinear Effects and Catalyst Evolution in the Asymmetric Addition of Diethylzinc to Benzaldehyde, Invited paper submitted to the special issue of Israel Journal of Chemistry in honor of Sharpless, Noyori and Kagan 2001, 41, 251-261.
     
  30. Gama, A; Flores-L?ez, L. Z.; Aguirre, G.; Parra-Hake, M.; Somanathan, R. and Walsh, P. J., Steric effects in the design of chiral Schiff base¯titanium complexes: new catalysts for asymmetric trimethylsilylcyanation of aldehydes, Tetrahedron: Asymmetry 2002, 13, 149-154.
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  31. Costa, A. M.; Jimeno, C.; Gavenonis, J.; Carroll, P. J.; Walsh, P. J., Achiral Activation: Optimization of Catalyst Enantioselectivity and Activity Using Achiral and Meso Ligands, J. Am. Chem. Soc. 2002, 124, 6929-6941.
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  32. Balsells, J.; Davis, T.J.; Carroll, P.J.; Walsh, P.J. Insight into the Mechanism of the Asymmetric Addition of Alkyl Groups to Aldehydes Catalyzed by Titanium-BINOLate Species, J. Am. Chem. Soc. 2002, 124, 10336-10348.
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  33. Rios, R.; Jimeno, C.; Carroll, P. J.; Walsh, P. J. Kinetic Resolution of Atropisomeric Amides J. Am. Chem. Soc. 2002, 124, 10272-10273.
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  34. Garcia, C; LaRochelle, L. K. and Walsh, P. J., A Simple, Reliable Catalyst for the Asymmetric Alkylation of Ketones, J. Am. Chem. Soc. 2002, 124, 10970-10971.
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  35. Waltz, K; Gavenonis, J.; and Walsh, P. J., A Simple, Reliable Catalyst for the Asymmetric Allylation of Ketones, Angew. Chem. Int. Ed. 2002, 41, 3697-3699.
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  36. Chen, Y. K.; Lurain, A. E.; Walsh, P. J. A General, Highly Enantioselective Method for the Synthesis of D and L alpha-Amino Acids and Allylic Amines, J. Am. Chem. Soc. 2002, 124, 12225-12231.
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  37. Buono, F.; Walsh, P. J.; Blackmond, D. G. Rationalization of Anomalous Nonlinear Effects in the Alkylation of Substituted Benzaldehydes, J. Am. Chem. Soc. 2002, 124, 13652-13653.
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  38. Davis, T. J.; Carroll, P. J.; Walsh, P. J. Synthesis and X-ray Structures of (Biphenoxide)Ti Species: Four and Five Coordinate Complexes that Crystallize as Mixtures of Diastereomers. J. Organometallic Chem. 2002, 663, 70-77.
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  39. Garcia, C.; Libra, E. R.; Carroll, P.J.; Walsh, P.J. A one-pot diastereoselective synthesis of cis-3-hexene-1,6-diols via an unusually reactive organozinc intermediate, J. Am. Chem. Soc. 2003, 125, 3210-3211.
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  40. Rios-Moreno G.; Aguirre G.; Parra-Hake M.; Walsh P.J. Synthesis, characterization, and structure of dinuclear copper(I) and silver(I) complexes of ortho-functionalized 1,3-bis(aryl)triazenide ligands, POLYHEDRON 2003, 22, 563-568.
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  41. Honda, A.; Waltz, K.; Carroll, P. J.; Walsh, P. J. Atropisomeric Amides: Achiral Ligands with Chiral Conformations, Invited paper submitted to the special issue of Chirality in honor of Sharpless, Chirality Medal. Chirality 2003, 15, 615-621.
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  42. Jeon, S.; Walsh, P. J. Asymmetric Addition of Alkylzinc Reagent to Cyclic a,b-Unsaturated Ketones and a Tandem Enantioselective Addition/Diastereoselective Epoxidation with Dioxygen, J. Am. Chem. Soc. 2003, 125, 9544-9545.
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  1. Walsh, P. J.; Lurain, A. E.; Balsells, J. Use of Achiral and Meso Ligands to Convey Asymmetry in Asymmetric Catalysis, Invited paper in for special issue "Frontiers in Asymmetric Catalysis" Chemical Reviews, 2003, 108, 3297-3344.
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  2. Walsh, P.J. Mechanistic Insight and Applications of the Titanium Catalyzed Addition of Alkyls to Aldehydes, Accounts of Chemical Research, 2003, ASAP.
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  3. Lurain, A. E.; Walsh, P. J. A Catalytic Asymmetric Method for the Synthesis of c-Unsaturated b-Amino Acid Derivatives, J. Am. Chem. Soc. 2003, 125, 10677-10683.
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  1. Garcia, Garcia, C.; Walsh, P. J. Highly Enantioselective Catalytic Phenylation of Ketones with a Constrained Geometry Titanium Catalyst, Org. Lett. 2003, 5, 3641-3644.
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  2. Blum, S. A.; Walsh, P. J.; Bergman, R. G.  Epoxide-Opening and Group-Transfer Reactions Mediated by Monomeric Zirconium Imido Complexes, J. Am. Chem. Soc. 2003, 125, 14276-14277.

