Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
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Glucose-responsive neurons of the paraventricular thalamus control sucrose-seeking behavior

Mon, 06/20/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4331

Authors: Gwenaël Labouèbe, Benjamin Boutrel, David Tarussio & Bernard Thorens

Feeding behavior is governed by homeostatic needs and motivational drive to obtain palatable foods. Here, we identify a population of glutamatergic neurons in the paraventricular thalamus of mice that express the glucose transporter Glut2 (encoded by Slc2a2) and project to the nucleus accumbens. These neurons are activated by hypoglycemia and, in freely moving mice, their activation by optogenetics or Slc2a2 inactivation increases motivated sucrose-seeking but not saccharin-seeking behavior. These neurons may control sugar overconsumption in obesity and diabetes.

Bidirectional prefrontal-hippocampal interactions support context-guided memory

Mon, 06/20/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4327

Authors: Ryan Place, Anja Farovik, Marco Brockmann & Howard Eichenbaum

We compared the dynamics of hippocampal and prefrontal interactions in rats as they used spatial contexts to guide the retrieval of object memories. Functional connectivity analysis indicated a flow of contextual information from the hippocampus to prefrontal cortex upon the rat's entry into the spatial context. Conversely, upon the onset of object sampling, the direction of information flow reversed, consistent with prefrontal control over the retrieval of context-appropriate hippocampal memory representations.

Neuronal activity enhances tau propagation and tau pathology in vivo

Mon, 06/20/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4328

Authors: Jessica W Wu, Syed A Hussaini, Isle M Bastille, Gustavo A Rodriguez, Ana Mrejeru, Kelly Rilett, David W Sanders, Casey Cook, Hongjun Fu, Rick A C M Boonen, Mathieu Herman, Eden Nahmani, Sheina Emrani, Y Helen Figueroa, Marc I Diamond, Catherine L Clelland, Selina Wray & Karen E Duff

The mouse cortico-striatal projectome

Mon, 06/20/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4332

Authors: Houri Hintiryan, Nicholas N Foster, Ian Bowman, Maxwell Bay, Monica Y Song, Lin Gou, Seita Yamashita, Michael S Bienkowski, Brian Zingg, Muye Zhu, X William Yang, Jean C Shih, Arthur W Toga & Hong-Wei Dong

Age-related myelin degradation burdens the clearance function of microglia during aging

Mon, 06/13/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4325

Authors: Shima Safaiyan, Nirmal Kannaiyan, Nicolas Snaidero, Simone Brioschi, Knut Biber, Simon Yona, Aimee L Edinger, Steffen Jung, Moritz J Rossner & Mikael Simons

Myelin is synthesized as a multilamellar membrane, but the mechanisms of membrane turnover are unknown. We found that myelin pieces were gradually released from aging myelin sheaths and were subsequently cleared by microglia. Myelin fragmentation increased with age and led to the formation of insoluble, lipofuscin-like lysosomal inclusions in microglia. Thus, age-related myelin fragmentation is substantial, leading to lysosomal storage and contributing to microglial senescence and immune dysfunction in aging.

A fast pathway for fear in human amygdala

Mon, 06/13/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4324

Authors: Constantino Méndez-Bértolo, Stephan Moratti, Rafael Toledano, Fernando Lopez-Sosa, Roberto Martínez-Alvarez, Yee H Mah, Patrik Vuilleumier, Antonio Gil-Nagel & Bryan A Strange

Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair

Mon, 06/13/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4321

Authors: Susanne Quintes, Bastian G Brinkmann, Madlen Ebert, Franziska Fröb, Theresa Kungl, Friederike A Arlt, Victor Tarabykin, Danny Huylebroeck, Dies Meijer, Ueli Suter, Michael Wegner, Michael W Sereda & Klaus-Armin Nave

Lrp4 in astrocytes modulates glutamatergic transmission

Mon, 06/13/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4326

Authors: Xiang-Dong Sun, Lei Li, Fang Liu, Zhi-Hui Huang, Jonathan C Bean, Hui-Feng Jiao, Arnab Barik, Seon-Myung Kim, Haitao Wu, Chengyong Shen, Yun Tian, Thiri W Lin, Ryan Bates, Anupama Sathyamurthy, Yong-Jun Chen, Dong-Min Yin, Lei Xiong, Hui-Ping Lin, Jin-Xia Hu, Bao-Ming Li, Tian-Ming Gao, Wen-Cheng Xiong & Lin Mei

