Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
Updated: 3 hours 21 min ago

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Mon, 02/01/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4228

Authors: Barbara Franke, Jason L Stein, Stephan Ripke, Verneri Anttila, Derrek P Hibar, Kimm J E van Hulzen, Alejandro Arias-Vasquez, Jordan W Smoller, Thomas E Nichols, Michael C Neale, Andrew M McIntosh, Phil Lee, Francis J McMahon, Andreas Meyer-Lindenberg, Manuel Mattheisen, Ole A Andreassen, Oliver Gruber, Perminder S Sachdev, Roberto Roiz-Santiañez, Andrew J Saykin, Stefan Ehrlich, Karen A Mather, Jessica A Turner, Emanuel Schwarz, Anbupalam Thalamuthu, Yin Yao, Yvonne Y W Ho, Nicholas G Martin, Margaret J Wright, Michael C O'Donovan, Paul M Thompson, Benjamin M Neale, Sarah E Medland & Patrick F Sullivan

Engineering microdeletions and microduplications by targeting segmental duplications with CRISPR

Mon, 02/01/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4235

Authors: Derek J C Tai, Ashok Ragavendran, Poornima Manavalan, Alexei Stortchevoi, Catarina M Seabra, Serkan Erdin, Ryan L Collins, Ian Blumenthal, Xiaoli Chen, Yiping Shen, Mustafa Sahin, Chengsheng Zhang, Charles Lee, James F Gusella & Michael E Talkowski

PV plasticity sustained through D1/5 dopamine signaling required for long-term memory consolidation

Mon, 01/25/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4231

Authors: Smitha Karunakaran, Ananya Chowdhury, Flavio Donato, Charles Quairiaux, Christoph M Michel & Pico Caroni

Separate circuitries encode the hedonic and nutritional values of sugar

Mon, 01/25/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4224

Authors: Luis A Tellez, Wenfei Han, Xiaobing Zhang, Tatiana L Ferreira, Isaac O Perez, Sara J Shammah-Lagnado, Anthony N van den Pol & Ivan E de Araujo

Epigenomic annotation of gene regulatory alterations during evolution of the primate brain

Mon, 01/25/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4229

Authors: Marit W Vermunt, Sander C Tan, Bas Castelijns, Geert Geeven, Peter Reinink, Ewart de Bruijn, Ivanela Kondova, Stephan Persengiev, Ronald Bontrop, Edwin Cuppen, Wouter de Laat & Menno P Creyghton

PTEN recruitment controls synaptic and cognitive function in Alzheimer's models

Mon, 01/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4225

Authors: Shira Knafo, Cristina Sánchez-Puelles, Ernest Palomer, Igotz Delgado, Jonathan E Draffin, Janire Mingo, Tina Wahle, Kanwardeep Kaleka, Liping Mou, Inmaculada Pereda-Perez, Edvin Klosi, Erik B Faber, Heidi M Chapman, Laura Lozano-Montes, Ana Ortega-Molina, Lara Ordóñez-Gutiérrez, Francisco Wandosell, Jose Viña, Carlos G Dotti, Randy A Hall, Rafael Pulido, Nashaat Z Gerges, Andrew M Chan, Mark R Spaller, Manuel Serrano, César Venero & José A Esteban

Nicotinic receptors in the ventral tegmental area promote uncertainty-seeking

Mon, 01/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4223

Authors: Jérémie Naudé, Stefania Tolu, Malou Dongelmans, Nicolas Torquet, Sébastien Valverde, Guillaume Rodriguez, Stéphanie Pons, Uwe Maskos, Alexandre Mourot, Fabio Marti & Philippe Faure

On-going computation of whisking phase by mechanoreceptors

Mon, 01/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4221

Authors: Avner Wallach, Knarik Bagdasarian & Ehud Ahissar

Illuminating next-generation brain therapies

Mon, 01/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4232

Authors: Emily Ferenczi & Karl Deisseroth

A clinical trial inspired and guided by optogenetics experiments in rodents reports the outcome of targeted transcranial magnetic stimulation in patients suffering from cocaine addiction.

