Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
Updated: 1 hour 34 min ago

Hypothalamic arcuate nucleus tyrosine hydroxylase neurons play orexigenic role in energy homeostasis

Mon, 08/22/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4372

Authors: Xiaobing Zhang & Anthony N van den Pol

Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca2+ channel–vesicle coupling

Mon, 08/15/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4364

Authors: Mathias A Böhme, Christina Beis, Suneel Reddy-Alla, Eric Reynolds, Malou M Mampell, Andreas T Grasskamp, Janine Lützkendorf, Dominique Dufour Bergeron, Jan H Driller, Husam Babikir, Fabian Göttfert, Iain M Robinson, Cahir J O'Kane, Stefan W Hell, Markus C Wahl, Ulrich Stelzl, Bernhard Loll, Alexander M Walter & Stephan J Sigrist

Representation of egomotion in rat's trident and E-row whisker cortices

Mon, 08/15/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4363

Authors: Edith Chorev, Patricia Preston Ferrer & Michael Brecht

Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration

Mon, 08/15/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4360

Authors: Melanie von Schimmelmann, Philip A Feinberg, Josefa M Sullivan, Stacy M Ku, Ana Badimon, Mary Kaye Duff, Zichen Wang, Alexander Lachmann, Scott Dewell, Avi Ma'ayan, Ming-Hu Han, Alexander Tarakhovsky & Anne Schaefer

Diminished KCC2 confounds synapse specificity of LTP during senescence

Mon, 08/08/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4357

Authors: Isabella Ferando, Guido C Faas & Istvan Mody

The synapse specificity of long-term potentiation (LTP) ensures that no interference arises from inputs irrelevant to the memory to be encoded. In hippocampi of aged (21–28 months) mice, LTP was relayed to unstimulated synapses, blemishing its synapse specificity. Diminished levels of the K+/Cl− cotransporter KCC2 and a depolarizing GABAA receptor-mediated synaptic component following LTP were the most likely causes for the spreading of potentiation, unveiling mechanisms hindering information storage in the aged brain and identifying KCC2 as a potential target for intervention.

Connectivity precedes function in the development of the visual word form area

Mon, 08/08/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4354

Authors: Zeynep M Saygin, David E Osher, Elizabeth S Norton, Deanna A Youssoufian, Sara D Beach, Jenelle Feather, Nadine Gaab, John D E Gabrieli & Nancy Kanwisher

Meta-analysis of 2,104 trios provides support for 10 new genes for intellectual disability

Mon, 08/01/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4352

Authors: Stefan H Lelieveld, Margot R F Reijnders, Rolph Pfundt, Helger G Yntema, Erik-Jan Kamsteeg, Petra de Vries, Bert B A de Vries, Marjolein H Willemsen, Tjitske Kleefstra, Katharina Löhner, Maaike Vreeburg, Servi J C Stevens, Ineke van der Burgt, Ernie M H F Bongers, Alexander P A Stegmann, Patrick Rump, Tuula Rinne, Marcel R Nelen, Joris A Veltman, Lisenka E L M Vissers, Han G Brunner & Christian Gilissen

To identify candidate genes for intellectual disability, we performed a meta-analysis on 2,637 de novo mutations, identified from the exomes of 2,104 patient–parent trios. Statistical analyses identified 10 new candidate ID genes: DLG4, PPM1D, RAC1, SMAD6, SON, SOX5, SYNCRIP, TCF20, TLK2 and TRIP12. In addition, we show that these genes are intolerant to nonsynonymous variation and that mutations in these genes are associated with specific clinical ID phenotypes.

Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder

Mon, 08/01/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4353

Authors: Arjun Krishnan, Ran Zhang, Victoria Yao, Chandra L Theesfeld, Aaron K Wong, Alicja Tadych, Natalia Volfovsky, Alan Packer, Alex Lash & Olga G Troyanskaya

The coding of cutaneous temperature in the spinal cord

Mon, 07/25/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4350

Authors: Chen Ran, Mark A Hoon & Xiaoke Chen

Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning

Mon, 07/25/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4351

Authors: Lin Xiao, David Ohayon, Ian A McKenzie, Alexander Sinclair-Wilson, Jordan L Wright, Alexander D Fudge, Ben Emery, Huiliang Li & William D Richardson

Sensory and decision-related activity propagate in a cortical feedback loop during touch perception

Wed, 07/20/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4356

Authors: Sung Eun Kwon, Hongdian Yang, Genki Minamisawa & Daniel H O'Connor

Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior

Mon, 07/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4347

Authors: Alexi Nott, Jemmie Cheng, Fan Gao, Yuan-Ta Lin, Elizabeta Gjoneska, Tak Ko, Paras Minhas, Alicia Viridiana Zamudio, Jia Meng, Feiran Zhang, Peng Jin & Li-Huei Tsai

Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics

Mon, 07/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4346

Authors: Yair Shemesh, Oren Forkosh, Mathias Mahn, Sergey Anpilov, Yehezkel Sztainberg, Sharon Manashirov, Tamar Shlapobersky, Evan Elliott, Laure Tabouy, Gili Ezra, Elaine S Adler, Yair J Ben-Efraim, Shosh Gil, Yael Kuperman, Sharon Haramati, Julien Dine, Matthias Eder, Jan M Deussing, Elad Schneidman, Ofer Yizhar & Alon Chen

Infantile amnesia reflects a developmental critical period for hippocampal learning

Mon, 07/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4348

Authors: Alessio Travaglia, Reto Bisaz, Eric S Sweet, Robert D Blitzer & Cristina M Alberini

ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks

Mon, 07/18/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4345

Authors: Ritchie Ho, Samuel Sances, Genevieve Gowing, Mackenzie Weygandt Amoroso, Jacqueline G O'Rourke, Anais Sahabian, Hynek Wichterle, Robert H Baloh, Dhruv Sareen & Clive N Svendsen

Postsynaptic, not presynaptic NMDA receptors are required for spike-timing-dependent LTD induction

Mon, 07/11/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4343

Authors: Brett C Carter & Craig E Jahr

Neural activity promotes long-distance, target-specific regeneration of adult retinal axons

Mon, 07/11/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4340

Authors: Jung-Hwan A Lim, Benjamin K Stafford, Phong L Nguyen, Brian V Lien, Chen Wang, Katherine Zukor, Zhigang He & Andrew D Huberman

Fast and slow transitions in frontal ensemble activity during flexible sensorimotor behavior

Mon, 07/11/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4342

Authors: Michael J Siniscalchi, Victoria Phoumthipphavong, Farhan Ali, Marc Lozano & Alex C Kwan

Multilaminar networks of cortical neurons integrate common inputs from sensory thalamus

Mon, 07/04/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4339

Authors: Nicolás A Morgenstern, Jacques Bourg & Leopoldo Petreanu

Segregated cholinergic transmission modulates dopamine neurons integrated in distinct functional circuits

Mon, 06/27/2016 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4335

Authors: Daniel Dautan, Albert S Souza, Icnelia Huerta-Ocampo, Miguel Valencia, Maxime Assous, Ilana B Witten, Karl Deisseroth, James M Tepper, J Paul Bolam, Todor V Gerdjikov & Juan Mena-Segovia