  3. Waltz, K.M.; Carroll, P. J.; Walsh, P. J. Solid State Structures and Solution Behavior of Titanium(IV) Octahydrobinaphtholate Complexes. Examination of Nonlinear Behavior in the Asymmetric Addition of Ethyl Groups to Benzaldehyde Organometallics 2004, 23, 127-134.
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  1. Mastranzo, V. M.; Quintero, L.; Anaya de Parrodi, C.; Juaristi, E.; Walsh, P. J. Use of diamines containing the  alpha-phenylethyl group as chiral ligands in the asymmetric hydrosilylation of prochiral ketones Tetrahedron 2004, 60, 1781-1789

  2. Li, H; García, C.; Walsh, P. J. Catalytic Asymmetric Addition of Diphenylzinc to Cyclic a,b-Unsaturated Ketones, Invited paper for a special issue dedicated to asymmetric catalysis, PNAS 2004, 101, 5425-5427.
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  1. Betancort, J. M.; García, C.; Walsh, P. J, Development of the First Practical Catalyst for the Asymmetric Addition of Alkyl and Aryl Groups to Ketones, Synlett (Account) 2004, 749-760.
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  2. Chen, Y. K.; Walsh, P. J.  A One-Pot Multicomponent Coupling Reaction for the Stereocontrolled Synthesis of (Z)-Trisubstituted Allylic Alcohols, J. Am. Chem. Soc. 2004, 126, 3702-3703.
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  1. Li, H.; Walsh, P. J. Asymmetric Vinylation of Ketones, J. Am. Chem. Soc. 2004, 126, 6538-6539.
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  1. Jimeno, C.; Rios, R.; Carroll, P. J.; Walsh, P. J.  Diastereoselective Addition of Organometallic Reagents to Atropisomeric 2-Formylarylamides, Invited paper for a special issue of Tetrahedron 2004, 60, 4543-4548.
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  2. Chan, V.; Kim, J. G.; Jimeno, C.; Carroll, P. J.; Walsh, P. J.  Dynamic Kinetic Asymmetric Transformation of Atropisomeric Amides, Org. Lett. 2004, 6, 2151-2153
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  1. Kim, J. G.; Waltz, K. M.; Garcia, I. F.; Kwiatkowski, D.; Walsh, P. J., Catalytic Asymmetric Allylation of Ketones and Cyclic Enones: Tandem Diastereoselective Epoxidation with TBHP, J. Am. Chem. Soc. 2004, 126,12580-12585.
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  1. Anaya de Parrodi, Cecilia; Walsh, Patrick J., trans-1,2-Diaminocyclopentane-Based Catalyst for the Asymmetric Addition of Alkyl-, Aryl-, and Vinyl Groups to Ketones, Invited paper in Synlett 2004, 2417-2420.
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  1. Lurain, A. L.; Maestri, A.; Kelly, A. R.; Carroll, P. J.; Walsh, P. J. Enantio- and Diastereoselective One-Pot Synthesis of Acyclic Epoxy Alcohols with Three Contiguous Stereocenters, J. Am. Chem. Soc. 2004, 126,13608-13609.
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  1. Jeon, S. J.; Li, H.; García, C.; Walsh, P. J., Catalytic Asymmetric Addition of Alkylzinc and Functionalized Alkylzinc Reagents to Ketones, J. Org. Chem. 2005; 70, 448-455.
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  1. Lurain, A. L.; Carroll, P. J.; Walsh, P. J. One-Pot Asymmetric Synthesis of Chiral Epoxy Alcohols: A Tandem Approach Using Vinylzinc Addition to an Aldehyde and in situ Epoxidation with Molecular Oxygen, J. Org. Chem. 2005; 70, 1262-1268.
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  1. Jeon, S. –J.; Chen, Y. K.; Walsh, P. J. Catalytic Asymmetric Synthesis of Hydroxy Enolethers: Approach to a Two-Carbon Homologation of Aldehydes Org. Lett. 2005, 7, 1729-1732.
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  1. Costa, A. M.; García, C.; Carrol, P. J.; Walsh, P. J.,  Dramatic Catalyst Evolution in the Asymmetric Addition of Diethylzinc to Benzaldehyde, Invited paper, Tetrahedron 2005, 61, 6442-6446.
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  1. Li, H.; Walsh, P. J. Catalytic Asymmetric Vinylation and Dienylation of Ketones, J. Am. Chem. Soc. 2005, 127, 8355-8361.
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