Microglial brain region−dependent diversity and selective regional sensitivities to aging

Mon, 01/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4222

Authors: Kathleen Grabert, Tom Michoel, Michail H Karavolos, Sara Clohisey, J Kenneth Baillie, Mark P Stevens, Tom C Freeman, Kim M Summers & Barry W McColl

KIF1A inhibition immortalizes brain stem cells but blocks BDNF-mediated neuronal migration

Mon, 01/11/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4213

Authors: Aurelie Carabalona, Daniel Jun-Kit Hu & Richard B Vallee

Parallel specification of competing sensorimotor control policies for alternative action options

Mon, 01/11/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4214

Authors: Jason P Gallivan, Lindsey Logan, Daniel M Wolpert & J Randall Flanagan

Bidirectional GABAergic control of action potential firing in newborn hippocampal granule cells

Mon, 01/11/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4218

Authors: Stefanie Heigele, Sébastien Sultan, Nicolas Toni & Josef Bischofberger

Activation of raphe nuclei triggers rapid and distinct effects on parallel olfactory bulb output channels

Mon, 01/11/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4219

Authors: Vikrant Kapoor, Allison C Provost, Prateek Agarwal & Venkatesh N Murthy

Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation

Mon, 01/11/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4211

Authors: Qiang Liu, Nader Sanai, Wei-Na Jin, Antonio La Cava, Luc Van Kaer & Fu-Dong Shi

Coherent neuronal ensembles are rapidly recruited when making a look-reach decision

Mon, 01/11/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4210

Authors: Yan T Wong, Margaret M Fabiszak, Yevgeny Novikov, Nathaniel D Daw & Bijan Pesaran

Laterodorsal tegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear

Mon, 01/04/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4208

Authors: Hongbin Yang, Junhua Yang, Wang Xi, Sijia Hao, Benyan Luo, Xiaobin He, Liya Zhu, Huifang Lou, Yan-qin Yu, Fuqiang Xu, Shumin Duan & Hao Wang

Adult mouse cortical cell taxonomy revealed by single cell transcriptomics

Mon, 01/04/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4216

Authors: Bosiljka Tasic, Vilas Menon, Thuc Nghi Nguyen, Tae Kyung Kim, Tim Jarsky, Zizhen Yao, Boaz Levi, Lucas T Gray, Staci A Sorensen, Tim Dolbeare, Darren Bertagnolli, Jeff Goldy, Nadiya Shapovalova, Sheana Parry, Changkyu Lee, Kimberly Smith, Amy Bernard, Linda Madisen, Susan M Sunkin, Michael Hawrylycz, Christof Koch & Hongkui Zeng

The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain

Mon, 12/21/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4199

Authors: Wenjie Ren, Maria Virginia Centeno, Sara Berger, Ying Wu, Xiaodong Na, Xianguo Liu, Jyothisri Kondapalli, A Vania Apkarian, Marco Martina & D James Surmeier

We examined adaptations in nucleus accumbens (NAc) neurons in mouse and rat peripheral nerve injury models of neuropathic pain. Injury selectively increased excitability of NAc shell indirect pathway spiny projection neurons (iSPNs) and altered their synaptic connectivity. Moreover, injury-induced tactile allodynia was reversed by inhibiting and exacerbated by exciting iSPNs, indicating that they not only participated in the central representation of pain, but gated activity in ascending nociceptive pathways.

Hypothalamic feedforward inhibition of thalamocortical network controls arousal and consciousness

Mon, 12/21/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4209

Authors: Carolina Gutierrez Herrera, Marta Carus Cadavieco, Sonia Jego, Alexey Ponomarenko, Tatiana Korotkova & Antoine Adamantidis