MCEP Chem.#502

Dr.Bill Dailey

University of Pennsylvania

Dept. of Chemistry

 

Information Technology&Experimental Chemistry

What Is Caffeine and How Does It Work?

Caffeine (C8H10N4O2) is the common name for trimethylxanthine (systematic name is 1,3,7-trimethylxanthine or 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione). The chemical is also known as coffeine, theine, mateine, guaranine, or methyltheobromine. Caffeine is naturally produced by several plants, including coffee beans, guarana, yerba maté, cacao beans, and tea. For the plants, caffeine acts as a natural pesticide. It paralyzes and kills insects that attempt to feed on the plants. The molecule was first isolated by the German chemist Friedrich Ferdinand Runge in 1819.

When purified, caffeine is an intensely bitter white powder. It is added to colas and other soft drinks to impart a pleasing bitter note. However, caffeine is also an addictive stimulant.

n humans, it stimulates the central nervous system, heart rate, and respiration, has psychotropic (mood altering) properties, and acts as a mild diuretic.

A normal dose of caffeine is generally considered to be 100 mg, which is roughly the amount found in a cup of coffee. However, more than half of all American adults consume more than 300 mg of caffeine every day, which makes it America's most popular drug. Caffeine is generally consumed in coffee, cola, chocolate, and tea, although it is also available over-the-counter as a stimulant.

Caffeine is believed to work by blocking adenosine receptors in the brain and other organs. This reduces the ability of adenosine to bind to the receptors, which would slow down cellular activity. The stimulated nerve cells release the hormone epinephrine (adrenaline), which increases heart rate, blood pressure, and blood flow to muscles, decreases blood flow to the skin and organs, and causes the liver to release glucose. Caffeine also increases levels of the neurotransmitter dopamine.

http://chemistry.about.com/od/moleculescompounds/a/caffeine.htm

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