Nature Neuroscience

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Nature Neuroscience offers a unique mix of opinion and reviews alongside top-quality research papers. Published monthly, in print and online, the journal reflects the entire spectrum of neuroscience, from molecular to cognitive.
Updated: 15 hours 2 min ago

Regulating anxiety with extrasynaptic inhibition

Mon, 08/31/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4102

Authors: Paolo Botta, Lynda Demmou, Yu Kasugai, Milica Markovic, Chun Xu, Jonathan P Fadok, Tingjia Lu, Michael M Poe, Li Xu, James M Cook, Uwe Rudolph, Pankaj Sah, Francesco Ferraguti & Andreas Lüthi

Molecular profiling of activated olfactory neurons identifies odorant receptors for odors in vivo

Mon, 08/31/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4104

Authors: Yue Jiang, Naihua Natalie Gong, Xiaoyang Serene Hu, Mengjue Jessica Ni, Radhika Pasi & Hiroaki Matsunami

Centrosomin represses dendrite branching by orienting microtubule nucleation

Mon, 08/31/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4099

Authors: Cagri Yalgin, Saman Ebrahimi, Caroline Delandre, Li Foong Yoong, Saori Akimoto, Heidi Tran, Reiko Amikura, Rebecca Spokony, Benjamin Torben-Nielsen, Kevin P White & Adrian W Moore

Large-scale transcriptional profiling of chemosensory neurons identifies receptor-ligand pairs in vivo

Mon, 08/31/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4100

Authors: Benoît von der Weid, Daniel Rossier, Matti Lindup, Joël Tuberosa, Alexandre Widmer, Julien Dal Col, Chenda Kan, Alan Carleton & Ivan Rodriguez

Neuronal pattern separation in the olfactory bulb improves odor discrimination learning

Mon, 08/24/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4089

Authors: Olivier Gschwend, Nixon M Abraham, Samuel Lagier, Frédéric Begnaud, Ivan Rodriguez & Alan Carleton

BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice

Mon, 08/24/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4095

Authors: Erica Korb, Margo Herre, Ilana Zucker-Scharff, Robert B Darnell & C David Allis

Coordinated forms of noradrenergic plasticity in the locus coeruleus and primary auditory cortex

Mon, 08/24/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4090

Authors: Ana Raquel O Martins & Robert C Froemke

GABAergic mechanisms regulated by miR-33 encode state-dependent fear

Mon, 08/17/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4084

Authors: Vladimir Jovasevic, Kevin A Corcoran, Katherine Leaderbrand, Naoki Yamawaki, Anita L Guedea, Helen J Chen, Gordon M G Shepherd & Jelena Radulovic

EAG2 potassium channel with evolutionarily conserved function as a brain tumor target

Mon, 08/10/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4088

Authors: Xi Huang, Ye He, Adrian M Dubuc, Rintaro Hashizume, Wei Zhang, Jüri Reimand, Huanghe Yang, Tongfei A Wang, Samantha J Stehbens, Susan Younger, Suzanne Barshow, Sijun Zhu, Michael K Cooper, John Peacock, Vijay Ramaswamy, Livia Garzia, Xiaochong Wu, Marc Remke, Craig M Forester, Charles C Kim, William A Weiss, C David James, Marc A Shuman, Gary D Bader, Sabine Mueller, Michael D Taylor, Yuh Nung Jan & Lily Yeh Jan

Cell type–specific manipulation with GFP-dependent Cre recombinase

Mon, 08/10/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4081

Authors: Jonathan C Y Tang, Stephanie Rudolph, Onkar S Dhande, Victoria E Abraira, Seungwon Choi, Sylvain W Lapan, Iain R Drew, Eugene Drokhlyansky, Andrew D Huberman, Wade G Regehr & Constance L Cepko

Instrumental learning of traits versus rewards: dissociable neural correlates and effects on choice

Mon, 08/03/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4080

Authors: Leor M Hackel, Bradley B Doll & David M Amodio

Humans learn about people and objects through positive and negative experiences, yet they can also look beyond the immediate reward of an interaction to encode trait-level attributes. We found that perceivers encoded both reward and trait-level information through feedback in an instrumental learning task, but relied more heavily on trait representations in cross-context decisions. Both learning types implicated ventral striatum, but trait learning also recruited a network associated with social impression formation.

Learning to expect the unexpected: rapid updating in primate cerebellum during voluntary self-motion

Mon, 08/03/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4077

Authors: Jessica X Brooks, Jerome Carriot & Kathleen E Cullen

Dynamic rewiring of neural circuits in the motor cortex in mouse models of Parkinson's disease

Mon, 08/03/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4082

Authors: Lili Guo, Huan Xiong, Jae-Ick Kim, Yu-Wei Wu, Rupa R Lalchandani, Yuting Cui, Yu Shu, Tonghui Xu & Jun B Ding

Cellular evidence for efference copy in Drosophila visuomotor processing

Mon, 08/03/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4083

Authors: Anmo J Kim, Jamie K Fitzgerald & Gaby Maimon

Naturalistic stimulation drives opposing heterosynaptic plasticity at two inputs to songbird cortex

Mon, 08/03/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4078

Authors: W Hamish Mehaffey & Allison J Doupe

Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome

Mon, 08/03/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4072

Authors: Jonathan Witton, Ragunathan Padmashri, Larissa E Zinyuk, Victor I Popov, Igor Kraev, Samantha J Line, Thomas P Jensen, Angelo Tedoldi, Damian M Cummings, Victor L J Tybulewicz, Elizabeth M C Fisher, David M Bannerman, Andrew D Randall, Jonathan T Brown, Frances A Edwards, Dmitri A Rusakov, Michael G Stewart & Matt W Jones

Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections

Mon, 07/27/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4068

Authors: Yonatan M Kupchik, Robyn M Brown, Jasper A Heinsbroek, Mary Kay Lobo, Danielle J Schwartz & Peter W Kalivas

It is widely accepted that D1 dopamine receptor–expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to mouse nucleus accumbens projections to the ventral pallidum. Thus, current thinking attributing D1 and D2 selectivity to accumbens projections akin to dorsal striatal pathways needs to be reconsidered.

Determinants of different deep and superficial CA1 pyramidal cell dynamics during sharp-wave ripples

Mon, 07/27/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4074

Authors: Manuel Valero, Elena Cid, Robert G Averkin, Juan Aguilar, Alberto Sanchez-Aguilera, Tim J Viney, Daniel Gomez-Dominguez, Elisa Bellistri & Liset Menendez de la Prida

Oscillatory dynamics coordinating human frontal networks in support of goal maintenance

Mon, 07/27/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4071

Authors: Bradley Voytek, Andrew S Kayser, David Badre, David Fegen, Edward F Chang, Nathan E Crone, Josef Parvizi, Robert T Knight & Mark D'Esposito

LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control

Mon, 07/27/2015 - 12:00am

Nature Neuroscience. doi:10.1038/nn.4069

Authors: Jianxun Wang, Francesca Telese, Yuliang Tan, Wenbo Li, Chunyu Jin, Xin He, Harihar Basnet, Qi Ma, Daria Merkurjev, Xiaoyan Zhu, Zhijie Liu, Jie Zhang, Kenny Ohgi, Havilah Taylor, Ryan R White, Cagdas Tazearslan, Yousin Suh, Todd S Macfarlan, Samuel L Pfaff & Michael G Rosenfeld