We are healthier, richer, safer, and better educated than ever before. Yet, paradoxically, depression is on the rise in the United States. Given the strong emphasis that positive psychology places on the importance of social relationships, I review direct and proxy evidence that relationships are deteriorating in the United States. Additionally, I outline next steps to strengthen this hypothesis. The implications of this work point toward a need to complement the joys of modernity with interventions and policies that support strengthening our weakened relationships.