Orientation selectivity and the functional clustering of synaptic inputs in primary visual cortex

Mon, 06/13/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4323

Authors: Daniel E Wilson, David E Whitney, Benjamin Scholl & David Fitzpatrick

Zeb2 recruits HDAC–NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination

Mon, 06/13/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4322

Authors: Lai Man Natalie Wu, Jincheng Wang, Andrea Conidi, Chuntao Zhao, Haibo Wang, Zachary Ford, Liguo Zhang, Christiane Zweier, Brian G Ayee, Patrice Maurel, An Zwijsen, Jonah R Chan, Michael P Jankowski, Danny Huylebroeck & Q Richard Lu

Topographical representation of odor hedonics in the olfactory bulb

Mon, 06/06/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4317

Authors: Florence Kermen, Maëllie Midroit, Nicola Kuczewski, Jérémy Forest, Marc Thévenet, Joëlle Sacquet, Claire Benetollo, Marion Richard, Anne Didier & Nathalie Mandairon

Hedonic value is a dominant aspect of olfactory perception. Using optogenetic manipulation in freely behaving mice paired with immediate early gene mapping, we demonstrate that hedonic information is represented along the antero-posterior axis of the ventral olfactory bulb. Using this representation, we show that the degree of attractiveness of odors can be bidirectionally modulated by local manipulation of the olfactory bulb's neural networks in freely behaving mice.

SHANK3 controls maturation of social reward circuits in the VTA

Mon, 06/06/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4319

Authors: Sebastiano Bariselli, Stamatina Tzanoulinou, Christelle Glangetas, Clément Prévost-Solié, Luca Pucci, Joanna Viguié, Paola Bezzi, Eoin C O'Connor, François Georges, Christian Lüscher & Camilla Bellone

YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells

Mon, 06/06/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4316

Authors: Yannick Poitelon, Camila Lopez-Anido, Kathleen Catignas, Caterina Berti, Marilena Palmisano, Courtney Williamson, Dominique Ameroso, Kansho Abiko, Yoonchan Hwang, Alex Gregorieff, Jeffrey L Wrana, Mohammadnabi Asmani, Ruogang Zhao, Fraser James Sim, Lawrence Wrabetz, John Svaren & Maria Laura Feltri

Decoding subjective decisions from orbitofrontal cortex

Mon, 06/06/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4320

Authors: Erin L Rich & Jonathan D Wallis

Hippocampal global remapping for different sensory modalities in flying bats

Mon, 05/30/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4310

Authors: Maya Geva-Sagiv, Sandro Romani, Liora Las & Nachum Ulanovsky

Opposing mechanisms mediate morphine- and cocaine-induced generation of silent synapses

Mon, 05/30/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4313

Authors: Nicholas M Graziane, Shichao Sun, William J Wright, Daniel Jang, Zheng Liu, Yanhua H Huang, Eric J Nestler, Yu Tian Wang, Oliver M Schlüter & Yan Dong

An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior

Mon, 05/30/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4315

Authors: Yonwoo Jung, Lawrence S Hsieh, Angela M Lee, Zhifeng Zhou, Daniel Coman, Christopher J Heath, Fahmeed Hyder, Yann S Mineur, Qiaoping Yuan, David Goldman, Angelique Bordey & Marina R Picciotto

Silencing CA3 disrupts temporal coding in the CA1 ensemble

Mon, 05/30/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4311

Authors: Steven J Middleton & Thomas J McHugh

Olfactory receptor for prostaglandin F2α mediates male fish courtship behavior

Mon, 05/30/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4314

Authors: Yoichi Yabuki, Tetsuya Koide, Nobuhiko Miyasaka, Noriko Wakisaka, Miwa Masuda, Masamichi Ohkura, Junichi Nakai, Kyoshiro Tsuge, Soken Tsuchiya, Yukihiko Sugimoto & Yoshihiro Yoshihara

Evaluation of ambiguous associations in the amygdala by learning the structure of the environment

Mon, 05/23/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4308

Authors: Tamas J Madarasz, Lorenzo Diaz-Mataix, Omar Akhand, Edgar A Ycu, Joseph E LeDoux & Joshua P Johansen