Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
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Reactivations of emotional memory in the hippocampus–amygdala system during sleep

Mon, 09/11/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4637

Authors: Gabrielle Girardeau, Ingrid Inema & György Buzsáki

Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis

Mon, 09/11/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4638

Authors: Stacey M Glasgow, Jeffrey C Carlson, Wenyi Zhu, Lesley S Chaboub, Peng Kang, Hyun Kyoung Lee, Yoanne M Clovis, Brittney E Lozzi, Robert J McEvilly, Michael G Rosenfeld, Chad J Creighton, Soo-Kyung Lee, Carrie A Mohila & Benjamin Deneen

Seeing faces is necessary for face-domain formation

Mon, 09/04/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4635

Authors: Michael J Arcaro, Peter F Schade, Justin L Vincent, Carlos R Ponce & Margaret S Livingstone

Parallel encoding of recent visual experience and self-motion during navigation in Drosophila

Mon, 09/04/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4628

Authors: Hiroshi M Shiozaki & Hokto Kazama

Impaired hippocampal place cell dynamics in a mouse model of the 22q11.2 deletion

Mon, 09/04/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4634

Authors: Jeffrey D Zaremba, Anastasia Diamantopoulou, Nathan B Danielson, Andres D Grosmark, Patrick W Kaifosh, John C Bowler, Zhenrui Liao, Fraser T Sparks, Joseph A Gogos & Attila Losonczy

An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome

Mon, 09/04/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4632

Authors: Bernard Ng, Charles C White, Hans-Ulrich Klein, Solveig K Sieberts, Cristin McCabe, Ellis Patrick, Jishu Xu, Lei Yu, Chris Gaiteri, David A Bennett, Sara Mostafavi & Philip L De Jager

Memory reactivation improves visual perception

Mon, 08/28/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4629

Authors: Rotem Amar-Halpert, Rony Laor-Maayany, Shlomi Nemni, Jonathan D Rosenblatt & Nitzan Censor

Human perception thresholds can improve through learning. Here we report findings challenging the fundamental 'practice makes perfect' basis of procedural learning theory, showing that brief reactivations of encoded visual memories are sufficient to improve perceptual discrimination thresholds. Learning was comparable to standard practice-induced learning and was not due to short training per se, nor to an epiphenomenon of primed retrieval enhancement. The results demonstrate that basic perceptual functions can be substantially improved by memory reactivation, supporting a new account of perceptual learning dynamics.

Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging

Mon, 08/28/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4631

Authors: Petra Füger, Jasmin K Hefendehl, Karthik Veeraraghavalu, Ann-Christin Wendeln, Christine Schlosser, Ulrike Obermüller, Bettina M Wegenast-Braun, Jonas J Neher, Peter Martus, Shinichi Kohsaka, Martin Thunemann, Robert Feil, Sangram S Sisodia, Angelos Skodras & Mathias Jucker

Glia initiate brain assembly through noncanonical Chimaerin–Furin axon guidance in C. elegans

Mon, 08/28/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4630

Authors: Georgia Rapti, Chang Li, Alan Shan, Yun Lu & Shai Shaham

Central amygdala circuits modulate food consumption through a positive-valence mechanism

Mon, 08/21/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4623

Authors: Amelia M Douglass, Hakan Kucukdereli, Marion Ponserre, Milica Markovic, Jan Gründemann, Cornelia Strobel, Pilar L Alcala Morales, Karl-Klaus Conzelmann, Andreas Lüthi & Rüdiger Klein

Selective inhibitory control of pyramidal neuron ensembles and cortical subnetworks by chandelier cells

Mon, 08/21/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4624

Authors: Jiangteng Lu, Jason Tucciarone, Nancy Padilla-Coreano, Miao He, Joshua A Gordon & Z Josh Huang

AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma

Mon, 08/14/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4620

Authors: Ryan D Chow, Christopher D Guzman, Guangchuan Wang, Florian Schmidt, Mark W Youngblood, Lupeng Ye, Youssef Errami, Matthew B Dong, Michael A Martinez, Sensen Zhang, Paul Renauer, Kaya Bilguvar, Murat Gunel, Phillip A Sharp, Feng Zhang, Randall J Platt & Sidi Chen

Selective attention within the foveola

Mon, 08/14/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4622

Authors: Martina Poletti, Michele Rucci & Marisa Carrasco

Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatry

Mon, 08/14/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4618

Authors: Hon-Cheong So, Carlos Kwan-Long Chau, Wan-To Chiu, Kin-Sang Ho, Cho-Pong Lo, Stephanie Ho-Yue Yim & Pak-Chung Sham

Cerebellar granule cell replenishment postinjury by adaptive reprogramming of Nestin+ progenitors

Mon, 08/14/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4621

Authors: Alexandre Wojcinski, Andrew K Lawton, N Sumru Bayin, Zhimin Lao, Daniel N Stephen & Alexandra L Joyner

Antipsychotic-induced Hdac2 transcription via NF-κB leads to synaptic and cognitive side effects

Mon, 08/07/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4616

Authors: Daisuke Ibi, Mario de la Fuente Revenga, Nebojsa Kezunovic, Carolina Muguruza, Justin M Saunders, Supriya A Gaitonde, José L Moreno, Maryum K Ijaz, Vishaka Santosh, Alexey Kozlenkov, Terrell Holloway, Jeremy Seto, Aintzane García-Bea, Mitsumasa Kurita, Grace E Mosley, Yan Jiang, Daniel J Christoffel, Luis F Callado, Scott J Russo, Stella Dracheva, Juan F López-Giménez, Yongchao Ge, Carlos R Escalante, J Javier Meana, Schahram Akbarian, George W Huntley & Javier González-Maeso

Structure in neural population recordings: an expected byproduct of simpler phenomena?

Mon, 08/07/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4617

Authors: Gamaleldin F Elsayed & John P Cunningham

Zika virus directly infects peripheral neurons and induces cell death

Mon, 07/31/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4612

Authors: Yohan Oh, Feiran Zhang, Yaqing Wang, Emily M Lee, In Young Choi, Hotae Lim, Fahimeh Mirakhori, Ronghua Li, Luoxiu Huang, Tianlei Xu, Hao Wu, Cui Li, Cheng-Feng Qin, Zhexing Wen, Qing-Feng Wu, Hengli Tang, Zhiheng Xu, Peng Jin, Hongjun Song, Guo-li Ming & Gabsang Lee

Zika virus (ZIKV) infection is associated with neurological disorders of both the CNS and peripheral nervous systems (PNS), yet few studies have directly examined PNS infection. Here we show that intraperitoneally or intraventricularly injected ZIKV in the mouse can infect and impact peripheral neurons in vivo. Moreover, ZIKV productively infects stem-cell-derived human neural crest cells and peripheral neurons in vitro, leading to increased cell death, transcriptional dysregulation and cell-type-specific molecular pathology.

Adults with autism overestimate the volatility of the sensory environment

Mon, 07/31/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4615

Authors: Rebecca P Lawson, Christoph Mathys & Geraint Rees

Dorsal hippocampus contributes to model-based planning

Mon, 07/31/2017 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4613

Authors: Kevin J Miller, Matthew M Botvinick & Carlos D Brody